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Formaldehyde cyclododecyl methyl acetal
Fragrance raw materials monographs
327
FORMALDEHYDE CYCLODODECYL METHYL ACETAL
Synonyms: Boisambrene; (methoxymethoxy)cyclododecane. CAS Registry No. 42604-12-6 CAS Index Name: cyclododecane, (methoxymethoxy)i
i
Structure: [CH2]II CH" O" CH2' O" CH 3 I
I
Description: A colourless liquid. Occurrence: Has apparently not been reported to occur in nature. Physical properties: Boiling point Flash point Refractive index Specific gravity
86°C 142°C 1.4695 0.9463
(Analytical data on the material as tested by RIFM.) Gas chromatogram and infra-red curve on file at RIFM.
Biological data Acute toxicity. The acute oral LDs0 in rats exceeded 5 g/kg based on 0/10 deaths at that dose, and the acute dermal LDs0 in rabbits exceeded 5 g/kg based on 0/10 deaths (Moreno, 1980). Irritation. As part of an acute dermal LDso study, the undiluted material produced irritant effects and scaly skin in rabbits patch-tested for 24 hr under occlusion at a dose of 5 g/kg (Moreno, 1980). A 48-hr closed-patch test at a concentration of 2% in petrolatum on the backs of 22 volunteers produced no irritation (Epstein, 1980). Sensitization. A maximization test (Kligrnan, 1966; Kligman & Epstein, 1975) was carried out on 22 volunteers. The material was tested at a concentration of 2% in petrolatum and produced no sensitization reactions (Epstein, 1980). This test concentration was based on a reported maximum concentration of 0.2% in consumer products.
References Epstein, W. L. (1980). Report to RIFM, 4 April. Kligrnan, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. invest. Derm. 47, 393. Kligman, A. M. & Epstein, W. (1975). Updating the maximization test for identifying contact allergens. Contact Dermatitis 1, 231. Moreno, O. M. (1980). Report to RIFM, 28 May.
327
FORMALDEHYDE CYCLODODECYL METHYL ACETAL
Synonyms: Boisambrene; (methoxymethoxy)cyclododecane. CAS Registry No. 42604-12-6 CAS Index Name: cyclododecane, (methoxymethoxy)i
i
Structure: [CH2]II CH" O" CH2' O" CH 3 I
I
Description: A colourless liquid. Occurrence: Has apparently not been reported to occur in nature. Physical properties: Boiling point Flash point Refractive index Specific gravity
86°C 142°C 1.4695 0.9463
(Analytical data on the material as tested by RIFM.) Gas chromatogram and infra-red curve on file at RIFM.
Biological data Acute toxicity. The acute oral LDs0 in rats exceeded 5 g/kg based on 0/10 deaths at that dose, and the acute dermal LDs0 in rabbits exceeded 5 g/kg based on 0/10 deaths (Moreno, 1980). Irritation. As part of an acute dermal LDso study, the undiluted material produced irritant effects and scaly skin in rabbits patch-tested for 24 hr under occlusion at a dose of 5 g/kg (Moreno, 1980). A 48-hr closed-patch test at a concentration of 2% in petrolatum on the backs of 22 volunteers produced no irritation (Epstein, 1980). Sensitization. A maximization test (Kligrnan, 1966; Kligman & Epstein, 1975) was carried out on 22 volunteers. The material was tested at a concentration of 2% in petrolatum and produced no sensitization reactions (Epstein, 1980). This test concentration was based on a reported maximum concentration of 0.2% in consumer products.
References Epstein, W. L. (1980). Report to RIFM, 4 April. Kligrnan, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. invest. Derm. 47, 393. Kligman, A. M. & Epstein, W. (1975). Updating the maximization test for identifying contact allergens. Contact Dermatitis 1, 231. Moreno, O. M. (1980). Report to RIFM, 28 May.