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F231 ALEXITHYMIA IN FIBROMYALGIA SYNDROME: ASSOCIATIONS WITH PAIN INTENSITY, ANXIETY, DEPRESSION AND WELL-BEING
POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295
of the male as female sex and to know if differences among both groups exist. Methods: 648 patients consecutively referred from the Rheumatology Service to the Fibromyalgia (FM) Unit were multidisciplinary assessed by means of a medical, psychological and occupational evaluation. All with FM of which 620 were women and 28 men. They characterized by highly levels of pain, suffering and difficulties for the execution of activities of the daily life. Results: Variable Demographic a greater proportion of women is observed clearly (FM women 94.4% vs men 4.3%). The age average of the men was of 43.5 that of the women was of 44.5. No they are observed differences in the marital status and level educational. The great majority of the patients they were born in Barcelona. Variable Clinical: The levels of Pain, Fatigue, Number of sensitive points, pain in months, pain in months, Limitation of mobility. Variable employment the men develop more specialized professions that the women, and more women than work as administrative. As for the type of activity the women develop in greater number an intellectual activity, and the men a mixed activity. In our analysis not differences of kind to clinical level are appreciated. All the prominent differences have been in the differences to employment level. The logistic decline showed differences between men and women in the employment characteristics related clearly with the differences of sex. Disclosure: None declared
F229 THE FREQUENCY OF FIBROMYALGIA SYNDROME IN PATIENTS WITH DIALYSIS: A PRELIMINARY REPORT M. Okumus¸ 1 *, H. Parpucu2 , S. Kocaoˇglu1 , E. Ceceli1 , P. Borman1 , M. Duranay2 . 1 Ankara Training and Research Hospital, Clinic of First Physical Medicine and Rehabilitation, 2 Ankara Training and Research Hospital, Clinic of Nephrology, Ankara, Turkey Background and objective: The aim of this study was to determine the frequency of FMS in patients on periton dialysis (PD), and to investigate its impact on the quality of life. Material and methods: Fifty patients with end stage renal disease who had undergone PD, and control group of 24 healthy volunteers were included to the study. FIQ and NHP were used to assess functional disability and quality of life (QoL) in patients. The relationship between disease characteristics, functional status and quality of life were determined in all patients. Results: The mean age of patients and controls were 42.93±13.98 and 41.61±10.32 years respectively. The mean duration of PD was 34.34±30.20 months. The frequency of FMS was similar between the groups (10.4% vs 12.5%). The mean FIQ score in the PD group with FMS was significantly higher than in control group with FMS (p < 0.024). The mean scores including function, fatigue, social subgroups of Nottingham Health Profile in the PD group were significantly higher than in the control group (p < 0.05). The frequency of headache, restless leg syndrome and sleep disturbance were found to be more common in PD patients than controls regardless of FMS (p < 0.05). Conclusions: Although the prevalence of FMS appears to be similar in PD patients and control subjects, the frequencies of associated symptoms are higher in PD patients. In conclusion fibromyalgia symptoms are suggested to be evaluated in patients receiving dialysis, in order to increase the quality of life of the patients suffering from this chronic condition. Disclosure: None declared
133
