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Focal Epithelial Hyperplasia in Yanomami Indians: Report of 9 Cases
OOOO Volume 120, Number 2 and maxillofacial region. A 46-year-old female patient was referred to a stomatology clinic for evaluation of an extensive, progressive, hard-on-palpation swelling of the right paranasal sinus, upper lip, and cheek. Oral examination revealed an ulcerated lesion on the ipsilateral mucosa. Panoramic radiography showed a diffuse radiopaque area in the right maxilla and maxillary sinus. The histopathological examination suggested malignant mesenchymal hematopoietic neoplasm. Immunohistochemical reactions were strongly positive for CD20 and CD30, consistent with a diagnosis of DLBCL. Currently, the patient is undergoing immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). After the third of 6 cycles of R-CHOP, the patient presented complete clinical remission of the lesion.
PCC-086 - FOCAL EPITHELIAL HYPERPLASIA IN YANOMAMI INDIANS: REPORT OF 9 CASES. NELIANA SALOMÃO RODRIGUES, MARCELA LUMI MIYASAKI, RAFAEL GONÇALVES MAZINI, GLÁUCIA RESENDE SOARES, NATALIA SILVA CARVALHO, CRISTIANE FURUSE. FACULDADE DE ODONTOLOGIA DE ARAÇATUBA e UNESP. Focal epithelial hyperplasia (FEH), or Heck’s disease, is a rare disease of the oral mucosa, apparently induced by human papillomavirus infection, which predominantly affects children and young adults. It is characterized by multiple, painless sessile papules that can coalesce to form larger lesions like plaques or nodules, of normal mucosa color. Here, we report cases of FEH in 9 individuals belonging to the Sanumá subgroup of the Yanomami tribe: 8 males and 1 female, with a mean age of 8.5 years (range, 3e14 years). The lesions were mainly on the lower lip, followed by the upper lip, tongue, and lip commissure. Diagnoses were made on the basis of the clinical and histopathological findings. At this writing, the lesions were being monitored and were soon to be excised, for functional or aesthetic reasons.
PCC-087 - FOLLICULAR THYROID CARCINOMA DIAGNOSED ON THE BASIS OF METASTASIS TO THE MANDIBLE. VITOR BONETTI VALENTE, ICLEIA SIQUEIRA BARRETO, ANDRESA SOARES BORGES, ANTONIO AUGUSTO FERREIRA DE CARVALHO, GLAUCO ISSAMU MIYAHARA, ÉDER RICARDO BIASOLI, DANIEL GALERA BERNABÉ. FACULDADE DE ODONTOLOGIA DE ARAÇATUBA e UNESP. Follicular thyroid carcinoma accounts for 10% of malignant tumors of the thyroid gland and usually affects women over 50 years of age. A 76-year-old White female who was an ex-smoker, diabetic, and hypertensive, with a history of colon cancer treated 20 years ago, was referred to a stomatology clinic for evaluation of facial and intraoral swelling in the right mandible. Radiography and computed tomography showed a destructive lesion in the angle/ramus of the mandible. Analysis of a biopsy sample showed a malignant epithelial neoplasm displaying a follicular arrangement and immunopositivity for TTF-1, thyroglobulin, and CK7, suggesting a metastatic lesion of probable thyroid origin. Investigation for primary tumor excluded tumors of the cervix, abdominal organs, and breast, as well colon cancer recurrence. Ultrasonography and PET-SCAN revealed thyroid nodules. Fineneedle aspiration biopsy of the thyroid indicated follicular lesion. The patient was submitted to thyroidectomy and radioiodine therapy. Currently, the patient is being monitored at an oral oncology center.
ABSTRACTS Abstracts e41 PCC-088 - GLANDULAR ODONTOGENIC CYST IN THE MAXILLA: A CASE REPORT. MARIA FERNANDA BARTHOLO SILVA, MATHEUS HENRIQUE ALVES DE LIMA, VICTOR PIANA DE ANDRADE, RODRIGO NASCIMENTO LOPES, ANDRÉ CAROLI ROCHA, GRAZIELLA CHAGAS JAGUAR. AC CAMARGO CANCER CENTER. Glandular odontogenic cyst (GOC) is a rare lesion that mainly occurs in the anterior mandible and affects men in the sixth decade of life. The radiographic presentation can be unilocular or multilocular. A 23-year-old male was referred to our facility for evaluation of a radiolucent lesion, in the anterior maxilla, that was discovered as an incidental finding on a radiograph that was taken for orthodontic treatment. Computed tomography showed a well-defined hypodense lesion with expansion of the cortical bones. The main diagnostic hypothesis was odontogenic cyst. The treatment consisted of enucleation of the lesion and bone grafting to fill the cavity. The histopathological analysis of the surgical specimen was suggestive of a GOC. No recurrence was observed after 8 months. In conclusion, GOC is a rare odontogenic cyst that should be included in the differential diagnosis of radiolucent lesions in the maxilla.
