Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): Bordeaux, France 17–20 May 2009

Marine Environmental Research 69 (2010) iii–xvi

Contents lists available at ScienceDirect

Marine Environmental Research journal homepage: www.elsevier.com/locate/marenvrev

Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): Bordeaux, France 17–20 May 2009 Sponsors of PRIMO15 Centre National de la Recherche Scientifique (CNRS) Institut d’Ecologie et d’Environnement (CNRS/INEE) Institut de Chimie (CNRS/INC) Université du Havre Laboratoire d’Ecotoxicologie des Milieux Aquatiques (LEMA) Université Bordeaux 1 Institut des Sciences Moléculaires (ISM) Environnements et Paléoenvironnements OCéaniques (EPOC) Union Européenne (Interreg IVa programme) Ministère de l’Environnement, de L’Energie, du Développement Durable, et de l’Aménagement du Territoire (MEEDDAT) Ministère de l’Enseignement Supérieur et de la Recherche (MESR) Institut Francais de Recherche pour l’Exploitation de la Mer (IFREMER) Institut National de l’EnviRonnement Industriel et des RISques (INERIS) Conseil Régional d’Aquitaine Mairie de Bordeaux Communauté Urbaine de Bordeaux (CUB) Société Chimique de France (SCF) Lyonnaise des Eaux Total Sigma–Aldrich Biosense Laboratories Fisher Scientific Partners European Association of Chemical and Molecular Sciences (Euchems) Bio-Tox Marine Environmental Research Environmental Science and Pollution Research Aquatic Living Resources Analytical and Bioanalytical Chemistry Pci-Spectra Analyses L’actualité Chimique Toxem Interreg European Programme Université De Bordeaux Gis Ecobag Gip Seine-Aval Exhibitors Leco Agilent Technologies doi:10.1016/j.marenvres.2010.04.002

Executive Committee Philippe Garrigues Christophe Minier International Scientific Committee Farida Akcha, IFREMER, France Afonso Bainy, Brazil Rebecca van Beneden, ME, USA Maria João Bebianno, Portugal Miren P. Cajaraville, Spain Lionel Camus, Norway Kevin Chipman, United Kingdom Malin Celander, Sweden David Epel, CA, USA Lars Förlin, Sweden Stephen George, United Kingdom Anders Goksøyr, Norway Ketil Hylland, Norway Tom Hutchinson, United Kingdom Margaret O. James, FL, USA Angela Köhler, Germany Michael N. Moore, United Kingdom Jean François Narbonne, France Cinta Porte, Spain Francesco Regoli, Italy Amy H. Ringwood, NC, USA Daniel Schlenk, CA, USA John J. Stegeman, MA, USA Peter Thomas, TX, USA Aldo Viarengo, Italy John Widdows, United Kingdom Local Organizing Committee University of Le Havre: Christophe Minier Joëlle Forget-Leray François Leboulenger Julie Letendre Perrine Géraudie-Maltret University of Bordeaux: Philippe Garrigues Magalie Beaudrimont Jean-Paul Bourdinaud Jérome Cachot Xavier de Montaudouin Bénédicte Morin

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Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

Conference Secretariat Karine Ndiaye Webmaster Fabrice Forlini Scientific session chairs Jean Paul Bourdineau/Richard Di Giulio Maria Cristina Fossi/Lionel Camus Maria Joao Bebianno/Anders Goksoyr Claude Amiard-Triquet/Mike Moore Jeanette Rotchell/Thierry Burgeot Shannon Bard/Till Lukenbach Laura Canesi/Margaret O. James Francesco Regoli/Malin Celander Cinta Porte/Daniel Schlenk Amy H. Ringwood/John Widdows Augustine Arukwe/Afonso Bainy Ketil Hylland/Jean Charles Massabuau Joëlle Forget-Leray/Mauro Rebello Bénédicte Morin/John Craft Nancy Denslow/Stephen George Tracy Collier/Magalie Baudrimont Miren P. Cajaraville/Peter Thomas Rebecca Von Beneden/Farida Akcha Jean François Narbonne/John Stegeman Malcolm B. Jones/Xavier de Montaudouin Aldo Viarengo/Kevin Chipman Angela Kölher/Jérôme Cachot SCIENTIFIC PROGRAMME INVITED LECTURE HYPOXIA IS AN ENDOCRINE DISRUPTOR AND A TERATOGEN IN FISH: WILL THIS ALSO HAPPEN IN HUMAN AND HIGHER VERTEBRATES? Rudolf Wu MECHANISMS OF TOXICITY Platform session 1 STRUCTURAL DETERMINANTS OF LOW RESPONSIVENESS TO 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) IN AN ARYL HYDROCARBON RECEPTOR (AHR) FROM THE FROG XENOPUS LAEVIS Sarah A. Holzman, Camila Odio, Michael S. Denison, Laura Bonati, Wade H. Powell FUNCTIONAL ANALYSIS OF THE ARYL HYDROCARBON RECEPTOR REPRESSOR FROM CHICKEN Jin-Seon Lee, Eun-Young Kim, Hisato Iwata CYTOCHROME P450 GENES IN BIVALVES (MYTILUS SP) AND EXPRESSION OF A NEW CYP1-LIKE GENE Juliano Zanette, Matthew J. Jenny, Jared V. Goldstone, Bruce R. Woodin, Afonso C.D. Bainy, John J. Stegeman DYNAMICS OF DIOXINS IN TAPES PHILIPPINARUM STUDIED BY COMBINING DETOXIFICATION EXPERIMENTS DATA AND ECOTOXICOLOGICAL MODEL Stefano Raccanelli, Simone Libralato THE CU-ATPASES AND COPPER HOMEOSTASIS: EVOLUTIONARY ASPECTS Matteo Minghetti, Michael J. Leaver, Stephen G. George

NUCLEAR RECEPTOR TARGETS FOR ENDOCRINE DISRUPTING EFFECTS–MECHANISMS OF ACTION FOR EMERGING ENVIRONMENTAL POLLUTANTS? Roger Lille-Langøy, Marte Rusten, Bruce Blumberg, Rune Male, Anders Goksøyr Platform session 2 UP-REGULATION OF HEPATIC ABCC2, ABCG2, CYP1A1 AND GST IN MULTIXENOBIOTIC RESISTANT KILLIFISH (FUNDULUS HETEROCLITUS) FROM THE SYDNEY TAR PONDS, NOVA SCOTIA, CANADA Solveig Christine Paetzold, Shannon Mala Bard EXPESSION AND ACTIVITIES OF MXR RELATED ABC TRANSPORTERS IN DANIO RERIO EMBRYOS Stephan Fischer, Kristin Schirmer, Nils Klüver, Mady Ahnert, Robert Suchsland, Kathrin Schlüssler, Till Luckenbach ESTROGENIC ACTIVITY OF TERNARY UV-FILTER MIXTURES IN FISH – AN ANALYSIS WITH NONLINEAR ISOBOLOGRAMS Petra Y. Kunz, Karl Fent THE INTERFERENCE OF NITRO- AND POLYCYCLIC MUSKS WITH ENDOGENOUS AND XENOBIOTIC METABOLIZING ENZYMES IN FISH Sabine Schnell, Denise Fernandes, Rebeca Martin-Skilton, Cinta Porte MOLECULAR MECHANISM OF E2 MODULATION OF CYP1A TRANSCRIPTIONAL REGULATION Martine H. Gjernes, Anne S. Mortensen, Augustine Arukwe Platform session 3 INVESTIGATION OF AHR PATHWAY FUNCTION AND PAH ADAPTATION IN FUNDULUS HETEROCLITUS USING MORPHOLINO GENE KNOCKDOWN Bryan W Clark, Cole W Matson, Dawoon Jung, Richard T Di Giulio ABSENCE OF EROD ACTIVITY IN FISH: THE CURIOUS CASE OF HYPOSTOMUS CYP1A Thiago E.M. Parente, Bruce R. Woodin, Jared V. Goldstone, Francisco J.R. Paumgartten, Mauro F. Rebelo, John J. Stegeman ACTIVE MACROPHAGE AGGREGATES IN THE LIVER OF FISH CAUSE SELFDAMAGE AND DAMAGE OF ADJACENT TISSUE Katja Broeg USING COMPARATIVE GENOMICS TO FACILITATE BIOMARKER DISCOVERY AND IDENTIFY BIOCHEMICAL PATHWAYS OF CHEMICAL OLFACTORY INJURY IN PACIFIC SALMON Evan Gallagher, Fred Tilton, Theo Bammler, Richard Beyer, Susan Tilton, Patricia Stapleton, H Espinoza, Nathaniel Scholz, David Baldwin, Federico Farin EFFECTS OF DIETARY METHYLMERCURY ON THE MITOCHONDRIAL ENERGY METABOLISM IN SKELETAL MUSCLES AND BRAIN OF ZEBRAFISH Sebastien Cambier, Gil Bénard, Nathalie Mesmer-Dudons, Patrice Gonzalez, Rodrigue Rossignol, Daniel Brèthes, Jean-Paul Bourdineaud Poster sessions EVALUATION OF THE SYNERGETIC TOXIC EFFECTS OF ORGANIC POLLUTANTS MIXTURES TO MARINE PHYTOPLANKTON Pedro Echeveste, Susana Agustí, Jordi Dachs ALTERATION OF CYTOCHROME P4503A ACTIVITY (CYP3A) AND ABCTRANSPORTER ACTIVITY BY ENVIRONMENTAL PHARMACEUTICALS IN FISH CELL LINES Karl Fent, Daniela Oggier, Verena Christen PFOA ALTERS EXPRESSION OF INFLAMMATORY FACTORS IN JAPANESE MEDAKA

Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

Jae-Ho Yang, Hyun-Gyo Lee, Sang-Hyun Kim RESPONSES OF THE MARINE MUSSEL, MYTILUS, TO CONCURRENT COPPER EXPOSURE AND NUTRITIONAL DEPRIVATION Jenny P. Shaw, Michael N. Moore, Christine Pascoe, Amanda Beesley, Dave R. Lowe FIRST EVIDENCE OF CYP1A INDUCTION IN LOGGERHEAD TURTLE LYMPHOCYTES EXPOSED TO PAHS AND PBDES Silvia Casini, Letizia Marsili, Cristina Panti, Stefania Ancora, Silvia Maltese, M. Cristina Fossi EXPRESSION OF TRIBUTYLTIN-BINDING PROTEIN TYPE 1 IN SILKWORMS USING BY A BACULOVIRUS GENE EXPRESSION SYSTEM Hina Satone, Jae Man Lee, Takahiro Kusakabe, Yumi Oba, Yohei Shimasaki, Yuji Oshima TRIBUTYLTIN-BINDING PROTEINS FROM BLOOD OF THE TIGER PUFFER, TAKIFUGU RUBRIPES Yumi Oba, Akira Yamauchi, Yuji Oshima, Yohei Shimasaki, Hina Satone, Takeshi Kitano, Miki Nakao, Shun-ichiro Kawabata, Tsuneo Honjo EFFECTS OF SALINITY ON METAL AND METALLOTHIONEIN MRNA LEVELS IN ORGANS OF TILAPIA EXPOSED TO CADMIUM, COPPER, AND ZINC IONS King Ming Chan, Chun Shum Shek DIOXIN-LIKE PCB126 MEDIATED ESTROGENICITY IN FISH IN VITRO SYSTEM INVOLVES BOTH RECEPTOR ACTIVATION AND RECEPTOR-PROTEIN STABILITY Martine H. Gjernes, Anne S. Mortensen and Augustine Arukwe ECOTOXICOLOGICAL STUDIES IN FIBROBLAST CELL CULTURES FROM DELPHINUS CAPENSIS AND BALAENOPTERA EDENI SKIN BIOPSIES OF THE GULF OF CALIFORNIA (MEXICO) Letizia Marsili, Silvia Casini, Laura Carletti, Silvia Maltese, Serena Porcelloni, Carlos A. Niño-Torres, Lorenzo Rojas-Bracho, Jorge Urbán, Maria Cristina Fossi COMPARISON OF CYP1A INDUCIBILITY IN ISOLATED LIVER AND IMMUNE CELLS OF RAINBOW TROUT Anja M. Möller, Ayako Nakayama, Bernd Köllner, Helmut Segner EFFECTS OF THE MODEL PAH PHENANTHRENE ON IMMUNE FUNCTION AND OXIDATIVE STRESS IN THE TEMPERATE SCALLOP PECTEN MAXIMUS Marie L. Hannam, Shaw D. Bamber, Tamara S. Galloway, A. John Moody, Malcolm B. Jones ILMENITE-WEIGHTED WATER-BASED DRILLING MUDS: EFFECT ON CELLULAR IMMUNE FUNCTION IN THE SCALLOP, PECTEN MAXIMUS Marie L. Hannam, Renee Bechmann, Stig Westerlund, Shaw D. Bamber, Tamara S. Galloway, A. John Moody, Malcolm B. Jones DRUG-METABOLIZING ENZYMES AND GILL MORPHOLOGY ARE SENSITIVE TARGETS OF TNT TOXICITY IN FISH Camilla Della Torre, Ilaria Corsi, Augustine Arukwe, Cristiana Sensini, Silvano Focardi RED MULLET PHASE I AND III DRUG-METABOLIZING ENZYMES ARE SENSITIVE INDICATORS OF PETROLEUM HYDROCARBON CONTAMINATION Camilla Della Torre, Ilaria Corsi, Tancredi Caruso, Guido Perra, Giacomo Guerrini, Silvano Focardi PHYLOGENETIC AND TISSUE DISTRIBUTION ANALYSIS OF FOUR ABCG2 ISOFORMS (ABCG2A-D) IN ZEBRAFISH (DANIO RERIO) Jovica Loncar, Marta Popovic, Roko Zaja and Tvrtko Smital BIOTRANSFORMATION AND GENOTOXICITY OF MODEL AQUATIC POLLUTANTS IN RAINBOW TROUT Iris Barjhoux, Christelle Clérandeau, Michèle Daubèze, Jean-François Narbonne, Jean-Luc Ravanat, Véronique André, Bénédicte Morin EUROPEAN SEABASS (DICENTRARCHUS LABRAX) PRIMARY HEPATOCYTES EXHIBIT MXR ACTIVITY

