F3 Hypertension,left ventricular hypertrophy, silent arrhythmias and myocardial ischemia

A]H

POSTERS:Prevention

1997;1O:145A-147A

F2

F1 PREVENTABLEMORTALITYFROM STROKEIN EASTERNEUROPE. CA Hormmg,EP McCutcheon,M Magherusan,G Vaidean,JL Spraggand R Capahreanu.USC Schoolof Medicine,Columhia,SC Death rates fromcardiovasculardisease(CVD) in Central and EasternEurope are amongthe highestin the world and, unlikeWesternindustrializedcountries,have heen rising sharplysincethe end of the 1980s.A commonbeliefis that the highCVD death rate is attributableto a highprevalence of smokingand elevatedserumcholesterol. We screened more than 17,500adults in CkrjNapoca,Romaniafor CVD risk factors including11,877workers age 26 to 65 at 8 industrialsites. The data suggestthat meanlevelsof serum cholesterolare belowthat found in the U.S. and that while the prevalenceof smokingis high(e.g., 54% in men), elevatedblood pressurecontributesmore to the high CVD death rate. Usinglogisticregressionparametersfor the 10 year probabilityof fatal stroketaken fromFraminghamand the Carter CenterHealthRisk Appraisal,projectedage-sex specificstrokemortalityrates based upon current risk factor protilesrange from2/1,000 for 26-35 year old femalesto 149/1,000for malesaged 56-65. With preventablerisks (e.g., smoking)set to zero, projected 10year mortalityrates are reducedby 16Y0in women26-35 years of age and by more than in 56-65year old men.For every 100,000 yearsof potentialwork force participation,more than 12,000 maleworkforceyearsand 4,200 femaleworkforceyears are of the projectedto be lost to stroke mortalitywith 7 yearslost amongmalesand 53% of the yearslost among femalesdue to preventablecauses.As muchas of this potentialreductionin stroke mortalitycould be achievedby effectivedetection,treatment and control of highblood [;;a;re. orals: Stroke, CorrmrunityScreening, Eastern Europe, Risk Reduction, Prevention

CAN CHRONIC HYPOXAEMIA INFLUENCE THE CIRCADIAN RHYTHM OF BLOOD PRESSURE ? J Carmona,J Cofraia,L Olivaifa,P Amado,N Vasooncelos.1 Santos, J Nararh, M C Abreu, V Ara@,Liabon,Poflugal In sleep apnoea hypoxaemia can inc$ease sympathetic aetivity,day and night blood praasura(BP). We investigated the circadian bleed prasaure rhythm (CSPR) in normotansive (N_Cl patiants (pts) with chronic raspiratoq failure (CRF) and chronic hypexaamia (CH). METHODS : We prospwtivaly studied 29 NT pta, 85°/0male, with CRF and CH(P02-40-69, mean-58 mmHg), by Ambulatory Slood Pressure Monitoring(ABPM), ECG and echo. Pts were on therapy with: xanthinas, bata2 agonists, antiallargica and inhalatad corticoids. We measured avarage 24hour, daytime (Dt)(6.00-22.00h) and nighttime (Nt)(22.00-6.00h) Syatolic (S) BP and Diaatolic (D) BP and Heart Rate (HR). We considered Dt - NI daerease < 10% as Non-Dippers (Ndip). Results ware compar~ to a Control Group (CG) of NT subjacts,79% male, without evidence of associated pathology(clinical, Helter ECG echo and ergomatty). I RESULTS I Hypoxsarrria I Control Group I p value Age S BP Dt D BP Dt HR Dt S BP Nt n BP Nt

- -.

I HR Nt

a a

a

p h 7

..

s bl..ki.s.

..l.i.m e

3 ..d

-w..i.l

. . e h .