F230 COMPARISON BETWEEN QUETIAPINE-XR AND AMITRIPTYLINE IN FIBROMYALGIA PATIENTS: A 16-WEEK, RANDOMIZED, OPEN-LABEL, NON-INFERIORITY TRIAL E.P. Calandre *, F. Rico-Villademoros, C.M. Rodriguez-Lopez, J.S. Vilchez-Perez, R. Molina-Barea, J. Hidalgo-Tallon, P. MorillasArques. Institute of Neurosciences, University of Granada, Granada, Spain Background: Some atypical antipsychotics have shown to improve fibromyalgia symptomatology. We aimed to assess the efficacy and tolerability of quetiapine-XR (50–300 mg/day) versus amitriptyline (10–75 mg/day) in the treatment of fibromyalgia. Patients and methods: 90 fibromyalgia outpatients were randomly assigned to either quetiapine-XR (N = 45) or amitriptyline (N = 45). Main outcome measure was the mean change from baseline to endpoint in the Fibromyalgia Impact Questionnaire (FIQ) total score. Secondary outcome measures included the Pittsburgh Sleep Quality Index (PSQI), the Beck Depression Inventory (BDI), and adverse drug events. Results: 56 patients completed the study, 34 in the amitriptyline group (mean final dose: 55±18 mg/day) and 22 in the quetiapine group (mean final dose: 200±75 mg/day). There were not statistically significant differences in the efficacy variables (between both drugs (ITT analysis, table). Table: Efficacy data Parameter
Amitriptyline (N = 43)
Quetiapine (N = 34)
P
FIQ total PSQI total BDI total
−13.9±16.7 −4.7±3.8 −5.4±7.8
−9.8±15.5 −4.8±4.0 −5.4±5.9
0.7065 0.5758 0.9227
Six (13.3%) patients in amitriptyline group and 19 (42.2%) in the quetiapine group dropped out due to adverse events; 9 (47.4%) of the 19 quetiapine dropouts ocurred with the first dose of the drug. Conclusions: Quetiapine-XR proved to be non-inferior to amitriptyline in improving fibromyalgia symptomatology. However, tolerability was poor, with a high number of early dropouts which could be due to the 50 mg/day starting dose. Disclosure: This study has been partially funded by Astra-Zeneca (Spain)
F231 ALEXITHYMIA IN FIBROMYALGIA SYNDROME: ASSOCIATIONS WITH PAIN INTENSITY, ANXIETY, DEPRESSION AND WELL-BEING 1 C. Penacoba ˜ , C. Ecija1 , M. Cigaran ´ 1 , L. Velasco1 *, D. Bedmar2 , J.M. Cuesta3 , M.M. Gonzalez ´ 2 . 1 Universidad Rey Juan Carlos, 2 Hospital Universitario de Fuenlabrada, Madrid, 3 AFIBROTAR, Toledo, Spain Background and Aims: Alexithymia, a lack of emotional awareness, is common in chronic pain patients. Previous research has shown that alexithymia was related with severity of depression and anxiety, but not with severity of pain in fibromyalgia (FM) patients (Evren, 2006). Likewise, new field research has focused on analyzing the relationship between psychological well-being, emotion regulation process and fibromyalgia (Belcher, 2009). The aim of this study was to investigate the relationship of alexithymia to pain intensity, anxiety, depression and well-being in a sample of females with Fibromyalgia Syndrome. Methods: Seventy women with fibromyalgia completed self-report measures on alexithymia (20-Item Toronto Alexithymia Scale), anxiety and depression (Hamilton Anxiety-Depression Scale, 1997) and psychological well-being (Ryff Psychological Well-Being Scale, 1989). Correlation and regression analysis was used to determine the prediction value of alexithymia on the criterion variables of pain intensity, anxiety, depression and psychological well-being. Results: As hypothesized, Alexithymia was significantly positive correlated with anxiety, depression and pain intensity and
134
POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295
significantly negative correlated with well-being. Similar correlations were found for the subscales of TAS-20. The regression analysis has shown that ‘difficulty in identifying feelings’ (DIP) and ‘externally orientated thinking’ (EOT) predicted depression symptoms. However, only the DIP scale of TAS-20 was significant to predict anxiety and psychological well-being. Anyone of the subscale of TAS-20 was significant to predict intensity pain. Conclusions: Alexithymia was related with current general psychiatric symptoms of depression and anxiety and it is significant to predict psychological well-being, but not with intensity of pain in FM patients. Disclosure: None declared
