- Email: [email protected]
Fundamentals of receptor molecular biology
269
Recent books Drug Design Using Biologically Active Peptide as Templates, edited by J. L. De Coen, J. Leonis and G. Schnek. Presses Universitaires de Bruxelles, Brussels, 1987, 183 p., US$ 15.00 The rational development of medications is an activity which henceforth will occupy a greater place in the pharmaceutical industry. In order to achieve this, diverse methods are used, but they all require a good understanding of the biological targets and effecters implicated in a given pathology. Furthermore, the very recent progress made in the understanding of the mechanisms of action of peptidic hormones and neurotransmitters at the molecular scale as well as the extension of structural information concerning enzymes and receptors are also being taken into consideration in designing drugs. This small book clearly illustrates the most recent advances made in these domains and the success already obtained or anticipated. This book, which is dedicated to the memory of Pr. A. Englert and whose preface was written by Pr. I. Prigogine, will be most useful to researchers in industry or public laboratories, who are studying the physicochemical and synthetic aspects of molecular pharmacology. B. P. Roques Asymmetric Synthesis, Construction of Chiral Molecules Using Amino Acids, edited by G. M. Coppola and H. F. Schuster. John Wiley & Sons, Chichester, 1987, 393 p., 5 52.75 This book is limited to a specific class of compounds, the a-amino acids and second generation intermediates that can be derived from them. The authors chose to include only those chemical transformations that would be of general interest. It is divided into nine chapters, each of which is devoted to a particular amino acid or a family of similar amino acids. Although the main focus of the book is on the naturally occurring L-amino acids, significant attention is also paid to manipulations of their corresponding unnatural D-isomers. References include papers published up to December 1985, but articles that have appeared in the literature after the preparation of the original manuscript are summarized in an addenda. Ikndamentals of Receptor Molecular Biology, by D. F. H. Wallach. Marcel Dekker, Inc., New York, 1987, 416 p., US$ 85.00 Integrating diverse information on receptors from many academic disciplines, this important new book discusses the systems regulating body fluids, cellular and humoral immunological systems, and related processes such as hemostatic and complement cascades... emphasizes homologies and parallels among receptors, including comparisons of small and large signal molecules and antigenic entities. Additionally, this monograph provides incisive examinations of hypothalamic, pituitary, and thyroid hormones, hormones regulating bone metabolism, pancreatic and gastrointestinal regulatory systems, steroid hormone circuits, neurotransmitters, peptide growth factors, and much more. Development of Drugs and Modern Medicine, edited by J. W. Gorrod, G. G. Gibson and M. Mitchard. VCH, Weinheim, 1987, 669 p., DM 295 This book provides an extensive survey of the methods involved in the discovery, design and development of drugs. It is based on a conference to honor Professor A. H. Beckett, retired Head of Pharmacy at Chelsea College. Written by leading specialists, it covers preparation, processing and testing of modern medicines. The reader will also find information on molecular aspects of drug action, on drug metabolism, drug delivery systems, clinical pharmacokinetics and toxicology. The book is unique in that it includes clinical evaluation and regulatory affairs. In its broad approach, it not only reviews three decades of drug development but also provides descriptions of current theories, models, techniques and results. QSAR in Drug Design and Toxicology, Proceedings of the 6th European Symposium on Quantitative Structure-Activity Relationships, Portoroi, Sept. 22-26, 1986, edited by D. Hadii and B. Jerman-BlaiiE. Elsevier Science Publishers, Amsterdam, 1987, 376 p., US$ 97.75
The book contains invited lectures, regular papers and posters presented at the Symposium. The contributions describe recent developments in methods complementing the QSAR approach to drug design, pharmacokinetics, toxicology and environmental problems. Numerous examples of applications in these related fields are included. A special section is devoted to ligand-receptor interactions, and applications of QSAR methods to peptide drugs. The five main section headings are: Chemometrics in drug design; QSAR in medicinal chemistry and pharmacokinetics; Ligand-receptor interactions; Structure-activity relations of peptides; QSAR in toxicology and non-medicinal areas. The rapid publication of these proceedings ensures the topicality of the contributions. The book will be of interest to a wide readership including those in the pharmaceutical industry, and will prove useful in practical applications. Progress in Medicinal Chemistry, Vol. 23, edited by G. P. Ellis and G. B. West. Elsevier, Amsterdam, 1986, 282 p., US$ 86.00 This volume comprises six reviews written by experts in their various fields. a-Adrenoreceptor antagonists are discussed in relation to diabetes, hypertension and depression, and cell surface receptors are investigated, along with structural features of CNS drugs, transmitters and peptides. The biological and chemical aspects of new anti-depressant drugs are reviewed. The action of