Genetics of disease

Bibliography

of the current world literature

This bibliography is drawn from the journals listed opposite and is selected from a comprehensive bibliography that is compiled by geneticists and is available on diskette. The bibliography is based on literature entered into our database between 1 st February 1993 and 31st January 1994 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

l

The number

in square

l Papers considered by the reviewers to be of special interest. m Papers considered by the reviewers to be of outstanding interest.

brackets

following

a selected

paper, e.g. [7], refers to its number corresponding review.

in the annotated

references

of the

Contents Genetics

of disease

Genetics of human disorders

484 491

Cloning genes

475

Mammalian

Cenome scanning methods

479

Cancer genetics

492

Cytogenetics

481

Animal models of human disease

494

Gene mapping data and bioinformatics

482

Gene therapy

496

Gene mapping in the mouse

483

Clinical genetics

496

484

Population

497

Gene mapping in other non-human

species

development

genetics

Genetics of disease Cloning genes Related review: Isolation of genes from cloned cDNA (pp 360-365) Adanw MD, Scarcs MB. Kerlavage AR. Fields C. Venter JC: Rapid (DNA Sequencing (Expnzsscd Scqumcc Tags) fmm a Dkctlonally amed Human Infant Brain CDNA ubnry. Nanwe *I 1993. 437~336. Akli S, Caillaud C, Vigne E, Stra~fofdpadaudet LD. Poenaru L. Perricaudct M. Kahn A. Peschanski MR: Transfer of a Foreign Gene into the Euxin Using Admwinu Vccton. NOrun? G?m?l1993. 5224-228. Aksemijevich I, Pns E. Grubcrg L. Shen Y. Holman K. Helling S. Prawn l. Sutherland CR, Richards RI. Ramstxq M. Dean M. Pras M. Amos Cl. Kaslner DL: Rdined Mapping of the Ccnc Causing Familial Mcdltarvmn Fever, by Iinkagc and Homozygosity Studks. AmJ Hum GeneI 1993,53:451-461. Albig W. Drabent 8. Kunz J. Kalflsuske M. Grzcschik KH. Doenecke D: All Known Human HI Historic Genes Except dlc HI(O) Gene ax auacrcd on alrcWllOsOmc 6. Genomics 1993. 16649-654. Allman s: RNA Enzym&&ctcd Gene Therapy. f’mc Nat/ Adscf USA 1993,90:1aR9%1owo. Akschul SF, Boguski MS; Gish W. Woollon JC: Lwucs l * in Zeuchhg Mokculu Seqwxc Databases. Nafure Cener 1994. 6:11%129. 1441. Anderson RA. Rae N. Byrum RS. Rothschild CB, Bowdcn DW, Haywonh R. Peuenati M: Insitu Localiation ddlcc&eticLocusEncodingdlcLysGsomal Acid Li~a.&Omkstcrvl Estcnx (UPA) D&&nt in W&&I Divvc to’Ouom&cl~23.2q23.3 Genomks 1993. 15~245-247. Andres DA, Milalovich A, Ozcelik 7: Wenzlau JM. Brown MS. Goldstein IL. Franckc U: cDNA Qoninn of dx R& Subunits ;Hwnan CAAX PamcSyl~ and Chtomosomal Mapping of FNTA and PNTB Loci and Related Sequences. Genomict 1993, 18:lG5-112 Anmist M. KaulTman E. Slauaenhaupt SA. Malise 1%. - Puffenberger EG. &sh&ton &. Lipson A. Cass DT. Rryna T. Weeks DE, Siebcr W. Chakravani A: A Gene for Hits&sprung Dixax (Mc~acolon) in tic RticcnMmaic Region of Human Chromosome-IO. Naluc? GemI 1993. 4:35l-356. Antignac C. Arduy CH. Bcckmann JS. Bcnrssy F. Gms E Mcdhioub M. Hildehrandl F, Duhcr JL, Klrinknechl

C. Broycr M. wisscnbach J. Habib R. Cohen D: A Gene for Familial Jwcnik Ncphmnophdtisis (Rcccssivc Mcdulkuy Cystic Kidney LX&se) Maps to Chmmosnmc-20. Nature Gewf 1993. 5342-345. Aso T. Tsai P, Kaw&chi T. Menningcr JC. Kit&a S. Yasukochi Y, Ward DC. Weissman SM: M@uncnt of dx Human GTF2Fl Gene to t%anosome-19p13.3 - Shat Communication. Gvomlcs 1993, 16:252-253. Austruy E. Jeanpierre C. Anlignac C. Whitmorc SA. Vancong N. Bemheim A, Callen DF. Junien C: Shart Gmmunicadon - Fhyskd and Gnedc Mappia$t cd dx LXmhhsc Gene DPEPI to 16x124.3. Genomlcs 1993. I5%&-6R7. Bapcchi G. Feldman SH. Crystal RG. Maslrangeli A: Direct lnvivo Gene Tnnsfu to Etxndnnal Cells in the Central N.avws Syslcm Using R&c&inant Adenovina Vectm. &urn Cener 1993, 3:22%234. Baker E. Guo XH. Orsbom AM. Suherland GR. Calkn DF. H&wmd JJ;MomisCp: lie MotquieA S+ W~~qmlysaccharidosis IVA) Gmc Maps to 16924.3.

. . Cent-t 1993, 3:27?-279. 1591. Bandam G. Mueller GM, Galealauri J, Tint&l MH. Georgcxu HI. Suchanek MK, Hung CL, Clorio.w JC. Robbins PD. Evans CH: lnttaarticululu Exwcssion d Biologically ‘Active lntcticukial Reap&-AntagonLU Rotein by Exvivo Gznc Tnnsfcr Pmc N&l Aad Scl 0 SA 1w3.90!10764-10769. Barber GN. Edelhoff S. Kalze MG. Distechc CM: Uuomoromal Assimnt of the Interfemwfndwfbk Doubk.5m~ RNA-Dcpmknt Fmteln IOnax (PRKR) to Human Chmm -2p21Q22 and Mouse Cbmmo3omc.17 E2. Genomlcs 1993. 16:765-767. Baronciani I.. Lkuder E: Analysis of mate lGna.w Dclickncy Mutations tin Produce NonrphcmcyIic Hcmolydc Anemia. Rx Nail Acad 0 S A 1993. 90:432ti327. Baaman JB. Kojis T, Heinzmann C. Kliik I. Diep A. Carper D, Nishimura C. Mohandas T, Sparkes RS: Mapping of Aldose Rcductax Gent Scqumces to Human Clwmosomcl, Chmmoscme 3. almmommc7, tZlucmosome-9. Owomaromcl 1 and Utnnnosane 13. Genomlu 1993. 17:56&565. Benothmant K. Middleton LT. Lnpfcst LJ. Wilkinson KM. Lennon F, Rolear MP, Staiich JM. Cwkell PC, Rmes AD. Pericakvance MA. Vance JM: l.ocaliration da

0 Current

Sci

Biology

Ltd ISSN 0959-437X

Gau (cMT2A) for Autosamal LlotttiMnt CharcotMa&Tooth LXscasc Typ-2 to Chmmosomclp and MdmccdGmetk Hnaogncity. Genmla 1993. 17:370-375. Beutler E: caclKr Discate as a Paradigm of Cumxtt Issues Rcgatd@ Sin@ Gcnc Mwations of Humans. ptoc Na/I Acad SC1 US A 1993.90~5384-5390. Bicknwe WA, Longbottom D. Oghene K. Fletcher JM. Vanheyningen V: Coloalization of the Human CD59 GrncTollpl3arith~MMICllG~~~An~. Gmomia 1993, 17~129-135. Blumenfeld & Slaugenhaupt SA, Axelmd FB. Lucentc DE, Maayan C. Liebert CB. Orelius LJ. Tmhtter JA. Hain~ JI Break&Id X0. Gusella JF: localbation of the tiax for Familial Dymutand on CIttomc&wttc+ and flciinitia~ of DNA Madurn fat Genetic Diagnosir. Nature GeneI 1993. 4:160-164. Bowes C. Li TS, Fnnkel WN. DanciRcr M. Coffin JM. Applebury ML, Farber DB: laaliadon of a lkutwii EkmcntWithindxRdGncCodinntixtbcBNSubunIt of CGMP Pboaphodkst&. PtDc Nad Awd Sci 0 S A 1993.90:295%2%9. Brant SR, Bernstein M. Wasmuth JJ. Taylor EW, Mcphcrson JD, Li X, Walker S. Pwysvgur J. Donowia M. Tse CM, Jabs EW: Physical and Genetic Mappins of a Human Apical Epithclfal Na+/H+ Exchan~a OYHE3) Lsoform to Chmm-5~15.3. Genomfcs 1993. 15:&!-672. Break&Id X0: GUK lkliwy into the Brain Usitqx Vitus Vcctm. Nafun? G’n.?I 1993.3:187-189. 8rown CA, Mahuran DJ: bcta.Haosaminiduc lsozymcs fmm Cd Cnuan&xcd with Alpba.cDNA and Beta. cDNA Cnnstrucls - AMly& of the Alph+Subuttit Missensc Mutath -ted wilh the Adult tbtm of Tay-Sacbs Dl-. AmJ Hum Gem-f 1993.533497-508. Bungs S. Wedemann H, David D, Tenvilliger DJ. Vandenbom LI, Aukhlascholz C. Slmanns C. Horn M. 011 J, Schwinger E, Schinal A, Denton MJ. Gal A: Shut Gnnmunkation - Mokcubr Anal+ and GmeticMlppinRdlhcRhodq&CencinFamilks tidt Autosantal -t Rctinitir -Flgmmtosl. Genomlcs 1993. 17~230-233. Burkin DJ. Kimbm KS, Barr Bl. Jones C. Taylor MW. CuptaSL:BrkfRcpon-LocalimtiondtheHuman lnddruninc I.,(IDO) Gene to tbc Rticcnuumaic Rc@o” ofHuman Chmmosomc.B. Gmonrlcs 1993, 17:262-263.