F232 DOES PERCEPTION OF CONTROL IMPROVE DISABILITY AND SYMPTOMS IN WOMEN WITH FIBROMYALGIA? 1 L. Velasco1 *, M. Cigaran ´ 1 , D. Bedmar2 , C. Penacoba ˜ , C. Ecija1 , C. Fernandez ´ de las Penas ˜ 1 . 1 Universidad Rey Juan Carlos, 2 Hospital Universitario de Fuenlabrada, Madrid, Spain Background and Aims: Different studies have examined the potentially beneficial role of positive variables in individuals with chronic pain and their effect in functionality and symptoms. This study examined the relationship of perception of control to general symptoms, functional limitation, and affective variables (anxiety and depression) in women with Fibromyalgia (FM). We targeted domains of perception of control that have been associated with health (internal locus of control, general self-efficacy and pain selfefficacy). Methods: 136 women with FM (53.18 years; SD = 8.86) participated in this study. We assessed internal locus of control, general selfefficacy and pain self-efficacy and FM symptoms with different validated questionnaires and self-report measures. Functional limitation and affective variables were measured with the Fibromyalgia Impact Questionnaire (FIQ). Results: General self-efficacy was a predictor of FM symptoms (F = 4.88; p < 0.001) and anxiety (F = 2.29; p < 0.05). Internal locus of control (F = 2.12; p < 0.05) and self-efficacy for physical activities (F = 2.87; p < 0.05) predicted functional limitation and self-efficacy over pain predicted FM symptoms (F = 3.86; p < 0.01) and anxiety (F = 3.33; p < 0.01). Conclusions: These findings suggest that perception of control may improve physical functioning, symptoms and anxiety in FM patients. The psychosocial treatment of FM should be emphasized in increasing positive factors like perception of control who may play an important role for a better physical functioning at reducing the disabling aspects of FM. Disclosure: None declared
F233 CAN WE CONSIDER INTERLEUKIN-6 AS A RESPONSIBLE BIOMARKER IN FIBROMYALGIA SYNDROME? B. Nugraha1,2 *, C. Korallus1 , S. Zastrutzki3 , M. May4 , U. Hoppmann3 , S. Engeli4 , B. Jaeger3 , M. Rihl1 , T. Framke5 , A. Koch5 , R. Lichtinghagen6 , C. Gutenbrunner1 . 1 Rehabilitation Medicine, Hannover Medical School, Hannover, Germany; 2 Chemistry, University of Indonesia, Depok, Indonesia; 3 Clinic for Psychosomatics and Psychotherapy, 4 Institute for Clinical Pharmacology, 5 Institute for Biometry, 6 Institute for Clinical Chemistry, Hannover Medical School, Hannover, Germany Background and Aims: Fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome. Its pathomechanisms are still poorly understood. Therefore it is important to further investigate it in order to develop successful management of FMS. Some studies regarding the role of in FMS still show discrepancies. Therefore further study aiming to correlate cytokines and FMS symptoms are of importance. In this study, we observed and compared interleukin (IL)-6 and -10 from healthy subject (HS) and FMS patients and
correlated them with FMS-symptoms such as pain, fatigue, anxiety and depression. Methods: Sixty two FMS patients who matched definition of ACR and eighteen HS filled-out 10 cm-visual analog scales of pain and fatigue. They also filled out the Hospital Anxiety and Depression Scale (HADS). IL-6 and -10 were measured from plasma samples in both groups. Statistics evaluation was done by using SPSS 18. Results: Concentration of plasma IL-6 (>2 ng/ml) was observed: 5.6% (1/18) and 43.6% (27/62) in HS and FMS patients, respectively. However, concentrations of IL-10 in all HS and patients were less than 5 ng/ml. Significance differences between the groups were demonstrated in pain, fatigue, depression, anxiety, BMI and percentage of fat. IL-6 (>2 ng/ml) was correlated with pain (p < 0.05) and fatigue (p < 0.05) but not with anxiety and depression. Conclusions: IL-6 as one of pro-inflammatory cytokines seems to play role in FMS and have correlation with intensity of pain and fatigue. As it is not seen in all patients other factors must be of relevance, too. Disclosure: None declared