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Marta Ferreira, Maria Armanda Reis-Henriques, Pedro Moradas Ferreira, Tvrtko Smital ESTERASE INHIBITION IN TADPOLES OF SCINAX FUSCOVARIUS AS BIOMARKERS OF ORGANOPHOSPHATE PESTICIDE EXPOSURE. Patrícia Zazeri Leite, Tatiana Cristina Stefani Margarido, Daína de Lima, Denise de Cerqueira Rossa-Feres, Eduardo Alves de Almeida THE EUROPEAN EEL ANGUILLA ANGUILLA AS BIOLOGICAL MODEL TO ASSESS QUALITY AND TOXICOLOGICAL RISKS OF SEDIMENTS Francesco Regoli, Francesco Ciaprini, Francesco Piva, Fulvio Onorati, Antonella Ausili, Matteo Giulietti, Maura Benedetti, Daniele Fattorini, Stefania Gorbi, Alessandra Notti, Fabio Sarti BIOAVAILABILITY AND TOXICOLOGICAL EFFECTS OF POLLUTED SEDIMENTS IN CLAMS, TAPES PHILIPPINARUM: A LABORATORY ASSESSMENT Raffaella Bocchetti, Alessandra Notti, Daniele Fattorini, Stefania Gorbi, Maura Benedetti, Francesco Regoli BIOMARKERS RESPONSES IN MYTILUS GALLOPROVINCIALIS FOR MONITORING DREDGING ACTIVITIES IN HARBOUR AREAS Marialuisa Pioppi, Stefania Gorbi, Raffaella Bocchetti, Maura Benedetti, Daniele Fattorini, Alessandra Notti, Erika Razzetti, Simona Macchia, Lisa Oliviero, Fabiano Pilato, David Pellegrini, Francesco Regoli ARSENIC BIOAVAILABILITY IN MUSSELS FROM THE ADRIATIC SEA: ENVIRONMENTAL VERSUS BIOLOGICAL FEATURES Daniele Fattorini, Alessandra Notti, Rossella Di Mento, Massimo Gabellini, Anna Maria Cicero, Francesco Regoli IDENTIFICATION OF CHANNEL CATFISH UDP-GLUCURONOSYLTRANSFERASE ISOFORM UGT1F01 James C. Sacco, David S. Barber, Margaret O. James STEREOSELECTIVE ACTIVATION OF SYNTHETIC PYRETHROIDS TO ESTROGENIC METABOLITES IN FISH Mae Grace Nillos, Jay Gan, Daniel Schlenk TOXICITY OF WEATHERED OIL TO MARINE ORGANISMS DURING LONG-TERM EXPOSURE IN MESOCOSM Andrea Tornambè, Camilla Della Torre, Silvia Giuliani, Ezio Amato, Carla Falugi, Antonella Crisari, Melania Buffagni, Barbara Catalano, Ginevra Moltedo, Fulvio Onorati, Federica Savorelli, Erika Magaletti THE TRYPTOPHAN PHOTOPRODUCT 6-FORMYLINDOLO[3,2B]CARBAZOLE BINDS MULTIPLE AHRS AND INDUCES MULTIPLE CYP1 GENES VIA AHR2 IN ZEBRAFISH Maria E. Jönsson, Diana G. Franks, Bruce R. Woodin, Matthew J. Jenny, Rita A. Garrick, Lars Behrendt, Mark E. Hahn, John J. Stegeman ANTIOXIDANT PARAMETERS IN THE GILLS OF THE BROWN MUSSEL PERNA PERNA EXPOSED TO ZINC: A TEMPORAL MODULATION Rafael Trevisan, Jacó Joaquim Mattos, Marilia Nardelli Siebert, Marcela Uliano Silva, Afonso Celso Dias Bainy, Alcir Luiz Dafré FORMATION, ACTIVITY, AND DISAGGREGATION OF MACROPHAGE AGGREGATES IN TURBOT LIVER IN RESPONSE TO ß-NAPHTHOFLAVONE Katja Broeg, Günther Krüner, Angela Koehler CHANGES IN MRNA EXPRESSION OF GENES ENCODING STEROIDOGENIC ENZYMES IN TESTES FROM NILE TILAPIA EXPOSED TO ESTROGENIC ENDOCRINE DISRUPTERS IN VITRO Cláudia Ribeiro, Ralph Urbatzka, L. Filipe C. Castro, Eduardo Rocha, João Carrola, António Fontainhas-Fernandes, Maria J. Rocha GENOME ANNOTATION AND PHYLOGENETIC ANALYSIS OF THE VERTEBRATE CYTOCHROME P450 2 FAMILY Nina Kirischian, Andrew G. McArthur, Caroline Jesuthasan, Birgit Krattenmacher, Joanna Y. Wilson RED BLOOD CELL CYTOTOXICITY IN HADDOCK (MELANOGRAMMUS AEGLEFINUS) AND DAB (LIMANDA LIMANDA)

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Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

Ketil Hylland, Bjørn Skei, Nicolai Bølling, Eivind Farmen Finne BIOCHEMICAL RESPONSES IN MOZAMBIQUE TILAPIA (OREOCHROMIS MOSSAMBICUS) EXPOSED TO PESTICIDE POLLUTED WATERS IN MOZAMBIQUE Joachim Sturve, Linda Andersson, Maria P. Scarlet, Leif Norrgren THE USE OF NILE TILAPIA AS AN EXPERIMENTAL MODEL FOR STUDYING LIVER NECROSIS AND ITS FUNCTIONAL CONSEQUENCES Pedro Matos, António Fontaínhas-Fernandes, Maria H. Galante, Rogério A.F. Monteiro, Eduardo Rocha THE FIRST CHARACTERISATION OF FISH P-GLYCOPROTEIN (ABCB1) ATPASE ACTIVITY Zaja Roko, Popovic Marta, Loncar Jovica, Smital Tvrtko PURINE CATABOLISM AS NEW TARGET OF ESTROGEN SIGNALLING? CLONING OF URATE OXIDASE IN BROWN TROUT AND EXPRESSION DURING THE ANNUAL REPRODUCTIVE CYCLE Ralph Urbatzka, L. Filipe C. Castro, Maria J. Rocha, Alexandre Lobo-da-Cunha, Rogério A.F. Monteiro, Eduardo Rocha v17-ALPHA-ETHINYLESTRADIOL HINDERS NUCLEOTIDE EXCISION REPAIR Gregory D. Ballard, Rebecca J. Van Beneden, Gregory D. Mayer PEROXIDE CONSUMPTION AS A FUNCTIONAL PEROXIDE DETOXIFICATION INDEX IN MARINE ORGANISMS Alcir Luiz Dafre, Rafael Trevisan IDENTIFICATION AND CHARACTERIZATION OF KILLIFISH (FUNDULUS HETEROCLITUS) MITOCHONDRIAL CYP1A1 AND ITS RELATIONSHIP TO EFFECTS OF POLYCYCLIC AROMATIC HYDROCARBONS ON ENERGY METABOLISM Dawoon Jung, Cole P. Thompson, Richard T. Di Giulio THE SYNERGISTIC DEVELOPMENTAL TOXICITY OF PAHS IS NOT ACCOMPANIED BY SYNERGISTIC INDUCTION OF VARIOUS PHASE I AND REDOX-RESPONSIVE GENES Lindsey A Van Tiem, Richard T Di Giulio HETEROLOGOUS EXPRESSION AND INITIAL CHARACTERIZATION OF FIVE ZEBRAFISH CYP1 GENES (CYP1A, CYP1B1, CYP1C1, CYP1C2 AND CYP1D1) Lars Behrendt, Bruce R. Woodin, John J. Stegeman MONITORING PAH LEVELS AND EFFECTS AFTER DISCHARGE OF 4400 M3 OIL AT STATFJORD A, THE NORTH SEA, DECEMBER 2007 Bjørn Einar Grøsvik, Sonnich Meier, Torbjørn Midtun, Kjell Westrheim, Guri Nesje, Stepan Boitsov, Anders Goksøyr, Jarle Klungsøyr EFFECTS OF XENOBIOTICS ON PXR-CYP3A SIGNALING IN RAINBOW TROUT Britt Wassmur, Johanna Gräns, Malin C. Celander INTERACTIONS OF PHARMACEUTICALS ON BIOMARKER RESPONSES IN RAINBOW TROUT Johanna Gräns, Britt Wassmur, Malin C. Celander CHARACTERIZATION OF A CYP3A-LIKE ACTIVITY IN THE DIGESTIVE GLAND OF MYTILUS GALLOPROVINCIALIS – INHIBITION BY 17áETHYNYLESTRADIOL Rémi Thibaut, Salvatore Nesci, Alessandra Pagliarani, Cinta Porte IDENTIFICATION AND COMPARISONS OF ABCB AND ABCC LIKE TRANSPORTERS FROM THREE MYTILUS SPECIES Till Luckenbach, Mirko Pietsch ASSESSMENT OF A NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) METABOLISM BY ZEBRAFISH LARVAE, USING LIQUID CHROMATOGRAPHYMASS SPECTROMETRY (LC-MS) Huw S Jones, Henry T Trollope, Thomas H Hutchinson, Grace H Panter, J Kevin Chipman GAMBUSIA AFFINIS: A FISH MODEL TO ASSESS THE TOXICOLOGICAL IMPACT OF PRODUCED WATERS Caliani Ilaria, Ferraro Maria, Casini Silvia, Porcelloni Serena, Maltese Silvia, Mori Gabriele, Marsili Letizia, Fossi Maria Cristina

PERFLUORINATED ORGANIC COMPOUNDS (PFOA/PFOS) DIFFERENTIALLY MODULATE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARS) IN LIVER AND KIDNEY OF SALMON EXPOSED THROUGH DIET Anne S. Mortensen, Robert J. Letcher, Augustine Arukwe COMBINED EFFECTS OF EXPOSURE TO DIFFERENT PAH COMPOUNDS ON BIOMARKER RESPONSES IN MYTILUS SPP. FROM THE LOW-SALINITY NORTHERN BALTIC SEA Raisa Turja, Galina Garnaga, Kari K. Lehtonen BIOTRANSFORMATION OF POLYBROMINATED DIPHENYL ETHERS IN RINGED SEALS FROM SVALBARD AND THE BALTIC SEA Heli Routti, Robert J. Letcher, Bert van Bavel, Shaogang Chu, Geir W. Gabrielsen A COMPARATIVE STUDY OF THE ACTIVATION OF PREGNANE X RECEPTOR ORTHOLOGS IN VARIOUS MARINE ORGANISMS Hilde E. Førde, Astrid E. Mork, Tonje A. Gjøystdal, Roger LilleLangøy, Marte Rusten, Rune Male, Bruce Blumberg, Anders Goksøyr AN INTEGRATED APPROACH TO DETERMINE OXIDATIVE STRESS IN MIRROR CARP (CYPRINUS CARPIO L.) Sanaa A. Mustafa, Simon J. Davies, Awadhesh N. Jha ROLE OF CYTOCHROME P450 1C GENES IN THE REDUCED MESENCEPHALIC VEIN BLOOD FLOW CAUSED BY ACTIVATION OF ARYL HYDROCARBON RECEPTOR 2 IN THE ZEBRAFISH EMBRYO Akira Kubota, Ryo Harano, John J. Stegeman, Takeo Hiraga, Hiroki Teraoka EXPOSURE ROUTE AS A KEY FACTOR IN BENZO(A)PYRENE DETOXIFICATION IN NILE TILAPIA Joana Costa, Marta Ferreira, Maria Armanda Reis-Henriques PHYSIOLOGICAL EFFECTS OF TEMPERATURE AND HERBICIDE WATER EXPOSURE ON THE SOFT-SHELL CLAM MYA ARENARIA (MOLLUSCA; BIVALVIA) Angela Sacchi, Luna Greco, Jocelyne Pellerin Ettore Capri, Florent Garnerot, Séverine Louis, Michel Fournier, Dominique Lapointe, Patrice Couture CARBARYL AND DIAZINON EFFECTS IN NILE TILAPIA AND ARMOURED CATFISH: A COMPARATIVE STUDY ON OXIDATIVE STRESS BIOMARKERS AND ESTERASE INHIBITION PROFILES Aline Cristina Ferreira Rodrigues, Camila Pereira Trídico, Lilian Nogueira, Eduardo Alves de Almeida BIOCHEMICAL BIOMARKERS IN NILE TILAPIA EXPOSED TO BENZO[A]PYRENE AND DIAZINON Camila Pereira Trídico, Daniele Caetano da Silva, Aline Cristina Ferreira Rodrigues, Lilian Nogueira, Eduardo Alves de Almeida COMPARATIVE STUDY OF DIESEL OIL EFFECTS IN BIOCHEMICAL BIOMARKERS OF FISHES WITH DIFFERENT HABITS Lilian Nogueira, Camila Pereira Trídico, Aline Cristina Ferreira Rodrigues, Carlos Eduardo Fossa, Eduardo Alves de Almeida BIOMARKER DEVELOPMENT IN SEA OTTERS (ENHYDRA LUTRIS): GENE SEQUENCES FOR CYTOCHROMES P450 1A1 AND 1A2 Sharon E. Hook, Michael E. Cobb, James T. Oris, Jack W. Anderson FATTY-ACID BINDING PROTEIN, A MOLECULAR BIOMARKER OF EXPOSURE TO DOMESTIC SEWAGE IN PACIFIC OYSTER, CRASSOSTREA GIGAS Marília N. Siebert, Guilherme Toledo-Silva, Igor D. Medeiros, Fabrício F. Nunes, Juliano Zanette, Gianinna Rotava, Claudio Manoel Rodrigues de Melo, Afonso C.D. Bainy SIZE DEPENDENT TOXICITY THRESHOLDS OF POLYCYCLIC AROMATIC HYDROCARBONS TO NATURAL AND CULTURED PHYTOPLANKTON POPULATIONS P. Echeveste, S. Agustí, J. Dachs COMPARATIVE STUDY ON THE EFFECTS OF MERCURY ON ACUTE TOXICITY AND STRESS GENE EXPRESSION IN CALANUS FINMARCHICUS AND C. GLACIALIS

Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

Ida Beathe Øverjordet, Bjørn Henrik Hansen, Dag Altin, Torunn Berg, Geir Wing Gabrielsen, Bjørn Munro Jenssen MODULATION OF OXIDATIVE STRESS GENES OF THE INTERTIDAL COPEPOD TIGRIOPUS JAPONICUS AFTER EXPOSURE OF SEVERAL KINDS OF CHEMICALS Jae-Seong Lee HEAT SHOCK PROTEIN (HSP) GENE RESPONSES OF THE INTERTIDAL COPEPOD TIGRIOPUS JAPONICUS TO ENVIRONMENTAL TOXICANTS Jae-Sung Rhee, Kyun-Woo Lee, Dae-Sik Hwang, Jae-Seong Lee MOLECULAR CLONING, PHYLOGENETIC ANALYSIS AND DEVELOPMENTAL EXPRESSION OF VITELLOGENIN (VG) GENES FROM THE INTERTIDAL COPEPOD, TIGRIOPUS JAPONICUS Dae-Sik Hwang, Kyun-Woo Lee, Jae-Seong Lee BIOTRANSFORMATION OF ORGANOCHLORINE PESTICIDES IN RINGED SEALS (PHOCA HISPIDA) FROM THE BALTIC SEA AND FROM SVALBARD Heli Routti, Bert van Bavel, Robert J. Letcher, Augustine Arukwe, Shaogang Chu, Geir W. Gabrielsen CHANGES ON THE EXRESSION OF HEAT SHOCK PROTEINS (HSP60 AND HSP90) IN THE OYSTER CRASSOSTREA BRASILIANA FOLLOWING EXPOSURE TO DIESEL FUEL WATER SOLUBLE FRACTION Ninna Granucci, Karim H. Lüchmann, Jacó J. Mattos, Marília. N. Siebert, Cláudio Manoel Rodrigues de Melo, Afonso C.D. Bainy UBIQUITIN GENE INDUCTION AS A POTENTIAL BIOMARKER IN FARMED SHRIMP, LITOPENAEUS VANNAMEI Muller I.C., Marques M.R.F. DEVELOPMENT, CHARACTERIZATION, AND TECHNICAL APPLICATIONS OF A PANEL OF MONOCLONAL ANTIBODIES GENERATED AGAINST RECOMBINANT MUMMICHOG, FUNDULUS HETEROCLITUS, ARYL-HYDROCARBON RECEPTOR-2 (AHR-2) Charles D. Rice, Mark E. Hahn, Rebecca R. Merson CELLULAR VAULTS AS INDICATORS OF ADAPTATION AND RESISTANCE TO HARSH CHEMICALS IN FISH LEUKOCYTES Charles D. Rice, Lisa J. Bain, Alison E. Springs, Yuang Xiang

ECOTOXICOLOGY IN SPECIAL AREAS Platform session 1 REGION: WILL THE ANTARCTIC CIRCUMPOLAR CURRENT OFFER PROLONGED PROTECTION? Susan Bengtson Nash, Stephen Rintoul, So Kawaguchi, Iain Staniland, John van den Hoff, Megan Tierney, Rossana Bossi ECOTOXICOLOGY AND USE OF BIOINDICATORS FOR MONITORING THE ANTARCTIC ENVIRONMENT Maura Benedetti, Marco Nigro, Francesco Regoli IDENTIFICATION OF 5 PARTIAL ABC PROTEINS AND INDUCTION OF ABCB1 AND ABCC2 IN LIVER AND BRAIN OF THE ANTARCTIC EMERALD ROCK COD TREMATOMUS BERNACCHII EXPERIMENTALLY EXPOSED TO ENVIRONMENTAL CONTAMINANTS Sara Zucchi, Ilaria Corsi, Till Luckenbach, Shannon Mala Bard, Francesco Regoli, Silvano Focardi TOXICITY OF P, P’-DDE TO EARLY LIFE STAGES OF AN ANTARCTIC KEYSTONE SPECIES – ANTARCTIC KRILL (EUPHAUSIA SUPERBA) Anita Hanako Poulsen, So Kawaguchi, Robert King, Susan Bengtson Nash COPOL – CONTAMINANTS IN POLAR REGIONS: THE EFFECTS OF CLIMATE CHANGE ON CONTAMINANT FLOW IN POLAR MARINE ECOSYSTEMS Anita Evenset, Guttorm Christensen, Nicholas Alexander Warner, Katrine BorgåAnders Ruus, Eldbjørg Sofie Heimstad, Michael Tessmann, Ingeborg G. Hallanger, Geir Wing Gabrielsen

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OIL AND GAS DEVELOPMENT IN THE ARCTIC-WHAT DO WE KNOW ABOUT BIOLOGICAL EFFECTS OF CRUDE OIL ON MARINE ARCTIC ANIMALS? Lionel Camus, Louise K. Jensen, Iris Jæger, Jasmine Nahrgang, Gro H. Olsen Platform session 2 HEPATIC ANTIOXIDANT DEFENCE RESPONSES IN ARCTIC HERRING GULL (LARUS ARGENTATUS) CHICKS EXPOSED TO HALOGENATED ORGANIC CONTAMINANTS Marit Nøst Hegseth, Lionel Camus, Setphania Gorbi, Lisa B Helgason, Francesco Regoli, Geir Wing Gabrielsen EFFECTS OF TEMPERATURE ON TOXICOKINETICS OF PYRENE IN THE AMPHIPOD GAMMARUS SETOSUS FROM SVALBARD Iris Jæger, Victor Carrasco Navarro, Jussi V.K. Kukkonen, Jani O. Honkanen REGIONAL AND TEMPORAL DIFFERENCES IN THE OXIDATIVE STRESS STATUS OF BALTIC SALMON FEEDING POPULATIONS Kristiina A. Vuori, Mirella Kanerva, Mikko Nikinmaa MERCURY POLLUTED SEDIMENTS – UPTAKE AND EFFECTS IN ATLANTIC COD (GADUS MORHUA) Marianne Brattås, Silje Tingstad, Victor Zgoda, Pål Olsvik, Anders Goksøyr THE POLAR COD (BOREOGADUS SAIDA) AS AN INDICATOR SPECIES FOR OIL BIOMONITORING IN ARCTIC REGIONS Jasmine Nahrgang, Lionel Camus, Mark Carls, Patrice Gonzalez, Martina Jönsson, Jørgen S. Christiansen, Haakon Hop, Renée Bechmann, Ingrid C. Taban Platform session 3 BIOMARKER RESPONSES AND CONTAMINANT LEVELS IN FIN WHALE (BALAENOPTERA PHYSALUS) SKYN BIOPSIES OF PELAGOS SANCTUARY (MEDITERRANEAN SEA) AND GULF OF CALIFORNIA (MEXICO) Fossi M.C, Urban J, Casini S, Maltese S, Spinsanti G, Porcelloni S, Panigada S, Lauriano G, Niño C, Rojas-Bracho L, Jimenez B, Muñoz J, Marsili L SHOTGUN REDOX PROTEOMICS IN SUB-PROTEOMES TRAPPED ON FUNCTIONALISED BEADS: IDENTIFICATION OF PROTEINS TARGETED BY OXIDATIVE STRESS David Sheehan AN INTEGRATED ECOTOXICOLOGICAL APPROACH REVEALS THE IMPACT OF AN OIL REFINERY IN A MARINE COASTAL AREA BY USING TWO BIOINDICATOR SPECIES MEDITERRANEAN MUSSEL AND RED MULLET Ilaria Corsi, Davide Baroni, Tancredi Caruso, Camilla Della Torre, Giacomo Guerrini, Michela Mariottini, Angela M. Pastore, Guido Perra, Cristiana Sensini, Anna Trisciani, Valerio Volpi, Sara Zucchi, Silvano Focardi MONITORING POLLUTION IN WATER ENVIRONMENTS USING THE THREE SPINED STICLEBACK, GASTEROSTEUS ACULEATUS AND QPCR Paul J. Baker, Caroline Kneller, Brian Miller, John Redshaw, John A. Craft ENDOCRINE EFFECTS IN POLAR COD (BOREGADUS SAIDA) LIVER TISSUE AFTER CRUDE OIL AND 17b-ESTRADIOL EXPOSURE Siri Nesbakken, Anne Mortensen, Jasmine Nahrgang, Augustine Arukwe, Knut- Erik Tollefsen Poster sessions EFFECT OF 2,4-DIHYDROXYBENZOPHENONE (BP1) ON DEVELOPMENT OFEARLY LIFE STAGES OF THE MARINE COPEPOD ACARTIA TONSA ATDIFFERENT TEMPERATURES AND SALINITIES

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K. Ole Kusk, Manola Avdolli IS INDIVIDUAL METALLOTHIONEIN ISOFORM A BETTER BIOMAKRER FORMONITORING METAL CONTAMINATION THAN TOTAL METALLOTHIONEINS? Luck K.Y. Chan, Michelle M.S. Cheung, Kenneth M.Y. Leung USE OF BIOMARKERS, GEOMORPHOLOGIC MEASUREMENTS AND PASSIVESAMPLERS TO INVESTIGATE THE EFFECTS IN OYSTERS OF PAH AND TBT POLLUTION IN AN UNESCO RESERVE OF THE BIOSPHERE (ESTUARY OF THEOKA RIVER, URDAIBAI, BASQUE COUNTRY) Mikel Astobieta, Julen Bustamante, Kepa Castro, Gorka Arana, Alberto de Diego, Juan Manuel Madariaga, Beñat Zaldibar, Manu Soto, Ionan Marigómez, RubénHiguera, Ruth Ibisate, Javier Elorza LONG-DISTANCE ATMOSPHERIC TRANSPORT OF SYNTHETIC ORGANICPOLLUTANTS AND HEAVY METALS WITH AFRICAN DUST – IS THERE ATHREAT TO CORAL REEFS? Virginia Garrison, Susan Genualdi, William Foreman, Michael Majewski, R. ScottCarr, Marion Nipper, Azad Mohammed, Staci Simonich ELEVATED PBDE CONCENTRATIONS IN ANTARCTIC KRILL (EUPHAUSIA SUPERBA) NEAR ACTIVE RESEARCH STATIONS: FURTHER EVIDENCE OFLOCAL ANTARCTIC SOURCES Susan M. Bengtson Nash, So Kawaguchi, Martin Schlabach METAL CONCENTRATIONS AND METALLOTHIONEIN LEVELS IN DEEP-SEAFISHES FROM MID-ATLANTIC RIDGE HYDROTHERMAL VENTS Rui Company, Helena Felícia, Angela Serafim, Armando J. Almeida, Manuel Biscoito, Maria J. Bebianno CHLORINATED BIPHENYLS AND PESTICIDES IN PENGUINS AND SEABIRDSFROM EAST AND WEST ANTARCTICA Simonetta Corsolini, Nicoletta Borghesi, Alessandra Schiavone, Silvano Focardi BIOACCUMULATION OF CHLORINATED BIPHENYLS AND PESTICIDES INARCTIC FISH COMPARED TO ANTARCTIC SPECIES Simonetta Corsolini, Nicoletta Ademollo, Silvano Focardi TRADITIONAL BIOMARKERS VERSUS REDOX PROTEOMICS IN MYTILUS EDULIS OF CORK HARBOUR, IRELAND: A FIELD STUDY Sara Tedesco, David Sheehan LINK BETWEEN BIOMARKER RESPONSES AND PHYSIOLOGICAL PERFORMANCE OF EUROPEAN SEA BASS JUVENILES (DICENTRARCHUS LABRAX) EXPOSED TO ACUTE HEAVY METALS CONTAMINATION Isil Filipuci, Eloide Kerambrun, Wilfired Sanchez, Virginie Lahaye, Francoise Henry, Lucie Courcot, Rachid Amara STUDY OF THE CORRELATION BETWEEN BIOMARKERS RESPONSES AND PHYSIOLOGICAL PERFORMANCE OF JUVENILE SEA BASS (DICENTRARCHUS LABRAX) EXPOSED TO CONTAMINATED SEDIMENTS Eloide Kerambrun, Isil Filipuci, Wilfired Sanchez, Virginie Lahaye, Francoise Henry, Lucie Courcot, Rachid Amar POLLUTION ASSESSMENT IN THE GALICIAN RÍAS (NW SPAIN) USING BIOMARKERS IN CAGED MUSSELS: AN INTEGRATED APPROACH Leticia Vidal-Liñán, Juan Bellas, Oscar Nieto, Ricardo Beiras STUDY OF THE LONG-TERM EFFECTS ON ATLANTIC HERRING (CLUPEA HARENGUS) EXPOSED TO AN OIL-POLLUTED CALANUS FINMARCHICUS DIET Sonnich Meier, Audrey Geffen, Bjørn Einar Grøsvik, Pål Olsvik, H. Craig Morton, Tor Andreas Samuelsen, Trond Nordtug, Anders Thorsen ARCTIC SPECIES SENSITIVITY DISTRIBUTION TO OIL-RELATED COMPOUNDS Gro Harlaug Olsen, Lionel Camus, Mathijs Gerard David Smit, Jolynn Carroll

