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FINAL DIAGNOSIS OF GARDNER SYNDROME DUE TO STOMATOLOGIC SUPPORT
ABSTRACTS
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lamotrigine intake. During her hospitalization, our dental team evaluated the patient and several ulcerated lesions were observed throughout her oral mucosa and lips. PBMT (660 and 808 nm, 100 mW, 2 J/cm2) was performed on all her oral mucosa and lips lesions, 3 sessions total. Healing of all ulcerated lesions and pain relief was observed, as well as her return to oral feeding. The knowledge of nonpharmacologic treatments proved to be effective for oral lesions in patients with SJS.
FINAL DIAGNOSIS OF GARDNER SYNDROME DUE TO STOMATOLOGIC SUPPORT. LILIANA APARECIDA PIMENTA DE BARROS, DANIELLA FABRES IZOTON, ALANA CORRENTE LOUREIRO, SERGIO LINS DE AZEVEDO ^ VAZ, ROSSIENE MOTTA BERTOLLO, TANIA REGINA e VELLOSO and, DANIELLE RESENDE CAMISASCA GRAO Gardner syndrome (GS) is an autosomal dominant disease characterized by adenomatous intestinal polyps, and if not treated, shows a great chance of becoming malignant. Multiple osteomas in the skull, maxilla, and mandible, along with multiple cutaneous and subcutaneous masses are also characteristics of GS. A 30-year-old woman reported an epidermoid cyst on the frontal bone and a scar on the left shoulder due to osteoma removal. Tooth absence, malocclusion, and osteoma in the palatal region were observed in the intraoral exam. A panoramic radiography analysis revealed permanent teeth retention, supernumerary teeth, and radiopaque areas suggestive of osteomas. Although there were Gardner syndrome manifestations, only after our evaluation, a colonoscopy examination was ordered and intestinal polyps were removed with a diagnosis of tubular adenoma with low grade dysplasia. Today, the patient is under follow-up with a gastroenterologist and oral and maxillofacial surgeons, orthodontists, and stomatology experts with a common goal of function, esthetic, and quality of life improvements.
ORAL SYPHILIS: A CASE SERIES WITH ORAL INVOLVEMENT OF A REEMERGING DISEASE. GERARDO GILLIGAN, EDUARDO PIEMONTE, MARTIN BRUSA, LORENA MOINE, CARRICA, FERNANDA GALINDEZ COSTA ANDRES and, RENE PANICO The current literature reported an increase in cases of syphilis in different regions of Latin America. The aim of this study is to present a series of 19 cases from the Oral Medicine Department, Dentistry College, National University of Cordoba in Argentina with secondary syphilis diagnosed by oral lesions and serologic antibody studies from 2010 to 2018. A wide range of variable clinical presentations and Venereal Disease Research Laboratory (VDRL) titers were recorded in order to establish an association between antibody tests and clinical progression of oral lesions. A high increase of the disease diagnosed at our institution in the last decade was also reported worldwide. This phenomenon suggests the reemergence of a sexually transmitted infection that was believed to have been controlled. Oral syphilis mimics many other diseases becoming a diagnostic challenge for the clinician. Early diagnosis of the disease could avoid the spread of the infection.
DESCRIPTIVE ANALYSIS: CLINICAL CHARACTERISTICS OF 34 PATIENTS WITH PROLIFERATIVE VERRUCOUS LEUKOPLAKIA. ADRIANA RACHEL LAMARCK, JAMILE DE OLIVEIRA SA,
OOOO January 2020 FRANCO PAES LEME, ALAN ROGER SANTOS-SILVA, PABLO AGUSTIN VARGAS and, MARCIO AJUDARTE LOPES Proliferative verrucous leukoplakia (PVL) is a subtype of oral leukoplakia, which is not commonly associated with risk factors such as alcohol and smoking; it has high rates of recurrence after treatment and has a high risk of malignant transformation. This study described the clinical features of 34 patients with PVL (1991-2016). Of these, the vast majority was female (31%91.17%) and the mean age was 69.08 years. Regarding risk factors, only 2 patients smoked and 5 consumed alcoholic beverages. The most frequently affected sites were the buccal mucosa and lateral border of the tongue. The average number of site affected with leukoplakia was 3.41 and the development of squamous cell carcinoma occurred in 7 of the patients (20%). PVL starts as an isolated lesion but develops important changes throughout the follow-up period. Therefore, constant clinical monitoring is necessary.