U a

a

t

h .. a

group, .saimt a tack a n o t L , NumkurCa.ses

a 1

3

4 $s

Heart Rate+

74

70 140/80

BlwdPreaure+

LVH

76

155/M

1 3

4 2 6

Normal ECOEpisc-k

S/rb

Ncfmd

h

A

7

1 2 I

I

3

Kay words: LCfl v

LVH

1 , 4 3 Supraveluliallar 4 Lmvn3b 3 Nmmal 2

I Ncme I

80 140/90

1~0?90

LVH

I <0.05

I 707 + 43

F4 THE fmwcroFfu)D IWWIUCIIGN AND RAPIDWEIGHT

a

e

la7+R

.---.”

I

Key Words: I Blood Praaaure, Hyposaarnia, Circadian Rhythm

C

m

711R + R R

W NS NS 0.0005 <0.0025

,..

m ....

59 +10 (42-80) 123 i 9 76+ 6 72+ 11 \ 112 * 13

. ... . .

H N

..

I

1“

Ifluancathe circadian blood pm ,-. heart rate daweases in both omu!x durirpa nirrhttime (D=O.02). thfinding of significantly highar-nighttime bioed- pressu& valu&e in chronically hypexaemic raapiratory patiants than in controls , can be clinically rdavant.

F3 H A

1(n=29)

1660.8 t 14 (20-82) 122.5 + 13 75.4 * 8.8 86.3 i 13 119.6 + 14

-. 1

; 1 1 1 None

I

OFPHCISPfKJUPfLE IN ILISSONFA’lTYACIDtXrMFC6fTIoN HEARTMUSCLE.JJ!k& V.WlriteJsmt, S. Gdbjamascsr,F. SimcnraJ, X. Jmqrh,B. Otfdana,ad T. Balarz.FDA,Wash.D.C. andUniv.oflc&rxl,,Reykj avik, Icdarsi. Weightreductmrduetofeedrestrictionis mmrrmrr; it canbe voluntaryas inthecaseofe&se patimtaor involuntary a3in pcpulaticmbatthg Starvatkar.Wlratcvcr’ thereason,theCtTcct of r-==w; the@y =id oqrmitkm oftlrt kart ism exammcd theefktoffccd restrictionard Clearly rmlerateweightlcmonthefattyscidcofrrpmition ofrmdmme phmphnlipids inrat heartnmscle.l%ty twofnaleSpragudlrwtey Pwe dividedinto7 @ rats,.XD@3g, groupsatrfpl=ed ona mtricbxldi~ of5gklayfor 12*. Controlfatswe fedrmmal rcdentclmwallib.Thiafcafdtcdina weightkm of 13i2%witha progressive akeradmOfthefarlywidcoqroaiduroftkheartof bothpfqrbaMylcJKlli3ke ad @@atidyl@JrarKdmsine, tktvm majmphmplmlipida fad inheartnsfaclenmhanea.hr aoimaison rcaui@ddiet,arzxhidaric ml stearicasid w si@tkmtJy incfeascd,36 & 17%,cnnKrared to contfds,repkwinglirdeic ad pab3ritic mid, Dxmakwmic aid, m alsoimm=al, 29%, rqdscifrglirdeic acid,’fhefattywid corrpe6idrm ofcardiolipfrr,, wm ml markedlycJm@,+l%, duringthepaiod Ofwigfstredwtam Sirfriliaf changesincarrikwphmplwlipkia areirrlucdby rqeated “ injcctkms ofqrinqrhrimad iqrotereml. ‘l%esc ehangcaare =htck~datcd totkdeamithticar or dmnregfdatkm cfthe recqmrzinthatdsq Canbeblockcdby simdtanKnra mablmltwithtlx beta-, prqadd. It_ ffun thesed6tat@focd reatfietkmadr@d weightkm repfeaenta a majofp@olegicd Sucaatotk hearttihtiti@_l. rc4kl&m inobesepstieetta cadd resultinalteratkm ecqceidonoftheheart.%tk .@iea are*d0&*tilK3fUle aarre of~* aids inslressa@@tlon m rdatcdtodielatrhr m.

N-

KSy WorWfe

art

MUs c 1 e,

Fatty acids ,

Phosphol ipids , Weight

loss , Stress.

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