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Fatigue in Pulmonary Hypertension Patients
Pulmonary Vascular Disease SESSION TITLE: Pulmonary Vascular Disease I SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM
Fatigue in Pulmonary Hypertension Patients Sonu Sahni MD* Sameer Verma Karan Singh MD Nina Kohn MBA; and Arunabh Talwar MD Division of Pulmonary, Critical Care and Sleep Medicine, Northwell Health, New Hyde Park, NY PURPOSE: Symptoms of fatigue are reported by patients with pulmonary hypertension (PHTN) Fatigue severity negatively impacts quality of life, psychosomatic health and may have multiple etiologies. Current management of PHTN focuses heavily on improvement of exercise tolerance and hemodynamics. However, understanding etiopathogenesis of fatigue in this disease is important, as one may be able to tailor-make therapies to improve this symptomatology. The aim of this study is to evaluate fatigue in PHTN patients as measured by the Fatigue Severity Scale (FSS) and its relationship to pulmonary hemodynamics.
RESULTS: There were 9 [21.4%] males and 33 [78.6%] females with a mean age of 55.8 years 13.0. The mean FSS score was 4.4 1.9 with a median score of 4.1 (Q1-Q3: 2.8-6.3). Of the 42 patients 11 (26.2%) were on supplemental oxygen and 7 (16.7%) has diagnosed obstructive sleep apnea. Mean PAP was 42.6 14.1 mmHg, RAP 12.0 6.3 mmHg and CO by Fick was 5.3 2.1 but there was no significant association between fatigue severity and hemodynamics. FSS in patients on supplemental oxygen was found to be higher 5.61.8 than those who were not 4.01.8 (p< 0.05). CONCLUSIONS: Patients with PHTN reported an elevated measurable component of fatigue. However, fatigue did not correlate with cardiopulmonary hemodynamics. It is possible that fatigue represents the psychosomatic domain of this illness. CLINICAL IMPLICATIONS: There is a higher level of fatigue present in the PHTN population which may be affecting health related quality of life. Further studies are needed to understand the correlates of fatigue severity. DISCLOSURE: The following authors have nothing to disclose: Sonu Sahni, Sameer Verma, Karan Singh, Nina Kohn, Arunabh Talwar No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.08.1272
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
journal.publications.chestnet.org
1163A
PULMONARY VASCULAR DISEASE
METHODS: 42 patients with a diagnosis of PHTN on right heart catheterization (mean pulmonary arterial pressure (mPAP) >25mmHg) diagnosed at the Advanced Lung Disease Center at Northwell Health completed a questionnaire to evaluate their baseline self reported fatigue as measured by the FSS. The FSS is a validated instrument that indicates a perception of fatigue that might require medical intervention where a score of 2.30.7 is considered normal [Krupp LB et al. Arch Neurol. 1989]. The association between hemodynamic parameters (mPAP, RAP, and CO) and fatigue was studied. Data was analyzed in Statistical Analysis System (SAS). The Spearman correlation coefficient was computed to determine the degree of correlation between the FSS and each hemodynamic parameter and a p<0.05 was considered statistically significant.
Fatigue in Pulmonary Hypertension Patients Sonu Sahni MD* Sameer Verma Karan Singh MD Nina Kohn MBA; and Arunabh Talwar MD Division of Pulmonary, Critical Care and Sleep Medicine, Northwell Health, New Hyde Park, NY PURPOSE: Symptoms of fatigue are reported by patients with pulmonary hypertension (PHTN) Fatigue severity negatively impacts quality of life, psychosomatic health and may have multiple etiologies. Current management of PHTN focuses heavily on improvement of exercise tolerance and hemodynamics. However, understanding etiopathogenesis of fatigue in this disease is important, as one may be able to tailor-make therapies to improve this symptomatology. The aim of this study is to evaluate fatigue in PHTN patients as measured by the Fatigue Severity Scale (FSS) and its relationship to pulmonary hemodynamics.
RESULTS: There were 9 [21.4%] males and 33 [78.6%] females with a mean age of 55.8 years 13.0. The mean FSS score was 4.4 1.9 with a median score of 4.1 (Q1-Q3: 2.8-6.3). Of the 42 patients 11 (26.2%) were on supplemental oxygen and 7 (16.7%) has diagnosed obstructive sleep apnea. Mean PAP was 42.6 14.1 mmHg, RAP 12.0 6.3 mmHg and CO by Fick was 5.3 2.1 but there was no significant association between fatigue severity and hemodynamics. FSS in patients on supplemental oxygen was found to be higher 5.61.8 than those who were not 4.01.8 (p< 0.05). CONCLUSIONS: Patients with PHTN reported an elevated measurable component of fatigue. However, fatigue did not correlate with cardiopulmonary hemodynamics. It is possible that fatigue represents the psychosomatic domain of this illness. CLINICAL IMPLICATIONS: There is a higher level of fatigue present in the PHTN population which may be affecting health related quality of life. Further studies are needed to understand the correlates of fatigue severity. DISCLOSURE: The following authors have nothing to disclose: Sonu Sahni, Sameer Verma, Karan Singh, Nina Kohn, Arunabh Talwar No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.08.1272
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
journal.publications.chestnet.org
1163A
PULMONARY VASCULAR DISEASE
METHODS: 42 patients with a diagnosis of PHTN on right heart catheterization (mean pulmonary arterial pressure (mPAP) >25mmHg) diagnosed at the Advanced Lung Disease Center at Northwell Health completed a questionnaire to evaluate their baseline self reported fatigue as measured by the FSS. The FSS is a validated instrument that indicates a perception of fatigue that might require medical intervention where a score of 2.30.7 is considered normal [Krupp LB et al. Arch Neurol. 1989]. The association between hemodynamic parameters (mPAP, RAP, and CO) and fatigue was studied. Data was analyzed in Statistical Analysis System (SAS). The Spearman correlation coefficient was computed to determine the degree of correlation between the FSS and each hemodynamic parameter and a p<0.05 was considered statistically significant.