A CASE SERIES OF ADENOMATOID ODONTOGENIC TUMOR: CLINICOPATHOLOGIC AND MOLECULAR CHARACTERIZATION. CAROLINA CAVALIERI GOMES, BRUNA PIZZIOLO COURA, SILVIA FERREIRA DE SOUSA, VANESSA FATIMA BERNARDES, JOSIANE ALVES FRANCA, ¸ MARINA GONCALVES ¸ DINIZ and, RICARDO SANTIAGO GOMEZ We report a series of 22 adenomatoid odontogenic tumors (AOTs). The patients’ age, tumor location, association with impacted teeth, and clinical size were obtained. Capsule thickness was evaluated. The patients’ mean age was 18.8 years (range 6-57 y). Considering the cases with known information, 16 occurred in women and 5 in men, 11 in the maxilla, and 10 in the mandible, 13 in the anterior regions, and 7 in the posterior regions, 8 in association with impacted teeth, and 9 not associated with impaction. We evaluated 3 AOT samples for mutations in a panel of 50 oncogenes and tumor suppressor genes by nextgeneration sequencing. The KRAS G12V mutation was detected in 3 samples. We screened the other 19 samples for KRAS codon 12 mutations. KRAS codon 12 mutations occurred in 15 out of 22 (68%), KRAS G12V in 14 out of 22 cases, and KRAS G12R in 1 out of 22. Codon 12 mutations were not associated with any of the clinicopathologic parameters tested (P > .05). Supported by FAPEMIG/CAPES/CNPq/Brazil.
SARCOMAS OF THE ORAL CAVITY: A STUDY OF A SERIES OF 22 CASES. PATRICIA MASQUIJO BISIO, LILIANA G. OLVI, FERNANDO CARRIZO and, MARIA L. PAPARELLA The study comprised 22 cases of oral sarcomas; clinical, histopathologic, and immunohistochemical features were evaluated. The studied series accounted for 0.1% of all oral-maxillofacial pathology, and 7% of all soft tissue tumors in the oral cavity; 59% (13 cases) were Kaposi sarcomas, mean age was 40 years (range 24-55 y), 85% occurred in male patients, and 54% cases involved the palate. The most prevalent microscopic variant was the solid type (60%), and all cases tested positive for human herpesvirus 8 (HHV-8). The remaining sarcomas were: leiomyosarcoma-3, fibrosarcoma-2, solid alveolar rhabdomyosarcoma-1, pleomorphic undifferentiated sarcoma-1, synovial sarcoma-1,
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lamotrigine intake. During her hospitalization, our dental team evaluated the patient and several ulcerated lesions were observed throughout her oral mucosa and lips. PBMT (660 and 808 nm, 100 mW, 2 J/cm2) was performed on all her oral mucosa and lips lesions, 3 sessions total. Healing of all ulcerated lesions and pain relief was observed, as well as her return to oral feeding. The knowledge of nonpharmacologic treatments proved to be effective for oral lesions in patients with SJS.
FINAL DIAGNOSIS OF GARDNER SYNDROME DUE TO STOMATOLOGIC SUPPORT. LILIANA APARECIDA PIMENTA DE BARROS, DANIELLA FABRES IZOTON, ALANA CORRENTE LOUREIRO, SERGIO LINS DE AZEVEDO ^ VAZ, ROSSIENE MOTTA BERTOLLO, TANIA REGINA e VELLOSO and, DANIELLE RESENDE CAMISASCA GRAO Gardner syndrome (GS) is an autosomal dominant disease characterized by adenomatous intestinal polyps, and if not treated, shows a great chance of becoming malignant. Multiple osteomas in the skull, maxilla, and mandible, along with multiple cutaneous and subcutaneous masses are also characteristics of GS. A 30-year-old woman reported an epidermoid cyst on the frontal bone and a scar on the left shoulder due to osteoma removal. Tooth absence, malocclusion, and osteoma in the palatal region were observed in the intraoral exam. A panoramic radiography analysis revealed permanent teeth retention, supernumerary teeth, and radiopaque areas suggestive of osteomas. Although there were Gardner syndrome manifestations, only after our evaluation, a colonoscopy examination was ordered and intestinal polyps were removed with a diagnosis of tubular adenoma with low grade dysplasia. Today, the patient is under follow-up with a gastroenterologist and oral and maxillofacial surgeons, orthodontists, and stomatology experts with a common goal of function, esthetic, and quality of life improvements.