DETECTION OF POLAR COD (BOREOGADUS SAIDA) LIVER PROTEINS USING ANTIBODIES AGAINST ATLANTIC COD (GADUS MORHUA) Jasmine Nahrgang, Anders Goksøyr, Lionel Camus, Haakon Hop, Jørgen S. Christiansen USE OF BIOLOGICAL AND CHEMICAL MEASUREMENTS IN MUSSELS AND PASSIVE SAMPLERS TO INVESTIGATE THE EFFECTS OF PAH, PCB AND TRACE METAL POLLUTION IN THREE RELEVANT HARBOURS OF THE NORTH OF SPAIN Mikel Astobieta, Nestor Etxebarria, Oscar Prieto, Ricardo Beiras, Maria Jesus Belzunze PAH TOXICITY TO THE EMBRYOS OF INTERTIDAL SPAWNING HERRING (CLUPEA HARENGUS) Jani O. Honkanen, Tim J. Smith STUDIES OF THE EELPOUT (ZOARCES VIVIPARUS) INDICATE ENVIRONMENTAL CHANGES IN COASTAL WATERS Lars Förlin, Joachim Sturve, Jari Parkkonen, Inger Holmqvist Erik Kristiansson, Noomi Asker, D.G.Joakim Larsson INFLUENCES OF SYMBIOTIC ASSOCIATIONS WITH DIATOMS ON OXIDATIVE METABOLISM AND TRACE ELEMENTS LEVELS IN SOME ANTARCTIC SPONGES Alessandra Notti, Daniele Fattorini, Valentina Poli, Marco Nigro, Francesco Regoli LEVELS OF CADMIUM, MERCURY AND LEAD IN MAGELLANIC PENGUIN (SPHENISCUS MAGELLANICUS) STRANDED AT THE BRAZILIAN COAST Claudia M. Vega, Salvatore Siciliano, Paulo R.G. Barrocas, Sandra Hacon, Reinaldo C. Campos, Silvana de Couto Jacobs, Paulo Ott ASSESSMENT OF SUB-LETHAL EFFECTS OF CONTAMINATED SEDIMENT ON THE POLYCHAETE HEDISTE DIVERSICOLOR Ginevra Moltedo, Barbara Catalano, Laura Gastaldi, Giacomo Martuccio, Antonella Ausili, Claudia Virno-Lamberti BIOCHEMICAL RESPONSES IN THE GILL AND DIGESTIVE GLAND OF OYSTER, CRASSOSTREA BRASILIANA, EXPOSED TO DIESEL FUEL WATER SOLUBLE FRACTION Karim H. Lüchmann, Jacó J. Mattos, Marília. N. Siebert, Ninna Granucci, Cláudio Manoel Rodrigues de Melo, Afonso C.D. Bainy ASSOCIATIONS BETWEEN PERSISTENT ORGANIC POLLUTANTS AND LIVER ENZYME ACTIVITY IN POLAR BEARS Jenny Bytingsvik, Jon Aars, Elisabeth Lie, Bjørn Munro Jenssen ASSESSMENT OF ENVIRONMENTAL QUALITY IN THE RIA FORMOSA LAGOON USING RUDITAPES DECUSSATUS Catarina Pereira, Tânia Gomes, Cátia Cardoso, Rita Pereira, Ana Almeida, Alexandra Cravo, Maria J. Bebianno EVALUATION OF ANTIOXIDANT, CYTOCHEMICAL AND GENOTOXICITY BIOMARKERS IN THE RAGWORM HEDISTE DIVERSICOLOR EXPOSED TO BENZO[A]PYRENE AND MERCURY Gastaldi Laura, Martuccio Giacomo, Moltedo Ginevra, Catalano Barbara, Tornambè Andrea, Virno-Lamberti Claudia, Ausili Antonella THE URGENT NEED TO IMPLEMENT THE BIOMARKER APPROACH IN THE ARCTIC Angela Koehler EFFECTS OF PERSISTENT ORGANIC POLLUTANTS (POPS) ON THYROID HORMONE STATUS IN FEMALE POLAR BEARS (URSUS MARITIMUS) FROM EAST-GREENLAND Gro D. Villanger, Rune Dietz, Christian Sonne, Robert Letcher, Derek C.G. Muir, Erik W. Born, Bjørn M. Jenssen POLYCYCLIC AROMATIC HYDROCARBONS IN AMAZON FISHES FROM BRAZIL João Paulo Machado Torres, Ronald Pause, Luz Claudio DIETARY ACCUMULATION OF P, P’-DDE IN AN ANTARCTIC KEYSTONE SPECIES – ANTARCTIC KRILL (EUPHAUSIA SUPERBA) Anita Hanako Poulsen, So Kawaguchi, Susan Bengtson Nash CYP1A TRANSACTIVATION POTENCIES OF ARYL HYDROCARBON RECEPTOR 1 AND 2 (AHR1 AND AHR2) FROM BLACK-FOOTED ALBATROSS BY DIOXINLIKE CONGENERS

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Thuruthippallil Leena Mol, Eun-Young Kim, Hisato Iwata CATALYTIC FUNCTION OF IN VITRO-EXPRESSED BAIKAL SEAL CYP1A1 Keisuke Yamaguchi, Eun-Young Kim, Hisato Iwata SEASONAL VARIATION OF HG, METAL BINDING PROTEINS AND OXIDATIVE STRESS IN BLACK-LEGGED KITTIWAKE (RISSA TRIDACTYLA) Magnus B. Kongsrud, Ida Beathe Øverjordet, Torunn Berg, Geir Wing Gabrielsen, Bjørn Munro Jenssen ANTIOXIDANT DEFENCE RESPONSES AND LYSOSOMAL PARAMETERS IN THREE SPECIES OF ARCTIC SEABIRD CHICKS, BLACK LEGGED KITTIWAKE (RISSA TRIDACTYLA), NORTHERN FULMAR (FULMARUS GLACIALIS) AND HERRING GULL (LARUS ARGENTATUS) Marit Nøst Hegseth, Lionel Camus, Lisa B. Helgason, Daniele Fattorini, Raffaela Bocchetti, Francesco Regoli, Geir Wing Gabrielsen EFFECTS OF ORGANOCHLORINES ON THYROID HORMONE LEVELS IN MOTHER-CUB PAIRS OF POLAR BEARS Hanna Otterholt Bertinussen, Jenny Bytingsvik, Jon Aars, Elisabeth Lie, Grethe S. Eggen, Bjørn Munro Jenssen LEVEL OF ORGANIC CONTAMINANT DETERMINED BY CHEMICAL AND BIOANALYSIS IN THE SEDIMENTS OF MEDITERRANEAN COASTAL LAGOONS IMPACTED BY WASTEWATER Arthur DAVID, Hélène Fenet, Sélim Aït-Aïssa, Dominique Munaron, Elena Gomez ICON (INTEGRATED ASSESSMENT OF CONTAMINANT IMPACTS ON THE NORTH SEA): AN INTERNATIONAL WORKSHOP Ketil Hylland, Thomas Lang, Dick Vethaak, John Thain, Alistair McIntosh, Thierry Burgeot, Conception Martinez ECOLOGICAL RISK ASSESSMENT IN THE INFLUENCE ÁREA OF AN OIL REFINING COMPLEX (CENTRO REFINADOR DE PARAGUANA), IN VENEZUELA: AN EVALUATIVE APPROACH USING TOXICITY BIOASSAY AND BIOMARKERS EXPRESSED IN THE ORGANISM PRESENT IN THIS MARINE COASTAL AXIS Elia M. García, Ruth Ramos, P. Manuitt, E. Guerra BIOAVAILABILITY AND TOXICOLOGICAL EFFECTS OF TWO DISPERSANT ON JUVENILE GOLDEN MULLET LIZA AURATA Thomas Milinkovitch, Héléne Thomas-Guyon, Morgane Danion, Anne Bado-Nilles, Nathalie Imbert, Stéphane LeFloch CAN PERMANENT TROUT CELL LINES BE USED TO DETECT CHEMICAL EFFECTS ON THE MXR SYSTEM? Till Luckenbach, Stephan Fischer, Jovica Loncar, Kristin Schirmer, Sabine Schnell, Roko Zaja, Tvrtko Smital BIOMARKERS IN FISH AS INDICATOR OF DIFFUSED CONTAMINATION Mirza U. Beg BIOACCUMULATION AND BIOLOGICAL EFFECTS ON THE ARCTIC SEA ICE AMPHIPOD G. WILKITZKII FROM OIL SPILL EVENT SIMULATED IN THE LABORATORY Thierry Baussant, Arnfinn Skadsheim, Rupert H. Krapp, Lionel Camus, Jørgen Berge, Steinar Sanni STRESS SYNDROME DEVELOPMENT IN MUSSELS EXPOSED TO A POLLUTED LAGOON ANALYSED BY COMBINED BIOMARKERS AND GENE EXPRESSION PROFILES Silvia Franzellitti, Elena Fabbri BIOLOGICAL EFFECTS OF ANTHROPOGENIC CHEMICAL STRESS: TOOLS FOR THE ASSESSMENT OF ECOSYSTEM HEALTH (BEAST): A BALTIC SEA BONUS+ PROGRAMME PROJECT Kari K. Lehtonen, Brita Sundelin, Thomas Lang, Doris Schiedek, Maija Balode, Henryka Dabrowska, Jakob Strand, Janina Baršienë, Elmira Boikova, Katja Broeg9, Jens Gercken, Sergey Golubkov, Sergey Kholodkevich, Galina Rodjuk, Rolf Schneider, Sirje Vilbaste, Pekka J. Vuorinen LONG TERM EFFECTS OF A LARGE OILSPILL IN THE PECHORA RIVER ECOSYSTEM, NORTHWEST RUSSIA

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Anatoly Lukin, Guttorm N. Christensen, Salve Dahle, Geir DahlHansen, Lionel Camus, JoLynn Carroll, Alexander P. Novosyolov, Marina Studionova, Igor Studionov, Olga Loskotova, Alexander Zaharov, Grigorii M. Chuiko, Zoya A. Zhakovskaya, Julia Sharova HYDROCARBONS BIOMARKERS IN THE MOLLUSK TIVELA MACTROIDES EXPOSED TO POLLUTED SEDIMENTS A. Sardi, R. Ramos, E. García THE EFFECTS OF TEMPERATURE AND PESTICIDES ON THE CORAL REEF FISH ACANTHOCHROMIS POLYACANTHUS, FROM THE GREAT BARRIER REEF Emmanuelle Botté, Carolyn Smith-Keune, Sue Codi King, Andrew Negri, Dean Jerry CONTAMINANT LEVELS AND BIOMARKER RESPONSES IN EIDERS FROM THE WHITE AND NORWEGIAN SEAS Violetta S. Amelina, Tatiana N. Savinova, Lionel Camus, Nina N. Nemova, Vladimir M. Savinov, Sveinn A. Hanssen, Geir W. Gablielsen WHICH PERSISTENT ORGANIC COMPOUNDS ARE RESPONSIBLE FOR EFFECTS ON TESTOSTERONE IN POLAR BEARS? Gunn Lise Haugestøl, Jenny Bytingsvik, Jon Aars, Elisabeth Lie, Grethe S. Eggen, Bjørn Munro Jenssen SEASONAL DEPENDENT SENSITIVITY OF ARCTIC BLUE MUSSEL TO OILRELATED COMPOUNDS Tim J. Smith, Gro H. Olsen, Lionel Camus, Lars-Henrik Larsen PASSIVE SAMPLING WITH SEMIPERMEABLE MEMBRANE DEVICES (SPMD’S) AS AN ALTERNATIVE TO THE USE OF SENTINEL ORGANISMS (OYSTERS) TO MONITOR PAH POLLUTION IN WATER. A CASE STUDY: ESTUARY OF THE OKA RIVER (BAY OF BISCAY, BASQUE COUNTRY) Mikel Astobieta, Julen Bustamante, Kepa Castro, Gorka Arana, Alberto de Diego, Juan Manuel Madariaga ASSESSING TOXICOLOGICAL EFFECTS OF AN OFFSHORE PLATFORM SEDIMENT USING THE POLYCHAETE HEDISTE DIVERSICOLOR Barabara Catalano, Ginevra Moltedo, Laura Gastaldi, Giacomo Martuccio, Antonella Ausili, Claudia Virno-Lamberti BIOLOGICAL IMPACT OF OIL POLLUTION: A CASE STUDY OF THE M/V HEBEI SPIRIT SPILL IN TAEAN, KOREA Jee-Hyun Jung, Un Hyuk Yim, Gi myeong Han, Joon geon An, Jong ho Won, Sung Yong Ha, Won Joon Shim THE EVALUATION OF THE CONTAMINATION BY BENZO [A] PYRENE IN MEDITERRANEAN MUSSELS, MYTILUS GALLOPROVINCIALIS. BIOCHEMICAL APPROACH Meriem Bagané, Mohamed Banni, Hamadi Boussetta LINKING LAND USE TO FISH HEALTH IN WADEABLE STREAMS IN COASTAL SOUTH CAROLINA Andrew Sayer, Peter van den Hurk ASSESSMENT OF DOÑANA NATIONAL PARK CONTAMINATION IN PROCAMBARUS CLARKII: PROTEOMIC APPROACHES Amalia Vioque-Fernandez, Eduardo Alves de Almeida, Juan López-Barea

OMICS Platform session 1 IMPACT OF TIDAL CONDITION ON THE PROTEOMIC RESPONSE TO PAHs EXPOSURE IN MYTILUS EDULIS Julie Letendre, Myrielle Dupont-Rouzeyrol, Béatrice Rocher, Philippe Chan, David Vaudry, Hubert Vaudry, François Leboulenger, Fabrice Durand CHANGES IN PROTEIN EXPRESSION PROFILES IN THE CLAM RUDITAPES DECUSSATUS EXPOSED TO CADMIUM AND NONYLPHENOL Suze Chora, Mireille Starita-Geribaldi, Jean-Marie Guigonis, Michel Samson, Michèle Roméo, Maria João Bebianno