F234 FAMILY DISTRESS IN PATIENTS WITH FIBROMYALGIA 1 1 E. Gomez-Casanovas ´ *, A. Arias1 , M. Gomez ´ , X. Torres1 , M. Mart´ı1 , E. Altarriba2 , A. Collado1 . 1 Rheumatology. Fibromyalgia Unit., Hospital Clinic Barcelona, 2 Fundaci´ on FF, Barcelona, Spain Background and Aims: Fibromyalgia (FM) causes high levels of distress both in patients and in their relatives. However, the changes in family function and organization due to the FM are unknown. To analyze the structure, organization and family dynamics in patients with FM compared to healthy people (HC). Methods: 59 patients with a mean age of 43.4(10) years with FM according to ACR 1990 criteria consecutively attended at the Fibromyalgia Unit of the Hospital Clinic of Barcelona, and 64 healthy controls with a mean age of 43.7(9) years selected from the social environment of patients were included. Results: Fibromyalgia patients showed a worse quality of life (both physical and mental), and higher levels of Anxiety and Depression. The Family structure of fibromyalgia patients and healthy control families are similar. However, there is a greater number of nonreconstituted divorces (12% in FM vs 3% in controls) and a higher percentage of families of FM patients in downturn (12% vs 2%). Patients show a higher degree of family distress and a higher number of stressful life events. In spite of the similarity of the patients’ and control networks, a reduction in recreational activities shared by family members in patients with FM and a lesser perceived social support (informational, emotional, instrumental and relational) were observed. Conclusions: Patients with Fibromyalgia express a worse situation in quality of life and in their family dynamics. There are differences in conflict levels respect to healthy people Disclosure: None declared
F235 COGNITIVE-BEHAVIOURAL GROUP THERAPY WITH HYPNOSIS FOR THE TREATMENT OF FIBROMYALGIA: SIX MONTH FOLLOW-UP 5,6 A. Castel1,2,3 *, A. Padrol1,2,4 , M. Perez ´ , J. Sala1 , M. Rull1,2,7 . 1 Pain Clinic, Hospital Universitari de Tarragona Joan XXIII, 2 IISPV, 3 Department of Psychology, Universitat Rovira i Virgili, 4 GiPSS, 5 Department of Nursing, Universitat Rovira i Virgili, 6 UFISS, GiPSS, 7 Department of Medicine, Universitat Rovira i Virgili, Tarragona, Spain Background and Aims: Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain and multiple symptoms. This study compared the efficacy of two psychological treatments for FM between each other and to standard care.
of the male as female sex and to know if differences among both groups exist. Methods: 648 patients consecutively referred from the Rheumatology Service to the Fibromyalgia (FM) Unit were multidisciplinary assessed by means of a medical, psychological and occupational evaluation. All with FM of which 620 were women and 28 men. They characterized by highly levels of pain, suffering and difficulties for the execution of activities of the daily life. Results: Variable Demographic a greater proportion of women is observed clearly (FM women 94.4% vs men 4.3%). The age average of the men was of 43.5 that of the women was of 44.5. No they are observed differences in the marital status and level educational. The great majority of the patients they were born in Barcelona. Variable Clinical: The levels of Pain, Fatigue, Number of sensitive points, pain in months, pain in months, Limitation of mobility. Variable employment the men develop more specialized professions that the women, and more women than work as administrative. As for the type of activity the women develop in greater number an intellectual activity, and the men a mixed activity. In our analysis not differences of kind to clinical level are appreciated. All the prominent differences have been in the differences to employment level. The logistic decline showed differences between men and women in the employment characteristics related clearly with the differences of sex. Disclosure: None declared
