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GENDER DIFFERENCES IN MORTALITY AMONG PATIENTS WITH SUPPLY-DEMAND TYPE 2 MYOCARDIAL INFARCTION, TYPE 1 MYOCARDIAL INFARCTION AND NON-MI CARDIAC TROPONIN I INCREASES
A93 JACC March 17, 2015 Volume 65, Issue 10S
Acute Coronary Syndromes Gender Differences in Mortality Among Patients with Supply-Demand Type 2 Myocardial Infarction, Type 1 Myocardial Infarction and Non-MI Cardiac Troponin I Increases Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m. Session Title: Insights from Subgroups: Age, Gender and Diabetes Abstract Category: 2. Acute Coronary Syndromes: Clinical Presentation Number: 1138-072 Authors: Yader Sandoval, Sarah Thordsen, Stephen Smith, MaryAnn M. Murakami, Karen Schulz, Fred Apple, Hennepin County Medical Center, Minneapolis, MN, USA
Background: Supply-demand type 2 myocardial infarction (T2MI) is frequently encountered. Little is known about gender differences in patients with T2MI in contrast to type 1 MI (T1MI) and non-MI troponin (cTn) increases. We sought to compare mortality according to gender among these groups.
Methods: Retrospective study of 1245 patients presenting to the ED in which serial cTnI (OCD VITROS ES assay; 99th URL: 0.034 μg/L) were measured on clinical indication. Characteristics and outcomes including in-hospital and 180-day mortality were compared according to gender among T1MI, T2MI and non-MI cTnI increases.
Results: 374 (240 men, 134 women) patients had at least one increased cTnI. 77 (6.2%) had T1MI, 255 (20.5%) T2MI, and 42 (3.4%) no MI with an increased cTnI. Mean maximum values within 24-h of admission according to men and women respectively were: 34.1 vs. 20.9 μg/L (p=0.4) in T1MI, 1.8 vs. 1.2 μg/L (p=0.5) in T2MI and 0.6 vs. 0.4 μg/L (p=0.3) in no MI with an increased cTnI. In-hospital mortality and post-discharge mortality in men was 5% and 9% in T1MI, 9% and 17% in T2MI, 12% and 16% in non-MI cTnI increases, and 2% and 5% in no MI with normal cTnI; whereas in women it was 0% (both) for T1MI, 14% and 25% for T2MI, 6% (both) for non-MI cTnI increases, and 1% and 4% for no MI with normal cTnI. Women with T2MI had a significantly worse post-discharge mortality in contrast to women with T1MI (25% vs. 0%, p=0.03; RR:11.1 CI:0.7-175). Conclusion: Women with T2MI have significantly worse outcomes in comparison to women with T1MI\
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Acute Coronary Syndromes Gender Differences in Mortality Among Patients with Supply-Demand Type 2 Myocardial Infarction, Type 1 Myocardial Infarction and Non-MI Cardiac Troponin I Increases Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m. Session Title: Insights from Subgroups: Age, Gender and Diabetes Abstract Category: 2. Acute Coronary Syndromes: Clinical Presentation Number: 1138-072 Authors: Yader Sandoval, Sarah Thordsen, Stephen Smith, MaryAnn M. Murakami, Karen Schulz, Fred Apple, Hennepin County Medical Center, Minneapolis, MN, USA
Background: Supply-demand type 2 myocardial infarction (T2MI) is frequently encountered. Little is known about gender differences in patients with T2MI in contrast to type 1 MI (T1MI) and non-MI troponin (cTn) increases. We sought to compare mortality according to gender among these groups.
Methods: Retrospective study of 1245 patients presenting to the ED in which serial cTnI (OCD VITROS ES assay; 99th URL: 0.034 μg/L) were measured on clinical indication. Characteristics and outcomes including in-hospital and 180-day mortality were compared according to gender among T1MI, T2MI and non-MI cTnI increases.
Results: 374 (240 men, 134 women) patients had at least one increased cTnI. 77 (6.2%) had T1MI, 255 (20.5%) T2MI, and 42 (3.4%) no MI with an increased cTnI. Mean maximum values within 24-h of admission according to men and women respectively were: 34.1 vs. 20.9 μg/L (p=0.4) in T1MI, 1.8 vs. 1.2 μg/L (p=0.5) in T2MI and 0.6 vs. 0.4 μg/L (p=0.3) in no MI with an increased cTnI. In-hospital mortality and post-discharge mortality in men was 5% and 9% in T1MI, 9% and 17% in T2MI, 12% and 16% in non-MI cTnI increases, and 2% and 5% in no MI with normal cTnI; whereas in women it was 0% (both) for T1MI, 14% and 25% for T2MI, 6% (both) for non-MI cTnI increases, and 1% and 4% for no MI with normal cTnI. Women with T2MI had a significantly worse post-discharge mortality in contrast to women with T1MI (25% vs. 0%, p=0.03; RR:11.1 CI:0.7-175). Conclusion: Women with T2MI have significantly worse outcomes in comparison to women with T1MI\
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