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BEHAVIOURAL RESPONSES AND PROTEOMIC CHANGES IN THE BRAIN OF ATLANTIC COD (GADUS MORHUA) EXPOSED TO MEHG AND 2,2’,4,4’,5,5’-HEXACHLOROBIPHENYL (PCB-153) Karin Berg, Anne Christine Utne Palm, Anne Gro Vea Salvanes, Stig Valdersnes, Pål Puntervoll, Anders Goksøyr PROTEOMIC STUDY OF A TILAPIA CELL LINE HEPA T1 EXPOSED TO Cu2+ King Ming Chan, Dong-Shi Chen INVESTIGATING PATHWAYS OF AQUATIC TOXICITY OF ENVIRONMENTAL ESTROGENS USING METABOLOMIC ANALYSES Elizabeth.M. Hill, Elena Cubero, Jeanette Rotchell, Christophe Minier, Anel M. Flores-Valverde Platform session 2 A NOVEL ABC TRANSPORTER: FIRST INSIGHT INTO ZEBRAFISH ABCH1 Popovic Marta, Zaja Roko, Loncar Jovica, Smital Tvrtko TRANSCRIPTOMIC RESPONSES TO MODEL POLLUTANTS IN FLOUNDER HEPATOCYTES FROM FISH EXPERIMENTALLY EXPOSED TO CLEAN OR MULTIPLY POLLUTED SEDIMENTS Michael J. Leaver, Amer Diab, Tim D. Williams, Craig D. Robinson, Kevin J. Chipman, Stephen G. George ANCHORING METABOLITE CHANGES TO PHENOTYPIC EFFECTS IN THE CHLOROPHYTE S. VACUOLATUS AFTER TOXIC EXPOSURE Frédéric Sans Piché, Christina Klünder, Rolf Altenburger, Mechthild Schmitt-Jansen ETHINYLESTRADIOL EXPOSURE ALTERS GENE EXPRESSION IN FATHEAD MINNOW TESTIS Nancy D. Denslow, Natàlia Garcia-Reyero, Kevin J. Kroll, Edward F Orlando, Karen H Watanabe, María S Sepúlveda, Daniel L Villeneuve, Edward J. Perkins, Gerald T Ankley DIFFERENTIAL GENE EXPRESSION IN POECILIA VIVIPARA EXPOSED TO DIESEL FUEL WATER SOLUBLE FRACTION Jacó J. Mattos, Karim H. Luchmann, Marília N. Siebert, Ninna Granucci, Afonso C.D. Bainy THE COPEPOD TIGRIOPUS: A PROMISING MARINE MODEL ORGANISM FOR ECOTOXICOLOGY AND ENVIRONMENTAL GENOMICS Jae-Seong Lee Platform session 3 IMPAIRMENTS FOLLOWING SUBLETHAL ESFENVALERATE EXPOSURES IN THE DELTA SMELT (HYPOMESUS TRANSPACIFICUS) Richard E. Connon, Jurgen Geist, Janice Pfeiff, Alex S. Loguinov, Leandro D’Abronzo, Henri Wintz, Christopher D. Vulpe, Inge Werner MOLECULAR ANALYSIS OF NEONICOTINOID INSECTICIDES MIXTURE TOXICITY IN THE MARINE MUSSEL (MYTILUS GALLOPROVINCIALIS) Francesco Dondero, Alessandro Negri, Flavio Migone, Aldo Viarengo PYROSEQUENCING OF MYTILUS EDULIS AND MYTILUS GALLOPROVINCIALIS CDNAS: TISSUE- AND SPECIES-SPECIFIC EXPRESSION PATTERNS John A Craft, Kate E Dempsey, Jack A Gilbert, Ben Temperton, J Kevin Chipman GENOMIC EFFECTS OF THE ANTI CONVULSANT DRUG CARBAMAZEPINE IN THE BRAIN OF ATLANTIC SALMON (SALMO SALAR) Miriam Hampel, Esteban Alonso, Irene Aparicio, James E. Bron. Juan Santos, John B. Taggart, Michael J. Leaver CAUGHT IN A NETWORK: RECOVERY FROM AROMATASE INHIBITION Natàlia G. Reyero, Tanwir Habib, Daniel Villeneuve, Dalma Martinovic, Youping Deng, Gerald Ankley, Nancy Denslow, Edward Perkins

THE TOTAL CYTOCHROME P450 COMPLEMENT OF ZEBRAFISH AND THE EXPRESSION OF CYP GENES DURING DEVELOPMENT Jared V. Goldstone, Andrew G. McArthur, Juliano Zanette, Maria Jonsson, Thiago Parente, John J. Stegeman Poster sessions PILOT APPLICATION OF HEPATIC CDNA MICROARRAY OF THE SENTINEL FISH STRIPED SEABREAM (LITHOGNATHUS MORMYRUS) AS ENVIRONMENTAL BIOMARKER Tom Moshe, Yudkovsky Yana, Ramšak Andreja, Auslander Meirav EFFECTS OF CADMIUM IN PROTEIN EXPRESSION PROFILES IN THE HYDROTHERMAL VENT MUSSEL BATHYMODIOLUS AZORICUS Rui Company, Angela Serafim, Oreto Antunez, Amparo Torreblanca, Miren Carajaville, Maria João Bebianno PROTEOMIC PROFILING OF METALLOTHIONEIN ISOFORMS IN THE GREEN-LIPPED MUSSEL PERNA VIRIDIS EXPOSED TO METAL AND NON-METAL STRESSORS Priscilla T.Y. Leung, Yu Wang, T.J. Park, Kenneth M.Y. Leung AMPHIBASE: AN ONLINE DATABASE FOR AMPHIPOD GENOMES Peter Kille, Gongda Yang, Christine Sambles, Daniel Pass, Steffan Adams, Alex T. Ford TOXICOLOGY TAILORED LOW DENSITY OLIGONUCLEOTIDE MICROARRAY FOR THE THICKLIP GREY MULLET CHELON LABROSUS: DEVELOPMENT, PRODUCTION AND VALIDATION Oihane Diaz de Cerio, Eider Bilbao, Miren P. Cajaraville, Ibon Cancio HEPATIC GENE EXPRESSION PATTERNS IN JUVENILE TURBOTS (SCOPHTHALMUS MAXIMUS) AFTER EXPOSURE TO NO2 FUEL OIL AND TO STYRENE Ibon Cancio, Eider Bilbao, Oihane Diaz de Cerio, Belén G. Pardo, Paulino Martínez, Miren P. Cajaraville APPLICATION OF PROTEOMIC ANALYSIS TO ASSESS THE EFFECTS OF METALS IN THE CLAM SCROBICULARIA PLANA AND THE POLYCHAETE NEREIS DIVERSICOLOR Tânia Gomes, Maria Gonzalez-Rey, Suze Chora, Maria J. Bebianno CHANGE IN PROTEIN VAULT EXPRESSION AFTER PAH EXPOSURE IN BLUE MUSSEL GILLS Béatrice Rocher, Julie Letendre, Fabrice Durand, Myrielle Dupont-Rouzeyrol, Philippe Chan Tchi Song, David Vaudry, Hubert Vaudry, François Leboulenger CHARACTERIZATION OF THE ZOARCES VIVIPARUS LIVER TRANSCRIPTOME USING MASSIVELY PARALLEL PYROSEQUENCING Noomi Asker, Erik Kristiansson, Lars Förlin, D.G. Joakim Larsson DEVELOPMENT AND EVALUATION OF AN ATLANTIC COD (GADUS MORHUA) OLIGONUCLEOTIDE MICROARRAY Mie Linnea Jareid, Tor Fredrik Holth, Knut-Erik Tollefsen POTENTIAL PHYSIOLOGICAL EFFECTS OF PHARMACEUTICAL COMPOUNDS IN ATLANTIC SALMON (SALMO SALAR), IMPLIED BY TRANSCRIPTOMIC ANALYSIS Miriam Hampel, Esteban Alonso, Irene Aparicio, James E. Bron. Juan Santos, John B. Taggart, Michael J. Leaver LIFE IN A MESOCOSM: A TOUGH FITNESS CHALLENGE Natàlia G. Reyero Vinas, Kevin J. Kroll, Robert J. Griffitt, David S. Barber, Nancy D. Denslow CHEMICAL DEFENSE GENES IN THE SEA ANEMONE NEMATOSTELLA VECTENSIS Jared V. Goldstone, Adam Reitzel, Ann M. Tarrant DEVELOPMENT AND EVALUTATION OF A MUSSEL (MYTILUS SP.) OLIGONUCLEOTIDE MICROARRAY Hanne Fosnes, Tor Fredrik Holth, Steven Brooks, Knut-Erik Tollefsen HOW USEFUL ARE MICROARRAYS FOR ECOTOXICOLOGICAL TESTING AND ENVIRONMENTAL MONITORING?

Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

Knut-Erik Tollefsen, Mie L. Jareid, Hanne Fosnes, Tor Fredrik Holth, Eivind Farmen Finne, Steve Brooks MULTI-ENDPOINT STUDIES ON ZOARCES VIVIPARUS, USING GENE EXPRESSION OLIGONUCLEOTIDE MICROARRAY Noomi Asker, Erik Kristiansson, D.G. Joakim Larsson, Lars Förlin TEMPORAL PATTERNS IN THE TRANSCRIPTOMIC RESPONSE OF RAINBOW TROUT, ONCORHYNCHUS MYKISS, TO CRUDE OIL Sharon E. Hook, Mark A. Lampi, Eric J. Febbo, Jeff A. Ward, Thomas F Parkerton INTEGRATED GENE EXPRESSION PROFILES IN PITUITARY, OVARY, AND LIVER: IDENTIFICATION OF GENES CONTROLLING SEXUAL MATURATION IN SALMONIDS Sharon E. Hook, Irvin R. Schultz, Joe Verducci, William Hayton, Jonghan Kim, Tim Cavileer, James Nagler GENE EXPRESSION PROFILING OF COPPER-INDUCED RESPONSES IN THE INTERTIDAL COPEPOD TIGRIOPUS JAPONICUS USING 6K OLIGOCHIP MICROARRAY Kyun-Woo Lee, Jang-Seu Ki1, Dae-Sik Hwang, Jae-Sung Rhee, Jae-Seong Lee EXPRESSION OF GLUTATHIONE S-TRANSFERASE (GST) GENES IN THE BRACKISH ROTIFER, BRACHIONUS ROTUNDIFORMIS EXPOSED TO TRACE METALS Dae-Sik Hwang, Kyun-Woo Lee, Jae-Sung Rhee, Jeonghoon Han, Jae-Chun Ryu, Jae-Seong Lee PROTEOMIC ALTERATIONS IN PROCAMBARUS CLARKII AFTER CONTROLLED EXPOSURE TO CHLORPYRIFOS AND CARBARYL Amalia Vioque-Fernandez, Eduardo Alves de Almeida, Juan López-Barea GENDER-SPECIFIC PROTEOME CHANGES IN ATLANTIC COD EXPOSED TO PRODUCED WATER AND C4-C7 ALKYLPHENOLS Mari Mæland, Anne Bjørnstad, Sonnich Meier, Odd Ketil Andersen ECOTOXICOLOGY GOES MUDPIT? Eivind Larssen, Kai-Erik Uleberg, Kjell Birger Øysæd, Mari Mæland, Anne Bjørnstad ECOLOGICAL RELEVANCE AND MULTI-STRESS Platform session 1 PREDICTING JOINT MIXTURE TOXICITY EFFECTS OF CONTAMINANTS FROM INDIVIDUALS TO POPULATIONS; A CRITICAL EVALUATION USING COPEPODS AND CLADOCERANS Carlos Barata, Albert Calbet, Enriz Saiz DERIVING CRITICAL TISSUE CONCENTRATIONS OF CONTAMINANTS IN MARINE MUSSELS FOR ECOLOGICAL RISK ASSESSMENT Jamius W.Y. Yeung, Vincent K.H. Chu, Kenneth M.Y. Leung IS TOXICOLOGICAL PATHOLOGY CHARACTERISED BY A LOSS OF SYSTEM COMPLEXITY? Michael N. Moore CONTAMINANTS REDUCE THE RICHNESS AND EVENNESS OF MARINE COMMUNITIES: A REVIEW AND META-ANALYSIS Emma L Johnston, David A Roberts ENVIRONMENTAL ASSESSMENT OF ESTUARINE ECOSYSTEMS Claude Amiard-Triquet, Philip S. Rainbow

Platform session 2 TEMPERATURE-DEPENDENT TOXICITIES OF CHLOROTHALONIL AND COPPER PYRITHIONE TO THE MARINE COPEPOD TIGRIOPUS JAPONICUS Vivien W.W. Bao, Apostolos Koutsaftis, Kenneth M.Y. Leung APPLICATION OF TOXICITY MONITORING IN THE WATER CYCLE Ron van der Oost

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LINKING IMPAIRED HEALTH TO REDUCED POPULATION VIABILITY IN ORDER TO CONVERT PRIMO INTO ACTION Tracy K. Collier, David H. Baldwin, Julann A. Spromberg, Mary R. Arkoosh, Lyndal L. Johnson, Scott A. Hecht, Nathaniel L. Scholz ENERGY AND CARBOHYDRATE METABOLISM ENZYMES AS BIOINDICATORS OF FISH HEALTH UNDER ANTHROPOGENIC TRANSFORMATION OF LAKE ECOSYSTEM Maria V. Churova, Olga V. Meshcheryakova, Nina N. Nemova GENE EXPRESSION LEVEL CHANGE IN MARINE DIATOM THALASSIOSIRA PSEUDONANA UPON EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS Stephanie K. Bopp, Raquel Carvalho, Teresa Lettieri Platform session 3 CAN BIOMARKERS MEASURE ENVIRONMENTAL HEALTH OF AQUATIC ECOSYSTEMS? Josephine A. Hagger, Malcolm B. Jones, Tamara S. Galloway POPULATION GENETICS AND BIOLOGICAL EFFECTS MONITORING: A STRATEGY FOR USING POPULTION MARKERS IN THE EUROPEAN SENTINEL FLATFISH SPECIES DAB (LIMANDA LIMANDA) Brett P. Lyons, Niklas Tysklind, Grant D. Stentiford, Stephen W. Feist, Martin I. Taylor, Ian McCarthy, Gary R. Carvalho BIOCHEMICAL, PHYSIOLOGICAL AND BEHAVIOURAL MARKERS AS TOOLS FOR THE ASSESSMENT OF THE HEALTH STATUS OF ESTUARINE POPULATIONS OF THE ENDOBENTHIC BIVALVE SCROBICULARIA PLANA Brigitte Berthet, Jean-Claude Amiard, Claude Amiard-Triquet, Odile Dedourge-Geffard, Isabelle Métais, Catherine Mouneyrac INTERACTION BETWEEN PATHOGENIC ORGANISMS AND CADMIUM CONTAMINATION IN THE COCKLE CERASTODERMA EDULE Ika Paul-Pont, Patrice Gonzalez, Natalie Raymond, Florence Jude, Line Bourasseau, Philippe Soudant, Christine Paillard, Magalie Baudrimont, Xavier de Montaudouin MODULATION OF SOME HEMATO-IMMUNOLOGICAL PARAMETERS IN THREE BIVALVE SPECIES DURING A NATURAL BLOOM OF THE DINOFLAGELLATE DINOPHYSIS ACUMINATA IN SANTA CATARINA ISLAND, BRAZIL Danielle F. Mello, Gabriele Rizzato, Rogério Gargioni, Margherita A. Barracco Poster sessions RESPONSE OF THREE CLAMWORM POPULATIONS TO WEATHER AND ENVIRONMENTAL IN THE FUTIAN ORGANIC-RICH MANGROVE WETLAND IN SHENZHEN BAY, CHINA CAI Li-Zhe, FU Su-Jing, ZHOU Xi-Ping, LIANG Jun-Yan and XU Hua-Lin VALVE ACTIVITY RESPONSE OF CRASSOSTREA GIGAS EXPOSED TO THE HARMFUL ALGAE ALEXANDRIUM MINUTUM Damien Tran, Hansy Haberkorn, Philippe Soudant, Jean-Charles Massabuau EFFECTS OF ENDOSULFAN AND METHOXYCHLOR ON CYP1A, CYP3A AND VITELLOGENIN (VTG) GENE EXPRESSION IN ZEBRAFISH EMBRYO-LARVAE Wing Shan Chow, King Ming Chan GAMTOX – A PROPOSAL FOR A NEW INTEGRATIVE MULTIMERIC AQUATIC TOXICITY ASSESSMENT Almut Gerhardt, Petra Y. Kunz, Cornelia Kienle, Daniela Tropiano, Sophie Campiche HAEMOLYMPH PARAMETERS AND GENOTOXIC RESPONSE IN FRESHWATER CRAYFISH ASTACUS LEPTODACTYLUS AFTER TEMPERATURE STRESS Simonetta Lorenzon, Olga Malev, Ivana Maguire, Maja Šrut, Anamaria Štambuk, Enrico A. Ferrero, Göran I.V. Klobuèar