475

476

Genetics

of disease

Cloning

genes

. Burns JC, Friedmann T. Driewr W, Burrascdno M, Ycc JK: Vesicuku Stomatids VI C Clycopmein Pseudotyped ltclmva veccm . calculvlti”n to very Hi@ litc, and Ef6cial Gene rrvula into Mammalian and N-m C4ls. Fnx Nail AcPn Sci US A 1993. 90:8033-6037. Bxkga.T, Chin HM. Kim H. Jung Htt, Kozak CA, Kke WA: lkgiod Exprcsicm and Chmmcamal Locatintion d the Dchmphtc llcccptor Gene. Pnlc Awl Auni SC1u s A 1993,9oz9305-9309. Calabm V, Mason PJ, Filasa S. Civilelli D, Cittadella R, Tagarelli A. Manini G. Bmncali C. Luuauo L: Gcncdc Heterc+%ndty of Glucose&’ hospbate Dehybqpluc Dcticimcy Rcvdcd by Sing*-Sumd Gmformation and SqAnalrJir. Am J I~um GeneI 1393. 52:527-536. Carrier L, Hengstenberg C. Beckmann JS. Guichenry P, Dufour C. Bermvici J. Daussc E. Bcrrbbibennnd I. Wisncwsky C. Pulwnis D. Fcder 1. Vi& A. Wissenbach J. Hillaire D. Feingold J. Bouhour JB. Hagege A, Demos M, lsnard R. Ixlbourg 0. Komajda M, Schwartz K: Mapping of a Novel Gee for Fmilii Hypcrtmpbic Cardiomynpalhy to ChrcmosQne-II. Norure Gen?f 1993. 4:3ll-313. &key Cl’: Rcsymptomadc Dtagnosis . a 1st Step Toward Gnctk Health Gut. sclmce 1993.2624w9. Caughey GH. Schaumberg TH. Zenveck EH, Buueficld JH. Hanson RD. Silv&an GA, Ley TJ: 7%~ Human Maw cdl alymasc Gene atA1)~ Mapping to the oahcpsiffi/GMzyme Gnc ame1 sod tincage Restricted Expression. Gwomlcs 1993. 15r614-620. Chakrabonv R. Srinivasan MR. Raskin S: Ldmation d the ln.zi&~~“faRucG&cDisa.ullw”“gha 2.lia Mumion Survey. Am J llum Gnwl 1993. 52:1129-1138. Chamber&in S, Fanall M. Shaw J. Wilkes D, Carvajal J. Hillerman R. Doudney K. Harding AE, Williamson R. Simgo G. Fujila R. Koenig M, Man&l JL, Palau F, Monrm E. Vilchez J. Prie~o F, Richter A. Vanassc M. Melanmn S. Cocoz7a S, R&ok? E. Cavakanli F, Pianew L. Filla A Didonato S. Pandolfo M: Genetic Recombination E&nu Which’Posidon Ihc Frkdmich Ataxia Locla Roxlmal to the D9SlS/DSJS5 tinkagc Group on tJuvmosome9q. Am J Hum Gener 1993, 52:9!+109. Chan YM. Yu QC. Fine JD. Fuchs E: The Goctic Basis of Wcber.Cakaynz Epidcnnolysis Buttosa Simpkx. Pmc NatI Aud Scl US A 1993, 90:7414-7418. Changyeh A, Jabs !ZW, Li X, Drdcopoli NC, Hwng RCC: ThCIPPCaKiSASSilUKd10H~ChI”lllC5”ll!Z1~32-1~22. GPMm& 199j. 15:239-241. Chaudhuri A, Polyakova J, Zbrrezna V, Williams K. Gulati S. Pago AO: Ooning of GtycopmtciwD (DNA. Which Encaks the Major Subunit of the Duffy Btcad Group System and the Receptor for the Ptlrmodtunwivu Malaria Par&w. Rw Narl Acad Scl II S A 1993, 90:1079~10797. Chen HM, Phillipa HA. Callcn DF, Kim RY. Wistow GJ. Amonarakis SE: Lnatiutian of the Human Gene for MwG+lh to Owomosomc-16p. Genomlcc 1992. 14:111~1116. Chevillwd C, Attall 8. &age F, Fames M. Barhanin J. lazdunski hf. Mallei MC: Lacatiution of a Pawium Channel Gene (KCNEI) to 21q22.lq22.2 by ImiN Hybridization and Somatic CCU Hybridintioo. G?n”w~lct 1993. 11:243-245. Church DM. Sloder CJ, Rutler JL, Murrell JR. Trofatter JA, . Buckler AJz Isotation of Gcncs from Cnnpkx Sourcu d Mammalian Gnomic DNA Using Exon Amptiiintion. NaIure Genes 1994.6:%7-105. 1351. Claverie JM, Hardelin JP, Lcgouis R. Levilliers J. Bouguekret 1 Mauri MG. Pelil C: Owactaintion sod Chmmosomal Assignment of a Human CDNA l?Jlcodine a Fmtdn lkhml to the Murinc 102-kD.a c%lh&Assoctacd Prouin (atpffiteoin). Genomlcs 1993, I%&20. Cohen D. Chumakov I. Weissenbach J: A FntGcncmtion 9. Fhysiol Map of the Human Genome. Naltrre 193. Z&69+701. 131. Collins C. Duff C, Duncan AMV, Planellwscs R, Sun W. Norremolle A. Michaelis E. Monlal M. Wonon R. Hayden MR: Short Comm~nic-ation _ Mapping d the Human NMDA Receptor Subunit (NMDAfll) and rhc Roposcd NMDA Rcccptor Glutamate-Binding Subunit (NMDAtlAI) to Chnnnc6”m~9q34.3 and Cbrom-8, Rcspccdwly. Genomks 1993. 17~237-239. Collins Fs:~Positional Ctoning: L&s not WI it licvusc . rlnnnorc. Nmm? GeneI 1992. 13-6. III. Cmzcn’ME. Bengt.%on U, Manah;” J. Wa-A”lh U. Arlin SM: Brkf R&“rl . A.d,pmcnt oi Ihe Cysteinyt.Tnnsfcr RNA SvnGene KAR.9 to 11~15.5. Genomlcs 1993, i5:692*3. . Danielson KG, Fauio A, Cohen I. Cannizzaro LA Eichstetler I. lorzo Rv: The Human Dccain Gcnc. 1nKon.Exon orpudzadon. Dlscavay of 2 Altcmativc1v Spliced Ex”ns i;l the 5’ Untnnsl&t Region. and Mappin d tk Gene to Ouomos”m+l2q23. Gmmmfcs 1993. 1s:14&160.

Davidson BL. Allen ED, Kozxsky KF, Wilson JM. Roesskr BJ: A Model System la lnvivo Gene Transfer into ti Gnual Nmous System Usin,? an Adcnovirat Vector. NaIure GeneI 1993.3~219-223. Davies B. Fried M: Thlhc&cturc of Ihe Human InhunGmninin~ SERibo!i”mal Protein Gnc and Delamkution of Iti Cbromosomal tncation at 1~32. p34. I. cenomiu 1993, 1568-75. D-mies K: Ooning the Meok- Di.%.u Gene. NOIY~P 1993. 361:%. Day KP, Karamalis F, Thompson J. Bnmcs DA. Peterson C, Brown H, Brown GV, Kemp DJ: Gcncs Necessary for Fxpmssion of a Virukncc tktemdnant and for Trzumbsion of Ptasmodiumfaltiparum illc Located cm a 0.3M~brsc Region of Chmmosomc9. /4x Null ACad scf us A 1993.90&292-82%. Dcllano JJM. Schncuwind 0. Skder G. Manning JM: Rccombiilnt Human Sickle Hemoalobin Exwwscd in Ynst. Rot Nat1 Acod Scl US A-.1993. 90;91l7-922. Dcloukas I’. Dauwcrx JG. Moschonas NK. Vanommcn CID. Vanloon APGM: Thnx Human Glutamate drh~dmgcmsc Cm (GLUDI, GLUDP2. and GLtiP3j am Located on Chmmos”mc-loq. But at-2 not a05dy Physicay Linked. G?n0mia 1993. 17:676&t. Dcmetrick DJ. Beach DH: Chmmaomc Mapping of Human CDC25A and CDC25tt Pharphatascs - Short Gmmunicadon. Gmomks 1993. l&144-147. Deng ZM. Liu P, Markon P. Claxton DF. Lane 5, Callcn DF. Collins FS. Sicilian” MJ: Smooth Musck Myosin HwyCbaintacus(MYHII)Mapat” 16pl3.13 ~13.12 and Establishes a New Region of Cooscrwd Syntcny Bawccn Humawl6p and Mouse-IL -Short Cunmunkations. Gerwmicr l99j. l&156159. Ditlrich B, Knoblauch Ii. Buiting K. Horslhcmke 8: Ci~vrcrcriptiom of a DNA Scqumcc Famity in

chc mdcr-wilri

~naclrmn Smdmmc chr”mos”mc .

