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Familial Congenital Cornea Guttata With Anterior Polar Cataracts: Reply
Vol. 109, No. 2
Familial
Congenital Anterior
245
Correspondence
Cornea Guttata Polar Cataracts
With
EDITOR:
In the article, "Familial Congenital Cornea Guttata With Anterior Polar Cataracts," by E. I. Traboulsi and R. J. Weinberg (Am. J. Ophthalmol. 108:123, August 1989), the authors discuss autosomal dominant cornea guttata and anterior polar cataracts. . In the .same issue, I described cornea guttata In two girls, not relatives, affected by an autosomal dominant neurocristopathy, mandibulofacial dysotosis.' I wonder if any of the 21 • members of the family reported was investigated fo~ neural crest disorders. Cornea guttata, Fuch s dystrophy, and Peter's anomaly are thought to depend on a neural crest defect," PAOLO NUCCI, M.D.
_ _ _ _ _ _ _ Reply EDITOR:
None of the 21 members of the family described were specifically investigated for neural crest disorders. Medical histories, however, were obtained and showed no evidence of other inherited disorders within the family. As Dr. Nucci notes, the occurrence of corneal guttata may indeed depend on a neural crest defect. Bahn and associates! have suggested that cornea guttata may be a result of defects of final differentiation and function of cells of neural crest origin that occur late and, therefore, might explain the lack of additional neural crest-related conditions. ELIAS I. TRABOULSI, M.D.
Arlington, Virginia J. WEINBERG, M.D. Vienna, Virginia
RICHARD
Milan, Italy
References 1. Nucci, P., Brancato, R., Carones, F., Alfarano,
R., and Bianchi, S.: Mandibulofacial dysostosis and cornea guttata. Am. J. Ophthalmol. 108:204, 1989. 2. Bahn, C. F., Falls, H. F., Varley, G. A., Meyer, R. F., Edelhauser, H. F., and Bourne, W. M.: Classification of corneal endothelial disorders based on neural crest origin. Ophthalmology 91:558, 1984.
_
Reference 1. Bahn, C. F., Falls, H. F., Varley, G. A., Meyer, R. F., Edelhauser, H. F., and Bourne, W. M.: Classification of corneal endothelial disorders based on neural crest origin. Ophthalmology 91:558, 1984.
Familial
Congenital Anterior
245
Correspondence
Cornea Guttata Polar Cataracts
With
EDITOR:
In the article, "Familial Congenital Cornea Guttata With Anterior Polar Cataracts," by E. I. Traboulsi and R. J. Weinberg (Am. J. Ophthalmol. 108:123, August 1989), the authors discuss autosomal dominant cornea guttata and anterior polar cataracts. . In the .same issue, I described cornea guttata In two girls, not relatives, affected by an autosomal dominant neurocristopathy, mandibulofacial dysotosis.' I wonder if any of the 21 • members of the family reported was investigated fo~ neural crest disorders. Cornea guttata, Fuch s dystrophy, and Peter's anomaly are thought to depend on a neural crest defect," PAOLO NUCCI, M.D.
_ _ _ _ _ _ _ Reply EDITOR:
None of the 21 members of the family described were specifically investigated for neural crest disorders. Medical histories, however, were obtained and showed no evidence of other inherited disorders within the family. As Dr. Nucci notes, the occurrence of corneal guttata may indeed depend on a neural crest defect. Bahn and associates! have suggested that cornea guttata may be a result of defects of final differentiation and function of cells of neural crest origin that occur late and, therefore, might explain the lack of additional neural crest-related conditions. ELIAS I. TRABOULSI, M.D.
Arlington, Virginia J. WEINBERG, M.D. Vienna, Virginia
RICHARD
Milan, Italy
References 1. Nucci, P., Brancato, R., Carones, F., Alfarano,
R., and Bianchi, S.: Mandibulofacial dysostosis and cornea guttata. Am. J. Ophthalmol. 108:204, 1989. 2. Bahn, C. F., Falls, H. F., Varley, G. A., Meyer, R. F., Edelhauser, H. F., and Bourne, W. M.: Classification of corneal endothelial disorders based on neural crest origin. Ophthalmology 91:558, 1984.
_
Reference 1. Bahn, C. F., Falls, H. F., Varley, G. A., Meyer, R. F., Edelhauser, H. F., and Bourne, W. M.: Classification of corneal endothelial disorders based on neural crest origin. Ophthalmology 91:558, 1984.