F229 THE FREQUENCY OF FIBROMYALGIA SYNDROME IN PATIENTS WITH DIALYSIS: A PRELIMINARY REPORT M. Okumus¸ 1 *, H. Parpucu2 , S. Kocaoˇglu1 , E. Ceceli1 , P. Borman1 , M. Duranay2 . 1 Ankara Training and Research Hospital, Clinic of First Physical Medicine and Rehabilitation, 2 Ankara Training and Research Hospital, Clinic of Nephrology, Ankara, Turkey Background and objective: The aim of this study was to determine the frequency of FMS in patients on periton dialysis (PD), and to investigate its impact on the quality of life. Material and methods: Fifty patients with end stage renal disease who had undergone PD, and control group of 24 healthy volunteers were included to the study. FIQ and NHP were used to assess functional disability and quality of life (QoL) in patients. The relationship between disease characteristics, functional status and quality of life were determined in all patients. Results: The mean age of patients and controls were 42.93±13.98 and 41.61±10.32 years respectively. The mean duration of PD was 34.34±30.20 months. The frequency of FMS was similar between the groups (10.4% vs 12.5%). The mean FIQ score in the PD group with FMS was significantly higher than in control group with FMS (p < 0.024). The mean scores including function, fatigue, social subgroups of Nottingham Health Profile in the PD group were significantly higher than in the control group (p < 0.05). The frequency of headache, restless leg syndrome and sleep disturbance were found to be more common in PD patients than controls regardless of FMS (p < 0.05). Conclusions: Although the prevalence of FMS appears to be similar in PD patients and control subjects, the frequencies of associated symptoms are higher in PD patients. In conclusion fibromyalgia symptoms are suggested to be evaluated in patients receiving dialysis, in order to increase the quality of life of the patients suffering from this chronic condition. Disclosure: None declared
133
F230 COMPARISON BETWEEN QUETIAPINE-XR AND AMITRIPTYLINE IN FIBROMYALGIA PATIENTS: A 16-WEEK, RANDOMIZED, OPEN-LABEL, NON-INFERIORITY TRIAL E.P. Calandre *, F. Rico-Villademoros, C.M. Rodriguez-Lopez, J.S. Vilchez-Perez, R. Molina-Barea, J. Hidalgo-Tallon, P. MorillasArques. Institute of Neurosciences, University of Granada, Granada, Spain Background: Some atypical antipsychotics have shown to improve fibromyalgia symptomatology. We aimed to assess the efficacy and tolerability of quetiapine-XR (50–300 mg/day) versus amitriptyline (10–75 mg/day) in the treatment of fibromyalgia. Patients and methods: 90 fibromyalgia outpatients were randomly assigned to either quetiapine-XR (N = 45) or amitriptyline (N = 45). Main outcome measure was the mean change from baseline to endpoint in the Fibromyalgia Impact Questionnaire (FIQ) total score. Secondary outcome measures included the Pittsburgh Sleep Quality Index (PSQI), the Beck Depression Inventory (BDI), and adverse drug events. Results: 56 patients completed the study, 34 in the amitriptyline group (mean final dose: 55±18 mg/day) and 22 in the quetiapine group (mean final dose: 200±75 mg/day). There were not statistically significant differences in the efficacy variables (between both drugs (ITT analysis, table). Table: Efficacy data Parameter
Amitriptyline (N = 43)
Quetiapine (N = 34)
P
FIQ total PSQI total BDI total
−13.9±16.7 −4.7±3.8 −5.4±7.8
−9.8±15.5 −4.8±4.0 −5.4±5.9
0.7065 0.5758 0.9227
Six (13.3%) patients in amitriptyline group and 19 (42.2%) in the quetiapine group dropped out due to adverse events; 9 (47.4%) of the 19 quetiapine dropouts ocurred with the first dose of the drug. Conclusions: Quetiapine-XR proved to be non-inferior to amitriptyline in improving fibromyalgia symptomatology. However, tolerability was poor, with a high number of early dropouts which could be due to the 50 mg/day starting dose. Disclosure: This study has been partially funded by Astra-Zeneca (Spain)
F231 ALEXITHYMIA IN FIBROMYALGIA SYNDROME: ASSOCIATIONS WITH PAIN INTENSITY, ANXIETY, DEPRESSION AND WELL-BEING 1 C. Penacoba ˜ , C. Ecija1 , M. Cigaran ´ 1 , L. Velasco1 *, D. Bedmar2 , J.M. Cuesta3 , M.M. Gonzalez ´ 2 . 