Region in 15qllq13 -Short Communication. CAnonrlcs 1993, 16:26%271. Dixon MJ. Dixon J. Houseal T. Shalt M. Ward DC, Klinger K, Landes GM: Narrowing Ihc Position of Ihc TmchcrCollins Syndrome Locus (0 a Smdt lmciwt Bctwxn Three New Microsatcltitc Markers at 5q32-33. I, Am J Hum G?wl I99j. 52%7-911. D0ltfu.s H. Matlei MC. Rozcl JM. Dclricu 0. Munnich A, Kaolan I: Physicat and Gcmxic Locatintioo of the G&a&b&t of the Cyclic GMP Phosphodkstcrvc on tic Long Arm of ChronlaMmc-17 <17q25>. Genomics 193, 173526528. Donaldron DH. Rrill DE, Jones C. Jackson CL, Patterson D: Lodiutim of Ihc Gnc for Ihc Wiary Ncumtmphic Factor Receptor (CNTFR) to Human olromosomc-9 . Short Gnnmunintion. G~mmlcs 1993, 17:782-7R4. Duric FH. Paw RA. Foy TM, Andlo A. lxdktler JA, Nwllc RJ: Rcrmtion of Collagcn-lnduccd Anhrids with an huhdy to Gp39. the li@and for CD40. Science 199j. 261:132E&l330. Edclhoff S. Cruhin CE. K&en AE. Adler DA. Foslcr D. Distcchc CM, Lemmark A: Mapping of Glutamk Acid Dcarboxykasc (GAD) Gcncs. Gnomiu 1$9j, 17:93-97. Engelkamp D. Schafer BW. Mattei MC. Emc P, lleianann NV: 6 SIOO Genes am austcrcd on Human axom--1 q2 I ~IdcndIicad”n of 2 G.zlKs Cdl116 for ti 2 Rniousty llnrcportcd WdumBindii~ Prot&SlOOD md Protein-SIOOE. /‘mc Nat/ Acad SC! USA 1993. w6547-5551. EniYoii K. Emi M. Mukai T, tmada M. Lcppcn ML, lalouet JM, Kale H: Human Tii Pactor &&way Inhtbitor O-FPD Gnc - Comoktc Gcnomic Structure and bcaliuticm on &Gaxdc Map of Cbmmosanc-2q. Gemmlcs 1993, 17:42j-i28 Eubanks JH. Puranam R5. Kleckner Mv. Beuler B. Heinemann SF. Mcnamara JO: The C&c Encoding the Glurvnatc Rcccptw Subunit GtuR5 is Located on Human Chromosome 21q21.1.22.1 in Ihc Mdnity of the Gnc for Famitial Amyotrophic lateral Sckrosis. Pmc Nd AcadSci USA 1993. 90:17B-IR2. Fames JA. Bickmorc WA. Fletcher JM. Batksla F, Hanson IM. Vanheyningcn V: Submicrcscopic D&dons II the WAGR tncus. Revealed by Nonrxlioacdvc Iosiru Hybridintion. AmJ Hum GeneI 1992.51:12&Z-1294. Fcdcrsppicl B. Melhado IG. Duncan AMV. Delaney A, Schappn K. Clarklewis I. Jirik FR: Mokculv aoning of the (DNA and Chmmcsomat Locatiudon of the Gene la a Putativr 7.Tmnsmcmbnnc Segment (7.TMS) Reccpca lsotatcd from Human Spkcn. Cienomlcs 199j, 16:707-712. Femandezruiz E. Armesilla AL. Sanchuzmadrid 1:. Vqa MA: GM Encoding Ihe Coltagcn WI and Thmmb”spomJin Rcccptor CD36 is Locltcd on Cbmmosome7qll.2 - Short Communtntioo. Gmomlcc 1993, 17~759-761. Fink TM. Zinmcr M. Tschopp J. Elienne J. Jenne DE. Lichkr P: Human Ctustcrin (CL0 Maps to 8p21 in Roximhy to the ljpoprotcin Uprw (LPL) Gene. Cenon~fcs 1993. 16:52652R

Fomlstone CJ. Byrd PJ. Amhruss HJ. Kilcy Jll. tlcmnndcz D. Mcmnvillc CM, Taylor AMR: The Onkr and Orientation of .a Cluster of Mctdtopmtcinasc Genes. Stmmclyxin-2. Cotln~nasc. and Stmmclysin. Twlha with DI lS3I35. on Uuomosomc-I lq22q23 - Short Communindon. Gcnomlcs 1993. 16:2@+291. Frank MB. ltoh K. Fuiisaku A. Pontmolli P. Mawi MG. Ncas ‘BR: Th; Mipping of the Human 52.kD R”/SSA Autoanliga~ Gac to Human ChmmosomeII. and Its Polymorphisms. Am J llrrm Corer l99j, 52:lUj-191. Gage Ftt: Parkinson’s Disease. Fad Implants Put to the Test. Na~urv 193, 361~405-406. Gxllagher PG. llpcnder M. Ward DC, Forgw 1%: The Gene for Human Erythmcytc Membrane Protein 0and-7.2 (EPB72) Maps to 9q33q34 Gntmmcrk to the Phitadclphi; Chm&o& Transtocation Breakpoint Region . &id Rcpo”. &nomlc~ 1993, 18: l67-169. Canguly A. Rock MJ. Prockop DJ: Conformation-Semilive Gel Ekctrophor&s for Rapid Detection of SingkNsc Dilfcrcnccs in Double-Stranded PCR Products and DNA Fraemcne - Evidcnrc for Sotvcm.lnduccd lkmk in DNA Hctcmdupkxcs. F?‘oc Null AC& Scl (1 S A 1993. w:lOj25-lOj29: tiantz I. Tashim T. I3arcml C. Konda Y. Shimoto Y, ,&a Ii. Giover T, Munzcn G. ;snmda T: bdizadon of Ihc Genes Encaling the Mcturoconin-2 (Adrcnoconicouopic Hormone) and Metanocordn-3 Rcccptors to Ctuomosoma lgp11.2 And 2Oql3.2. q13.3 by Ftuorc~~~mx Insitu Hytnidintion - lhicf Rcpon. Cmtomlu 1995, 10:16&167. Ganncr J. Kcams W. Hoscnkrg C. t’cwson I: Copchnd NC. Gilbert DJ. Jenkins NA. Valle I>: tacaliraion of the 7@kDa Rroxiscmat Membrane Prowin to Human 1~21~22 and Mouse3. Gwmmlcs 1995. 15vtl2-414 tiearing Dt: Druck 1; Hurbncr K. Overhauser J. Gilbcn DJ. Copeland NG. Jenkins NA: The Leukemia Inhibitory Factor Rcccptor (UFR) Gcnc is tacatcd Within a Cluncr of Cytokinc Rcccptor loci on Mowc Chmmosomc-I 5 and Human ~2uomosomcdpl2-pl3 Short Communicadon. Gwon~ics 1995. IR: l48-150. George AL, Crackowcr MA, Abdalla JA. flu&on AJ. libcrs tic: Molccutv Basis of Ihomscn’s Disca% (Aurosomd Dominant MyovmJaConpniW. Nunwe Gem?/ 1995, 3:30MKl. Geraghty MT, Kcwns WG. Pearson PL. Valtc D: lsotndon and Charactcrintion of an Dmithinc AminotransfcnscRclatcd Scqucncc (OATL3) Mapping to 10q26. Gnomlcs 199j. 17.51%515. Chi.w NS. Parckh It. Lennon GG A Subsa of 1200 Haamm is SuMcicnt to Sequence Over 9+Paccnt of CDNAs by Haamcr Suing Prima Walking. thief Rcwrt. Genomlcs I995 17~79%799 Gish W. Svac.s DJ: IdcnliRcation of ProteinCoding Regions l by Databvc Similarity Search. Natwe GeneI I99j. 3~266-272. 1431. Girtxn S. Twclls R; Orozc” C. Rncc A. Wcber J. tlcrcdero 1. Scheutler K. Riley R. Altotcy R. Nothers C. llilkrmann R. Lunkes A. Khali C. Slcvdnin C. tlemnndez A, Magwin” C. Klockgethcr T. Durr A, Chnciwciss II. Enclmann J. FarraIl M. &ckmnnn J. Mulkm M. Wcrwl t’, Agid Y. Freund HJ, Williamn~on R. Auhurgcr G. Chambcrtain S: Cbromosomat Assignment of the 2nd Locw for Autosomal Dominant Cnrbcllv Atuia (SCAZ) to Chmmcsomc 12q2324. I. NuIwv Gmel 1993, 4:29Cr299 Gorlin JO. Hcnskc E. Warren ST. Kunsl CD. Durso M. Palmicri C. Hamvig JH. Bmns G. Kwialkowski DJ. Acdn.Binding Protein (ABP-;?A01Filamin Gene @LN? Maps Tclomcric to the Color Viiion tis (WGCP) and Gntromcric to G6PD in X028 C~tronrtcc 1995 17:43M98. Gostout B. Liu Q, Sommrr SS Gypdc Rcpcadng Triplets of Purincs and Pyrimidim (cRRY(i)) am Frequent and Polymorphic . Analysis d Coding CRRYG) in lhc Roopiomclanwonin (POMP and TATABiidinp Protein CIBP) Gma. Am J Ilum Genel 1995. 52:lJR2-1130 tioudic DR. Yuilk MAR. Leversha MA. Furlong RA. Caner NP, Lush MJ. Affam NA. Fcrgu?ionsmilh MA: Mutdpk S&Heating Squamous Epithetiomata (ESSI) Mapped to Chromosome 9q22q31 in Famitics with Common Ancrctry. Nolure Gmel 1993. 5165-169. Cough AC, Smith CAD, Howell SM. Wolf CR, Bryanl SP, Spurr NK: Localization of the CYPzlzGorc Locus I” Human Chmmosomc-22q13.1 by Potymcnv Chain Reaction. InsiN Hybridindon. and Linkage Andysis. Gmonrlu 1993. 15.430-432. Gould SJ: Use of Ihc DNA Polymcnsc Chain Ranion for Homotogy Probing. Isolation of Partial CDNA or Gcnomic am Elmding the Iron- sutfur Protein of Succinarc tkhydmgcnasc from Sewat Specks O’ot f&6. Pg 1934, 1989) Correction. 1% Nail Acwf Scl /IS A 1993. 90:2556. Gray PW, Cormrran AE. Eddy RI., I3ycrs MG. Shows TD: The Gnus for the tipopolysaccharide Rinding Pmtdn (LUP) and the IIacwricidal Rmwabitity Increasing Pmtrin (DPD am Encwkd in the Same

Genetics Rcdon d Hunun oUanosomc-20.