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USE OF BIOMARKERS IN THE ASSESSMENT OF ECOTOXICOLOGICAL EFFECTS RELATED TO DREDGING PROCEDURES IN THE HARBOUR OF LA SPEZIA (LIGURIAN SEA, ITALY) USING THE BIOINDICATOR DICENTRARCHUS LABRAX Gabriele Mori, Serena Porcelloni, Ilaria Caliani, Maria Elena Piccione, Silvia Casini, Letizia Marsili, Antonella Ausili, Maria Cristina Fossi EXPERIMENTAL TRACING OF CD DIRECT AND TROPHIC PATHWAYS IN OYSTERS (CRASSOSTREA GIGAS) BY STABLE ISOTOPES SPIKES Emilie Strady, Magalie Baudrimont, Jörg Schäfer, Gérard Blanc ACUTE AND CHRONIC TOXICITIES OF ZINC PYRITHIONE ALONE AND IN COMBINATION WITH COPPER TO THE MARINE COPEPOD TIGRIOPUS JAPONICUS Vivien W.W. Bao, Kenneth M.Y. Leung INFLUENCE OF SHORT TERM EXPOSURE TO HYDROCARBONS ON MID TERM GROWTH AND ENERGY STORAGE OF JUVENILE COMMON SOLE (SOLEA SOLEA L.): A MESOCOSM EXPERIMENT Camille Gilliers, Véronique Loizeau, Olivier Le Pape USING BIOLOGICAL EFFECT MEASUREMENTS FOR DETERMINING GOOD ENVIRONMENTAL STATUS: AN APPROACH John. Thain, Matt Gubbins, Brett Lyons, Grant Stentiford METHODOLOGY AND TOOLS FOR SHIPS IMPACTS ASSESSMENT ON THE MARINE ENVIRONMENT Marion Prinçaud, Alain Cornier GENOTOXICITY OF DIURON IN THE MARINE MICROALGAE, KARENIA MIKIMOTOI Farida Akcha, N. Recek, Sabine Stachowski-Haberkorn MUSSEL SAMPLING – QUALITY ASSURANCE WITH A HISTOLOGICAL PERSPECTIVE John Paul Bignell, Tim Bean, Brett Lyons, John Thain POLLUTION DECREASES GENETIC DIVERSITY OF DREISSENA POLYMORPHA Godila Emilia Thomas, Alfred Seitz ACTIVE BIOMONITORING OF A POLLUTED HARBOUR USING BIOMARKES ON CAGED MUSSELS (Mytilus galloprovincialis) AND THICKLIP GREY MULLETS (Chelon labrosus) Oihane Diaz de Cerio, Urtzi Izagirre, Mikel Astobieta, Nestor Etxebarria, Ionan Marigómez, Miren P. Cajaraville, Guzman Diez, Ibon Cancio TOXICITY OF COMMERCIAL PESTICIDE FORMULATIONS AND THEIR ACTIVE INGREDIENTS TO LARVAL FATHEAD MINNOW (PIMEPHALES PROMELAS) Sebastian Beggel, Inge Werner, Richard Connon, Juergen Geist TOXICITY AND MECHANISM OF A BINARY MIXTURE OF TRIBUTYLTIN AND POLYCHLORINATED BIPHENYLS NANOINJECTED IN MEDAKA (ORYZIAS LATIPES) EMBRYOS Yuji Oshima, Shuhei Matsumoto, Sang Gyoon Kim, Kei Nakayama, Ik Joon Kang, Tohru Suzuki, Yohei Shimasaki, Tsuneo Honjo CONTEMPORARY ECOLOGICAL THREATS FROM HISTORICAL POLLUTION SOURCES: EXPERIMENTAL AND REAL WORLD RESUSPENSION OF CONTAMINATED SEDIMENTS Emma Johnston, Luke Hedge, Nicole Hill, Stuart Simpson, Nathan Knott EVALUATION OF RNA/DNA RATIO IN MUSSELS AS A BIOMARKER FOR POLLUTION MONITORING: INFLUENCES OF ANIMAL SIZE, TISSUE TYPES AND NUTRITIONAL STATUS Jamius W.Y. Yeung, Kenneth M.Y. Leung HARMONISED FRAMEWORK FOR ECOLOGICAL RISK ASSESSMENT OF SEDIMENTS FROM PORTS AND ESTUARINE ZONES OF THE ATLANTIC Choueri, R.B., Cesar, A., Abessa D.M.S., Torres R.J., Pereira C.D.S., Riba I., Nascimento M.R.L., Morais R.D., Mozeto A.A., DelValls T.A. CONTAMINATION ASSESSMENT OF A COASTAL ZONE (SAO PAULO, BRAZIL) INTEGRATING BIOACCUMULATION, EXPOSURE BIO-

MARKERS AND HISTOPATOLOGICAL DATA IN TRANSPLANTED MUSSELS Camilo D.S. Pereira, Maria L. Martin-Díaz, Helcy L.N. Silbiger, M.G.C. Semmler, Marina B.A. Vasconcelos, Augusto Cesar, Rodrigo B. Choueri, Màrcia C. Bicego, Satie Taniguchi, Juliano Zanette, Afonso C.D. Bainy, Tomàs A. DelValls, Eduinetty C.P.M. Sousa BIOMARKER RESPONSES OF THE BULLHEAD (COTTUS GOBIO) IN SEVERAL REFERENCE SITES IN THE NORTH OF FRANCE Sabrina Jolly, Olivier Palluel, Jean-Maxence Ditche, Jean Prygiel, Jean-Marc Porcher and Wilfried Sanchez METAL STRESS ON THE TRANSCRIPTOME AND THE PHYSIOLOGY OF THE SCALLOP ARGOPECTEN PUPURATUS (LAMARCK, 1819) IN BAY OF SAN JORGE OF THE AREA OF ANTOFAGASTA OF CHILE Manuel Zapata, Marianne Lang, Domingo Roman, Dario Moraga, Carlos Riquelme FREQUENCY OF HEPATOCELLULAR FIBRILLAR INCLUSIONS IN THE EUROPEAN FLOUNDER FROM THE DOURO RIVER ESTUARY, PORTUGAL João Carrola, António Fontaínhas-Fernandes, Pedro Matos, Diogo Carvalho, Susana Parra, Eduardo Rocha THE TAPEWORM LIGULA INTESTINALIS INHIBITS THE REPRODUCTIVE FUNCTION IN ITS TELEOST HOST, THE ROACH (RUTILUS RUTILUS) Perrine Géraudie, Marie Gerbron, Céline Lecomte, Jeanette Rotchell, Elizabeth Hill, Christophe Minier FROM POLLUTION TO ALTERED FISH PHYSIOLOGICAL PERFORMANCE; THE CASE OF FLATFISH IN THE SEINE ESTUARY Christophe Minier, Rachid Amara, Jean Laroche, Alain Devaux, Jean-Marc Porcher, Jeanette Rotchell, Elizabeth Hill COMPARISON BETWEEN INVERTEBRATE AND DIATOM COMMUNITY RESPONSES AND BIOMARKER RESPONSES IN OUTDOOR MESOCOSMS EXPOSED TO ORGANIC CONTAMINANTS Kevin Cailleaud, Anne-Laure Scelo, Blandine Davail-Cuisset, Christelle Clerandeau, Bénédicte Morin, Michèle Daubeze, Anne Basseres, Jean-François Narbonne IDENTIFICATION OF GENES EXPRESSED IN HALIOTIS RUFESCENS IN RESPONSE TO DIFFERENCE COPPER CONCENTRATION Fernando Silva-Aciares, Manuel Zapata, Jennifer Tournois, Dario Moraga, Carlos Riquelme THE INSECTICIDE CHLORDECONE IN FISHES ANS SEAFOOD FROM THE FRENCH CARIBBEAN ISLAND MARTINIQUE Bertrand Jacques, Bocquene Gilles, Abarnou Alain, Chiffoleau Jean-François LIPID PEROXIDATION AND OXIDATIVE STRESS BIOMARKERS IN NATURAL POPULATIONS OF CARCINUS MAENAS (NW PORTUGAL) WITH DIFFERENT CONTAMINATION HISTORIES Laura Guimarães, Teresa Neuparth, Carlos Gravato, Lúcia Guilhermino MONITORING THE EFFECTS OF ESTUARINE OIL-DERIVED POLLUTION ON WILD POPULATIONS OF COMMON GOBY POMATISCHISTUS MICROPS Laura Guimarães, Carlos Gravato, André Sousa, Lúcia Guilhermino TEMPORAL EVOLUTION OF THE IMPOSEX PHENOMENON IN NUCELLA LAPILLUS ALONG THE WEST EUROPEAN COASTS Martial Huet, Didier Claisse, Marcel Koken CONTAMINATION OF BIVALVE HAEMOLYMPH SAMPLES BY ADDUCTOR MUSCLE COMPONENTS: IMPLICATIONS FOR BIOMARKERS STUDIES Sherain Al-Subiai, Awadhesh N. Jha, A. John Moody FIRST TRIALS TO ESTABLISH BIODIAGNOSTIC TOOLS FOR SITE SELECTION OF OFFSHORE MUSSEL CULTIVATION AREAS Matthias Brenner, Bela H. Buck, Angela Koehler BIOACCUMULATION OF METHYLMERCURY IN RAY SPECIES FROM THE GULF OF TRIESTE (NORTHERN ADRIATIC SEA)

Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

Degenek Nina, Lipej Lovrenc, Horvat Milena, Faganeli Jadran IN SITU STUDY OF THE IMPACT OF POLLUTANTS ON IMMUNE DEFENSE MECHANISMS IN THE PACIFIC OYSTER CRASSOSTREA GIGAS Andrea Luna-Acosta, Eric Rosenfeld, Ingrid Fruitier-Arnaudin, Paco Bustamante, Hélène Thomas-Guyon THE POTENTIAL FOR INTERACTIONS BETWEEN ENDOCRINE DISRUPTING POLLUTANTS AND PARASITES IN THE THREE-SPINED STICKLEBACK, GASTEROSTEUS ACULEATUS Macnab, Vicki, Katsiadaki Loanna, Barber Iain EFFECTS OF HIGH HYDROSTATIC PRESSURE ON SELECTED BIOMARKERS IN SILVER EEL Justyna Kopecka-Pilarczyk, João Coimbra FROM THE EXPOSURE TO CONTAMINANTS, TO THE MOLECULAR AND PHYSIOLOGICAL RESPONSES: A MULTI-ESTUARIES APPROACH CONDUCTED ON A FLATFISH PLATICHTHYS FLESUS Jean Laroche, Louis Quiniou, Ricardo Riso, Hélène Budzinski, Jérôme Cachot, Christophe Minier, Alain Devaux, Yan Chérel, Thierry Burgeot AN INTEGRATED APPROACH TO DETERMINE EFFECTS OF COPPER IN BIVALVE MOLLUSC, MYTILUS EDULIS Sherain N. Al-Subiai, A. John Moody, Sanaa Mustafa and Awadhesh N. Jha CRASSOSTREA RHIZOPHORAE: A MORFOLOGICAL AND ULTRASTRUCTURAL STUDY Eliane S. Figueiredo, Cíntia M. de Barros, Juliana A. Americo, Leonardo T. Salgado, João Paulo M. Torres, Silvana Allodi, Mauro F. Rebelo

EMERGING COMPOUNDS Platform session 1 (Pharmaceuticals) THE MAJOR RESPONSES IN FISH EXPOSED TO MEDETOMIDINE, A NEW ANTIFOULING AGENT Anna Lennquist, Annelie Hilvarsson, Lars Förlin CROSS-SPECIES COMPARISON OF FLUOXETINE METABOLISM IN FISH Emily M. Smith, Chris D. Metcalfe, Joanna Y. Wilson THE EFFECTS OF DICLOFENAC ON THE PHYSIOLOGY OF THE GREEN SHORE CRAB CARCINUS MAENAS Chris Eades, Colin P. Waring HEPATIC TRANSCRIPTIONAL RESPONSES IN ZEBRAFISH (DANIO RERIO) EXPOSED TO WATERBORNE DICLOFENAC Knut Erik Tollefsen, Tor Fredrik Holth, Kathrine Langford, Kevin V. Thomas TRICLOSAN GLUCURONIDATION AND SULFONATION IN THE CHANNEL CATFISH ICTALURUS PUNCTATUS Christopher J. Marth, Margaret O. James

Platform session 2 (Nanoparticles) THE EFFECTS OF SILVER NANOPARTICLES ON OYSTER EMBRYOS Amy H. Ringwood, Melissa McCarthy, Joel Berry, David Carroll BIVALVE MOLLUSCS AS TARGETS FOR NANOPARTICLE TOXICITY: IN VITRO AND IN VIVO EFFECTS OF NANOSIZED CARBON BLACK, C60 FULLERENE, TiO2 AND SiO2 IN MYTILUS Laura Canesi, Caterina Ciacci, Rita Fabbri, Michele Betti, Antonio Marcomini, Giulio Pojana DO FULLERENE AND FULLEROL NANOPARTICLES AFFECT GENE EXPRESSION AND METABOLITE PROFILES IN STICKLEBACKS? Tim Williams, Takeshi Kitano, Ioanna Katsiadaki, Andy Southam, Matthew Sanders, Mohamed Balousha, Huw Jones, Emilia Cieslak, Mark Viant, Jamie Lead, Kevin Chipman

