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Fish oils increase apo (a) levels
$92
Poster session abstracts / Atherosclerosis 115 (Suppl.) (1995) $45-S129 P11 Lipoprotein ( a )
343
345
EFFECTS OF M A G N E S I U M - O X I D E ON SERUM LIPIDS AND LP(A) IN HYPERLIPIDEM1C PATIENTS WITH INCREASED LP(A) LEVELS N. Hoogerbrugge, C.M. Cobbaert, L. de Heide. J C . Birkenh~ger University Hospital Dijkzigt. Rotterdam, The Netherlands
EXERCISE I N D U C E D INCREASE IN LIPOPROTEIN(a). RESULTS FROM T H E OSLO DIET AND EXERCISE S T U D Y (ODES) I. Holme. P. Urdal, S. Anderssen, I. Hjermann Ullevaal University Hospital, University of Sport and Physical Education, Oslo, Norway
The hardness of drinking water is determined by both calcium and magnesium concentration, and inversely correlates with the incidence of cardiovascular diseases. In cholesterol fed atherosclerotic rabbits. magnesium therapy decreases the area of the atherosclerotic lesion in a dose dependent mariner. Patients with hyperlipidemia and Lpla) level > 300 U/I have increased risk for the development of premature atherosclerosis. We studied the effect of supplemental magnesium on the serum concentration of Lp(a) and the lipid profile in hyperli pidemic patients with increased Lp(a). 24 hyperlipidemic patients with Lp(a) concentration > 300 U/1 were treated for 6 weeks with 2 x 500 mg magnesium-oxide Before. during and 6 weeks after discontinuation of supplemental magnesium-oxide, the serum concentration of Lp(a), lipids and apolipoproteins were measured. During treatment magnesium concentration increased, however the serum concentration of cholesterol, LDLc. HDLc, apo-A1 and apo-Bl00 were not affected The concentration of Lp(a) even slightly increased during magnesium therapy from 974 + 509 U/I to 1177 + 565 U/I ( P < 0 . 0 5 ) . respectively. In conclusion, supplemental magnesium-oxide in a daily dose of 1000 mg did not produce significant changes in the serum lipid concentration of hyperlipidemic patients and slightly increased Lp(a) levels.
344 FISH OILS INCREASE APO (a) LEVELS J.M. Silva, 1. Souza ~, F. Rodrigues 2, J.P. Moura, H. Ribeiro2~ F. Teixeira3, P.S. Silva 2nd Dept of lnt Med of Univ Hosp, :Dept Clin Pathol of Univ Hosp, 3Inst Pharmacol and Experimental Therapeutic of Faculty of Med, Coimbra. Portugal, and IFederal Univ. of Pernambuco, Brazil The purpose of this study was to determine the efficacy of fish oil in portuguese patients, usually high consumers of fish, olive oil and red wine, with hypertriglyceridaemia and mixed hyperlipidaemia. Thirtysix patients participated in this double-blind study, which consisted of a 4-week dietary or wash-out baseline period after which patients were randomly assigned to receive either 12 fish oil (FO) capsules (3.6g/dal of omega 3) or similar 12 soya oil (SO) capsules per day for a period of two months. Compliance was assessed by pill count. Apo(a) was measured by IRMA, Pharmacia [1 unit of apo(a) is very approximately equal to 0.7 mg of Lp(a)]. Apo(a) values were logtransformed before every statistic calculation. The results are presented as mean + SEM. Patients consumed a mean of 4.8 meals with fish per week. 44% of the patients were teetotallers. Five patients, all taking SO capsules, withdrew from the study because of clinical side effects. Apo(a) increased 43% with FO (from 234 + 59 to 335 ± 79 U/L) (p=0.003, paired t-test, 2-tail), and didn't change with OO (from 189 5:60 to 179 ± 54 U/L). Sex, alcohol and tobacco consumption, and BMI didn't influence FO's effect on Apo(a) levels. Considering the whole population and the baseline measurement of apo(a), we found no significant correlations between Apo(a) levels and age, BMI, and the number of meals with fish per week, and no significant differences on Apo(a) levels between type 11 diabetics and non-diabetics, alcohol consumers and teetotallers, and smokers and non-smokers (t-test, 2-tail). These findings suggest that a high daily dose of FO increase apo(a) blood levels in patients with hypertriglyce ridaemia and mixed hyperlipidaemia. Supported by a grant of Hebron, Caruaru, Brazil
In the Oslo Diet and Exercise Study (ODES) 219 healthy middle aged physically inactive persons with moderately deranged risk factors levels (increased bodyweight, diastolic blood pressure, serum cholesterol, triglycerides, decreased HDL-cholesterol) were randomised to 4 intervention groups: dietary intervention, exercise, diet + exercise and control. The purpose of the study was to test if physical exercise would be associated with increased levels of Lp(a) as a result of intervention. Those who exercised increased their Lp(a) levels with 15.4 ( S E = 8 . 0 ) mg/L as compared to no exercise ( P < 0,05). Also, dietary intervention tended to increase Lp(a), but the increase did not reach statistical significance. There was no detectable interaction on the effect on Lp(a) of the two intervention modalities. A dose-response relationship was found between change in the exercise specific variables heat-t rate and peak oxygen uptake, and Lp(a)-change and this dose-response was most pronounced in the exercise group. Change in Lp(a) was associated to change in several life style related variables such as alcohol intake and waist circumference~ pointing to the possibility that Lp(a) at least in some subpopulations is more amenable to change through life style alterations than reported so far.