Gmomlcs

19933.

15%8-190. Grqq

HG. Couch F, HoI-@” K. Pov.ws I’& AssignmcnI of the Human Gene for ~hc AIDha- SubuniI d the Skcktal Mwck DHPScnsIhve Ca2+ Channel (CACNLIAD to Chrmnnsomc1q3lq32. GmonrlcC 199j. 15:107-112. Gregg RC. Powers PA. I-lo&t” K: Assignment of ~bc Human GM la Ihc IkwSubuniI d the Vol1a~c0qxndcnl calcium Channel (CACNLBI) to Chru”laumc-17 UsinR Somadc Cdl HybriOI and Linkagc Mapping. Cknonrics 1993. 15:185-187. Griffin CA, Ding CL, Jabs EW, Hawkins AL. Li X, Levine MA: Human Rod CGMPtiaCd Catinn Channel by Chromac.mal Gene Mace To 4~I2.Xcntroni.x Insitu Hybidiz&” Ihid Rcpon. &onrlu 19?‘j. l6:302-jOj. Griffiihs II. Tiwvari D: The Isolation d Mokculv Gndc hlarkm for Ibc 1dcnIiflotio” of Sa. /+rx NiJfl ACud Scl 0 S A ,993. 9o.Bj2~j26. Grompc M: The Rapid Lktccdun uf Unknown Mucations in Nuckic Acid% Nalum Gmcl l99j. 5:ll I-117. Gurricri F. Trask BJ. Vandcncngh G. Krauss CM. Schinzcl A. PelIcnaIi MJ. Schindler D. Dieuband J. Vcrgnaud G. Schercr SW, Tsui LC. Muenke M: Physical Mapping of Ihc Holupmrcnccphaly Critical Region on Chmmosomc7q?6. Nalrrrp G?nd l99j. 3:247-251. llall C. Manor E. Spur, NK. Lim L: Assigruncnl of dx Human Grbuxweptidasc.E (CPD Gene IO Chmmaxnnc4. r;oiwiiu I99j. 15:461463. llanlida CD. Doerflingcr N. B&l S. Lindcr C. Reulenauer L. Dib C. Gyapay G. Vignal A, Lepaslicr D. Cohen D. Pandolfo M. hlokini V. Novclli G. llenllli F, Bcnhamida M. Mandcl JL. Koenig M: Localization d Fricdmich Alvria Pbcnntypc with Sckcdvc Vilvnin E Dcficicncy IO chmmcsomc Rq by Homozygoshy Mapping. Nafurp Gene/ 1993, 519%200. Hanrmchi Y. ChunR AB, Tormni A, Swpien G, Shoffner jii. Wasmuth il. CosIi@an DA, P&k M. Allherr MR. Winokur ST, Wallaw DC: C~nctic Mapping d Human HearI-SkckIal Mwck A&nine Nuckotidc Tn”sl”caIa and Its Relationship 1” Ihc Facimnpulohumcnl Murutar DyJvophy Locus. Genomlcs 199j. 16~479-485. I lallori M. Shihata A. Yoshioka K. Sakaki Y: Orphan Rak Mysk - a Nuvcl Mcthud for DcIccIion of Point Muladom UsinR an AuIomatcd Flum-escc”cc DNA scqucnccr. c%&“rrcs 199j. I5:4 1cr 17. llayasaka K. Himorn M. Want YM. Takata M. Minoshima S. Shimizu N. Miura M. Uyemun K. Takada C: Suucrurc and Ouornosomal Loclliution uf the Gene Encoding the Human Myclin Rotein Zero (hIPI) - Shon Gmununica~ion. Genonrics 1993, 17:755-758. Hazan J. Lamy C. Mclki J. Munnich A. Dcrccondo J. Wcisscnbxh I: Autuwmal Dominant Familial S~vtic Panpkgn is Gcncdcally HcIcmgcncour and dc Locus Maps to Ouomosomc I4q. NaIurxz C~nel19933. 5.16j--167. Hellslen E. Vesa J. Spear MC, Makela Tp, Jarwla I, Ali K. 011 J. P&oncn L: RcruKd Assignment nf Ihc Infrdk Ncuronal Ccrdd tiud,wzinosb (INCL. CLNI) Locus AI 1~32 - Incc&ntion of Linkaw Disequilibrium in MultipoinI AnaIysis. Crmonrlu 199j. 16:72Q-725. Ilcrrin G. Pr&abiliiy of MaIching RFLP Rucrns from UruclaIcd Individuals. Am J llrrm Gwd 1993. 52491-497. lloovers JMN. Redckcr E. Spclcman I:, Iloppww JWM. Bhola S, Blick J, Vanmy N, Lcxhot NJ. WcsIerveld A, Mnnnens M: High-Resolution Chmmosanal Localintion d the Human Wchunin/CGIU’MPP Gene Family Mcmbas. Gerromlu 1993. l5:525-529. I low? JR. iairrnore TC. Mishra SK, Da S. Vcik R. Wells SA Doniskeller H: lmwuvcd Rcdicdvc Tea for MENZ. iking Flanking Dinucl&irk Repeals and RFLPs. Am J Hum Gmel 1992. 51:14jO-o-1442. lnglehearn CF, Caner SA. Keen TJ. Lindsey J. SIephenson AM, Bashir R. Almaghtheh M. Moon: AT, Jay M. Bird AC. Bhanacharya SS A New Locus for Autnsomal Dcdnmf RcdnitisPigmmtau on Chmmcarne-7p. Noturw GeneI ,993. 4:51-53. Incue S. Orimo A. Ho.wi T, Kondo S. Toyoshima Ii. Kondo T. lkegami A. Ouchi Y, Otimo II, Muramaau M: Cmomic Bindin~SiIc arming Reveals an L~mgc~ Rcsponrivc Gmc 1h.1 Encaks a RlNG Fin~cr Pmlein. &UC Nal/Ac&SclUSA l99j. 9o:llll7-11121. 1cw~l.oRV. Naso MF, Cannizzam LA. Wasmuth JJ. Mcpherso” JO: Mappinp, of ~bc Vcrsican PmIcqzly~-an Gene (CiPG2) 10 Ihc Long Arm of Human Chmn~osomc-5 (sq12-5q14). G-&lcs 1992. 14:845-85I lwahana I-I. Yoshimao K. Shinekivo T. Shirakami A. Sailo .. 5. lukura M: Mokculu and Ccnedc Analysk da Compound Hc~cr~zy~~rc fur Dysproduurnbincmia of Pmduornbin Tnkushima and Hypopnhrcmbincnda. Am J Hum Ge?W 1992. 51:1j86-lj95. Jalx EW. Li X, Love,, M. Yarmoka Ltl. Taylor E. Spwr MC. Cuss C. Cadk R. llnll B. Brown K. Kidd KK. Dolganov

