- Email: [email protected]
F7 Haptoglobin polymorphism and hypertension in the elderly
A
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!ARTER IAL HYPERTENSION
ARTERIAL HYPERTENSION AND MYOCARDIAL INFARCTION: EVALUATION OF DEGREE OF LEFT VENTRICULAR HYPERTROPHY AND CORONARY ATHEROSCLEROSIS. 5A Matveeva. Medical Russia. University, Ryazan, The aim of research was to investigate the degree of left ventricular hypertrophy and coronary atherosclerosisin patients with diagnosed arterial hypertension and acute myocardial infarction of various age groups. In 234 cases (109-46.6% men, 12553.4% women, aged 39-79) clinical conducted anatomical comparison w according to the symptoms of left ventricular hypertrophy and coronary atherosclerosis. Arterial hypertension varying from 160/100 to 230/120 mm Hg in a period of 1-45 years. We had 5 age groups with 10-years intervals. Acute myocardial infarction was accompanied in all age groups by left ventricular hypertrophy in most cases: maximum in men -+1.7~0.2 cm (aged 70-79), in women - 1.8-0.15 cm (aged 50-59). The stenosis of coronary arteries reached up to 50% in 52 (22.2%) patients, ~~;7~j)in 97 (41.5%), over 75% in 85 ., irrespective of age. Left ventricular hypertrophy in patients with arterial hypertension and myocardial infarction does not depend on the level of arterial pressure or the duration of the disease. Neither does coronary atherosclerosis. Left ventricular hypertrophy and coronary atherosclerosis in such patients do not depend on their age and do not influence each other.
AND CARD IAC DISTURBANCES:RELATIONSHIP WITH SYNDROMES
!OFHYPERTROPHY AND DILATATION. 5A MatveevaF t edical University, Ryazan, Russia. h The purpose of study consists in investigating the interdependencebetween arterial hypertension (AH), cardiac disturbances, left auricle (LA) and left ventricle (LV) dilatation, as well as LV ‘hypertrophyin patients selected at random~ ,Allthe 107 patients (56-52.3% men, 51were investigated 47.7% women, aged 18-69) by clinical, electrocardiographic(ECG) and echocardiographic (EchoCG) methods. On average they had suffered from AH varying from 160/90 to 220/120 mm Hg for 9.2 years. Depending on the EchoCG data the patients divided into 3 groups. Group 1 (34-31.8%) had LV hypertrophy and LV dilatation. Group 2 (41-38.3%) had LA and LV dilatation. Group 3 (32-29.9%) had LV hypertrophy according to the data of ECG, but showed no signs of either LV hypertrophy or LA/LV dilatation according to EchoCG examination. In Group 1 !nyocardialinfarction was registered in 71.8%, in Group 2 - in 17.1%, in Group 3 9.4%. In Group 1 various arrhythmias were found in 20.6%, in Group 2 - in 46.3%, in Group 3 - in 18.8%. Thus, AH, cardiac disturbances and LA/LV dilatation are found in such patients more frequently than AH and cardiac disturbances combined with ECG-diagnosed hypertrophy and LA/LV dilatation. The syndromes registered reciprocally aggravate each other but are relatively independent of each other. KeyWords: arterial hypertension, cardiac disturbances, hypertrophy LV, dilatation LA/LV.
F7
F8 F A
n
HPI-1
HP2-1
HP2-2
22
75
59
Age(years)
74*2
SBP(mmHg)
167*34*
DBP(nunHg)
88*1O
75+2
154+23
86*12
86+12
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75*2
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hypertension, myocardial infarction, hypertrophy, coronary atherosclerosis.
Key Worda:
HAPTOGLOBINPOLYMORFHISMANDHYPERTENSIONIN THEELDERLY.JDelanghe,DDuDrsz*,MlkBIIY.zIs,M Langlois,HVandenbussche,snd DClement*.UniversityHospital Gent,Belgium. Thereisepidemiologicalevidencethat systelicblocd pressure(SBP)increaseswithage.However,it isunknownwhether geneticfactorsare predisposingforhigberSBPin the eldsrly. Haptoglobin(Hp)isaplasmaprotein, chsracterizedbyagenetic polymorphismwith threemajorphsnotypss:Hpl-1,2-l,8nd2-2. Functionaldifferencesbshvssnthe Hppbenotypeshavebeen dewribed.Hpl-lhas beenassociatedwith saltsensitivityandHp2-2 withrefractoryhypertension.Inthisstudy, Hppbenotypedistribution was investigatedunessentialhypertension(HT)intheelderly (>70 years). Agroupof 156elderlypatientrwithHT(81 males,75 females;age 75 *2 years)wasinvestigated.Hpphenotypingwasperfonrrsdby Warchgele lectrophoresis.Aconmolgroupof255 healthyblood donorrwssphenotypedsswell. Intheeldedy HTpatients,the HplaNelefrsquency (0.381)was compmabletothatoftbe controls(0.395).RelativeHppheno~ t?equenciesinthepatientswereO.14(Hpl-l), 0,48(Hp2-l),md 0.38(Hp2-2), wbichis inHsrdy-Weinbergequilibrium.
