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Exploring Support Networks and Quality of Life of Metastatic Breast Cancer Patient in Nigeria and Turkey
Abstracts / The Breast 36 S1 (2017) S19–S76
collection rate for the total of 12 weeks was 84.6% (IQR, 44.3–100). The main reasons for missing data were forgetting, worsening of disease and device malfunction. The number of patients who experienced MID was eight and the median time to deterioration was 30 days (95%CI, 7.7–52.3). Conclusions: Compliance with electronic HRQOL data collection in this cohort was acceptable. We plan a prospective study to determine whether the use of electronic real-time feedback of HRQOL results (by means of CHES) improves patient-physician communication and patient’s overall HRQOL.
PO133 EXPLORING SUPPORT NETWORKS AND QUALITY OF LIFE OF METASTATIC BREAST CANCER PATIENT IN NIGERIA AND TURKEY Runcie Chikeruba Wilson Chidebe2, Ebru Tontas1, Charles Tochukwu Orjiako4, Ernest Ike Onyishi3,4 1 Kanserle Dans Dernegi, Palliative Care, Istanbul, Turkey; 2Project PINK BLUE Health & Psychological Trust Centre, Patient Advocacy & Research, Abuja, Nigeria; 3University of Muenster, Germany and University of Nigeria, Nsukka, Nigeria, Department of Psychology, Muenster, Germany; 4University of Nigeria Nsukka, Department of Psychology, Enugu State, Nigeria Objective: Metastatic breast cancer (MBC) is now a critical issue in breast health, as over 70% of the breast cancer patients present late stages (III & IV) with few patients having access to palliative care needs, treatment facilities and information in Nigeria. Studies have consistently explored the effects of different psychosocial interventions in improving the quality of life of cancer patients at different stages of breast cancer, very few studies looked at metastatic breast cancer. This study explores support networks, such as, NGO support programmes, metastatic breast cancer support group, family, government and faith-based support in improving the quality of life of women living with metastatic breast cancer in Nigeria and Turkey. To examine which of the different support networks are perceived by MBC patients to be more effective in improving their quality of life, we utilized the Union for International Cancer Control (UICC) SPARC metastatic breast cancer project in Turkey and Nigeria. The study attempts to explore and understand the available and the most effective support networks for mitigating the pains of women living with metastatic breast cancer, including disclosure issues and how to better provide a more significantly improved support and palliative care. Method: The study will survey 100 metastatic breast cancer patients in Nigeria and Turkey that are covered in the Union for International Cancer Control (UICC) SPARC metastatic breast cancer project. A questionnaire will be developed to assess the available support networks for MBC patients and the level of patients’ satisfaction with the identified support networks. The 16-item McGill Quality of Life questionnaire will be used to assessed patient QOL. Descriptive statistics ( percentages and graphs) will be used to present data relating to frequency of support while regression analysis will be used to test for the relationship among support networks, satisfaction and quality of life. Implications of Results: The results of the study will help in understanding the available support networks for metastatic breast cancer patients in Nigeria and Turkey. The study will also provide useful information on the efficacy of the available support networks in meeting patients’ expectations of care in the two countries. In addition, the results of the study will provide empirical evidence for the link between support networks and satisfaction with care, and quality of life of MBC patients. The findings are expected to have implications for effective management of MBC patients and provide insight for future research in the area.