G. Pdy”wopoulos MH. Mcycrs DA: GcncIic and Physical Mapping d the ~chuCoUtnr Syndrcmc l.xxus with Respect I” w in dx Chmm-593 Ilegion. Cmomlu 199j, 187-l 3. Jazwinska EC, Lee SC, Webb SI. Halliday JW. Powell LW: Localization d dx Hcmuchmmatosis Gene ause IO D6S105. Am J Hum Gmcl lw3. 53347-352. Johns DR Ncufcld MJ: PiIfaIIs in dtc Mokcular Gnctic Diagnosis d Izba Hcmdfuy Optic Ncumpathy &HOW Am J Hum Gener 1993.53:916-920. Johnson 8. Brooks DA. Heinunann C, Diep A. Mohandas T, Sparkes RS. Reyes H, Hoffman E. Lange E. Gaui RA. Xia YR. Lusis Al. Hankinson 0: llu Ah Rcceplor N&u T~lncat; tine GUlNTl is Located on’Q21 d Human Chmmus”me I and on Mouse Chrorno~nnc 3 NN U-3. Chomlcs 19993.17:592-5%. Jordan SA. Parmr GJ. Kenna P, Humphries MM, Sheik DM. Kumarsingh R. Sharp EM, Soriano N. Ayuyus~C. Benilez J. Humphries P: tiintiun d an AulDSOmal Dornkunt RednilL+PigmcnIosa Gcnc IO Chm”tosOme7q. Nature Gmel 1993. 4:54-56. JouleI i. Bousser MG. Biousst! V. labaugc P, Chabrial H. Nib&o A. Maciazek I. Mew, B. Bach MA. Wcissenbach J. Lath& GM. Tour~erla’wrv~ E: A Gcnc for Familial Hcrniplcgic Mi@nc Maps IO Clucmosw-19. Nafurc cTr?nei1993,5:4MS. Kanamc T. Kuwano A, Murano I, Ueharn K. MuramaW T. Kajii T: Midkinc Gax (MDK), a Gznc for Prenatal DiITcrendation and Ncuromgulation. Maps IO Band.1 Ipl I.2 by Fluonzsccnax In&u Hytxidintion. Genomrcs 1993. 17514-515. Kaplan J. Gerber S. Bnnneau D. RozeI JM. D&ieu 0. Briard ML Ddlfus I-1. Ghazi 1. Duher JL. Fnzzal J. Munnich i: A Gene fur Usher Syndn& rypC-I (USHIA) Maps I” Chmmosumc-149. GeMmlCS 1992. 14:979-987. Kas K, Schoennuakers E. Vandcven W, Uleber G. Nordcnskjdd M. Michicls L. MerrcgaerI J. lasson C: AssignmcnI d Ihc Human PAU Gcnc IO a Subt’~&” d Chmmaromrl lq13. Gnomlcs l(nj. 17:3B7-392. Kerc J. Grzeschik KH. Limo” J. Grcmaud M. Schlessingcr D. Ddachanclle A: Anhidmdc Ectrxkmul Dysplr*r G&R R&n Clnncd in Yarn Ard6cial Chr&&mCr. Gmomlcs ,993, 16:30+3lO. Kr‘rc J. Sislonen P, Hol&rg C. Dclachapclk A: The Gnc fur C.m~+miIaJ Odnrkk Diarrha Map aOSC (0 But is Diaincl from the Gene for cysric Fibmrir Tmnsmonbranc Conductance Regularor. Rot Nu/f AcadScl USA l99j. W:l~lO689. Kido S. Sakungi N. Bronncr MP, Say& R. Barge, R. PatIerson D. Slrauss JF: Shon Communintion D2lS418E Idcn&cs-a CAMP-RqwIatcd Gene l.aatcd al auom21q22.3 that is Expwscd in Placcnul Syncydwophoblvl and Cburiucarcino~. Glls. Gmomla 1993. 1732%259. Kline AD. While ME. Wapner II. R&s K. Bieswkcr LG. Kamholz J. Zackai EH. Muenke M. Scull Cl. Overhauser J: Mokculv Analysis d rhc I&l-Synbomc - and Carcllticn wilh F’hmntypc. Am J Hum Gene?’ 1993.52:895-906. Koi M. Johnson LA. Kalikin LM. Lntlc PFR. Nakamura Y, Feinbcrg AP: lhmor Cdl Gmwh Axrest Cau.ud by Subchmmaun’tal Tnnsfenbk DNA Fragments fmm C2uumosome-I I. Science 1993.26B:361-364. Kdbk K. Lu JH. Mole SE. Kaluz 5, Reid KBM: Assignmcnl d dw Human Fulmonuv Surfactant F’nxeb+D Gmc wrP4) (0 1Oq22q23 dodc 10 Ibc Surfactant PmtcirrA ccn~ a-80. cmorn~~ 1993. 17294-29s. Korenbcrg JR. Chen XN, Dccgc K. Grover J. RoughIcy PJ: Assinnmcnl d IIK Human A@xcan Gcnc (AGCI) To i5q26 Using Fl-cc lnshu Hybridimti”” Analvsis. G=nomics 1993. 16:546-548. Kumarsingh R, Wang H. Humphries P, Farrar GJ: Autosanal Domlnanr Raini~i+Pip,mcnIosa . no Evidence for Nonalklic Genetic Htiaogcnchy on 3q. Amj Iium G-net 1993, 52:jl9-j26. KwiaIkowski TJ. Orr HT. Banli S. Mccall AE. Jodice C. Persichc”~ F, NovellcIIo A, Lcborgncdemarquoy F. Duvick LA, FrnnIali M. Subramony SH. Beau&l AL, Terrenalo L. ZoRhbi HY, Ranum LPW: The Gene for Aulc.sun,al &nina”t Spinu~~ebellv A(uh (SCAI) Maps Ccn~mmcn ‘c to D6SE9 and Shows no Recombiitiu”. I” 9 LyRc Kindred% with I DinuckuIkk Repeal 11 Ihc AM10 locw. Am J Hum r~ll99j, 53391~00. Lme SA. Baker E. Surherland GR, Tanks I, Hayward N. Ellcm K: Brief Rcpw~ . the Human Cell Cyck Gcnc CDC25B b Locxcd aI 2Opl3. Cenomlcs 1993. I5:69j-694. Lwdle GL. Robe” JJ. Berrard S. Ridoux V. SIoIfordpxricaudel LD. PcrricaudeI M. Mallet J: A” Admovii Vector for Gene Transfer into Neumns and Glia in Ihc Brain. Science 1993. 25998%95Q. LasslRne H. RessoI C. Matlei MG. Gachon AMF: Assignment if the Human Tar Lipocalin Gene fLCN1) to 9q34 by lnshu Hvbridintinn . Brief Reuort. Gwomlcr 1993. l&160-i6l.

of disease Cloning

genes

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LOW-Minity ,kc.&c Gmomr& 1993. 16:248-251. Morris CM, IId@ ME Localization d the Humaa polyo Binding Pmtcin Gene (PABI) IO olmmOSo”Ml ItC@Orr

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3@w5. Won4~lkl4. atId Rclliorr13912q13 by hiN Hybt’ldbh. Ge”Omlcr 1993, 15209-211. Morris SW, Valentine MB. Kirstein MN, Huebner K: Sbon canmuniclolon _It-t d the Hlmlstl ARH9 RAs-R&dGnctoalmtn -1pl3p21. Gmomfa 1993, 35677479. hkdlier P, Boht D. Heard JM, Dsnos 0: Comx&tt c4LysoNmalstmghthclivaMdSpkcndMPS vn Mice by lmplrnuttal d Gcnmk7Jty Modihrd skin l%uobkm. Abhm? G?tell993. 4156159. Mullan M. Houlden H. Whtdelsptxh~ hi. Fidani 1. Lcnnbardi C, Diaz P, Rossor M. Cmok R. Hard/J, Duff K. Crawford F: A Locw for Fsmilisl EulyonSn Nddmcr’SDbcrrconche~hdOvamaanc 14. Pmximsl to dK AlphsltAmkhymouypsin Gel% Nonrn? Gmell992, 2~340-342. Mulky JC. Kozmsn HM. Phillips HA, G&eon AK, Mccure JA, lks DE, Gregg RG. Ho@ K. Couch FJ. Maclennan DH. Haan EA: Retincd Genetic Lcalindcm for CcnttaJ colr Dbux. AmJ Hum Gore, 1993.52:39&UX. Munir KM. French DC. Loeb LA: Thnnidinc Kinue MULU~U C&&cd by & sCg&S&ciiott. PIVC No11 AuadW USA 1993.90:4012-4016. Nab4 GJ. Nabcl EG. Yang ZY, Fox BA. Plautz GE, Gao X Huann L Shu SY. Gordon D. Charm AE: Dimn Ginc -h-i& wltl~DN&Li,, C&pkxcs in Mdrnanr _ E~prs~ion. Bid~@c Actlvtty, sitd lack d Toxicity in Humsns. PKJCNati AC& SC! U S A 1993.9&11307-11311. Nag MK. Thai IT, RuR EA, Selvamurulpn N. Kunnimslaiysan M. Elk&i CL Gmcs for El. E2. and 63 Smalt Nu&dar RNAs. hx Mill Acad Scl I/ S A 1993,90:5ilO1+%Q5. Nielsen DA. Dean M. Goldman D: ~cmic ~app@~ dthc Humvl TqQtCQhm Hydtoxylmc Gate on avamaancl I, usin 111Intlwtic conlamatioNl b+x@ism. AmlHum Gener 1932.51:1~1371. Noolsndi J. Forsyth R. Shi AC: segumcing using pulsed Fild ‘UN! b”UW bXOW~O,l. proC NC,,, A& &, ” 5’ A 1593. 9O:iOlOl-10104. OkstttbeBJR. Rnnra MA, Begovich AB. Mitchell D. Erlich HA. MU~V RS.Shimonkevitz R Shcrritt M. Rothhrd J. &rnard ?t%, Steinmsn 1: Se&don la ~.Ccll Reccptorvbn+Dbnr-Jbm Gene wts with Sprcikity for 1 MydIn Basic Rotein Rptidc in Brsh Mom d MukiDk sdaosis. Naturn 1993, 362:6&70. Okuyams T. Batsnian JR, sly \vs: ~cnanic -ndm mdLocrliZttiOttdGmf~HumvlCyboni~ AnhydmeN to Ovan17q. Genmlllcs 1993, 16:678-6!34. Olds RJ. Lane DA, Bwesford CH. Abild@s,d U, Hughes PM, Thein SL: A Rcctmcttt D&don in die Amichmmbh Gene. ATIOfGlOBM lip). ldmtiticd by DNA Hnaodupla Detection -Brief Report. Gmomics 1993.16:29%299. Ormttre&w A, Tmkhtenbroi 1 Bcnkvy R, Wcn DZ Rechsvi G. Lanai P, Yarden Y: Neunl &xprr+riott snd Ouwnosamtsl Mappbq of NN Dlfkrmtiatton Prtato8pl2Q2l.PtDc~lA~SclUSAl993. 9t%le67-1871. OW K. Fujii J. Pedassmy M. Dilippantonio M. Uppendrr M, Ward IX, Macknnsn DH: Ovaommc Mawinn . . -d 5 Human cydinc snd Skcktsl Mtnclc Sarcoplssmk Rettcuhlm RoteIn Gctlcs. Gemmlcr 1993,17:507-509. Park KC, Chinlamancni CD, Hslabsn R. Witkop CJ. Kwon B5: Mokculat Adyxs of a TyahmeN@ve A0ino Family. AmJ Hum Gmef 1993* 52~406-413. Pstlerson D. Jones C. Han I. Blesksn J. Berger Il. Geyer D. Eisenbxg SP, Smith MF, Arend WP: The Hums” hlurkoklwl Receptor Attugonist (ILIRN) Gcnc is Incated In du alNmosomc. 2ql4 Region. GP?tmlllcs 1993. 15~173-176. Parson~ti. Vonchek WR. Xu SJ, Berger Il. Hart I, Vannais D. Patterson D: Idmtiticstion of Oass.Mu GhttsdtkmeTts&cnse GeaesGSTMIGsIM5 on HllrmnOtoJ8ll osomelpl3. AmJ Hum G-net 1593, 53~220-233. Peren FP, Hemminki K. Gryzbowska E. Motykiewicz G. Michdsks J. Lnklla RM. Young Tl. Dickey C, Bnndtnuf P. Lkvivo I. Blsner W. Tsal WY. Chonzv M: Mokculi snd G&tic m in H&u fto0.i Envltunmmut pollution In blsnd (Nsw. Vd 360, PR 25615’92) _ carcction. Narwe 1993.561564. Philioson LH. Eddv RL Shows TB. Bell GI: Assimtmcm h H”“&” F&&t” Olstmd~ccnC KCNAi(KvI.4, Paw to almm--I 1913.4 ->Ql4.l. Genornlcc 1993.lr:463-464. Plaulz GE. Yang ZY, Wu BY, Gao X, Hoan6 I, Nabcl GJ: lmmlttl~ d kkiupancy by h-wivo Gxlc ~intoTlvnas.ProcNallA~SclUSAl393. w4645-4649. Pollak MR. Chcu YHW. Certls JJ. Stcinmsnn B. Ladu BN. Seidman JG, kidman CE: Homosy@ty Mapping d the Gene for Nkaptonti to ovomosomc 3q2. Nallm? GeneI 1993. 5:201-M4.

