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Extracranial internal carotid artery occlusion-a prospective study
Abstracts / Journal of the Neurological Sciences 405S (2019) 116541
Methods In 2016-2017, in Emergency of Durres Hospital, 870 cases were diagnosed with Stroke. Of all cases, 802 were diagnosed by emergency physicians and 69 by family physicians. In the total number with Stroke 228 patients (26%) were recurrent and 642 (74%) were new cases. Are classified as Ischemic Stroke 574 cases (66%) and 296 cases (34%) classified as haemorrhagic Stroke. Results In hemorrhagic cases 29 patients (9.8%) were diagnosed with HSA, of which 18 cases were subjected to neurosurgical intervention. Were presented within the first 3 hours of starting ischemic Stroke only 54% (309), of these 115 patients (37.2%) are sent for thrombolysis and 12 cases (6.1%) for thrombectomia in Universitary Hospital of Tirana. By gender 53% of cases (457) were female and 47% of cases (413) were males. The average age of patients was 64.7 years for ischemic Stroke and 56.4 years for haemorrhagic Stroke. The main risk factor in all cases was HTA 61% (530), the second most frequent factor being smoking (55%) (482), with hyperlipidemia 54% (477), 17% (173) atrial fibrillation, 18% (187) diabetes mellitus, (92) 10.5% alcohol consuming, post myocardial infarction 9% (89).
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the CDU study from which 56 cases were determined total EICA occlusions. RESULTS: Of these 56 (11.38%) patients with complete occlusion of EICA, men were predominant (81.6%) with mean age of 58.0±14.8 years and sex ratio 2.5:1. Symptomatic EICA was detected in 49 (87.5%) cases with mean age of 57.5±17.6 while asymptomatic EICA was determined in 7 cases (12.5%) with mean age of 48.3±15.3 years. The most frequent identified risk factors were hypertension (87.5%), smoking (63.6%) and coronary artery disease (69.2%)(pb0.05). By grading atherosclerotic plaques, low echo-density was 16 (28.5%), echodensity with substantial areas of echo lucent were 19 (33.9%), and highechodensity were 21 (37.5%). CONCLUSIONS: Our study showed that frequency of EICA is higher among men, similar to other countries. The EICA is frequently occurred among younger population which requires more consideration. Another important finding of the study is that asymptomatic EICA is more common than symptomatic EICA among youth. Keywords: Extracranial internal carotid artery, Asymptomatic occlusion, Duplex sonography
Symptomatic,
doi:10.1016/j.jns.2019.10.481
Conclusions First risk factor in our study was Hypertension and by gender females had higher prevalence in front of males
WCN19-0619 doi:10.1016/j.jns.2019.10.480
Journal of the Neurological Sciences 405S (2019) 104144 Poster Session 1
WCN19-0609 Journal of the Neurological Sciences 405S (2019) 104143 Poster Session 1 Extracranial internal carotid artery occlusion-a prospective study B. Gongora, D. Tsagaankhuub, T. Guntevb a Mongolian Neurological Society, Stroke Unit, Neurology Center, The Third State Central Hospital, Ulaanbaatar, Mongolia b Mongolian Neurological Society, Department of Neurology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia Backround Symptomatic and asymptomatic occlusions of the extracranial internal carotid artery (EICA) is linked with high risk of stroke event. Objective This study aimed to compare symptomatic and asymptomatic occlusion of EICA by carotid duplex ultrasonography (CDU) and determine the risk factors of atherosclerotic plaques and identify the clinical features. Methods This was a hospital based prospective study, conducted at the Third General Central Hospital , between 2015- 2017. Totally, 492 ischemic stroke and complained before symptoms of transient ischemic attack patients aged below and above 50 years of both sexes were included in
PGE2/EP4 receptor and TRPV1 channel are involved in repeated restraint stress-induced prolongation of sensitization pain evoked by subsequent PGE2 challenge W. Maa, L. Lib, S. Xingb a McGill University, Douglas Mental Health University Institute, Dept. of Psychiatry, Montreal, Canada b McGill University, Douglas Mental Health University Institute, Montreal, Canada Prevalence of prior stressful experience is linked to high incidence of chronic pain. Stress, particularly repeated stress, is known to induce maladaptive neuroplasticity along peripheral and central pain transmission pathways. These maladaptive neuroplastic events facilitate sensitization of nociceptive neurons and transition from acute to chronic pain. Pro-inflammatory and pain mediators are involved in inducing neuroplasticity. Pain mediators such as prostaglandin E2 (PGE2), EP4 receptor and transient receptor potential vanilloid-1 (TRPV1) contributes to the genesis of chronic pain. In this study, we examined role of PGE2/EP4 signaling and TRPV1 signaling in repeated restraint stress-induced prolongation of sensitization pain, a model for transition from acute to chronic pain, in both in vivo and in vitro models. We found that pre-exposure to single restraint stress induced analgesia that masked sensitization pain evoked by subsequent PGE2 challenge. However, pre-exposure to 3d consecutive restraint stress not only prolonged sensitization pain, but also increased stress hormone corticosterone (CORT) in serum, COX2 levels in paw skin, EP4 and TRPV1 levels in dorsal root ganglion (DRG) and paw skin. Pre-exposure to CORT for 3d, not 1d,
Methods In 2016-2017, in Emergency of Durres Hospital, 870 cases were diagnosed with Stroke. Of all cases, 802 were diagnosed by emergency physicians and 69 by family physicians. In the total number with Stroke 228 patients (26%) were recurrent and 642 (74%) were new cases. Are classified as Ischemic Stroke 574 cases (66%) and 296 cases (34%) classified as haemorrhagic Stroke. Results In hemorrhagic cases 29 patients (9.8%) were diagnosed with HSA, of which 18 cases were subjected to neurosurgical intervention. Were presented within the first 3 hours of starting ischemic Stroke only 54% (309), of these 115 patients (37.2%) are sent for thrombolysis and 12 cases (6.1%) for thrombectomia in Universitary Hospital of Tirana. By gender 53% of cases (457) were female and 47% of cases (413) were males. The average age of patients was 64.7 years for ischemic Stroke and 56.4 years for haemorrhagic Stroke. The main risk factor in all cases was HTA 61% (530), the second most frequent factor being smoking (55%) (482), with hyperlipidemia 54% (477), 17% (173) atrial fibrillation, 18% (187) diabetes mellitus, (92) 10.5% alcohol consuming, post myocardial infarction 9% (89).
