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Expression pattern of immune checkpoint-associated molecules in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors
32nd Annual EAU Congress, 24-28 March 2017, London, United Kingdom
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Expression pattern of immune checkpoint-associated molecules in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors Eur Urol Suppl 2017; 16(3);e1479
Takuto H., Miyake H., Nakano Y., Fujisawa M. Kobe University Graduate School of Medicine, Division of Urology, Dept. of Surgery Related, Kobe, Japan INTRODUCTION & OBJECTIVES: To analyze the expression pattern of immune checkpoint-associated molecules in tumor tissues to determine the prognostic significance of these molecules in metatstatic renal cell carcinoma (mRCC) patients treated with tyrosine kinase inhibitors (TKIs). MATERIAL & METHODS: Radical nephrectomy specimenswere obtained from 62 patients treated with TKIs as first-line systemic therapyfor mRCC. The proportions of programmed death-1 (PD-1)-positive tumor infiltrating lymphocytes (TILs) as well as those of tumor cells positive for PD-ligand 1 (PD-L1) and PD-L2 were analyzed by immunohistochemical staining. RESULTS: Twelve patients (19.3%) were revealed to be positive for PD-1-positive TILs, while positive expression of PD-L1and PD-L2 were detected in 12 (19.3%) and 10 (16.1%) patients, respectively. Patients with positive PDL-L1 expression had significantly unfavorable progression-free survival (PFS) compared with those without positive PD-L1 expression, despite the remaining two molecules having no significant impact on PFS. Additionally, overall survival (OS) in patients positive for PD-1, PD-L1 or PDL2 expression was significantly poorer than that in those without expression of each immune checkpointassociated molecule. Multivariate analyses of several parameters identified the following independent prognostic predictors after the introduction of TKIs: PD-L1 expression status for PFS, and lymph node metastasis, Memorial Sloan-Kettering Cancer Center classification and expression statuses of PD-1-positive TILs and PD-L1 for OS. CONCLUSIONS: Positive expression of immune checkpoint-associated molecules in tumor tissues, particularly that of PD-L1, could be useful prognostic indicator in mRCC patients receiving TKIs as firstline systemic therapy.
Eur Urol Suppl 2017; 16(3);e1479 Powered by TCPDF (www.tcpdf.org)
848
Expression pattern of immune checkpoint-associated molecules in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors Eur Urol Suppl 2017; 16(3);e1479
Takuto H., Miyake H., Nakano Y., Fujisawa M. Kobe University Graduate School of Medicine, Division of Urology, Dept. of Surgery Related, Kobe, Japan INTRODUCTION & OBJECTIVES: To analyze the expression pattern of immune checkpoint-associated molecules in tumor tissues to determine the prognostic significance of these molecules in metatstatic renal cell carcinoma (mRCC) patients treated with tyrosine kinase inhibitors (TKIs). MATERIAL & METHODS: Radical nephrectomy specimenswere obtained from 62 patients treated with TKIs as first-line systemic therapyfor mRCC. The proportions of programmed death-1 (PD-1)-positive tumor infiltrating lymphocytes (TILs) as well as those of tumor cells positive for PD-ligand 1 (PD-L1) and PD-L2 were analyzed by immunohistochemical staining. RESULTS: Twelve patients (19.3%) were revealed to be positive for PD-1-positive TILs, while positive expression of PD-L1and PD-L2 were detected in 12 (19.3%) and 10 (16.1%) patients, respectively. Patients with positive PDL-L1 expression had significantly unfavorable progression-free survival (PFS) compared with those without positive PD-L1 expression, despite the remaining two molecules having no significant impact on PFS. Additionally, overall survival (OS) in patients positive for PD-1, PD-L1 or PDL2 expression was significantly poorer than that in those without expression of each immune checkpointassociated molecule. Multivariate analyses of several parameters identified the following independent prognostic predictors after the introduction of TKIs: PD-L1 expression status for PFS, and lymph node metastasis, Memorial Sloan-Kettering Cancer Center classification and expression statuses of PD-1-positive TILs and PD-L1 for OS. CONCLUSIONS: Positive expression of immune checkpoint-associated molecules in tumor tissues, particularly that of PD-L1, could be useful prognostic indicator in mRCC patients receiving TKIs as firstline systemic therapy.
Eur Urol Suppl 2017; 16(3);e1479 Powered by TCPDF (www.tcpdf.org)