PCC-089 - GRANULAR CELL TUMOR IN A CHILD: CASE REPORT. IARA RAFAELLA FERREIRA TAVARES, LAURA PRISCILA BARBOZA CARVALHO, MURILO QUINTÃO DOS SANTOS, TIBURTINO JOSÉ DE LIMA NETO, JOÃO ROBERTO TRINDADE COSTA FILHO, MARIA SALETE TRIGUEIRO DE ARAÚJO, LEONARDO COSTA DE ALMEIDA PAIVA. CENTRO UNIVERSITÁRIO DE JOÃO PESSOA. Granular cell tumor is a slow-growing, benign neoplasm that most often affects women between 40 and 60 years of age, being considered rare in children. Clinically, it presents as a stiff submucosal nodule that is usually painless. A 9-year-old white female sought dental care, complaining of a painless, progressive swelling on the dorsum of the tongue that had first appeared 6 months earlier. Intraoral examination revealed a sessile nodular lesion, with a fibroelastic consistency, measuring 1.2 0.4 cm. An incisional biopsy was performed, and the histopathological analysis showed a non-encapsulated benign neoplasm, composed of groups of polygonal cells with normochromatic or slightly hyperchromatic egg-shaped nuclei and granular eosinophilic cytoplasm. Narrow muscle strips intercepted those cell groups, constituting a lobular arrangement. The final diagnosis was granular cell tumor. The patient underwent surgical excision of the lesion under general anesthesia and is still being followed-up.
PCC-090 - HEREDITARY ECTODERMAL DYSPLASIA. ROBECI ALVES MACEDO FILHO, FLAVIANA DORNELA VERLI, DMITRY JOSÉ DE SANTANA SARMENTO, SÉRGIO HENRIQUE GONÇALVES DE CARVALHO, GUSTAVO GOMES AGRIPINO, MANUEL ANTONIO GORDÓN-NÚÑEZ, SANDRA APARECIDA MARINHO. UNIVERSIDADE ESTADUAL DA PARAÍBA. Ectodermal dysplasia is a recessive hereditary condition characterized by hypohidrosis, hypotrichosis, and hypodontia. An 11-year-old White male sought treatment at a dental clinic complaining that the tips of his upper incisors were hurting his tongue. The parents reported that the boy had ectodermal dysplasia and his 35-year-old uncle had the same
PCC-086 - FOCAL EPITHELIAL HYPERPLASIA IN YANOMAMI INDIANS: REPORT OF 9 CASES. NELIANA SALOMÃO RODRIGUES, MARCELA LUMI MIYASAKI, RAFAEL GONÇALVES MAZINI, GLÁUCIA RESENDE SOARES, NATALIA SILVA CARVALHO, CRISTIANE FURUSE. FACULDADE DE ODONTOLOGIA DE ARAÇATUBA e UNESP. Focal epithelial hyperplasia (FEH), or Heck’s disease, is a rare disease of the oral mucosa, apparently induced by human papillomavirus infection, which predominantly affects children and young adults. It is characterized by multiple, painless sessile papules that can coalesce to form larger lesions like plaques or nodules, of normal mucosa color. Here, we report cases of FEH in 9 individuals belonging to the Sanumá subgroup of the Yanomami tribe: 8 males and 1 female, with a mean age of 8.5 years (range, 3e14 years). The lesions were mainly on the lower lip, followed by the upper lip, tongue, and lip commissure. Diagnoses were made on the basis of the clinical and histopathological findings. At this writing, the lesions were being monitored and were soon to be excised, for functional or aesthetic reasons.