1 Universidad Rey Juan Carlos, 2 Hospital Universitario de Fuenlabrada, Madrid, 3 AFIBROTAR, Toledo, Spain Background and Aims: Alexithymia, a lack of emotional awareness, is common in chronic pain patients. Previous research has shown that alexithymia was related with severity of depression and anxiety, but not with severity of pain in fibromyalgia (FM) patients (Evren, 2006). Likewise, new field research has focused on analyzing the relationship between psychological well-being, emotion regulation process and fibromyalgia (Belcher, 2009). The aim of this study was to investigate the relationship of alexithymia to pain intensity, anxiety, depression and well-being in a sample of females with Fibromyalgia Syndrome. Methods: Seventy women with fibromyalgia completed self-report measures on alexithymia (20-Item Toronto Alexithymia Scale), anxiety and depression (Hamilton Anxiety-Depression Scale, 1997) and psychological well-being (Ryff Psychological Well-Being Scale, 1989). Correlation and regression analysis was used to determine the prediction value of alexithymia on the criterion variables of pain intensity, anxiety, depression and psychological well-being. Results: As hypothesized, Alexithymia was significantly positive correlated with anxiety, depression and pain intensity and
134
POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295
significantly negative correlated with well-being. Similar correlations were found for the subscales of TAS-20. The regression analysis has shown that ‘difficulty in identifying feelings’ (DIP) and ‘externally orientated thinking’ (EOT) predicted depression symptoms. However, only the DIP scale of TAS-20 was significant to predict anxiety and psychological well-being. Anyone of the subscale of TAS-20 was significant to predict intensity pain. Conclusions: Alexithymia was related with current general psychiatric symptoms of depression and anxiety and it is significant to predict psychological well-being, but not with intensity of pain in FM patients. Disclosure: None declared
F232 DOES PERCEPTION OF CONTROL IMPROVE DISABILITY AND SYMPTOMS IN WOMEN WITH FIBROMYALGIA? 1 L. Velasco1 *, M. Cigaran ´ 1 , D. Bedmar2 , C. Penacoba ˜ , C. Ecija1 , C. Fernandez ´ de las Penas ˜ 1 . 1 Universidad Rey Juan Carlos, 2 Hospital Universitario de Fuenlabrada, Madrid, Spain Background and Aims: Different studies have examined the potentially beneficial role of positive variables in individuals with chronic pain and their effect in functionality and symptoms. This study examined the relationship of perception of control to general symptoms, functional limitation, and affective variables (anxiety and depression) in women with Fibromyalgia (FM). We targeted domains of perception of control that have been associated with health (internal locus of control, general self-efficacy and pain selfefficacy). Methods: 136 women with FM (53.18 years; SD = 8.86) participated in this study. We assessed internal locus of control, general selfefficacy and pain self-efficacy and FM symptoms with different validated questionnaires and self-report measures. Functional limitation and affective variables were measured with the Fibromyalgia Impact Questionnaire (FIQ). Results: General self-efficacy was a predictor of FM symptoms (F = 4.88; p < 0.001) and anxiety (F = 2.29; p < 0.05). Internal locus of control (F = 2.12; p < 0.05) and self-efficacy for physical activities (F = 2.87; p < 0.05) predicted functional limitation and self-efficacy over pain predicted FM symptoms (F = 3.86; p < 0.01) and anxiety (F = 3.33; p < 0.01). Conclusions: These findings suggest that perception of control may improve physical functioning, symptoms and anxiety in FM patients. The psychosocial treatment of FM should be emphasized in increasing positive factors like perception of control who may play an important role for a better physical functioning at reducing the disabling aspects of FM. Disclosure: None declared
F233 CAN WE CONSIDER INTERLEUKIN-6 AS A RESPONSIBLE BIOMARKER IN FIBROMYALGIA SYNDROME? B. Nugraha1,2 *, C. Korallus1 , S. Zastrutzki3 , M. May4 , U. Hoppmann3 , S. Engeli4 , B. Jaeger3 , M. Rihl1 , T. Framke5 , A. Koch5 , R. Lichtinghagen6 , C. Gutenbrunner1 . 1 Rehabilitation Medicine, Hannover Medical School, Hannover, Germany; 2 Chemistry, University of Indonesia, Depok, Indonesia; 3 Clinic for Psychosomatics and Psychotherapy, 4 Institute for Clinical Pharmacology, 5 Institute for Biometry, 6 Institute for Clinical Chemistry, Hannover Medical School, Hannover, Germany Background and Aims: Fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome. Its pathomechanisms are still poorly understood. Therefore it is important to further investigate it in order to develop successful management of FMS. Some studies regarding the role of in FMS still show discrepancies. Therefore further study aiming to correlate cytokines and FMS symptoms are of importance. In this study, we observed and compared interleukin (IL)-6 and -10 from healthy subject (HS) and FMS patients and
