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Formulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir
Pharmaceutics
Formulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir Bhosale UV, Kusum Devi V, Jain N Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore - 560 027, India Address for correspondence: Mr. Uday Bhosale; E-mail: [email protected]
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INTRODUCTION
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Journal of Young Pharmacists Vol 3 / No 4
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Bhosale, et al.: Mucoadhesive nano drug delivery system of acyclovir
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In vitro characterization of PLGA nanoparticles Journal of Young Pharmacists Vol 3 / No 4
Bhosale, et al.: Mucoadhesive nano drug delivery system of acyclovir Table 1: ([perimental GesiJn anG parameters for 23 fXll factorial GesiJn batcKes Batch code MF1 MF2 MF3 MF MF MF MF MF C
Variable level in Particle % Drug % Drug Average % coded form size entrapment release intestinal (nm) in 12 h retention X3§ X1* X2# +1 +1 +1 1 93 93 í1 +1í1 +1 121 99 92 21 +1 í1 +1 13 91 332 í1 +1 +1 12 12 3 +1 +1 í1 12 33 2 í1 í1 í1 1 11 3 +1 í1 í1 91 2 32 2 í1 í í1 1 9 2 9 í í 11 9 3 -
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Bhosale, et al.: Mucoadhesive nano drug delivery system of acyclovir
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b Figure 1: SEM of PLGA nanoparticles Journal of Young Pharmacists Vol 3 / No 4
Figure 3: Comparison of % drug entrapment and % drug release in JQHHCEVQTKCNCPFEJGEMRQKPVHQTOWNCVKQPU 279
Bhosale, et al.: Mucoadhesive nano drug delivery system of acyclovir
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hosale et al.: Mucoadhesive nano drug delivery system of acyclovir
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Figure 4: Average % drug release of mucoadhesive factorial formulations
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Formulation
Predicted values Observed values Particle % Drug % Particle % Drug % size entrapment Drug size entrapment Drug (nm) release (nm) release in 12 h in 12 h 112 31 3 11 9 3
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Bhosale, et al.: Mucoadhesive nano drug delivery system of acyclovir
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CONCLUSION
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Figure 5: Response surface plots of effects of factorial variables on % drug entrapment
Figure 6: Response surface plots of effects of factorial variables on particle size
Figure 7: Response surface plots of effects of factorial variables on % drug release in 12 h 282
Figure 8: DSC thermograms Journal of Young Pharmacists Vol 3 / No 4
hosale et al.: Mucoadhesive nano drug delivery system of acyclovir
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Journal of Young Pharmacists Vol 3 / No 4
283
Formulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir Bhosale UV, Kusum Devi V, Jain N Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore - 560 027, India Address for correspondence: Mr. Uday Bhosale; E-mail: [email protected]
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INTRODUCTION
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Journal of Young Pharmacists Vol 3 / No 4
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In vitro characterization of PLGA nanoparticles Journal of Young Pharmacists Vol 3 / No 4
Bhosale, et al.: Mucoadhesive nano drug delivery system of acyclovir Table 1: ([perimental GesiJn anG parameters for 23 fXll factorial GesiJn batcKes Batch code MF1 MF2 MF3 MF MF MF MF MF C
Variable level in Particle % Drug % Drug Average % coded form size entrapment release intestinal (nm) in 12 h retention X3§ X1* X2# +1 +1 +1 1 93 93 í1 +1í1 +1 121 99 92 21 +1 í1 +1 13 91 332 í1 +1 +1 12 12 3 +1 +1 í1 12 33 2 í1 í1 í1 1 11 3 +1 í1 í1 91 2 32 2 í1 í í1 1 9 2 9 í í 11 9 3 -
For PL*A ;1 transIormed levels in polymer weight are í1 = 1 mg +1 = 2 mg í = 193 mg #For surIactant pluronic F ;2 transIormed levels in are í1 = 2 +1 = 3 í = 22 §For mucoadhesive polymer polycarbophil ;3 transIormed levels in are í1 = 1 +1 = 1 í = 112
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hosale et al.: Mucoadhesive nano drug delivery system of acyclovir
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4
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Figure 4: Average % drug release of mucoadhesive factorial formulations
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Table 3: Parameters of cKecN point formXlation
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Formulation
Predicted values Observed values Particle % Drug % Particle % Drug % size entrapment Drug size entrapment Drug (nm) release (nm) release in 12 h in 12 h 112 31 3 11 9 3
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Bhosale, et al.: Mucoadhesive nano drug delivery system of acyclovir
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CONCLUSION
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Figure 5: Response surface plots of effects of factorial variables on % drug entrapment
Figure 6: Response surface plots of effects of factorial variables on particle size
Figure 7: Response surface plots of effects of factorial variables on % drug release in 12 h 282
Figure 8: DSC thermograms Journal of Young Pharmacists Vol 3 / No 4
hosale et al.: Mucoadhesive nano drug delivery system of acyclovir
nanRSaUWiFOHV WaiORUHd WR aFKiHYH FRnWUROOHd UHOHaVH RI SUHdHWHUPinHd TXanWiWiHV RI WKH dUXJ UHVXOWinJ in nRW RnO\ RSWiPi]inJ dUXJ dHOiYHU\ EXW aOVR dHYHORSPHnW RI a SOaWIRUP WHFKnRORJ\ ZKiFK KaV H[WHnViYH SaWHnWinJ SRWHnWiaO and Fan EH XVHIXO IRU VR Pan\ RWKHU VXFK dUXJV REFERENCES
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Author Query Q1: Please define legends???
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Journal of Young Pharmacists Vol 3 / No 4
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