Poster session abstracts / Atherosclerosis 115 (Suppl.) (1995) $45-S129 P11 Lipoprotein ( a )
343
345
EFFECTS OF M A G N E S I U M - O X I D E ON SERUM LIPIDS AND LP(A) IN HYPERLIPIDEM1C PATIENTS WITH INCREASED LP(A) LEVELS N. Hoogerbrugge, C.M. Cobbaert, L. de Heide. J C . Birkenh~ger University Hospital Dijkzigt. Rotterdam, The Netherlands
EXERCISE I N D U C E D INCREASE IN LIPOPROTEIN(a). RESULTS FROM T H E OSLO DIET AND EXERCISE S T U D Y (ODES) I. Holme. P. Urdal, S. Anderssen, I. Hjermann Ullevaal University Hospital, University of Sport and Physical Education, Oslo, Norway
The hardness of drinking water is determined by both calcium and magnesium concentration, and inversely correlates with the incidence of cardiovascular diseases. In cholesterol fed atherosclerotic rabbits. magnesium therapy decreases the area of the atherosclerotic lesion in a dose dependent mariner. Patients with hyperlipidemia and Lpla) level > 300 U/I have increased risk for the development of premature atherosclerosis. We studied the effect of supplemental magnesium on the serum concentration of Lp(a) and the lipid profile in hyperli pidemic patients with increased Lp(a). 24 hyperlipidemic patients with Lp(a) concentration > 300 U/1 were treated for 6 weeks with 2 x 500 mg magnesium-oxide Before. during and 6 weeks after discontinuation of supplemental magnesium-oxide, the serum concentration of Lp(a), lipids and apolipoproteins were measured. During treatment magnesium concentration increased, however the serum concentration of cholesterol, LDLc. HDLc, apo-A1 and apo-Bl00 were not affected The concentration of Lp(a) even slightly increased during magnesium therapy from 974 + 509 U/I to 1177 + 565 U/I ( P < 0 . 0 5 ) . respectively. In conclusion, supplemental magnesium-oxide in a daily dose of 1000 mg did not produce significant changes in the serum lipid concentration of hyperlipidemic patients and slightly increased Lp(a) levels.
344 FISH OILS INCREASE APO (a) LEVELS J.M. Silva, 1. Souza ~, F. Rodrigues 2, J.P. Moura, H. Ribeiro2~ F. Teixeira3, P.S. Silva 2nd Dept of lnt Med of Univ Hosp, :Dept Clin Pathol of Univ Hosp, 3Inst Pharmacol and Experimental Therapeutic of Faculty of Med, Coimbra. Portugal, and IFederal Univ. of Pernambuco, Brazil The purpose of this study was to determine the efficacy of fish oil in portuguese patients, usually high consumers of fish, olive oil and red wine, with hypertriglyceridaemia and mixed hyperlipidaemia. Thirtysix patients participated in this double-blind study, which consisted of a 4-week dietary or wash-out baseline period after which patients were randomly assigned to receive either 12 fish oil (FO) capsules (3.6g/dal of omega 3) or similar 12 soya oil (SO) capsules per day for a period of two months. Compliance was assessed by pill count. Apo(a) was measured by IRMA, Pharmacia [1 unit of apo(a) is very approximately equal to 0.7 mg of Lp(a)]. Apo(a) values were logtransformed before every statistic calculation. The results are presented as mean + SEM. Patients consumed a mean of 4.8 meals with fish per week. 44% of the patients were teetotallers. Five patients, all taking SO capsules, withdrew from the study because of clinical side effects. Apo(a) increased 43% with FO (from 234 + 59 to 335 ± 79 U/L) (p=0.003, paired t-test, 2-tail), and didn't change with OO (from 189 5:60 to 179 ± 54 U/L). Sex, alcohol and tobacco consumption, and BMI didn't influence FO's effect on Apo(a) levels. Considering the whole population and the baseline measurement of apo(a), we found no significant correlations between Apo(a) levels and age, BMI, and the number of meals with fish per week, and no significant differences on Apo(a) levels between type 11 diabetics and non-diabetics, alcohol consumers and teetotallers, and smokers and non-smokers (t-test, 2-tail). These findings suggest that a high daily dose of FO increase apo(a) blood levels in patients with hypertriglyce ridaemia and mixed hyperlipidaemia. Supported by a grant of Hebron, Caruaru, Brazil
In the Oslo Diet and Exercise Study (ODES) 219 healthy middle aged physically inactive persons with moderately deranged risk factors levels (increased bodyweight, diastolic blood pressure, serum cholesterol, triglycerides, decreased HDL-cholesterol) were randomised to 4 intervention groups: dietary intervention, exercise, diet + exercise and control. The purpose of the study was to test if physical exercise would be associated with increased levels of Lp(a) as a result of intervention. Those who exercised increased their Lp(a) levels with 15.4 ( S E = 8 . 0 ) mg/L as compared to no exercise ( P < 0,05). Also, dietary intervention tended to increase Lp(a), but the increase did not reach statistical significance. There was no detectable interaction on the effect on Lp(a) of the two intervention modalities. A dose-response relationship was found between change in the exercise specific variables heat-t rate and peak oxygen uptake, and Lp(a)-change and this dose-response was most pronounced in the exercise group. Change in Lp(a) was associated to change in several life style related variables such as alcohol intake and waist circumference~ pointing to the possibility that Lp(a) at least in some subpopulations is more amenable to change through life style alterations than reported so far.