correlated them with FMS-symptoms such as pain, fatigue, anxiety and depression. Methods: Sixty two FMS patients who matched definition of ACR and eighteen HS filled-out 10 cm-visual analog scales of pain and fatigue. They also filled out the Hospital Anxiety and Depression Scale (HADS). IL-6 and -10 were measured from plasma samples in both groups. Statistics evaluation was done by using SPSS 18. Results: Concentration of plasma IL-6 (>2 ng/ml) was observed: 5.6% (1/18) and 43.6% (27/62) in HS and FMS patients, respectively. However, concentrations of IL-10 in all HS and patients were less than 5 ng/ml. Significance differences between the groups were demonstrated in pain, fatigue, depression, anxiety, BMI and percentage of fat. IL-6 (>2 ng/ml) was correlated with pain (p < 0.05) and fatigue (p < 0.05) but not with anxiety and depression. Conclusions: IL-6 as one of pro-inflammatory cytokines seems to play role in FMS and have correlation with intensity of pain and fatigue. As it is not seen in all patients other factors must be of relevance, too. Disclosure: None declared
F234 FAMILY DISTRESS IN PATIENTS WITH FIBROMYALGIA 1 1 E. Gomez-Casanovas ´ *, A. Arias1 , M. Gomez ´ , X. Torres1 , M. Mart´ı1 , E. Altarriba2 , A. Collado1 . 1 Rheumatology. Fibromyalgia Unit., Hospital Clinic Barcelona, 2 Fundaci´ on FF, Barcelona, Spain Background and Aims: Fibromyalgia (FM) causes high levels of distress both in patients and in their relatives. However, the changes in family function and organization due to the FM are unknown. To analyze the structure, organization and family dynamics in patients with FM compared to healthy people (HC). Methods: 59 patients with a mean age of 43.4(10) years with FM according to ACR 1990 criteria consecutively attended at the Fibromyalgia Unit of the Hospital Clinic of Barcelona, and 64 healthy controls with a mean age of 43.7(9) years selected from the social environment of patients were included. Results: Fibromyalgia patients showed a worse quality of life (both physical and mental), and higher levels of Anxiety and Depression. The Family structure of fibromyalgia patients and healthy control families are similar. However, there is a greater number of nonreconstituted divorces (12% in FM vs 3% in controls) and a higher percentage of families of FM patients in downturn (12% vs 2%). Patients show a higher degree of family distress and a higher number of stressful life events. In spite of the similarity of the patients’ and control networks, a reduction in recreational activities shared by family members in patients with FM and a lesser perceived social support (informational, emotional, instrumental and relational) were observed. Conclusions: Patients with Fibromyalgia express a worse situation in quality of life and in their family dynamics. There are differences in conflict levels respect to healthy people Disclosure: None declared
F235 COGNITIVE-BEHAVIOURAL GROUP THERAPY WITH HYPNOSIS FOR THE TREATMENT OF FIBROMYALGIA: SIX MONTH FOLLOW-UP 5,6 A. Castel1,2,3 *, A. Padrol1,2,4 , M. Perez ´ , J. Sala1 , M. Rull1,2,7 . 1 Pain Clinic, Hospital Universitari de Tarragona Joan XXIII, 2 IISPV, 3 Department of Psychology, Universitat Rovira i Virgili, 4 GiPSS, 5 Department of Nursing, Universitat Rovira i Virgili, 6 UFISS, GiPSS, 7 Department of Medicine, Universitat Rovira i Virgili, Tarragona, Spain Background and Aims: Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain and multiple symptoms. This study compared the efficacy of two psychological treatments for FM between each other and to standard care.