Poly&ropoulos MH. Xiso Cl.Sikela JM. Adams M. . Vcnler IC. Menil CR: Chromcsorml Dismbution of 320 G&s hnm a Brain CONA Liinry. Nalure Gwel 1993. 4:%l-386. [571. Pribyl TM, Cwnpagnoni CW, Kampf K. Kashima T. Handley VW. Mcmshon I. Camoannoni AT: The Human Mvclin B&c Ptotcin G&x is in&cd Within s 179.Kil& Tmttscriptiot~ Unit -Fxptession in dx Immune snd Gmtmt Nmout Systems. Fmc Nall Ad Scl US A 1993. w:lc695-10699. Ramamcxmhy S, Bsumsn AL, Moore KR, Han H. Yan.b$en~T. Chang AS, Canapathy V. Blakely RD: Antidcp-tscnsitivc and Cocain&wnsitivc Human .scrotodn Tkalspona _ Mokmtu a0dq. Expression. snd Chmmosomsl Loalintion. Pmc Narl AC& SC/U S A 1993. 90:2542-2546. Richards RI. Sutherland CR: Simple Rcpcst DNA is not . Rcoliotcd Simolv. Ncuurv Gene, 1994. 6:114-l 17. 161. Rird T. Rudy B. Dcmien EV. lau D. Ward.DC. Sen K: . . Laalintion of s Highly Conserved Human Potawium Channel Grmr (NGK2.KVI. KCNCI) to Ouomosomr 11~15. Gmomlcs 1993. 15:4OWl1. Ritvani&i P, Hyland J. lg&s J. Kivirikko KI. Pmckop DJ. Alakokko L: Short Communiation . a 4th Exampk Sqx#wts that Rmaturr Tamination Gdons In thcCOLlA1Gmcalr~CommonGuscdthc Stkkkr Syndrome. Amlysis of the COL2AI Gcnc by Dmatutin~ Gndimt Gel Uectmphorcsis. Gmonrfu 1993, 17:216221. Roelink H. Wang J. Black DM. Solomon E. Nuac R: Molecular Ckming snd Chnmtosomal Localintion to 17921 of the Humsn WNT3Genc - Short Commudntlon. Gmomks 1993, 17790-792. Rose G. Dclun M. Falmne E. Giacchelto C. Dchenediclis G: Rapid I&nti6cadon of VNIR Alkks d the Human ‘Thyroid Rroxidssx Gux by PCR - s Study in 1 Fc~ulatlo~~ Svnpk from South Italy. Brief Report. Genomlcs 1993. 17:796-79S. Rose TM. lagmu MJ, Frdnsson I, Wcrclius B. Dclartrc 0. Thomas G. Deinn A. Todam GI. Dumsnrki IP: llx Gmm far 0ncoststin.M (D&l) md Leuk& hhibitory Factor (Ul? = Ti@y Linked on Human -22. chonlfa 1993. 17:1M140. Ross VL. Board PG. Ulebb Cc: Chm&so& Mapping of dx Humul Mu Class Gluwhionc STc,,,sfc,xscs ,o 1p13. Gmornfcs 1993, ItuT-91. Rouquier S. Giorgi D. Trask 8. Bergmann A. Phillips MS. Maclennan DH. Dcpng P: A Cosmid s,td Yesst Anihctat amnnosomc conttg Gmtsining dx Compktc Ryanodinc Rcccpta (RYRI) Gene Gwomla 1993. 17:33&340. Rousscsumcrck MF, Algcr M. Loosfell Ii. Milgmm E. Burger R: The ovOmosomsl LocsliPtion d dtc Hums Fdlkk-Stimulrtin~ Hamone Rcccpta Gcnc (PSHR) on 2~21~16 ir Similst to dut d the Lutciniring Hormone Receptor Gene. Cenomlcs 1993. 15222-224. Ssleh M. Sellen’ L. Evans GA: A NowI Zinc Fii.qx Gene on Human chmmosomc lqta that Lr Altcmstivcly splic.xl in Humsn Iii snd Cell Lines. Am J Hum G-net 1993. 52:192-203. Sskh M. Selleri 1 Liulc PI:R. Evans GA: Isolation ad Explusion of Linked zinc Fllg%r ccnc oustas on Hltmsn Chmmosomcl Iq. Genomlcs 1992. 14:97&978. Satoh C. Takahashi N. Asskswa J. Hiyama K. Kodsin M: VSrlatlo~ .hnon~ Japanese of dtc FsctcwlX Gene tl9) Detected by PCR.Denatwing Grsdicnt Gel Ekcwohotuis. Am I tium GeneI 1993. 52167-175 Schalling M: Hudson TJ. i3uelow KH. Ho&an DE: D&t lktcctkm of Novel Espsnded Trinuckoddc Repeats in tk Humsn Genonte. No(lrre Gmer 1993. 4:13%139. Schercr SW. Neukld EJ, Lievens PMJ. Orkin SH. Kim J. Tsui Lc: Brief Report. Regional LocaliEadon d dw CCAAT Displsccmcnt Rotein Gcnc (CUTLI, to 7q22 ~:~al,of Somatic Glt Hybrids. Gmomfcs 1993,

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Schnittger S. Rso WNG, Abrahamson M. Hansmsnn I: CYstathC tCSl3,. the Candidate Gent for Hacditsry Cynatinc Amyfdd A@opathy (HCCAA), snd Other Membcts of the cvststin Gene Fsmilv ur almeted on Ott’omosome2Opil.2. Ge?wmlcs lti3. 1650-55. Schultz D. Mikala G. Yalani A, En& DB. llcs DE, Scgws 8. Sinke RJ. wghuis DO, Klockncr U. Wakamori M. WangJJ. Melvin D. Varadi G. Schwartz A: aoning. Chnnnosomalbxxliotion, ud F~ncdtiwl Expression d do AlphI-Subunit of the LTypc Vdugc-Dcpcndcnt Wdum Chsmxl fnnn Normal Honun licstt. Pmc Nrrll Acarl .%I US A 1993. 9+622&6232. Schwwnmle S. Wlff K. Palmucci LM. Grimm T. Lchmannhom F, Hubncr C. Hauser E. lks DE. Macknnan DH. Mulkr CR: Short Communksdon . Multipoint Mapping of Ihc Gmml Cwc Disau Lxus. G?mmlcs 1993. 17~20%207. Sckhsstia S. Gallin Jl. Linlon CF. Mallory RM. Mulligan RC. Malech HL: Rripharl BloaJ PmRcniton u a Tupl for Ccnetic Gmwtion d P47(phox>Dchcicm

