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Familial Osteogenic Sarcoma Occurring in Pagetoid Bone
ONCOLOGY AND CHEMOTHERAPY
192
Abstracter's comment. I recommend that this article be read in toto. A good bibliography is included. J. D. S. 2 tables, 65 references Estrogens and Endometrial Cancer J.
L.
AMBRUS,
M.
GILLETTE,
C.
NOLAN,
0.
JUNG, S. REGALLA-
P. SPAVENTO, A. NOVICK, C. SUCHETZKY AND C. M. AMBRUS, Roswell Park Memorial Institute and Departments of Medicine and Pediatrics, State University of New York at Buffalo, Buffalo, New York SPAVENTO,
J. Med., 12: 81-88, 1981 There were 450 patients with documented endometrial carcinoma seen between 1970 and 1978, and compared to 450 controls seen during the same period. Socioeconomically and geographically the groups were comparable. Estrogen use for gynecologic disease or menopausal symptoms was similar in each group, while oral contraceptives and estrogens for uncertain reasons were used more in the control group. There were significantly more diabetes, hypertension and obesity in the uterine cancer patients than in the controls. A significant increase in uterine cancer risk with nulliparity or family history of uterine malignancy could not be demonstrated in this study. D.J.A. 2 figures, 2 tables, 18 references
Osteoid Osteoma. Articular Communication and Minimal Pain
C.
BLEIFELD, St. John's Hospital, Smithtown Hospital and Veterans Administration Hospital, Northport, New York
N. Y. State J. Med., 81: 1371-1372 (Aug.) 1981 Osteoid osteoma is a rare benign bone tumor but the clinical features are so characteristic and constant to be familiar to most orthopedic surgeons. The author presents a case of osteoid osteoma with unusual features. A 13-year-old boy had acute synovitis of the right elbow, which cleared rapidly after a short course of anti-inflammatory agent and immobilization with a splint. The patient remained free of pain after 10 days. He never vhad the kind of pain that usually is seen in osteoid osteoma. The synovitis completely subsided after removal of the osteoid osteoma and curettage of the cavity. This observation may explain that the pain in osteoid osteoma is from vascular pressure on local nerve endings. This case may serve as a reminder to the clinicians that osteoid osteoma may be a cause of synovitis. F. T. A. 1 figure, 5 references
Familial Osteogenic Sarcoma Occurring in Pagetoid Bone V. H. NASSAR AND M. B. GRAVANIS, Department of Pathology, Emory University School of Medicine and the Veterans Administration Medical Center, Decatur, Georgia Amer. J. Clin. Path., 76: 235-239 (Aug.) 1981 Familial clusterings of osteogenic sarcoma and of Paget's disease of bone have been documented. This case is the first example of a vertical male-to-male transmission in which secondary osteogenic sarcoma developed in pagetoid bones at identical anatomic sites in both generations. The son had an expansile lesion involving the entire proximal right tibia, an area known to have pagetoid changes for 13 years. A supracon-
dylar amputation confirmed the diagnosis of osteogenic sarcoma superimposed on Paget's disease of bone. The son died of metastatic disease 11 months later. The father, who had a long documented history of Paget's disease, had osteogenic sarcoma in the identical location. He died 6 months after the initial diagnosis. Paget's disease is considered a heritable disorder transinitted as an incomplete dominant gene carried on an Xchromosome. There have been 37 instances of familial osteogenic sarcoma occurring in 15 families reported. This family represents the only instance of male-to-male transmission of Paget's disease not implicating other genetic factors such as retinitis pigmentosa. D. J. A. 3 figures, 1 table, 22 references
IV Hyperalimentation and Chemotherapy for Stage ill Testicular Cancer: A Randomized Study D. E. SELIG, s. OGDEN, C. GRANT AND B. Department of Medicine and Nutrition and Food Service, Nursing and Biomathematics, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas
M. L.
SAMUELS,
BROWN,
Cancer Treat. Rep., 65: 615-627 (July/Aug.) 1981 Thirty evaluable patients with stage III metastatic testicular cancer were prospectively randomized to receive intravenous hyperalimentation starting on day 1 of hospitalization. There were 16 intravenous hyperalimentation patients and 14 controls. The intravenous hyperalimentation patients received 35 kcals./ kg. daily of 25 per cent dextrose with 4.25 per cent amino acids, while control patients received 3 1. daily of 5 per cent dextrose in 0.5 normal saline when gastrointestinal side effects from chemotherapy impaired the normal ingestion of food and fluids. Chemotherapy consisted of vinblastine, bleomycin and, in some cases, low dose cis-platinum. The authors noted that the control patients showed a mean weight loss of 4.85 kg. per trial compared to 1.67 kg. per trial for the intravenous hyperalimentation patients. However, other serious side effects were not lessened. The control group included 2 cases of bacteriologically proved septiceinia with prompt recovery, while the intravenous hyperalimentation group included 5 cases of proved septicemia and 2 cases of pneumonia. Thus, the increased number of lifethreatening infections in the intravenous hyperalimentation group was statistically significant despite the fact that only 1 case of septicemia was related to catheterization. Three control patients who had high weight loss after initial chemotherapy were changei to intravenous hyperalimentation and 2 have remained in stable, complete remission beyond the 2-year risk period. Thus, the authors suggest that aggressive, effective chemotherapy was made possible by the addition of intravenous hyperalimentation in these selected patients. However, in the patients with testis cancer receiving vinblastine, bleomycin and cis-platinum intravenous hyperalimentation should be restricted to those who present with significant weight loss or those who fail to regain lost weight during rest periods between courses of therapy. W J. C. 1 figure, 17 tables, 28 references
Total Parenteral Nutrition in the Cancer Patient
M. F. BRENNAN, Surgery Branch of the National Cancer Institute, National Institutes ofHealth, Bethesda, Maryland New Engl. J. Med., 305: 375-382 (Aug. 13) 1981 Total parenteral nutrition is a life-saving method of nutri-
192
Abstracter's comment. I recommend that this article be read in toto. A good bibliography is included. J. D. S. 2 tables, 65 references Estrogens and Endometrial Cancer J.
L.
AMBRUS,
M.
GILLETTE,
C.
NOLAN,
0.
JUNG, S. REGALLA-
P. SPAVENTO, A. NOVICK, C. SUCHETZKY AND C. M. AMBRUS, Roswell Park Memorial Institute and Departments of Medicine and Pediatrics, State University of New York at Buffalo, Buffalo, New York SPAVENTO,
J. Med., 12: 81-88, 1981 There were 450 patients with documented endometrial carcinoma seen between 1970 and 1978, and compared to 450 controls seen during the same period. Socioeconomically and geographically the groups were comparable. Estrogen use for gynecologic disease or menopausal symptoms was similar in each group, while oral contraceptives and estrogens for uncertain reasons were used more in the control group. There were significantly more diabetes, hypertension and obesity in the uterine cancer patients than in the controls. A significant increase in uterine cancer risk with nulliparity or family history of uterine malignancy could not be demonstrated in this study. D.J.A. 2 figures, 2 tables, 18 references
Osteoid Osteoma. Articular Communication and Minimal Pain
C.