S71
PO134 HOMESTATIC CORRELATIONS IN PATIENTS WITH BREAST AND OVARIAN CANCER Elina Beleva1,3, Tanya Deneva2, Snejana Stoencheva2, Vesselin Popov1, Cvetelina Peicheva3, Mariana Valcheva3, Antoaneta Georgieva3, Ivanka Nenova1,3, Janet Grudeva1,3 1 Medical University, Plovdiv, Clinical Oncology, Medical Faculty, Plovdiv, Bulgaria; 2Medical University, Plovdiv, Clinical Laboratory, Faculty of Pharmacy, Plovdiv, Bulgaria; 3University Hospital ‘Sveti Georgi’, Clinic of Medical Oncology, Plovdiv, Bulgaria Introduction: Prothrombotic tendency is characteristic of solid tumors. However, the rate of thrombotic complications is largely dependent on the primary tumor site. Clinically breast cancer is associated with lower thromboembolic risk as compared to other cancers such as lung cancer or gynecologic tumors. Aim of this study was to compare hemostatic parameters – procoagulant activity of microparticles (MP-TF), tissue factor antigen (TFAg), soluble urokinase activator receptor (suPAR) and angiopoietin-2 (ANG2) between patients with breast and ovarian cancer. Methods: MPTF, TFAg, suPAR, ANG-2, CA15-3 and CA125 were measured in 44 breast and 20 ovarian cancer patients treated at a single oncology unit. Patients were tested at chemotherapy initiation and sequentially. TFAg, ANG-2 and suPAR were measured by ELISA, MPTF – by immunochromogenic assay. Written informed consent was obtained by all study participants. Results: No significant difference was found between breast and ovarian cancer patients for all tested parameters. However, significant correlations were found for the CA 15-3 tumor marker and MP procoagulant activity (ρ = 0.305), TFAg (ρ = −0.267) and ANG-2 (ρ = −0,29). For CA125 significant correlation was determined only in regard to MPTF activity (ρ = −0.343), which was negative compared to the positive direction found in breast cancer. No relationship was found for suPAR and either of the tumor markers. Conclusion: Based on the findings it might be suggested that even though there is low clinical propensity to thrombosis in breast cancer, subtle changes in hemostatic system occur or possibly a different pattern of hemostatic dysregulation is present.
Clinical Issues: Other Topics
OR135 EFFECT OF EXERCISE ON CARDIOVASCULAR FITNESS AND QUALITY OF LIFE OUTCOMES IN ADVANCED BREAST CANCER PATIENTS Eduardo Oliveira, Jose Soares, Andre Seabra, Sofia Magalhaes, Sara Oliveira, Diana Carvalho, Maria Joao Cardoso Mama Help, Physical Exercise, Porto, Portugal With 1.3 million new breast cancer cases reported every year and improved survival, it is important to develop interventions to maintain quality of life (QOL) during and after cancer treatment. Aerobic and strength training is an intervention that can enhance QOL and physical components during treatment. However, regarding metastatic breast cancer, there are few interventions regarding physical exercise and quality of life outcomes. Purpose: To examine the effect of 12 weeks of supervised exercise in physical capacity measurement, strength and QOL in advanced breast cancer patients during treatment compared to a control group.
collection rate for the total of 12 weeks was 84.6% (IQR, 44.3–100). The main reasons for missing data were forgetting, worsening of disease and device malfunction. The number of patients who experienced MID was eight and the median time to deterioration was 30 days (95%CI, 7.7–52.3). Conclusions: Compliance with electronic HRQOL data collection in this cohort was acceptable. We plan a prospective study to determine whether the use of electronic real-time feedback of HRQOL results (by means of CHES) improves patient-physician communication and patient’s overall HRQOL.
PO133 EXPLORING SUPPORT NETWORKS AND QUALITY OF LIFE OF METASTATIC BREAST CANCER PATIENT IN NIGERIA AND TURKEY Runcie Chikeruba Wilson Chidebe2, Ebru Tontas1, Charles Tochukwu Orjiako4, Ernest Ike Onyishi3,4 1 Kanserle Dans Dernegi, Palliative Care, Istanbul, Turkey; 2Project PINK BLUE Health & Psychological Trust Centre, Patient Advocacy & Research, Abuja, Nigeria; 3University of Muenster, Germany and University of Nigeria, Nsukka, Nigeria, Department of Psychology, Muenster, Germany; 4University of Nigeria Nsukka, Department of Psychology, Enugu State, Nigeria Objective: Metastatic breast cancer (MBC) is now a critical issue in breast health, as over 70% of the breast cancer patients present late stages (III & IV) with few patients having access to palliative care needs, treatment facilities and information in Nigeria. Studies have consistently explored the effects of different psychosocial interventions in improving the quality of life of cancer patients at different stages of breast cancer, very few studies looked at metastatic breast cancer. This study explores support networks, such as, NGO support programmes, metastatic breast cancer support group, family, government and faith-based support in improving the quality of life of women living with metastatic breast cancer in Nigeria and Turkey. To examine which of the different support networks are perceived by MBC patients to be more effective in improving their quality of life, we utilized the Union for International Cancer Control (UICC) SPARC metastatic breast cancer project in Turkey and Nigeria. The study attempts to explore and understand the available and the most effective support networks for mitigating the pains of women living with metastatic breast cancer, including disclosure issues and how to better provide a more significantly improved support and palliative care. Method: The study will survey 100 metastatic breast cancer patients in Nigeria and Turkey that are covered in the Union for International Cancer Control (UICC) SPARC metastatic breast cancer project. A questionnaire will be developed to assess the available support networks for MBC patients and the level of patients’ satisfaction with the identified support networks. The 16-item McGill Quality of Life questionnaire will be used to assessed patient QOL. Descriptive statistics ( percentages and graphs) will be used to present data relating to frequency of support while regression analysis will be used to test for the relationship among support networks, satisfaction and quality of life. Implications of Results: The results of the study will help in understanding the available support networks for metastatic breast cancer patients in Nigeria and Turkey. The study will also provide useful information on the efficacy of the available support networks in meeting patients’ expectations of care in the two countries. In addition, the results of the study will provide empirical evidence for the link between support networks and satisfaction with care, and quality of life of MBC patients. The findings are expected to have implications for effective management of MBC patients and provide insight for future research in the area.