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the CDU study from which 56 cases were determined total EICA occlusions. RESULTS: Of these 56 (11.38%) patients with complete occlusion of EICA, men were predominant (81.6%) with mean age of 58.0±14.8 years and sex ratio 2.5:1. Symptomatic EICA was detected in 49 (87.5%) cases with mean age of 57.5±17.6 while asymptomatic EICA was determined in 7 cases (12.5%) with mean age of 48.3±15.3 years. The most frequent identified risk factors were hypertension (87.5%), smoking (63.6%) and coronary artery disease (69.2%)(pb0.05). By grading atherosclerotic plaques, low echo-density was 16 (28.5%), echodensity with substantial areas of echo lucent were 19 (33.9%), and highechodensity were 21 (37.5%). CONCLUSIONS: Our study showed that frequency of EICA is higher among men, similar to other countries. The EICA is frequently occurred among younger population which requires more consideration. Another important finding of the study is that asymptomatic EICA is more common than symptomatic EICA among youth. Keywords: Extracranial internal carotid artery, Asymptomatic occlusion, Duplex sonography
Symptomatic,
doi:10.1016/j.jns.2019.10.481
Conclusions First risk factor in our study was Hypertension and by gender females had higher prevalence in front of males
WCN19-0619 doi:10.1016/j.jns.2019.10.480
Journal of the Neurological Sciences 405S (2019) 104144 Poster Session 1
WCN19-0609 Journal of the Neurological Sciences 405S (2019) 104143 Poster Session 1 Extracranial internal carotid artery occlusion-a prospective study B. Gongora, D. Tsagaankhuub, T. Guntevb a Mongolian Neurological Society, Stroke Unit, Neurology Center, The Third State Central Hospital, Ulaanbaatar, Mongolia b Mongolian Neurological Society, Department of Neurology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia Backround Symptomatic and asymptomatic occlusions of the extracranial internal carotid artery (EICA) is linked with high risk of stroke event. Objective This study aimed to compare symptomatic and asymptomatic occlusion of EICA by carotid duplex ultrasonography (CDU) and determine the risk factors of atherosclerotic plaques and identify the clinical features. Methods This was a hospital based prospective study, conducted at the Third General Central Hospital , between 2015- 2017. Totally, 492 ischemic stroke and complained before symptoms of transient ischemic attack patients aged below and above 50 years of both sexes were included in
PGE2/EP4 receptor and TRPV1 channel are involved in repeated restraint stress-induced prolongation of sensitization pain evoked by subsequent PGE2 challenge W. Maa, L. Lib, S. Xingb a McGill University, Douglas Mental Health University Institute, Dept. of Psychiatry, Montreal, Canada b McGill University, Douglas Mental Health University Institute, Montreal, Canada Prevalence of prior stressful experience is linked to high incidence of chronic pain. Stress, particularly repeated stress, is known to induce maladaptive neuroplasticity along peripheral and central pain transmission pathways. These maladaptive neuroplastic events facilitate sensitization of nociceptive neurons and transition from acute to chronic pain. Pro-inflammatory and pain mediators are involved in inducing neuroplasticity. Pain mediators such as prostaglandin E2 (PGE2), EP4 receptor and transient receptor potential vanilloid-1 (TRPV1) contributes to the genesis of chronic pain. In this study, we examined role of PGE2/EP4 signaling and TRPV1 signaling in repeated restraint stress-induced prolongation of sensitization pain, a model for transition from acute to chronic pain, in both in vivo and in vitro models. We found that pre-exposure to single restraint stress induced analgesia that masked sensitization pain evoked by subsequent PGE2 challenge. However, pre-exposure to 3d consecutive restraint stress not only prolonged sensitization pain, but also increased stress hormone corticosterone (CORT) in serum, COX2 levels in paw skin, EP4 and TRPV1 levels in dorsal root ganglion (DRG) and paw skin. Pre-exposure to CORT for 3d, not 1d,