BLEIFELD, St. John's Hospital, Smithtown Hospital and Veterans Administration Hospital, Northport, New York
N. Y. State J. Med., 81: 1371-1372 (Aug.) 1981 Osteoid osteoma is a rare benign bone tumor but the clinical features are so characteristic and constant to be familiar to most orthopedic surgeons. The author presents a case of osteoid osteoma with unusual features. A 13-year-old boy had acute synovitis of the right elbow, which cleared rapidly after a short course of anti-inflammatory agent and immobilization with a splint. The patient remained free of pain after 10 days. He never vhad the kind of pain that usually is seen in osteoid osteoma. The synovitis completely subsided after removal of the osteoid osteoma and curettage of the cavity. This observation may explain that the pain in osteoid osteoma is from vascular pressure on local nerve endings. This case may serve as a reminder to the clinicians that osteoid osteoma may be a cause of synovitis. F. T. A. 1 figure, 5 references
Familial Osteogenic Sarcoma Occurring in Pagetoid Bone V. H. NASSAR AND M. B. GRAVANIS, Department of Pathology, Emory University School of Medicine and the Veterans Administration Medical Center, Decatur, Georgia Amer. J. Clin. Path., 76: 235-239 (Aug.) 1981 Familial clusterings of osteogenic sarcoma and of Paget's disease of bone have been documented. This case is the first example of a vertical male-to-male transmission in which secondary osteogenic sarcoma developed in pagetoid bones at identical anatomic sites in both generations. The son had an expansile lesion involving the entire proximal right tibia, an area known to have pagetoid changes for 13 years. A supracon-
dylar amputation confirmed the diagnosis of osteogenic sarcoma superimposed on Paget's disease of bone. The son died of metastatic disease 11 months later. The father, who had a long documented history of Paget's disease, had osteogenic sarcoma in the identical location. He died 6 months after the initial diagnosis. Paget's disease is considered a heritable disorder transinitted as an incomplete dominant gene carried on an Xchromosome. There have been 37 instances of familial osteogenic sarcoma occurring in 15 families reported. This family represents the only instance of male-to-male transmission of Paget's disease not implicating other genetic factors such as retinitis pigmentosa. D. J. A. 3 figures, 1 table, 22 references
IV Hyperalimentation and Chemotherapy for Stage ill Testicular Cancer: A Randomized Study D. E. SELIG, s. OGDEN, C. GRANT AND B. Department of Medicine and Nutrition and Food Service, Nursing and Biomathematics, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas
M. L.
SAMUELS,
BROWN,
Cancer Treat. Rep., 65: 615-627 (July/Aug.) 1981 Thirty evaluable patients with stage III metastatic testicular cancer were prospectively randomized to receive intravenous hyperalimentation starting on day 1 of hospitalization. There were 16 intravenous hyperalimentation patients and 14 controls. The intravenous hyperalimentation patients received 35 kcals./ kg. daily of 25 per cent dextrose with 4.25 per cent amino acids, while control patients received 3 1. daily of 5 per cent dextrose in 0.5 normal saline when gastrointestinal side effects from chemotherapy impaired the normal ingestion of food and fluids. Chemotherapy consisted of vinblastine, bleomycin and, in some cases, low dose cis-platinum. The authors noted that the control patients showed a mean weight loss of 4.85 kg. per trial compared to 1.67 kg. per trial for the intravenous hyperalimentation patients. However, other serious side effects were not lessened. The control group included 2 cases of bacteriologically proved septiceinia with prompt recovery, while the intravenous hyperalimentation group included 5 cases of proved septicemia and 2 cases of pneumonia. Thus, the increased number of lifethreatening infections in the intravenous hyperalimentation group was statistically significant despite the fact that only 1 case of septicemia was related to catheterization. Three control patients who had high weight loss after initial chemotherapy were changei to intravenous hyperalimentation and 2 have remained in stable, complete remission beyond the 2-year risk period. Thus, the authors suggest that aggressive, effective chemotherapy was made possible by the addition of intravenous hyperalimentation in these selected patients. However, in the patients with testis cancer receiving vinblastine, bleomycin and cis-platinum intravenous hyperalimentation should be restricted to those who present with significant weight loss or those who fail to regain lost weight during rest periods between courses of therapy. W J. C. 1 figure, 17 tables, 28 references
Total Parenteral Nutrition in the Cancer Patient
M. F. BRENNAN, Surgery Branch of the National Cancer Institute, National Institutes ofHealth, Bethesda, Maryland New Engl. J. Med., 305: 375-382 (Aug. 13) 1981 Total parenteral nutrition is a life-saving method of nutri-