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Genetic markers for multiple sclerosis and retrobulbar neuritis in the Russian population
GENETIC MARRERS FOR MULTIPLE SCLEROSIS RETROBULBAR NEURITIS IN THE RUSSIAN POPULATION.
V.I.Konenkov, V.F.Prokotiev, I.A.Gribacheva, A.P.Ierusalimsky,Institute of Clinical Immunology,
Novosibirsk.
=‘l‘Oly
VE.
D.pt.
o*
Ni.iprWsu
Pr,
u.uromyy,
Worooyn
SOut.Mcy
AD. w.
c.ntsr.
T.14”i”.
*cr..1
PATTERNS OF EMOTIONAL DISTRESS IN ADVANCED MULTIPLE SCLEROSIS (MS): THE RELATION TO IMPAIRMENT AND DISABILITY
AND
D. W. Lanadon. A. J. Thompson.
Russia
National
Aim of study: to determine
The task of thii work is to detect HLA gene allele variants and their combinations in groups of patients with .k.olated retrobulbar neuritis (RBN) (101 persons) and multiple sclerosis (MS) that developed after its manifestation in the form of RBN (65 persons). Follow-up from RBN onset is IO years in both groups of patients. The analysis of immunogenetic examination findings has revealed some differences in occurance frequency of 19 HLA gene alleles and their combinations. Seven of them are reliably more often revealed among patients with MS that developed after RBN while 12 are reliably more often revealed among patients with RBN that did not progress to MS during IO years follow-up. One can assume that the presence of either immunogenetic markers contributes to make an early diagnosis of a rapid progress of RBN to MS and an essential &lay (or absence) of thii process. To simplify a problem of making decision about favourable or unfavourable prognosis concerning subsequent RBN development, the assessment of probabi!ity-derived in&x to reveal immunogenetic and clinical features in patients together with the estimation of prognostic factor value has been carried out. Tables based on these data allow to detect in proper time patients with RBN that are at risk of MS development. On the other hand these findings indicate MS immunogenetic heterogenety and an important role of genetic predisposition during its development.
Institute
Hospital
for Neurology
of Neurology.
the pattern
and Neumsurgety,
U. K.
U. K.
of emotional
distress
in advanced
MS
MS patients with hiih levels of physical disabiliiy are frequent users of rehabilitation services. Yet detailed studies of their emotional experience are rare. 40 patients were recruited. Severe cognitive dysfundion excluded 9 from the study. The remaining 31 had clinically definite, progressive muttiple sclerosis (mean duration 12.4 years; mean age 41.5 years; 17 were women). The mean Verbal IQ was 94.2 (standard deviation 12.8). The median EDSS was 7.75 (range 5.0-8.0). The median FIM motor score was 60.0 (range 13 85). 16 patients were clinically depmssed on the Beck Depression Inventory. The mean percentile for immediate anxiety was 51 and for generalised anxiety 85 (STAI). The mean percentile for immadiale anger was 64 and for generalisad anger 57 (STAXI). Depression. anxiety and anger were significanlly intercorrelated. Disease duration and disability (FIM) were related to both immediate anger (p=O.O28, p=O.O03. resqedively) and generalised anger (p’O.004. p=O.O04, respectively). Verbal IQ was sliihtly correlated with expressed anger (p=O.O44). Impairment (EDSS) was unrelated to emotion scores. It may be that depression and anxiety are not strongly related to disability, because lhey are btuntecl by poor insight However. anger may be a more short term response to concrete aspects of the immediate situation.
-65-
V.I.Konenkov, V.F.Prokotiev, I.A.Gribacheva, A.P.Ierusalimsky,Institute of Clinical Immunology,
Novosibirsk.
=‘l‘Oly
VE.
D.pt.
o*
Ni.iprWsu
Pr,
u.uromyy,
Worooyn
SOut.Mcy
AD. w.
c.ntsr.
T.14”i”.
*cr..1
PATTERNS OF EMOTIONAL DISTRESS IN ADVANCED MULTIPLE SCLEROSIS (MS): THE RELATION TO IMPAIRMENT AND DISABILITY
AND
D. W. Lanadon. A. J. Thompson.
Russia
National
Aim of study: to determine
The task of thii work is to detect HLA gene allele variants and their combinations in groups of patients with .k.olated retrobulbar neuritis (RBN) (101 persons) and multiple sclerosis (MS) that developed after its manifestation in the form of RBN (65 persons). Follow-up from RBN onset is IO years in both groups of patients. The analysis of immunogenetic examination findings has revealed some differences in occurance frequency of 19 HLA gene alleles and their combinations. Seven of them are reliably more often revealed among patients with MS that developed after RBN while 12 are reliably more often revealed among patients with RBN that did not progress to MS during IO years follow-up. One can assume that the presence of either immunogenetic markers contributes to make an early diagnosis of a rapid progress of RBN to MS and an essential &lay (or absence) of thii process. To simplify a problem of making decision about favourable or unfavourable prognosis concerning subsequent RBN development, the assessment of probabi!ity-derived in&x to reveal immunogenetic and clinical features in patients together with the estimation of prognostic factor value has been carried out. Tables based on these data allow to detect in proper time patients with RBN that are at risk of MS development. On the other hand these findings indicate MS immunogenetic heterogenety and an important role of genetic predisposition during its development.
Institute
Hospital
for Neurology
of Neurology.
the pattern
and Neumsurgety,
U. K.
U. K.
of emotional
distress
in advanced
MS
MS patients with hiih levels of physical disabiliiy are frequent users of rehabilitation services. Yet detailed studies of their emotional experience are rare. 40 patients were recruited. Severe cognitive dysfundion excluded 9 from the study. The remaining 31 had clinically definite, progressive muttiple sclerosis (mean duration 12.4 years; mean age 41.5 years; 17 were women). The mean Verbal IQ was 94.2 (standard deviation 12.8). The median EDSS was 7.75 (range 5.0-8.0). The median FIM motor score was 60.0 (range 13 85). 16 patients were clinically depmssed on the Beck Depression Inventory. The mean percentile for immediate anxiety was 51 and for generalised anxiety 85 (STAI). The mean percentile for immadiale anger was 64 and for generalisad anger 57 (STAXI). Depression. anxiety and anger were significanlly intercorrelated. Disease duration and disability (FIM) were related to both immediate anger (p=O.O28, p=O.O03. resqedively) and generalised anger (p’O.004. p=O.O04, respectively). Verbal IQ was sliihtly correlated with expressed anger (p=O.O44). Impairment (EDSS) was unrelated to emotion scores. It may be that depression and anxiety are not strongly related to disability, because lhey are btuntecl by poor insight However. anger may be a more short term response to concrete aspects of the immediate situation.
-65-