acyclovir against herpes is surveyed, and the volume closes with the first detailed description of the antibiotic and probable anti-tumor agent, sparsomycin. Comprehensive treatment of highly relevant topics remains the hallmark of this most enlightening series. Memhrane Proteins: Isolation and Characterization, edited by A. Azzi, L. Masotti and A. Vecli. Springer-Verlag, Berlin, 1986, 195 p., DM 38 Contents: Membrane Proteins: Purification of Cytochrome c Reductase and Oxidase by Affinity Chromatography. Molecular Weight Estimation of Membrane Proteins. The Problem of Light Scattering in the Absorbance and Fluorescence Studies of Proteins in Membranes. Reproducible Preparation of Vesicles for Studies of Protein Incorporation into Lipids Using Fluorescence Spectroscopy. Preparation and Reconstitution of the Proton Translocating Membrane Bound Inorganic Pyrophosphatase from Rhodospirillum rubrum. The Function of Transmembrane Channels. Membrane Signal Transduction via Protein Kinase C. Extraction, Partial Purification, and Reconstitution of a Mixture of Carriers from the Inner Mitochondrial Membrane. - Lipid Protein Interaction: The Effect of Polypeptides on the Fluidity of Lipid Bilayers. Polypeptide-LipidInteractions as Studied by13CNMR. Conformational Changes in Polypeptides and Proteins Brought About by Interactions with Lipids. - Protein Modification: Two Examples of Selective Fluorescent Labeling of SH-Groups with Eosin-5-Maleimide. Hydrophobic Photolabeling with lZ51-TID of Red Blood Cell Membranes. Use of Fluorescent Probes of the Adenine Nucleotide Carrier for Binding Studies and Analysis of Conformational Changes. Spin Labeling of Membranes and Membrane Proteins. - Protein Reconstitution: Functional Reconstitution of the Mitochondrial Complex. Changes of the Membrane Surface Cytochrome b-c,. Potential Measured by Amphiphilic Fluorescent and ESR Probes. Reconstitution of Cytochrome c Oxidase. Measurement of Pyruvate Transport in Mitochondria. Based on an international advanced course sponsored by FEBS and the Italian Research Council, this volume is the third in a series of laboratory manuals, protocolling experiments on the biochemistry of the most important membrane proteins, from plasma membrane proteins to those of mitochondria and bacteria. Particular care has been taken to make the planning and execution of the experiments as simple as possible. Like the previous manuals, this one is suitable for use in the research laboratory for designing new experiments based on carefully checked routine protocols. It should also be welcomed by the clinician, looking for new, simple methodology applicable to the field of human clinical testing. Furthermore it can be used as a textbook for laboratory practicals in biochemistry and biophysics.
Recent books Drug Design Using Biologically Active Peptide as Templates, edited by J. L. De Coen, J. Leonis and G. Schnek. Presses Universitaires de Bruxelles, Brussels, 1987, 183 p., US$ 15.00 The rational development of medications is an activity which henceforth will occupy a greater place in the pharmaceutical industry. In order to achieve this, diverse methods are used, but they all require a good understanding of the biological targets and effecters implicated in a given pathology. Furthermore, the very recent progress made in the understanding of the mechanisms of action of peptidic hormones and neurotransmitters at the molecular scale as well as the extension of structural information concerning enzymes and receptors are also being taken into consideration in designing drugs. This small book clearly illustrates the most recent advances made in these domains and the success already obtained or anticipated. This book, which is dedicated to the memory of Pr. A. Englert and whose preface was written by Pr. I. Prigogine, will be most useful to researchers in industry or public laboratories, who are studying the physicochemical and synthetic aspects of molecular pharmacology. B. P. Roques Asymmetric Synthesis, Construction of Chiral Molecules Using Amino Acids, edited by G. M. Coppola and H. F. Schuster. John Wiley & Sons, Chichester, 1987, 393 p., 5 52.75 This book is limited to a specific class of compounds, the a-amino acids and second generation intermediates that can be derived from them. The authors chose to include only those chemical transformations that would be of general interest. It is divided into nine chapters, each of which is devoted to a particular amino acid or a family of similar amino acids. Although the main focus of the book is on the naturally occurring L-amino acids, significant attention is also paid to manipulations of their corresponding unnatural D-isomers. References include papers published up to December 1985, but articles that have appeared in the literature after the preparation of the original manuscript are summarized in an addenda. Ikndamentals of Receptor Molecular Biology, by D. F. H. Wallach. Marcel Dekker, Inc., New York, 1987, 416 p., US$ 85.00 Integrating diverse information on receptors from many academic disciplines, this important new book discusses the systems regulating body fluids, cellular and humoral immunological systems, and related processes such as hemostatic and complement cascades... emphasizes homologies and parallels among receptors, including comparisons of small and large signal molecules and antigenic entities. Additionally, this monograph provides incisive examinations of hypothalamic, pituitary, and thyroid