PCC-087 - FOLLICULAR THYROID CARCINOMA DIAGNOSED ON THE BASIS OF METASTASIS TO THE MANDIBLE. VITOR BONETTI VALENTE, ICLEIA SIQUEIRA BARRETO, ANDRESA SOARES BORGES, ANTONIO AUGUSTO FERREIRA DE CARVALHO, GLAUCO ISSAMU MIYAHARA, ÉDER RICARDO BIASOLI, DANIEL GALERA BERNABÉ. FACULDADE DE ODONTOLOGIA DE ARAÇATUBA e UNESP. Follicular thyroid carcinoma accounts for 10% of malignant tumors of the thyroid gland and usually affects women over 50 years of age. A 76-year-old White female who was an ex-smoker, diabetic, and hypertensive, with a history of colon cancer treated 20 years ago, was referred to a stomatology clinic for evaluation of facial and intraoral swelling in the right mandible. Radiography and computed tomography showed a destructive lesion in the angle/ramus of the mandible. Analysis of a biopsy sample showed a malignant epithelial neoplasm displaying a follicular arrangement and immunopositivity for TTF-1, thyroglobulin, and CK7, suggesting a metastatic lesion of probable thyroid origin. Investigation for primary tumor excluded tumors of the cervix, abdominal organs, and breast, as well colon cancer recurrence. Ultrasonography and PET-SCAN revealed thyroid nodules. Fineneedle aspiration biopsy of the thyroid indicated follicular lesion. The patient was submitted to thyroidectomy and radioiodine therapy. Currently, the patient is being monitored at an oral oncology center.
ABSTRACTS Abstracts e41 PCC-088 - GLANDULAR ODONTOGENIC CYST IN THE MAXILLA: A CASE REPORT. MARIA FERNANDA BARTHOLO SILVA, MATHEUS HENRIQUE ALVES DE LIMA, VICTOR PIANA DE ANDRADE, RODRIGO NASCIMENTO LOPES, ANDRÉ CAROLI ROCHA, GRAZIELLA CHAGAS JAGUAR. AC CAMARGO CANCER CENTER. Glandular odontogenic cyst (GOC) is a rare lesion that mainly occurs in the anterior mandible and affects men in the sixth decade of life. The radiographic presentation can be unilocular or multilocular. A 23-year-old male was referred to our facility for evaluation of a radiolucent lesion, in the anterior maxilla, that was discovered as an incidental finding on a radiograph that was taken for orthodontic treatment. Computed tomography showed a well-defined hypodense lesion with expansion of the cortical bones. The main diagnostic hypothesis was odontogenic cyst. The treatment consisted of enucleation of the lesion and bone grafting to fill the cavity. The histopathological analysis of the surgical specimen was suggestive of a GOC. No recurrence was observed after 8 months. In conclusion, GOC is a rare odontogenic cyst that should be included in the differential diagnosis of radiolucent lesions in the maxilla.
PCC-089 - GRANULAR CELL TUMOR IN A CHILD: CASE REPORT. IARA RAFAELLA FERREIRA TAVARES, LAURA PRISCILA BARBOZA CARVALHO, MURILO QUINTÃO DOS SANTOS, TIBURTINO JOSÉ DE LIMA NETO, JOÃO ROBERTO TRINDADE COSTA FILHO, MARIA SALETE TRIGUEIRO DE ARAÚJO, LEONARDO COSTA DE ALMEIDA PAIVA. CENTRO UNIVERSITÁRIO DE JOÃO PESSOA. Granular cell tumor is a slow-growing, benign neoplasm that most often affects women between 40 and 60 years of age, being considered rare in children. Clinically, it presents as a stiff submucosal nodule that is usually painless. A 9-year-old white female sought dental care, complaining of a painless, progressive swelling on the dorsum of the tongue that had first appeared 6 months earlier. Intraoral examination revealed a sessile nodular lesion, with a fibroelastic consistency, measuring 1.2 0.4 cm. An incisional biopsy was performed, and the histopathological analysis showed a non-encapsulated benign neoplasm, composed of groups of polygonal cells with normochromatic or slightly hyperchromatic egg-shaped nuclei and granular eosinophilic cytoplasm. Narrow muscle strips intercepted those cell groups, constituting a lobular arrangement. The final diagnosis was granular cell tumor. The patient underwent surgical excision of the lesion under general anesthesia and is still being followed-up.
PCC-090 - HEREDITARY ECTODERMAL DYSPLASIA. ROBECI ALVES MACEDO FILHO, FLAVIANA DORNELA VERLI, DMITRY JOSÉ DE SANTANA SARMENTO, SÉRGIO HENRIQUE GONÇALVES DE CARVALHO, GUSTAVO GOMES AGRIPINO, MANUEL ANTONIO GORDÓN-NÚÑEZ, SANDRA APARECIDA MARINHO. UNIVERSIDADE ESTADUAL DA PARAÍBA. Ectodermal dysplasia is a recessive hereditary condition characterized by hypohidrosis, hypotrichosis, and hypodontia. An 11-year-old White male sought treatment at a dental clinic complaining that the tips of his upper incisors were hurting his tongue. The parents reported that the boy had ectodermal dysplasia and his 35-year-old uncle had the same