ORAL SYPHILIS: A CASE SERIES WITH ORAL INVOLVEMENT OF A REEMERGING DISEASE. GERARDO GILLIGAN, EDUARDO PIEMONTE, MARTIN BRUSA, LORENA MOINE, CARRICA, FERNANDA GALINDEZ COSTA ANDRES and, RENE PANICO The current literature reported an increase in cases of syphilis in different regions of Latin America. The aim of this study is to present a series of 19 cases from the Oral Medicine Department, Dentistry College, National University of Cordoba in Argentina with secondary syphilis diagnosed by oral lesions and serologic antibody studies from 2010 to 2018. A wide range of variable clinical presentations and Venereal Disease Research Laboratory (VDRL) titers were recorded in order to establish an association between antibody tests and clinical progression of oral lesions. A high increase of the disease diagnosed at our institution in the last decade was also reported worldwide. This phenomenon suggests the reemergence of a sexually transmitted infection that was believed to have been controlled. Oral syphilis mimics many other diseases becoming a diagnostic challenge for the clinician. Early diagnosis of the disease could avoid the spread of the infection.
DESCRIPTIVE ANALYSIS: CLINICAL CHARACTERISTICS OF 34 PATIENTS WITH PROLIFERATIVE VERRUCOUS LEUKOPLAKIA. ADRIANA RACHEL LAMARCK, JAMILE DE OLIVEIRA SA,
OOOO January 2020 FRANCO PAES LEME, ALAN ROGER SANTOS-SILVA, PABLO AGUSTIN VARGAS and, MARCIO AJUDARTE LOPES Proliferative verrucous leukoplakia (PVL) is a subtype of oral leukoplakia, which is not commonly associated with risk factors such as alcohol and smoking; it has high rates of recurrence after treatment and has a high risk of malignant transformation. This study described the clinical features of 34 patients with PVL (1991-2016). Of these, the vast majority was female (31%91.17%) and the mean age was 69.08 years. Regarding risk factors, only 2 patients smoked and 5 consumed alcoholic beverages. The most frequently affected sites were the buccal mucosa and lateral border of the tongue. The average number of site affected with leukoplakia was 3.41 and the development of squamous cell carcinoma occurred in 7 of the patients (20%). PVL starts as an isolated lesion but develops important changes throughout the follow-up period. Therefore, constant clinical monitoring is necessary.
A CASE SERIES OF ADENOMATOID ODONTOGENIC TUMOR: CLINICOPATHOLOGIC AND MOLECULAR CHARACTERIZATION. CAROLINA CAVALIERI GOMES, BRUNA PIZZIOLO COURA, SILVIA FERREIRA DE SOUSA, VANESSA FATIMA BERNARDES, JOSIANE ALVES FRANCA, ¸ MARINA GONCALVES ¸ DINIZ and, RICARDO SANTIAGO GOMEZ We report a series of 22 adenomatoid odontogenic tumors (AOTs). The patients’ age, tumor location, association with impacted teeth, and clinical size were obtained. Capsule thickness was evaluated. The patients’ mean age was 18.8 years (range 6-57 y). Considering the cases with known information, 16 occurred in women and 5 in men, 11 in the maxilla, and 10 in the mandible, 13 in the anterior regions, and 7 in the posterior regions, 8 in association with impacted teeth, and 9 not associated with impaction. We evaluated 3 AOT samples for mutations in a panel of 50 oncogenes and tumor suppressor genes by nextgeneration sequencing. The KRAS G12V mutation was detected in 3 samples. We screened the other 19 samples for KRAS codon 12 mutations. KRAS codon 12 mutations occurred in 15 out of 22 (68%), KRAS G12V in 14 out of 22 cases, and KRAS G12R in 1 out of 22. Codon 12 mutations were not associated with any of the clinicopathologic parameters tested (P > .05). Supported by FAPEMIG/CAPES/CNPq/Brazil.
SARCOMAS OF THE ORAL CAVITY: A STUDY OF A SERIES OF 22 CASES. PATRICIA MASQUIJO BISIO, LILIANA G. OLVI, FERNANDO CARRIZO and, MARIA L. PAPARELLA The study comprised 22 cases of oral sarcomas; clinical, histopathologic, and immunohistochemical features were evaluated. The studied series accounted for 0.1% of all oral-maxillofacial pathology, and 7% of all soft tissue tumors in the oral cavity; 59% (13 cases) were Kaposi sarcomas, mean age was 40 years (range 24-55 y), 85% occurred in male patients, and 54% cases involved the palate. The most prevalent microscopic variant was the solid type (60%), and all cases tested positive for human herpesvirus 8 (HHV-8). The remaining sarcomas were: leiomyosarcoma-3, fibrosarcoma-2, solid alveolar rhabdomyosarcoma-1, pleomorphic undifferentiated sarcoma-1, synovial sarcoma-1,