Chronic Gnnulomatous Discssc. &IX Nut/ Acd Scl us A 1993.90:744&7450. Scllar GC. Whikhcad AS: Locsliotion Of 4 Homsn Serum Amyloi&A (SAA) Protein Supcrfvnily Genes to Chmm momc-I 1p - Chsnctaintion of 15th SAARelated Gcnc Scqumcr. Cmtomfc~ 1993, 16~774-776. .Sena EP, Zsrling DA: Tar&wing in Lbxsr DNA Dupkxcs with 2 Comphmentvy FTC& Stnmls for Hybrid Stsbility. Nalwe Gwef 1993. 336M72. Sheffield VC. Beck JS. Kwkck AE. Sandstrom DW. Wow EM: The Sensitivity of SingkStmnd conlonnstion Polymorphism Analysis for the Dctcction cd Single Bax Substltutiom. Cmonrlcr 1993. 16:32+j32. Sheffield VC, Slow EM. Alward WLM:bmck AV,johnson AT, Slrrb LM, Nichols BE: Genetic Linkap d Psmilisl Open AI# Glaucoma to Chromosome-lq2lq31. Na/um Gntcr 1993. 4~47-50. Shcphard EA. Dolphin CT. Fox MF. Povcy S. Smith R. Phillips IR: Locslintion of Gmcs EncodIng 3 Disthc~ Fla-raining Monooxyllcnucs to Humsn Chmmosomrlq. Gwomlcr 1993, 16:H5-69. Shich BH. Soxkes RS. Gsvnor RB. t.usis At: Locslintion of the Gnc+hxxltng Upstream Stimulwwy hctm (USD to Human chromosome-lq22q23. Short Communintion. GBlomlcr 1993, 16:266-2&l. Shinohara A. O@wx tl. Msuuda Y. Ushio N. lkeo K. O~wa T: Cloning of Hums, Mouse and Fission Ycasl Rccombiition Genes Homologous to RADS t and RccA. Nafwe GeneI 1993. 4~239-243. Shipley JM. Klinkcnbcrg M. Wu BM. Bxhinsky DR. Gmbb JH, Sly WS: Mutstionsl Analysis of 1 Rdcnt with Mwopdysaccbaridosis Typ&ll. and IdmdBntion d Fscu~. Am J llum Tenet 1993, 52:5 17-526. Sikcla JM. Auffmy c: Fmdinp New Gents Paslcr man Eva. . Nature Gem-t 1993. 3:1.!+&191. 14881. Sinkc RJ. Tanigami A, Nnkamun Y, %kessel AC: Rcvcrsc Mapping of tlx Gcoc Encoding the Human PosRclstcd Amign-t (In-t) Within Chromosome BanQllq13 tkid Rcoort. G~mmlu 1993. l&165. Smith LW: Tl& Future of DNA Scqwncinu. Scfewce 1993. 262:53&532. Smith RJH. Coppage KB. Ankewjernc JKB. Capper DT, Kumsr S. Kcnvon I. Tinlev S. Conwau K. Kimbcrlinn WJ: Locriution of the tine for Bmr&mtomul ” syndmmc to ChnmlaromcBq. Gerronllcs 1992. 14:841-844. Smith RJti. Lee EC, Kimhurling WJ. Daiger SP, Pelias MZ. Kc-Is RJR. Jay ht. llird A. Reardon W. Guest M. Ayyagari R. I-leitnsncik JF: Locslintion d 2 Gnus for Usher Syndrome Type-1 to Chmm-t I. Gmomlcr 1992. 14x995--1002. Soarc!s VM. Brruslowicx LM. Kleyn PW. Knowles JA. Pslmcr DA. Asoknn S. Pcnchawadeh GK. Munsat TL. Gilliam Tc: Rdincmcnt of rhc Spinal Musculu Avophy Locw to the Intcwrl Between D5S435 and MAPIB. C-omlcr I993, 15365-371. SongJJ. Walker S. Chcn I<.Johnson EE. Spychala J. Cribbin T. Mitchell Il.% Gcnomk Stmctum snd Ctwancsomal katiudm of the Human Dcoxy~dinc Kinuc Gnc. Pmc NaflAcadW USA l99j. 90:4jl-i34. Sorrentino V. Giannini G. Msbac P, Mauei MG. tiiution of a Novct Rymodinc Receptor Gmc (RYR3) to Human Chromosome-l5qt4qtS by I&N Hybridization - Brief Report. Gnomlcs t99j. t8:16+165. Sparks CA. Bangs PL. Mcncil GP, law-em-c JO. Fey EC: Short Communicsdon - Assi~mcm of dtc Nuckst Mitotic Appsrstus Protein NuMA Gcnc to Human Chromosome11913. Cmromicr l99j. 17:222-224. Spencer SR. TaylorJB. Cmvell IG. Xia CL, Penlble SE. Kcwrcr B: The Humsn Mitochondrisl NADH ubiquinonc Oxidomducusc 51.kDs Subunit Msps Adjacent to dtc Gtutadtionc STrmsfcmsc PI.1 Gene on ChmmosomellqlE Got0mlc.t 1932. 14:11161118. Sprinkle TJ. Koud RE. Fain PD. Stoming TA. Whitney JB: Chromosomat Mapping of the Human CNP Gene Using I Mctotk Cmrsma DNA Psnd, PCR, md Nkk.SpcriRc Probes. Gorom1c.t 1993. 16542-545. Squire J. Mews EF, Chong KL. Mcmillan NAJ. Hovancssian AG. Williams BRG: Lasliudon of chc Humw# IntcrfcrowInduccd. &RNA Activated p68 Kitwe Chc (PRKR) to oUanosomc-2p2tQ22. Gewomfu 1993, t6:7&770. Stankovics J. Ledlcy FD: Cloning of FunctionsI Nph, Pmpionyl CoA cvboxylssc snd Cntmction of Enzyme Dchcicncv in PccA Fibmblssts. Am I t/l&m C&w 199j. 52:144-151. Ste@wnn APA, Honden MW. Balk MWJ, Wcssels J. Wilkmzu R. Landegnl JE: Assignment cd the Humvl DmxycyltdkK Kinvc (Lxx) GcrK to chmmosanc-4 Bsndql3.3q21.1. Gmomlu I99j. 17528-529. Stein PM. Stass SA. Kagsn J: The Human UmkinascPlaSminogcn Activata Gnc (PIALl) is Located on ChromosomelOq24 Gmmmcric to dx HOXI I Gene. P&f Report. Genon~lc~ l99j. 16:jOl-302.

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Genetics Mapping of Hwm” Chmnt19 - CytogrnCtiC Band LocatIon d 540 Camids and 70 Genes or DNA Mulras. c&lonllcs 1993, 15:133-145. Tunnacliffc A. Perry H. Radice P, Budarf ML. E~nanuel BS: A Panel d Scqucnm Tawd Sites for Chmntoson~ Band-l lq23 -Short Conununicatin”. Coromlcs 1993. 17744-747. Tynan K, Hoffnxm SMG. Tsujinwm S. Brandriff B. Cordon L, Carrano AV. Mohrenweixr IIW: Oqpnbation of lhc Multipk Folymorphic Sites of the Dl9Sl I-LOW Whhin a 6SlIkb Cosmid Condg. Gwomfcr 1993, 17:316-323. Vanhul W, Vancamp C. Sluyvcr L. Dclabar JM. Mcinnis MG. Warren AC. An&marakis SE. Vanbmeckhoven C: A Conliguous Physical Map of the Rricentmmcrk ncpio” d chm”lc6ane-21q Llawccn D2ltl and DZlSl3E. Gnomlcs 1993, 15:626-630. Vctric I>. Bobrow M. Harris A: Construction of a 5.2Mvbasc Physical Map d the Human XChmnwmmc at Xq22 Using F?dsc&Fxld Gel Ekclrophomsis and Ycm Ardflcid auv”lc4o”lcs. G-mmllcs 1993. 15:63l-642. Vidal F, Mougncau E. Glaichenhaus N. Vaigol I: Darmon M. Cudn p: Caxdimtcd Postwanwiational Contml of C&c Expression by Modular Ocnxn~ Including Alw Llkc Repelhive Sequences. f+nc Nat/ Acwf Scf 0 S A 199j. 90:2aS-212. Wwhunon D. Yu MT, Tanlrwahi IJ. Lee C. tiyanis E. Russa J. Fischer SG: llcgional Localintirm of 32 Nnd4ii”dlll Fngmcnts from a Human Chnnnnsmnc. 13 Library by a Somatic Cell Hybrid Rncl and lnshu Hytxidiudon. Ger)omfcs 199j. 16:355+60. Ward JRT, Courcll S. Thonx~s HJW, Jones TA. Howe CM, Hamplan GM. Dcaven L. Sheer D. Bodnw WF, Solomon E. Frischauf AM: A Lon@anp Rcstricdon Mm of Hunun Ouomosaw 5~121.~23. Gi?nomlcs 163. 17:15-24. Whiunkcr PA, Wood l. Mathrubulhaln M. Anand it: Gncntion d oldcrcd Phaec Sub&arks of YAC a0m consvuction or 14oOkb Fhrw Cmig in the Human mtmphin Cole. Gmomlcs 1993. 151453-456. Winokur .ST,khune 8. WciRnbach 8. Washin#on SS, Mcclligun D. Chaknvani A, Wasmulh JH. Ahherr MR: A Radiadnn Hybrid Map of 15&xi on the Diilal Long Arm d Chmmcsmc4. ti lkglon Containing Ihc Gne Rcsponribk for Faciacapulohumrnl Murculrr Dystmphy (FSHD). AmJ Hum Cmre) 1993. 53:R74-&lo. Worky KC, Ellison KA. %hang YH. Wang DF. Mason J. Roth EJ. Adams V. Fog1 DD. Zhu XM. Towbin JA. Chinauh AC, Zoghbi H. Mcrabc ERB: Yeast Anihrial auun~ourr aoning in the Glycerol Kinvc and Admnal Hypnplui;rcongnila Rc#on of Xp21. Genomlu 1993, 16:407-416. Zhcng CJ. Byers B. Modgavkar SH: Alklic lnsrabilhy in Mitosis. a Uni6cd M&l for Dominant Disorders. Prrx NaflAcorlScl (ISA 1993, W:1017~101H2. Zicgk JS. Su Y. Corcofa” KP. Nie L. Mayrand PE, Hoff LB, Mchridc LJ. Kmnick MN. Diehl SR: Applicaion of Auwmatcd DNA Sizing Technology for Genntypin~ Micmsatcllitc Loci. Gerromfcs 1992, 14:1026-1031.

