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Fetal and amniotic α1-acid glycoprotein
Clinica Chimica Acta, 208 (1992) 133 0 1992 Elsevier Science Publishers B.V. All rights reserved. 0009-8981/92/$05.00
133
CCA 05303
Letter to the Editor
Fetal and amniotic q-acid
glycoprotein
(Received 22 February 1992; revision received 3 March 1992; accepted 3 March 1992)
Dear Editor, The report by Seta et al. [l] does, as the authors state, ‘confirm earlier assumptions of fetal synthesis of cri-acid glycoprotein’ (AAG) and of the maternal origin of the protein in amniotic fluid. The studies cited by the authors are, like their own observations, only suggestive concerning the origin of fetal and amniotic fluid AAG. Alper, Schmidt and I reported in 1969 that the phenotypes of AAG in cord (fetal) and maternal serum were discordant in 7 of 11 cases studied, demonstrating unequivocally that the fetal protein was synthesized by the fetus [2]. The concentration difference noted by Seta et al. was also noted. The fetal origin of AAG was later confirmed in a second set of 10 paired samples [3], with gestational ages ranging from 29 to 37 weeks at the time of sampling. In the latter study, the phenotypes in amniotic fluid corresponded completely with the maternal types, even when the cord serum types were discordant. Thus, there is no question that amniotic fluid AAG is of maternal origin, while the fetal AAG is synthesized by the fetus rather than the mother. Andrew Myron Johnson University of North Carolina, School of Medicine, Director, Pediatric Teaching Service, Moses H. Cone Memorial Hospital, Greensboro, NC (USA)
References I 2 3
Seta N, Tissot B, Forestier F, Feger J, Daffos F, Durand G. Changes in at-acid glycoprotein serum concentrations and glycoforms in the developing human fetus. Clin Chim Acta 1991;203:167-176. Johnson AM, S&mid K, Alper CA. Inheritance of human at-acid glycoprotein (orosomucoid) variants. J Clin Invest 1969,48:2293-2299. Johnson AM, Umansky I, Alper CA, Everett C, Greenspan G. Amniotic fluid proteins: maternal and fetal contributions. J Pediatr 1974;84:588-593.
Correspondence to: Andrew Myron Johnson, University of North Carolina, School of Medicine, Director, Pediatric Teaching Service, Moses H. Cone Memorial Hospital, Greensboro, NC, USA.
133
CCA 05303
Letter to the Editor
Fetal and amniotic q-acid
glycoprotein
(Received 22 February 1992; revision received 3 March 1992; accepted 3 March 1992)
Dear Editor, The report by Seta et al. [l] does, as the authors state, ‘confirm earlier assumptions of fetal synthesis of cri-acid glycoprotein’ (AAG) and of the maternal origin of the protein in amniotic fluid. The studies cited by the authors are, like their own observations, only suggestive concerning the origin of fetal and amniotic fluid AAG. Alper, Schmidt and I reported in 1969 that the phenotypes of AAG in cord (fetal) and maternal serum were discordant in 7 of 11 cases studied, demonstrating unequivocally that the fetal protein was synthesized by the fetus [2]. The concentration difference noted by Seta et al. was also noted. The fetal origin of AAG was later confirmed in a second set of 10 paired samples [3], with gestational ages ranging from 29 to 37 weeks at the time of sampling. In the latter study, the phenotypes in amniotic fluid corresponded completely with the maternal types, even when the cord serum types were discordant. Thus, there is no question that amniotic fluid AAG is of maternal origin, while the fetal AAG is synthesized by the fetus rather than the mother. Andrew Myron Johnson University of North Carolina, School of Medicine, Director, Pediatric Teaching Service, Moses H. Cone Memorial Hospital, Greensboro, NC (USA)
References I 2 3
Seta N, Tissot B, Forestier F, Feger J, Daffos F, Durand G. Changes in at-acid glycoprotein serum concentrations and glycoforms in the developing human fetus. Clin Chim Acta 1991;203:167-176. Johnson AM, S&mid K, Alper CA. Inheritance of human at-acid glycoprotein (orosomucoid) variants. J Clin Invest 1969,48:2293-2299. Johnson AM, Umansky I, Alper CA, Everett C, Greenspan G. Amniotic fluid proteins: maternal and fetal contributions. J Pediatr 1974;84:588-593.
Correspondence to: Andrew Myron Johnson, University of North Carolina, School of Medicine, Director, Pediatric Teaching Service, Moses H. Cone Memorial Hospital, Greensboro, NC, USA.