Experimental thrombogenesis, a method of prophylaxis

College obtained,

a mrasured

infused

into

constant

rat?.

thr

amount

left

Seventy-seven

blood could be recovered sinus, the rest diffusing even

though

occur. was

also

concentrations myocardial

fatty

tantly,

acids

blood

dioxide

the

flow

and

glucose

these

delivered

data

it can

to the heart

is immediately

that

for use. The

ment

Peter

Bent

Brigham

Division,

Harvard

Surgical

oratories.

Harvard

Medical

School,

of stainless

the right atrium

of dogs to stimulate divided

were

slight,

a few fibrin

tween wire loops of the prosthesis; present

between

of

Hospital, Boston,

into

VOLUME 19, FEBRUARY 1967

six

and Lab-

Mass.

no thromstrands

moderate,

be-

thrombus

wire loops of the prosthesis:

total thrombosis

severe.

of the prosthesis. at the end of 28 to 30 days.

Results

were as follows:

All 7 animals

severe

thrombosis

the

of

prosthesis

In and

group 6 died

group

rhage.

In group

In group

in group

prosthesis.

3, 6 of

of hemorrhage.

In

1 had

group

2

5, 5 of 16 dogs had clear

there were no complications The

best

provided

protection

in group

treated with dipyridamole

1,

perience

ness. This

type

clear

group

4.

prosthesis.

prosthesis,

and

in groups 5 and 6.

against

thrombogenesis

6 or in those

anticoagulant-treated

had

In

and 1 died of hemor-

6, 11 of 12 dogs had clear

in

thrombogenesis. groups:

dipyridamolc.

clear,

15 dogs

Method

Research

with

as follows:

dianri-

hemorrhage.

of

steel wire was inserted

l‘he

dogs

treated

with

partially

route

implications

a

‘IYhoracic

A prosthesis

and

were graded

treated 6,

and 13 dogs died of

SHAKEAB ALSHABKHOUN, M.D., Depart-

of Surgery,

results

5.

; group

1 of 7 dogs had clear prosthesis,

Thrombogenesis,

Prophylaxis,

(Persantin”L)

coagulant-treated

anticoagulant-treated

group

2 of 16 dogs had clear prosthesis,

these data are discussed. Experimental

partially

with

with sodium

blood

by the intramyocardial

available

4,

The dogs were sacrificed

Concomi-

and the pH of

be concluded

anticoagulant-treated

xvarfarin;

bus on the prosthesis;

the blood was lowered. From

group

sodium

pattern infusion

blood.

warfarin;

2.

3. anticoagulant-treated

The

during

arterial

group group

Roent-

of oxygen,

was produced,

untreated;

pyridamole

did not

of arterial

of metabolites

from

carbon

of the

32.5

heparin; with

chambers

was observed.

extraction

a

of the infused

of the endocardium

Determination

showed

was at

from the coronary

into the ventricular

verification

venous and

per cent

formation

obtained.

blood

myocardium

promptly

puncture

No hematoma

genographic

of arterial

ventricular

News

with

animals

sodium

warfarin

to depress platelet

of antithrombogenic

has not been reported

study

previously-.

was

partiall) and

adhesiveand

ex-