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d r ,
m b % H n h 2 t m n i f
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a m
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F5
F6
!ARTER IAL HYPERTENSION
ARTERIAL HYPERTENSION AND MYOCARDIAL INFARCTION: EVALUATION OF DEGREE OF LEFT VENTRICULAR HYPERTROPHY AND CORONARY ATHEROSCLEROSIS. 5A Matveeva. Medical Russia. University, Ryazan, The aim of research was to investigate the degree of left ventricular hypertrophy and coronary atherosclerosisin patients with diagnosed arterial hypertension and acute myocardial infarction of various age groups. In 234 cases (109-46.6% men, 12553.4% women, aged 39-79) clinical conducted anatomical comparison w according to the symptoms of left ventricular hypertrophy and coronary atherosclerosis. Arterial hypertension varying from 160/100 to 230/120 mm Hg in a period of 1-45 years. We had 5 age groups with 10-years intervals. Acute myocardial infarction was accompanied in all age groups by left ventricular hypertrophy in most cases: maximum in men -+1.7~0.2 cm (aged 70-79), in women - 1.8-0.15 cm (aged 50-59). The stenosis of coronary arteries reached up to 50% in 52 (22.2%) patients, ~~;7~j)in 97 (41.5%), over 75% in 85 ., irrespective of age. Left ventricular hypertrophy in patients with arterial hypertension and myocardial infarction does not depend on the level of arterial pressure or the duration of the disease. Neither does coronary atherosclerosis. Left ventricular hypertrophy and coronary atherosclerosis in such patients do not depend on their age and do not influence each other.
AND CARD IAC DISTURBANCES:RELATIONSHIP WITH SYNDROMES
!OFHYPERTROPHY AND DILATATION. 5A MatveevaF t edical University, Ryazan, Russia. h The purpose of study consists in investigating the interdependencebetween arterial hypertension (AH), cardiac disturbances, left auricle (LA) and left ventricle (LV) dilatation, as well as LV ‘hypertrophyin patients selected at random~ ,Allthe 107 patients (56-52.3% men, 51were investigated 47.7% women, aged 18-69) by clinical, electrocardiographic(ECG) and echocardiographic (EchoCG) methods. On average they had suffered from AH varying from 160/90 to 220/120 mm Hg for 9.2 years. Depending on the EchoCG data the patients divided into 3 groups. Group 1 (34-31.8%) had LV hypertrophy and LV dilatation. Group 2 (41-38.3%) had LA and LV dilatation. Group 3 (32-29.9%) had LV hypertrophy according to the data of ECG, but showed no signs of either LV hypertrophy or LA/LV dilatation according to EchoCG examination. In Group 1 !nyocardialinfarction was registered in 71.8%, in Group 2 - in 17.1%, in Group 3 9.4%. In Group 1 various arrhythmias were found in 20.6%, in Group 2 - in 46.3%, in Group 3 - in 18.8%. Thus, AH, cardiac disturbances and LA/LV dilatation are found in such patients more frequently than AH and cardiac disturbances combined with ECG-diagnosed hypertrophy and LA/LV dilatation. The syndromes registered reciprocally aggravate each other but are relatively independent of each other. KeyWords: arterial hypertension, cardiac disturbances, hypertrophy LV, dilatation LA/LV.
F7
F8 F A
n
HPI-1
HP2-1
HP2-2
22
75
59
Age(years)
74*2
SBP(mmHg)
167*34*
DBP(nunHg)
88*1O
75+2
154+23
86*12
86+12
●p
A
H
R F
S
L
D ‘
M
L
A
J
A
l
zPAwycarecultem,AJbmaespkl. -
‘ H b ‘ c E
t
w
a
m k c
A
f ~
f t
i
r
m (
t a
-Of--
Thkhctcan
K
“n,qui@l.
n
a
M—&infamifyofcatravsconhvk. beoonkauyluefw intbefollou-up oforkgmup ~
L
●g
Y
@ r f u W 0 o l W l ~ p R a t l n u F U m = t I t B O & l . . O f C d i b ~ a L Iw--imlmartiwitb aac,acndaurdcurauurbmu Carwkbka,wm 6CW. T y 1 a f a t 6 ( 2 I 3 p V H b l 1 3 1 l m * A b i ( 2 1 L ~ ‘ S b d c k ‘ m w t s p K c i a A ; T f a O “J S ‘ w b W o r
75*2
155+=25
hypertension, myocardial infarction, hypertrophy, coronary atherosclerosis.
Key Worda:
HAPTOGLOBINPOLYMORFHISMANDHYPERTENSIONIN THEELDERLY.JDelanghe,DDuDrsz*,MlkBIIY.zIs,M Langlois,HVandenbussche,snd DClement*.UniversityHospital Gent,Belgium. Thereisepidemiologicalevidencethat systelicblocd pressure(SBP)increaseswithage.However,it isunknownwhether geneticfactorsare predisposingforhigberSBPin the eldsrly. Haptoglobin(Hp)isaplasmaprotein, chsracterizedbyagenetic polymorphismwith threemajorphsnotypss:Hpl-1,2-l,8nd2-2. Functionaldifferencesbshvssnthe Hppbenotypeshavebeen dewribed.Hpl-lhas beenassociatedwith saltsensitivityandHp2-2 withrefractoryhypertension.Inthisstudy, Hppbenotypedistribution was investigatedunessentialhypertension(HT)intheelderly (>70 years). Agroupof 156elderlypatientrwithHT(81 males,75 females;age 75 *2 years)wasinvestigated.Hpphenotypingwasperfonrrsdby Warchgele lectrophoresis.Aconmolgroupof255 healthyblood donorrwssphenotypedsswell. Intheeldedy HTpatients,the HplaNelefrsquency (0.381)was compmabletothatoftbe controls(0.395).RelativeHppheno~ t?equenciesinthepatientswereO.14(Hpl-l), 0,48(Hp2-l),md 0.38(Hp2-2), wbichis inHsrdy-Weinbergequilibrium.
2
f m & f h
i
a
d r ,
m b % H n h 2 t m n i f
w a
r
a m