- Email: [email protected]
Galanin is induced in the vestibular and cochlear efferent neurons after labyrinthectomy
s250
16-10
GALANIN IS INDUCED IN THE VESTIBULAR AND COCHLEAR EFFERENT NEURONS AFTER LABYRINTHECTOMY KOJI OHNO', HIROSHI KIYAMA2, NORIAKI TAKEDA', TORU MATSUNAGA' AND MASAYA TOHYAMA2, Department of Otolaryngology', and Anatomy & Neuroscienc.e2, Osaka University Medical School In this study we show that labyrinthectomy induces the temporal increase of galanin-like immunoreactivity (GAL-IR) in the vestibular and cochlear efferent neurons. Under normal condition, GAL positive neurons were hardly seen in these efferents. However, at 3 days after labyrinthectomy, GAL-IR appeared substantially in the vestibular and cochlear efferents and it was most noticeable between 1 week and 2 weeks. A retrograde tracer method combined with immunohistochemistry demonstrated that galanin was only induced in the neurons which give their axons to the injured labyrinth, suggesting that the temporal increase of galanin is a response to the axonal injury.
16-10
GALANIN IS INDUCED IN THE VESTIBULAR AND COCHLEAR EFFERENT NEURONS AFTER LABYRINTHECTOMY KOJI OHNO', HIROSHI KIYAMA2, NORIAKI TAKEDA', TORU MATSUNAGA' AND MASAYA TOHYAMA2, Department of Otolaryngology', and Anatomy & Neuroscienc.e2, Osaka University Medical School In this study we show that labyrinthectomy induces the temporal increase of galanin-like immunoreactivity (GAL-IR) in the vestibular and cochlear efferent neurons. Under normal condition, GAL positive neurons were hardly seen in these efferents. However, at 3 days after labyrinthectomy, GAL-IR appeared substantially in the vestibular and cochlear efferents and it was most noticeable between 1 week and 2 weeks. A retrograde tracer method combined with immunohistochemistry demonstrated that galanin was only induced in the neurons which give their axons to the injured labyrinth, suggesting that the temporal increase of galanin is a response to the axonal injury.