S71
PO134 HOMESTATIC CORRELATIONS IN PATIENTS WITH BREAST AND OVARIAN CANCER Elina Beleva1,3, Tanya Deneva2, Snejana Stoencheva2, Vesselin Popov1, Cvetelina Peicheva3, Mariana Valcheva3, Antoaneta Georgieva3, Ivanka Nenova1,3, Janet Grudeva1,3 1 Medical University, Plovdiv, Clinical Oncology, Medical Faculty, Plovdiv, Bulgaria; 2Medical University, Plovdiv, Clinical Laboratory, Faculty of Pharmacy, Plovdiv, Bulgaria; 3University Hospital ‘Sveti Georgi’, Clinic of Medical Oncology, Plovdiv, Bulgaria Introduction: Prothrombotic tendency is characteristic of solid tumors. However, the rate of thrombotic complications is largely dependent on the primary tumor site. Clinically breast cancer is associated with lower thromboembolic risk as compared to other cancers such as lung cancer or gynecologic tumors. Aim of this study was to compare hemostatic parameters – procoagulant activity of microparticles (MP-TF), tissue factor antigen (TFAg), soluble urokinase activator receptor (suPAR) and angiopoietin-2 (ANG2) between patients with breast and ovarian cancer. Methods: MPTF, TFAg, suPAR, ANG-2, CA15-3 and CA125 were measured in 44 breast and 20 ovarian cancer patients treated at a single oncology unit. Patients were tested at chemotherapy initiation and sequentially. TFAg, ANG-2 and suPAR were measured by ELISA, MPTF – by immunochromogenic assay. Written informed consent was obtained by all study participants. Results: No significant difference was found between breast and ovarian cancer patients for all tested parameters. However, significant correlations were found for the CA 15-3 tumor marker and MP procoagulant activity (ρ = 0.305), TFAg (ρ = −0.267) and ANG-2 (ρ = −0,29). For CA125 significant correlation was determined only in regard to MPTF activity (ρ = −0.343), which was negative compared to the positive direction found in breast cancer. No relationship was found for suPAR and either of the tumor markers. Conclusion: Based on the findings it might be suggested that even though there is low clinical propensity to thrombosis in breast cancer, subtle changes in hemostatic system occur or possibly a different pattern of hemostatic dysregulation is present.
Clinical Issues: Other Topics
OR135 EFFECT OF EXERCISE ON CARDIOVASCULAR FITNESS AND QUALITY OF LIFE OUTCOMES IN ADVANCED BREAST CANCER PATIENTS Eduardo Oliveira, Jose Soares, Andre Seabra, Sofia Magalhaes, Sara Oliveira, Diana Carvalho, Maria Joao Cardoso Mama Help, Physical Exercise, Porto, Portugal With 1.3 million new breast cancer cases reported every year and improved survival, it is important to develop interventions to maintain quality of life (QOL) during and after cancer treatment. Aerobic and strength training is an intervention that can enhance QOL and physical components during treatment. However, regarding metastatic breast cancer, there are few interventions regarding physical exercise and quality of life outcomes. Purpose: To examine the effect of 12 weeks of supervised exercise in physical capacity measurement, strength and QOL in advanced breast cancer patients during treatment compared to a control group.