Familial ovarian cancer in Israeli Jewish women

158

Cirutiuns from

the Literature

Epidermal growth factor receptor expression in normal ovarian

times the risk of positive peritoneal

epithelium and ovarian cancer. II. Relationship between receptor

Seventy-four

expression and response to epidermal growth factor

cytology were stage IC or more. In contrast.

Rodriguez

GC;

Clarke-Pearson

Berchuck DL;

Duke University 27710, AM

A; Whitaker

RS; Schlossman

D;

with normal

Center. PO Box 3079,

Durham.

NC

GYNECOL

1991. l64/3 (745-750)

Previously we have shown that epidermal In this study we examined

growth

factor

on

proliferation

epithelial cells in monolayer

of

normal

of epidermal

human

ovarian

culture. We found that epidermal increases in pro-

Serial

of

tagged

high-affinity

analysis of binding of epider-

with

iodine

receptors

125

in

all

indicated

of

the

the

ovarian

epithelial ceils and ovarian cancer cell lines. The number and affmity of receptors was similar in the normal epithelium cancer cell lines, and there was no relationship epidermal

factor

growth

receptor factor.

number

and

We conclude

endometrial

advanced-stage

tumor,

and

and

between epider-

responsiveness

that

human

to

ovarian

125 levels during chemotherapy

for metastatic

or

Fanning J; Piver MS School q/‘Medicinc~. PO Box 19230, Springfield, USA

factor

or IB. Patients

Division c?f’ Gynecologic Oncology, Southc+-n Illinois

OBSTET

mal growth

were stage IA

who have malignant

are more likely to require extended surgical staging.

CA

< 0.01). In addition, growth

cervical

70% of patients

recurrent endometrial cancer

liferation in epithelial cells from each of five normal ovaries (p Scatchard

malignant

cells detected by cervical cytology are at increased risk of havtherefore

cancer cells in

the effect

growth factor stimulated twofold to fourfold

presence

carcinoma

with

growth factor acts

for some, but not all, ovarian

culture.

washings (33 versus 10%).

patients

ing a deeply invasive. high-grade,

USA

J OBSTET

as a mitogen

mal

of

cervical cytology

with endometrial

Bast RC Jr

Medical

percent

GYNECOL

Universiiy.

IL 62794-9230.

1991, 77/2 (278-280)

The purpose of this study was to evaluate the role of serial CA

125 in monitoring

disease status during chemotherapy

women with metastatic

or recurrent

endometrial

cancer.

in CA

125 was measured in 21 women receiving cisplatin. etoposide. and Adriamycin

for a total of 275 courses of chemotherapy

(median eight). Eight of ten patients had elevated pre-therapy CA 125 levels (median 233 U/mL).

CA

I25 became and/or

re-

epithelial cells normally express epidermal growth factor recep-

mained negative in all 20 women with responding or stable dis-

tors and that epidermal

ease and was elevated in all nine patients who relapsed.

growth

these cells. Although

factor acts as a mitogen

the mitogenic

growth factor often is attenuated

response

in ovarian

for

to epidermal

cancer cell lines,

median level at the time of relapse was 56 U/mL.

elevated before clinical relapse in five of nine patients (56%).

loss of responsiveness to epidermal growth factor does not ap-

Serial CA 125 may aid in the management

pear to be due to decreased receptor expression.

chemotherapy

B; Warshal

Raubertas

RF

Dqwrlment

uf

DP; Angel C; Dvoretsky and

Rochester School c$ Medicine, GYNECOL

Gymwlugy,

Srrong Mcmoriul

Elmwuod Avenue, Rochester, NY OBSTET

14642.

Medicul

Huspirul, 601

OBSTET

carcinoma.

preoperative

prognostic

factors

is helpful

therapy.

Extended

surgical

staging,

including

node dissection, is indicated invasion or high-grade

factors for extrauterine

iden-

in planning pelvic

in patients

and

with deep

Centw.

und Gynccolo~y,

GYNECOL

1991. 7712 (276-277) families were identified.

for 24 cases. Five first-degree relatives underwent oophorectomy,

and early ovarian carcinoma

one of them. Familial

aggregation

prophylactic

was diagnosed in

of ovarian cancer occurs in

carci-

Prognostic factors in stage IB squamous cervical cancer patients with low risk for recurrence Smiley LM; Burke TW; Silva EG; Morris Wharton

cytology was normal in 20 patients (23%). whereas suspicious

Dcpurtmem

or malignant endometrial

Cwkr.

cells were present in 23 and 43 cases Suspicious

or malignant

cytology was associated with deeper myometrial tumor

origin,

accounting

the Israeli Jewish population.

noma, all of whom underwent surgical staging, to correlate the

.01 I), higher postoperative

The Chuim Shcha

Td Hushomc~r. ISR

cytologic results with surgical and pathologic findings. Cervical

respectively.

cancer.

tumor, or when other risk

spread are present. In this study, cervi-

cal cytology was reviewed in 86 patients with endometrial

(27 and 50%).

of women receiving endometrial

G

of Ohsrelrics

eight ovarian cancer-prone

of poor

or recurrent

Among 310 women with ovarian cancer of epithelial

1991, 7713 (458-462)

In patients with endometrial

myometrial

Menczer J: Ben-Baruch

u/

Universily

USA

tification periaortic

PM; Lin JY;

Depurrmcnr 0hsietric.v

for advanced

Familial ovarian cancer in Israeli Jewish women

Endometrial carcinoma: The relevance of cervical cytology DuBeshter

The

Levels were

cervical

invasion (P =

grade (P = .006),

positive

OBSTET About

M; Gershenson

DM;

JT of Gynecology.

1515 Holcomhr GYNECOL one-half

Box

Boulevard,

67,

MD

An&won

How~on.

Cuncer

TX 77030.

USA

1991. 77/2 (271-275) of cervical

cancer

patients

whose tumors

recur after radical surgery have negative lymph nodes and clear

peritoneal washings (P = ,012). and more advanced stage by In-

resection margins. We evaluated 95 patients with squamous cell

ternational

tumors who underwent

= ,024).

Federation

of Gynecology

When compared

and Obstetrics criteria (P

with patients

with normal

cervical

cytology, those who had malignant

endometrial

cells had over

twice the risk of deep myometrial

invasion (67 versus 30%).

twice the risk of grade 2 or 3 tumor (60 versus 30%). and three

Inr J Gynecol Ohstrt 37

phadenectomy

radical

between January

who were thought

hysterectomy

and pelvic lym-

1975 and December

1985 and

to be at low risk for recurrence

whether other clinical or histopathologic tive of tumor recurrence.

Detailed

to see

factors were predic-

retrospective

record review