hormones, hormones regulating bone metabolism, pancreatic and gastrointestinal regulatory systems, steroid hormone circuits, neurotransmitters, peptide growth factors, and much more. Development of Drugs and Modern Medicine, edited by J. W. Gorrod, G. G. Gibson and M. Mitchard. VCH, Weinheim, 1987, 669 p., DM 295 This book provides an extensive survey of the methods involved in the discovery, design and development of drugs. It is based on a conference to honor Professor A. H. Beckett, retired Head of Pharmacy at Chelsea College. Written by leading specialists, it covers preparation, processing and testing of modern medicines. The reader will also find information on molecular aspects of drug action, on drug metabolism, drug delivery systems, clinical pharmacokinetics and toxicology. The book is unique in that it includes clinical evaluation and regulatory affairs. In its broad approach, it not only reviews three decades of drug development but also provides descriptions of current theories, models, techniques and results. QSAR in Drug Design and Toxicology, Proceedings of the 6th European Symposium on Quantitative Structure-Activity Relationships, Portoroi, Sept. 22-26, 1986, edited by D. Hadii and B. Jerman-BlaiiE. Elsevier Science Publishers, Amsterdam, 1987, 376 p., US$ 97.75
The book contains invited lectures, regular papers and posters presented at the Symposium. The contributions describe recent developments in methods complementing the QSAR approach to drug design, pharmacokinetics, toxicology and environmental problems. Numerous examples of applications in these related fields are included. A special section is devoted to ligand-receptor interactions, and applications of QSAR methods to peptide drugs. The five main section headings are: Chemometrics in drug design; QSAR in medicinal chemistry and pharmacokinetics; Ligand-receptor interactions; Structure-activity relations of peptides; QSAR in toxicology and non-medicinal areas. The rapid publication of these proceedings ensures the topicality of the contributions. The book will be of interest to a wide readership including those in the pharmaceutical industry, and will prove useful in practical applications. Progress in Medicinal Chemistry, Vol. 23, edited by G. P. Ellis and G. B. West. Elsevier, Amsterdam, 1986, 282 p., US$ 86.00 This volume comprises six reviews written by experts in their various fields. a-Adrenoreceptor antagonists are discussed in relation to diabetes, hypertension and depression, and cell surface receptors are investigated, along with structural features of CNS drugs, transmitters and peptides. The biological and chemical aspects of new anti-depressant drugs are reviewed. The action of acyclovir against herpes is surveyed, and the volume closes with the first detailed description of the antibiotic and probable anti-tumor agent, sparsomycin. Comprehensive treatment of highly relevant topics remains the hallmark of this most enlightening series. Memhrane Proteins: Isolation and Characterization, edited by A. Azzi, L. Masotti and A. Vecli. Springer-Verlag, Berlin, 1986, 195 p., DM 38 Contents: Membrane Proteins: Purification of Cytochrome c Reductase and Oxidase by Affinity Chromatography. Molecular Weight Estimation of Membrane Proteins. The Problem of Light Scattering in the Absorbance and Fluorescence Studies of Proteins in Membranes. Reproducible Preparation of Vesicles for Studies of Protein Incorporation into Lipids Using Fluorescence Spectroscopy. Preparation and Reconstitution of the Proton Translocating Membrane Bound Inorganic Pyrophosphatase from Rhodospirillum rubrum. The Function of Transmembrane Channels. Membrane Signal Transduction via Protein Kinase C. Extraction, Partial Purification, and Reconstitution of a Mixture of Carriers from the Inner Mitochondrial Membrane. - Lipid Protein Interaction: The Effect of Polypeptides on the Fluidity of Lipid Bilayers. Polypeptide-LipidInteractions as Studied by13CNMR. Conformational Changes in Polypeptides and Proteins Brought About by Interactions with Lipids. - Protein Modification: Two Examples of Selective Fluorescent Labeling of SH-Groups with Eosin-5-Maleimide. Hydrophobic Photolabeling with lZ51-TID of Red Blood Cell Membranes. Use of Fluorescent Probes of the Adenine Nucleotide Carrier for Binding Studies and Analysis of Conformational Changes. Spin Labeling of Membranes and Membrane Proteins. - Protein Reconstitution: Functional Reconstitution of the Mitochondrial Complex. Changes of the Membrane Surface Cytochrome b-c,. Potential Measured by Amphiphilic Fluorescent and ESR Probes. Reconstitution of Cytochrome c Oxidase. Measurement of Pyruvate Transport in Mitochondria. Based on an international advanced course sponsored by FEBS and the Italian Research Council, this volume is the third in a series of laboratory manuals, protocolling experiments on the biochemistry of the most important membrane proteins, from plasma membrane proteins to those of mitochondria and bacteria. Particular care has been taken to make the planning and execution of the experiments as simple as possible. Like the previous manuals, this one is suitable for use in the research laboratory for designing new experiments based on carefully checked routine protocols. It should also be welcomed by the clinician, looking for new, simple methodology applicable to the field of human clinical testing. Furthermore it can be used as a textbook for laboratory practicals in biochemistry and biophysics.