Expression vectors and delivery systems Web alert

Expression vectors and delivery systems Web alert

445 Expression vectors and delivery systems Web alert Jean-Louis Boulay* and Herve R6cipon A selection of World Wide Web sites relevant to papers pub...

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445

Expression vectors and delivery systems Web alert Jean-Louis Boulay* and Herve R6cipon A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in

Biotechnology. Addresses *Division of Oncology, Room 301 ZLF, Departmentof Research, Canton Hospital, 20 Hebelstrasse,CH-4031 Basel, Switzerland; e-mail: [email protected] tdiaDexus, LLC, 3303 Octavius Drive,Santa Clara, CA 95054; e-mail: [email protected]

Current Opinion in Biotechnology 1998, 9:445 http://biomednet.com/elecref/0958166900900445 © Current BiologyLtd ISSN 0958-1669

National Gene Vector Laboratory http://www.iupui.edu/~iucc/ngvl/ The home page of the US National Gene Vector Laboratory (NGVL) provides links to its three different sites. The NGVL at the University of Michigan (http://www-ngvl.med.umich.edu/) presents objectives, on site produced non-viral vectors and a list of publications about gene transfer methods. The Institute for Human Gene Therapy at the University of Pennsylvania (http://www.med.upenn.edu/~ihgt/) displays overviews, events and training. The NGVL at the Indiana University (http://www.iupui.edu/~iucc/ngvl/IU.html) proposes vectors produced on site and relevant references.

Vector Database http://vectordb.atcg.com/ VectorDB contains annotations and sequence information for many vectors commonly used in molecular biology. Information for more than 2,600 vectors is available with search facilities. Vectors that are also in GenBank have direct links to that database via the Entrez browser of the National Center for Biotechnology Information (NCBI).

Gene Transfer Vector Core http://www.uiowa.edu/~gene/ By Patrick Stabler from the College of Medicine at the University of Iowa. The site presents an overview, a list of viral vectors with custom ordering. The 'All theeVirology on the WWW' index provides links and catalogs virology;microbiology and related pages world-wide. Additionally, on line courses, tutorials, and a catalog of viral images is available.This comprehensive page lists Severs for General Virology, Specific Viruses, Microbiology, AIDS, Emerging Viruses, Electronic journals, Scientific Societies, Government Sites and much, much more. If you're looking for specific virusrelated information, or if you're a virology/microbiology professional, this is the place to start.

Virus Databases On-line http://life.anu.edu.au/viruses/welcome.htm This site, maintained by Cornelia Bucher Osmond at the Australian National University, presents, in particular, taxonomy of all viruses approved by the International Committee and provides links to diverse sites relevant to all viruses of animals (vertebrates, invertebrates, protozoa), plants (higher plants and algae), bacteria, fungi, and archaea from the family level down to strains and isolates.

Virology http://www-micro.msb.le.ac.uk/335/BS335.html The virology course by Alan Cann and Shaun Heaphy from the University of Leicester contains sections covering virus structure, physiology, taxonomy, with a section about virus vectors for gene therapy and DNA transfer designed by David Peel.

Gene Transfer http://www.nd.edu/~ mmossing/418/BactGen/Genetransfer.html This short table written by Mike Mossing from Notre-Dame University recapitulates all of the different pathways for DNA transfer into bacteria.

Gene Therapy Vectors http://www.wiley.co.u k/genetherapy/vectors.html This site provides information on all aspects of gene therapy in humans. It features a comprehensive summary of both pubJished and ongoing clinical trials world-wide. The site is updated every two months from numerous sources, including published material, information obtained at meetings, and surveys conducted on a regular basis with investigators and regulatory agencies. This site lists 351 gene therapy clinical trials currently approved worldwide. Most have started actual recruitment, resulting in 2,687 patients treated to date.

Cell-free Translation http ://celsp 10. riken.go.jp/~ noj ima/Translation.html This page, designed by Takahiko Nojima from the Institute of Physical and Chemical Research (Saitama, Japan), describes the fabrication of a microbiochemical reactor for in vitro cell-free translation. Other pages are available in Japanese only.

Epstein-Barr Virus http://fiona.umsmed.edu/~yar/ebv.html This page of the University of Mississippi describes the physiology and pathology of the Epstein-Barr virus.

Sindbis Virus Vectors

http://www.microbiology.wustl.edu./Sindbis/sinVectors This full description of the Sindbis virus vectors includes a bibliography and the molecular biology of Sindbis viruses.