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EXPOSURE TO SILVER NANOPARTICLES ALTERS GENE EXPRESSION IN THE BRAIN OF THE THREE-SPINED STICKLEBACK (GASTEROSTEUS ACULEATUS) Bean Tim P, Sanders Matthew B, Lyons Brett, Christian Paul, Williams Tim D, Katsiadaki Ioanna, J. Kevin Chipman DIETARY EXPOSURE TO TITANIUM DIOXIDE NANOPARTICLES IN RAINBOW TROUT, (ONCORHYNCHUS MYKISS): NO EFFECT ON GROWTH, BUT SUBTLE BIOCHEMICAL DISTURBANCES AND A PROTECTIVE ROLE FOR THE SPLEEN Timothy J. Smith, Christopher S. Ramsden, Benjamin J. Shaw, Richard D. Handy STAGE-SPECIFIC TOXICITY OF SILVER NANO-COLLOIDS DURING DEVELOPMENT IN MEDAKA Tara Sabo-Attwood, Shosaku Kashiwada, Maria-Eugenia Ariza, Sean McGee, P. Lee Ferguson, Yoshihiro Kagam, G. Thomas Chandler Poster sessions ACUTE TOXICITY OF PERFLUOROOCTANE SULFONIC ACID ON EARLY LIFE STAGES OF DAPHNIA MAGNA, SIRIELLA ARMATA, PARACENTROTUS LIVIDUS SEA URCHIN, AND TURBOT (SCOPHTHALMUS MAXIMUS L.) Lazhar Mhadhbi, Salvador Pérez, Diego Rial, Moncef Boumaiza, Ricardo Beiras EFFECTS ON FEEDING RATE AND BIOMARKER RESPONSES OF MUSSELS EXPERIMENTALLY EXPOSED TO PROPRANOLOL AND ACETAMINOPHEN Montserrat Solé, Jennifer Shaw, Trish Frickers, James Readman, Thomas H. Hutchinson EFFECTS OF COPPER NANOPARTICLES IN MYTILUS GALLOPROVINCIALIS Tânia Gomes, Maria J. Bebianno THE EFFECT OF NSAID MIXTURES ON THE PHYSIOLOGY OF THE SHORE CRAB, CARCINUS MAENAS, IN ESTUARINE WATER Robert Everill, Colin Waring SUBSTANCES WITH FRAGRANCE PROPERTIES IN SURFACE WATERS Gabriele Schmidt, Claudia Lange, Bertram Kuch, Jorg A. Pfeiffer, Jorg W. Metzger PCBS AND PBDES IN FISH, MUSSELS AND SEDIMENTS OF LAKE CONSTANCE, GERMANY Jorg A. Pfeiffer, Harald Hetzenauer, Bertram Kuch, Herbert Löffler, Gabriele Schmidt, Claudia Lange, Jorge W. Metzger UPTAKE OF PLATINUM GROUP ELEMENTS BY THE MARINE MICROALGA, CHLORELLA STIGMATOPHORA, AND THEIR TOXICOLOGICAL EFFECTS Leyla Shams, Andrew Turner, Murray Brown, Geoff Millward GENETIC AND ENDOCRINAL IMPACTS OF EUGENOL USED AS ANESTHETIC ON THE EUROPEAN EEL (ANGUILLA ANGUILLA) Sophie Renault, Patrice Gonzalez, Francoise Daverat, Magalie Baudrimont BIOMARKER RESPONSES IN SOLEA SENEGALENSIS EXPOSED TO TWO ANTIFOULING PRODUCTS: SODIUM HYPOCHLORITE AND ALIPHATIC AMINES (MEXEL 432) Cristina López-Galindo, Luis Vargas-Chacoff, Daniel Rubio, Enrique Nebot, José F. Casanueva, Montserrat Solé, Juan M. Mancera TOXICOLOGICAL EFFECTS OF WIDELY USED PHARMACEUTICALS ON THE MARINE AMPHIPOD, ECHINOGAMMARUS MARINUS Yasmin Guler, Alex T. Ford THE EFFECTS OF IBUPROFEN UPON THE PHYSIOLOGY AND BIOCHEMISTRY OF THE SHORE CRAB CARCINUS MAENAS Robert G. Taylor, Colin P. Waring THE NEED FOR A NEW TOOL TO ASSESS THE ENVIRONMENTAL RISK OF THE USE OF OFFSHORE CHEMICALS Matthieu B. Duchemin, Paul C. Thomas

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Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

ORGANOTIN POLLUTION IN DEVELOPING COUNTRIES: A CASE STUDY IN BRAZIL Marcos Antonio Fernandez EVALUATING THE GENOTOXIC POTENTIAL OF TIO2 NANOPARTICLES IN ISOLATED BOTTLENOSE DOLPHIN (TURSIOPS TRUNCATUS) LEUKOCYTES Margherita Bernardeschi, Patrizia Guidi, Vittoria Scarcelli, Giada Frenzilli, Marco Nigro EFFECTS OF POLLUTION DERIVED FROM POWER PLANTS DISCHARGES ON SELECTED BIOMARKERS IN COMMON MUSSEL, MYTILUS GALLOPROVINCIALIS Cristina López-Galindo, Daniel Rubio, Luis Vargas-Chacoff, Enrique Nebot, José F. Casanueva, Juan M. Mancera, Montserrat Solé TOXICITIES OF NANO-ZINC OXIDE TO MARINE ORGANISMS: THE IMPORTANCE OF PARTICLE SIZE AND ION SOLUBILITY Stella W.Y. Wong, Kenneth M.Y. Leung IN VIVO EXPOSURE OF EXCISED MYTILUS GILLS TO NANO-FE VS SOLUBLE FE2CL3 AND RELATED TOXICOLOGICAL RESPONSES IN ISOLATED BLOOD CELLS Eniko KADAR TOXICITIES OF NANOPARTICLES IN AN ENVIRONMENTALLY RELEVANT FISH MODEL Judi Blatt-Nichols, R. Christopher Chambers, Lung-Chi Che, Terry Gordon, Isaac Wirgin ENDOCRINE DISRUPTION Platform session 1 STEROIDOGENESIS IN WILD ROACH (RUTILUS RUTILUS): ALTERATIONS BY ENVIRONMENTAL POLLUTANTS Perrine Géraudie, Nathalie Hinfray, Marie Gerbron, Jeanette Rotchell, Elizabeth Hill, François Brion, Christophe Minier STEROID ACYLTRANSFERASES REGULATE ENDOGENOUS LEVELS OF TESTOSTERONE AND ESTRADIOL IN THE MARINE MUSSEL MYTILUS GALLOPROVINCIALIS Denise Fernandes, Consuelo Riva, Silvia Bordonali, Cinta Porte MODULATION OF INTERRENAL CAMP/PKA SIGNALLING CASCADE, PPAR ISOTYPES AND HORMONAL RESPONSES IN ATLANTIC SALMON BY TRIBUTYLTIN AND FORSKOLIN Trond M Kortner, Nela Pavlikova, Augustine Arukwe ESTROGEN RECEPTORS IN RAINBOW TROUT IMMUNE ORGANS; LOCALIZATION AND POSSIBLE ROLE IN IMMUNE CELLS Ayako Nakayama, Bernd Köllner, Elisabeth Eppler, Helmut Segner ARE STEROIDS THE CAUSE? TIE EVALUATION OF ESTROGENIC ACTIVITY IN SURFACE WATERS FROM THE CENTRAL VALLEY OF CALIFORNIA USA Ramon Lavado, Jorge Loyo-Rosales, Edward Kolodziej, Shane Snyder, David Sedlak, Daniel Schlenk ENDOCRINE DISRUPTION AND REPRODUCTIVE IMPAIRMENT IN ATLANTIC CROAKER EXPOSED TO CHRONIC HYPOXIA IN THE NORTHERN GULF OF MEXICO DEAD ZONE Peter Thomas, Md. Saydur Rahman Platform session 2 RECEPTOR-AFFINITY EXTRACTION FOR ISOLATING ENDOCRINE DISRUPTORS FROM COMPLEX MIXTURES P. Lee Ferguson, Lauren K. Shaw AN INTEGRATED STUDY OF ENDOCRINE DISRUPTORS IN SEDIMENTS AND REPRODUCTION-RELATED PARAMETERS IN AQUATIC ORGANISMS OF THE BIOSPHERE´S RESERVE OF URDAIBAI Eunate Puy-Azurmendi, Maren Ortiz-Zarragoitia, Marina Kuster, Elena Martínez, Míriam Guillamón, Carmen Domínguez, Miren

López de Alda, Maria Carmen Barbero, Teresa Serrano, Denise Fernandes, Cinta Porte, Josep M. Bayona, Damiá Barceló, Miren P. Cajaraville RESPONSIVENESS OF A XENOPUS LAEVIS CELL LINE TO THE ARYL HYDROCARBON RECEPTOR (AHR) LIGAND 6-FORMYLINDOLO[3,2B]CARBAZOLE (FICZ) Leo Laub, Brian D. Jones, Wade H. Powell TWO EXPOSURE SCENARIOS TO A MIXTURE OF ENDOCRINE DISRUPTING CHEMICALS USING THE THREE-SPINED STICKLEBACK Ioanna Katsiadaki, Matthew B. Sanders, Yvonne Allen, Grant D. Stentiford, Alexander P. Scott EFFECT OF THE PHARMACEUTICAL FUNGICIDE CLOTRIMAZOLE ON STEROIDOGENIC ENZYMES IN ZEBRAFISH (DANIO RERIO) Nathalie Hinfray, Olivier Palluel, Marcello Leal, Selim Ait-Aissa, Olivier Kah, Rüdiger Schulz, Jean-Marc Porcher, François Brion IMMEDIATE AND DELAYED ORGAN-SPECIFIC EFFECTS OF PERFLUOROOCTANE SULFONATE (PFOS) AND PERFLUOROOCTANE CARBOXYLATE (PFOA) ON THE ENDOCRINE SYSTEM OF JUVENILE SALMON EXPOSED THROUGH DIET Anne S. Mortensen, Augustine Arukwe Poster sessions IN VITRO ASSESSMENT OF PAHS AS ESTROGEN AND ARYLHYDROCARBON RECEPTOR AGONISTS AND ANTAGONISTS Karina Petersen, Oscar Fogelberg, Inger Katharina Gregersen, Ketil Hylland, Knut-Erik Tollefsen THE IMPORTANCE OF BEING IDLE: EFFECTS OF ESTRADIOL EXPOSURE IN MUSSELS MYTILUS EDULIS DURING EARLY GAMETOGENESIS Corina M. Ciocan, Mirel A. Puinean, Elizabeth M. Hill, Thomas Knigge, Christophe Minier, Makoto Osada, Naoki Itoh, Jeanette M. Rotchell INVESTIGATION ON ORGANOCHLORINE EFFECTS IN MEDITERRANEAN SWORDFISH (XIPHIAS GLADIUS, LINNEO 1758) USING BIOCHEMICAL AND HISTOLOGICAL BIOMARKERS Serena Porcelloni, Letizia Marsili, Gabriele Mori, Silvia Casini, Fossi Maria Cristina DETECTION OF PREGNANE X RECEPTOR (PXR) ACTIVE CHEMICALS IN FRENCH RIVERS BY USING IN VITRO BIOASSAY AND CHEMICAL ANALYSES Creusot Nicolas, Kinani Saïd, Porcher Jean-Marc, Balaguer Patrick, Tapie Nathalie, Budzinski Hélène, Aït-Aïssa Sélim THE THREE-SPINED STICKLEBACK AND THE OECD TEST GUIDELINES FOR ENDOCRINE DISRUPTORS Ioanna Katsiadaki, Yvonne Allen, Ian Mayer, Tom G. Pottinger, Georgina S.E. Rimmer, Matthew B. Sanders, Marion Sebire, Alexander P. Scott IN VITRO AND IN VIVO EVALUATION OF ESTROGENIC ACTIVITY AND CHEMICAL CONTAMINATION IN SURFACE WATERS OF THE SACRAMENTO RIVER DELTA, CA USA Ramon Lavado, Jorge Loyo-Rosales, David Sedlak, Inge Werner, Daniel Schlenk ENDOCRINE DISRUPTION AND OXIDATIVE STRESS IN RUDITAPES DECUSSATUS Catarina Pereira, Tânia Gomes, Cátia Cardoso, Rita Pereira, Alexandra Cravo, Maria J. Bebianno THE ESTROGENIC ACTIVITY OF DEODORANTS AND SELECTED INGREDIENTS Claudia Lange, Gabriele Schmidt, Bertram Kuch, Jorg A. Pfeiffer, Jorg W. Metzger MODULATION OF STEROIDOGENIC GENES, PROTEINS AND ACTIVITY LEVELS IN MULTIPLE ORGANS OF ATLANTIC SALMON BY NONYLPHENOL AND EHTYNYLESTRADIOL Marianne D Hansen, Trond M Kortner, Anne S Mortensen and Augustine Arukwe

Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

TIME-COURSE EXPRESSION OF THE RETINOID X RECEPTOR GENE IN TISSUES OF THE ROCK SHELL THAIS CLAVIGERA EXPOSED TO TRIPHENYLTIN Toshihiro Horiguchi, Tomohiro Nishikawa, Yasuhiko Ohta, Hiroaki Shiraishi, Masatoshi Morita TEMPORAL EXPRESSION AND TRANSCRIPTIONAL REGULATION OF THE LARGEMOUTH BASS (MICROPTERUS SALMOIDES) VITELLOGENIN RECEPTOR GENE Tara Sabo-Attwood, Gustavo Dominguez, Kevin J. Kroll, Nancy D. Denslow EVALUATION OF THE ESTROGENIC POTENCY OF SFAX MUNICIPAL SEWAGE TREATMENT: SHORT-TERM BIOACCUMULATION AND METABOLISM OF ESTROGENIC COMPOUNDS IN THE CLAM RUDITAPES DECUSSATES Swassan Mezghani-Chaari, Christophe Minier, Amel HamzaChaffai DIFFERENTIAL EXPRESSION OF VITELLOGENIN GENES IN THE LIVER OF ZEBRAFISH, DANIO RERIO AND A ZEBRAFISH CELL LINE (ZFL) Xiang Meng, Chris Bartholomew, John A Craft COUNTERACTING EFFECTS OF 17b-TRENBOLONE IN MALE EELPOUT ZOARCES VIVIPARUS (L.) EXPOSED TO 17b-ETHINYLESTRADIOL Yohana M. Velasco-Santamaría, Steffen Madsen, Poul Bjerregaard, Bodil Korsgaard DIFFERENTIAL OSMOREGULATORY RESPONSES TO 17b-ETHINYLESTRADIOL IN THREE-SPINED STICKLEBACKS (GASTEROSTEUS ACULEATUS) AND RAINBOW TROUT (ONCORHYNCHUS MYKISS) Noura J. Al-Jandal, Charles R. Tyler, Anke Lange, Ioanna Katsiadaki, Rod W. Wilson ENDOCRINE DISRUPTION IN WILD POPULATION OF CHUB (LEUCISCUS CEPHALUS) IN CONTAMINATED FRENCH STREAMS Nathalie Hinfray, Olivier Palluel, Benjamin Piccini, Wilfried Sanchez, Selim Ait-Aissa, Patrice Noury, Jeanne Garric, Elena Gomez, François Brion, Jean-Marc Porcher RISK ASSESSMENT OF MARINE OUTFALL DISCHARGES USING CAGED MUSSELS AND CHEMICAL AND BIOMARKER ANALYSIS Ana de los Ríos, José A. Juanes, Maren Ortiz-Zarragoitia, Miren P. Cajaraville ACTIVATION OF FLOUNDER PEROXISOME PROLIFERATER-ACTIVATED RECEPTORS AND GLUCOCORTICOID RECEPTORS BY ORGANIC POLLUTANTS Louise Colliar, Armin Sturm, Michael J. Leaver 7-PENTOXYRESORUFIN-O-DEPENTILASE AND 7-BENZYLOXYRESORUFIN-ODEBENZYLASE AS POTENTIAL BIOMARKERS OF EXPOSURE TO 17b-ESTRADIOL IN NILE TILAPIA Franciele Bittencourt, Rosa T.S. Frighetto, Júlio F. Queiroz, Marcos E. Losekann, Alfredo J.B. Luiz, Eduardo Alves de Almeida EFFECTS OF BISPHENOL A ON VITELLOGENIN (VTG) GENE EXPRESSION IN ZEBRAFISH EMBRYO-LARVAE Wing Shan Chow, King Ming Chan SEX-RELATED GENES FROM THE SELF-FERTILIZING FISH, KRYPTOLEBIAS MARMORATUS AND MODULATION OF THEIR EXPRESSION BY EXPOSURE TO ENVIRONMENTAL POLLUTANTS Jae-Sung Rhee, Young-Mi Lee, Jae-Seong Lee

GENOTOXICOLOGY/CARCINOGENICITY Platform session 1 RELATIONSHIP BETWEEN PAH BIOTRANSFORMATION AS MEASURED BY BILIARY METABOLITES AND EPOXIDE HYDROLASE ACTIVITY, AND GENOTOXICITY IN JUVENILES OF SOLE (SOLEA SOLEA) Farida Akcha, Nathalie Wessel, R. Santos, Dominique Menard, Vincent Buchet, Nicolas Lebayon, Véronique Loizeau, Thierry. Burgeot, Hélène Budzinski, Karyn LeMenach

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REGULATION OF THE TUMOR SUPPRESSOR P53 IN BIVALVE MOLLUSCS Rebecca J. Van Beneden, Annette F. Muttray, Teagan O’Toole, Wendy Morrill, Susan A. Baldwin BENZO[A]PYRENE METABOLISM, DNA DAMAGE AND LIVER INJURY IN AN ADAPTED POPULATION OF FUNDULUS HETEROCLITUS Richard Di Giulio, Lauren Battle, Dawoon Jung, David Hinton, Kristine Willett PERSPECTIVES ON TRANSMISSION OF MUTATIONS TO PROGENY OF MUTAGEN-EXPOSED PARENTS Richard Winn, Michelle Norris, Don Ennis LINKING GENOTOXIC RESPONSES WITH CYTOTOXIC AND PHYSIOLOGICAL/BEHAVIOURIAL RESPONSES Martin N. Canty, Rebecca J. Brown, Thomas H. Hutchinson, Malcolm B. Jones, Awadhesh N. Jha

Poster sessions COMPARATIVE QUANTIFICATION OF GENOME-WIDE METHYLATION IN FISH LIVER USING REVERSE-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) Leda Mirbahai, Stanley O. Aniagu, Timothy D. Williams, J. Kevin Chipman THE ROLE OF CYCLOOXYGENASE AS A MOLECULAR ANALYTICAL TOOL OF ESTROGENIC EXPOSURE IN THE MARINE MUSSEL MYTILUS EDULIS Elena Cubero, Elizabeth M. Hill, Christophe Minier, Thomas Knigge, Jeanette M. Rotchell METABOLISM AND GENOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS (PAH) IN SOLE: IN VITRO STUDIES Nathalie Wessel, Marie Le Dû-lacoste, Hélène Budzinski, Dominique Ménard, Farida Akcha IONIZING RADIATION DNA DAMAGE RESPONSE IN THE MARINE MUSSEL Ohoud AlAmri, Jeanette M. Rotchell EXPRESSION OF CANCER RELATED GENES IN MUSSELS (MYTILUS EDULIS) EXPOSED TO STYRENE AND HEAVY FUEL OIL # 2 Pamela Ruiz, Amaia Orbea, Jeanette Rotchell, Miren P. Cajaraville INTEGRATED EFFECT MONITORING USING PROTEIN EXPRESSION, ENZYMATIC ACTIVITY AND TRANSCRIPTOME EFFECTS IN THE BLUE MUSSEL, MYTILUS EDULIS Steven Brooks, Merete Grung, Tor Fredrik Holth, Eivind Farmen Finne, Mie Linnea Jareid, Knut-Erik Tollefsen GENOTOXIC AND ANTIOXIDANT BIOMARKERS IN THE FRESHWATER BIVALVE UNIO PICTORUM MANCUS (MOLLUSCA, UNIONIDAE). A CASE-STUDY FROM CECINA RIVER (TUSCANY, ITALY) Patrizia Guidi, Maura Benedetti, Margherita Bernardeschi, Daniele Fattorini Vittoria Scarcelli, Giada Frenzilli, Alessandra Falleni, Francesco Regoli, Marco Nigro COMPARISON OF TOXIC EFFECTS IN FISH EXPOSED TO PAHS BY DIRECT- OR FOOD-TRANSFER Jerome Cachot, Sara E. Sundberg-Jones, Mac Law, Didier Pottier, Veronique André, Farida Akcha, Hélène Budzinski, Richard Winn P53 GENE EXPRESSION OF THE INTERTIDAL COPEPOD TIGRIOPUS JAPONICUS TO ENVIRONMENTAL TOXICANTS Dae-Sik Hwang, Kyun-Woo Lee, Jae-Sung Rhee, Jeonghoon Han, Jae-Seong Lee IDENTIFICATION OF MOLECULAR LEVEL INDICATORS OF GENOTOXICANT ACTIVATION AND EXPOSURE IN DAPHNIA MAGNA Rhiannon M. David, Vanja Dakic, Timothy D. Williams, Matthew J. Winter, J. Kevin Chipman OXIDATIVE STRESS AND GENOTOXIC EFFECTS OF DELTAMETHRIN IN JUVENILE MULLET (CHELON LABROSUS)

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Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): / Marine Environmental Research 69 (2010) iii–xvi

Abir Malek, Adnen Kacem, Raouf Besbes, Zouhour Ouanes-Ben Othmen APPLICATION OF STEREOLOGICAL TOOLS TO THE CHARACTERIZATION OF PRENEOPLASTIC AND NEOPLASTIC LIVER LESIONS IN FISH – PRELIMINARY DATA FROM THE MARINE FLATFISH DAB Marta Santos, Stephen W. Feist, Grant D. Stentiford, Rogério A.F. Monteiro, Eduardo Rocha DETERMINATION OF OXIDATIVE DNA DAMAGE AND CELLULAR VIABILITY IN MARINE INVERTEBRATES Martin N. Canty, Rebecca J. Brown, Thomas H. Hutchinson, Malcolm B. Jones, Awadhesh N. Jha THE GENOTOXIC POTENTIAL OF ENDOCRINE DISRUPTING CHEMICALS Josephine Hagger, Jörg Oehlmann, Susan Jobling, Tamara Galloway THE SELF-FERTILIZING MANGROVE KILLIFISH KRYPTOLEBIAS MARMORATUS: A POTENTIAL MODEL SPECIES FOR MOLECULAR CARCINOGENESIS AND ECOTOXICOGENOMICS Jae-Seong Lee EXPRESSION OF DNA DAMAGE RESPONSE GENES IN THE MARINE COPEPOD TIGRIOPUS JAPONICUS EXPOSED TO UVB Kyun-Woo Lee, Dae-Sik Hwang, Jeonghoon Han, Jae-Seong Lee GENOTOXIC EFFECT OF CADMIUM AND BENZO[A]PYRENE ON HEPG2 AND JAPANESE MEDAKA LARVAE: NEW EMERGENT BIOASSAYS IN RISK ASSESSMENT Saadia Berrada, J. Gasset, Bénédicte Morin, Cristelle Clerandeau, Jerome Cachot EFFECTS ON REPRODUCTION AND DEVELOPMENT Platform session 1 BENZO(A) PYRENE EFFECTS ON FUNDULUS GLYCINE N-ETHYLTRANSFERASE EXPRESSION AND ACTIVITY Xiefan Fang, Wu Dong, Cammi Thornton, Brian Scheffler, Kristine L. Willett A NEW EMBRYO-LARVAL ASSAY FOR TOXICITY ASSESSMENT OF HYDROPHOBIC AND SEDIMENT-ASSOCIATED POLLUTANTS Vicquelin Ludovic, Leray-Forget Joëlle, Morin Bénédicte, Budzinski Hélène, Cachot Jérôme EMBRYONIC EXPOSURE TO ENVIRONMENTALLY RELEVANT CONCENTRATIONS OF PCB126 AFFECTS PREY-CAPTURE ABILITY OF MUMMICHOG (FUNDULUS HETEROCLITUS) LARVAE Catherine M. Couillard, Benoît Légaré, Andréane Bernier, Zara Dionne DISRUPTION OF ZEBRAFISH (DANIO RERIO) EMBRYONIC DEVELOPMENT AFTER FULL LIFE-CYCLE PARENTAL EXPOSURE TO ETHINYLESTRADIOL Joana Soares, Coimbra AM, Reis-Henriques MA, Monteiro NM, Vieira MN, Oliveira JMA, Guedes-Dias P, Fontaínhas-Fernandes A, Silva Parra S, Carvalho AP, L Filipe C Castro, Miguel Machado Santos GONADAL HISTOPATHOLOGY OF SEA URCHINS: APPLICATION IN TOXICOLOGY

Sabine Schäfer, Angela Köhler DEVELOPING PHYSIOLOGICAL AND MOLECULAR BIOMARKERS FOR DEMASCULINISATION IN CRUSTACEA Gongda Yang, Peter Kille, Alex T. Ford Poster sessions POPULATION DENSITY EFFECT ON ENDOCRINE DISRUPTOR RESPONSES IN THE MARINE COPEPOD TIGRIOPUS JAPONICUS Stella W.Y. Wong, Vivien W.W. Bao, Kenneth M.Y. Leung DEVELOPMENT OF TRANSGENIC ZEBRAFISH FOR BIOASSAY OF METAL CONTAMINATION King Ming Chan, Guohui Wan EFFECTS OF U ON THE REPRODUCTION AND THE ACCUMULATION LEVELS OF IN DANIO RERIO Olivier Simon ENDOCRINE ALTERATION OF 4-NONYLPHENOL: IN VIVO STUDIES OF INTERSPECIES DIFFERENCE Jee-Hyun Jung, Kyoung-lan Baeck, Chang Hee Han, Won Joon Shim ACROSOMAL PROTEIN M7 AS A BIOMARKER OF MALE MATURATION STAGE IN MYTILUS GALLOPROVINCIALIS Benjamin Piña, Sergio Jarque, Alba Olivares, Marta Casado, Montserrat Ramón RELATIONSHIP BETWEEN ENVIRONMENTAL CONTAMINANTS AND HATCHING SUCCESS IN THE LEATHERBACK TURTLES Elodie Guirlet E., Krishna Das, Jean-Pierre Thomé, Marc Girondot FOLLOWING OF GROWTH AND SEXUAL DEVELOPMENT IN MALE AND FEMALE OYSTERS, CRASSOSTREA GIGAS, IN ARCACHON BASIN, CORELATED TO HAEMOLYMPH SEX STEROID LEVELS Blandine Davail-Cuisset, Christelle Clérandeau EFFECTS OF THE HEAVY METAL LEAD ON THE OVARIAN TISSUE OF THE SEA URCHIN PSAMMECHINUS MILIARIS Sabine Schaefer, Angela Koehler BIOMARKER RESPONSES AND STEROID LEVELS IN JUVENILE RAINBOW TROUT (ONCORHYNCHUS MYKISS) EXPOSED TO AN HERBICIDE, ITS NONYLPHENOL POLYETHOXYLATE ADJUVANT AND CADMIUM Anne-Laure Scelo, Blandine Davail-Cuisset, Christelle Clerandeau, Bénédicte Morin, Michèle Daubeze, Anne Basseres, Jean-François Narbonne PREDICTING POPULATION LEVEL EFFECTS OF INFERTILITY IN CRUSTACEANS Alex T Ford, Irene Martins, Alison M. Dunn CITRAL HYDROGENATION OVER RH/ZNO-AL2O3 CATALYSTS Mouna Aoun, Patrice Marecot, Catherine Especel, Gwendoline Lafaye, Mohamed Chater INTERSEX RATIO IN GREY MULLETS FROM THE MONDEGO, DOURO AND AVE ESTUARIES, PORTUGAL – PRELIMINARY DATA João Carrola, António Fontaínhas-Fernandes, Miguel A. Pardal, Bela Castro, Eduardo Rocha