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Cytogenetics Related review: New methods cytogenetics (pp 374-382)

in

Anlonardkis SE, Awamopoulos D. Blouin JL. Talba CC, Schinzcl M: Mitodc Errors in !kmutic Cells Cause Trisomy-21 in Abou14.~Rrccnt of Cats and arc “M Assochtcd whh Advanrcd Maternal A@. Nature Gmell99j. 3:146150. AntonPrakis SE, Blouin JL. Mahcr J. Avramopoulos D. Thanas C. Talbol Cc: Ma~cmal Unipvcntal Disomy for Hunun Chron~osomc-14. Due m Loss of a a”w”l14 fmn~ Somatic Cells with T(l3;14) Trisnn~y-14. Am/Hunt Cent’! 1993,52:114~1152. Bailey DMD. Caner NP. DC Vos D. Levcrsha MA. Perryman . MT. Femuson-Smkh MA: Coincidence Faintinn: a &mid Me&l-ix Cloning Rc&n Sfxci6c DNA SC,“, Nuckic Acti l&s 193, 21:5117-5123. 1491. B&l S. Panayidcs K. SiruI(o G, Benhamida C. loannou P, Henlali F, Beckmann J. Koenig M. Mandel JL. Bcnhamida M. Middkmn LT: Study of large lnbml Fricdrcich Alaxia Ftilks Revcab a Rcccmbinadon lktwccn D9SIS and rhc Discas Lccus. Am J Ifum Gnlcr 1992. 51:1372-1376. Blcnnow E. Anncrcn G. Eui TH. Bcrggrcn I:. Asadi E. Nordcnskpld M: Ch~rctcrintio” of Supcmumaary Ring Marker Chron~~omcs by Fh~orcsccncc InsiN Hybridiution (FlSH). Am J llum Cm 1993. 53:4jW42. Bomhmn DT. Smith SJL. Fames J. Gasden CM: DC Now Micnxkkdon on an lnbcrilcd Robcnronian Tnnslocadon Chmnmwnc . a Ca.u for Dysmorphism

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Fsc”dqtena

Dkcli”lbutcd

using Fl-“cc

~vbtidiud~i~ tith cenomi~ knu~ (DNA Roba. &0”,fcs 1993, 16:619-629 Kalousek DK. langlois 5, Barren 1, Yam 1. Wilson DR. Howxdpccblcs PN. Johnson MP. Giorgiuui E: Unipyrnul Disany for Cluwn--16 in Hununs. Am J Hum Gmel 1993, 52:8-16. Kitsberg D. Sclig S. Kcshel I. Cedar H: Replication l * Suucfurr of dx Hunu” &Cdobi” Gene Donvain. Na/um 193, 366588-51)o. 168). Konuninoth P, Long M: In SNu Fulymcnu olain l Rcacd”“. Mrcbous AK/J B Ccl/ PallwlW93.64:67-73. 1191. Lcanacox J. Lwin S. Sunna R Wulfsbcrg E. Kecne CL, RatTcl LJ. Sullivan B. Schwartz S: Chanctaizition of De Now Duplications in Eight Padents by Using Flu‘,rm”~ 1lUiN Hybridintio” with Chm”I‘x”“ICSpccbic DNA libmrks. Am J Hum Gmer 1993. 52:1067-1073. Lcmieux N. Malfoy B. Fomsl Ct: Human cybonyl Rcduaasc (CBR) Localiz.cd 10 Ban621 q22.1 by Hi& Rcsol”Uo” Fluwcscc”cc f”siN Hybridintio” Msplays Gnc Dosage Effects in Trisonty-21 C&s. Gmomicc 1993. 15:169-172. lengaucr C. Spcichcr MR. Popp S. Jauch A. Tanawaki M. l * Nagan@ R. Rcilhman HC. Don&Keller H. D’Urso M. Schlessinger D. Cramer T: Chnnnasonul Bar Coda Produced by Multicolor Ruomsccn cc In SIfU Hyixidiution with Multipk YAC Oancs and Whok Chmmaromc Painting Probes. Hum Mel Gem 1993, 2:505-512. 191. Li lq Bray PI’: Honwlogwr Rccmnbiitio” Among Three l”vrgcnc Al” Scqucnm calws a” l”vcrsiLn+ Dcktio” Rcsuldn~ I” Ihc Hereditary Bkcd@~ Disorder Glanzn~ann Tlucmbasthcnia. Am J Hum C.&e/ 1993, 53:14*149.

of disease Cytogenetics

Lindsay EA. Halford S. Wadey R. Scambkr PJ. Baldini A: Mokcukv Cy~c+wmic 01 ancmi?auNlddlc Dla Sy”drm”c R+m Usi”ff FluCc f&N Hyb&i?ation. Gmonlfcs 1993. 17:403-407. larber BJ. Gnntham M. Pclefs J. Willard HF. Hassold TJ: Nmdkjjm d Chmm -21. compvirau d Cytslcncric and Mokcular SNdk$ of the Mdc& Sugc and Pafen1 d Origin. Am J Hum &?&?I 1992. 51:126>1276. Luns JN, Sachs RK: Us@ 3.Cnla Chmmosmnc Paindnfj ,o Tut chmmAbmation Models. B,x Nail AC,%, Sci USA 1993,90:1484-1487. Ma C. Marlin S. Ttask 8. Hamlin JL: Slna Chmmadd Fusion . Initiates Amplification d the LXhydmfblae Rcductase Gene I” alhcsc Halmla Cells. Gpner Lku 1993. 7605-620. 1591. March RE. Pun W. Hollyoakr M. IvesJH. Lovepve JU. Hopkinson DA, Edwards YH. Whilehouse DB: The Classical Human Fhosphoghmnnuusc (FGMI) Isozy”lc Fdymorphlsm is Gc”enIcd by lnln~c Wxmbiiation. Prw Nat1 Acad Scf II S A 1993, 90:10730-10733. Mrkzer PS. Gus” X-Y. l’ren~ J: TelCapture StabOizs l aVanhakqc. Nalum Cenec 1993, 4:252-255. 1141. Mikwin DM. Wilz AM, Smkh ACM, Manchester DK. Wakkkin G. Byers PH: Pvcnnl Somatic and Germ IJnc Mosdck”~ for a Muldcxo” Dckdo” with Unusual Endpdnts in a ryPBl Cd&” KOL3AI) Alkk Roduca EhkmDanlos syndmnc Typdv in the Hctaoygarr Of&win& Am J Hum GeneI 1993, 53~62-70. ,Monlgonwy KT. Leblanc JM. Tsai P, Mcninch JS. Ward DC, Depng PJ. Kuchcrlapali R. Kraulcr KS: ~mcrcl~lion Of Two awan12Gxmid tibnrksandDcvelnpnxntdSTSsfnanCwmi& Mapped by NH. Cemmfcs 1993,17:682-693. Morris T, Thacker J: Fornudo” d Lya Dcwons by Ilkgitimatc Recombination in Ihc HFRT Gac h FrknarvHu”u”Flbmblasts.RxNailAcadSclUS A I,, 90~1392-1396. Munme DJ. Haas M. Eric E. Whinon T, Atwalani H. Hunlcr l * K, Ward D. Hcusnta” DE: IFCftaRap4d Method for Fllidat and Rcprrscntalivc Am@i6odon d Hwnan Gcnondc DNA Scpfmm Cam+ Sours Gmomfcs 1970, 19:~514. 121. Ning Y, LoveIl M. Co&y LD. Pcrcinanith OM: FCl? KyMvpc d Monochmmommal Samadc Cell Hybrids. G’nomla 1993. 16:758-7&I Pana I, Windk 8: Hi#h Resolution Visual Mappins d l * Suet&cd DNA by RI Hybridbapion. Nairrw Gmei 1993, S:l7-21. 1281. Fanrrson D. Han I. lai LW, Bnhe C. Mosceni A, Tawne F, Raimondl E. Jones C: Makcuhr and Cyxwtic aUnc~ai?adm of a Chincx HanuterI Huntan Hybdd Cell Line containi” a Da wmpar->ccnyccn21>2iqw ouom-. -fc~ 1993, is:in-179. Rack KA,.Hanis PC. Macnnhy AB. Boone R. Raynham H. Mckinkv M. Filchen M. Towe CM. Rudd p. Armour AL. ti~~de&~~ RH. 8&e VJ: B&n dThrcc’ fk Now Daivati*c Chmm -16byRcvm Chromosome and Molccuhr Analysis. Am J Hum Gener 1993. sXtW997. Rae PH. Muny WVS. Gaidano G. Hauptschein R. Dallafavera R. Chaganti RSK: S&r@aml Mi.udon d2OSin&Xopyhciro~by FIB INiN Hybrklindon. Genomfcs 1993. 16:426-430. Rasch P, Wiedrmann U. Wienbcrg J. Heck1 WM: Arulysfs d Banded Hunu” awmwmws ‘2nd 1miN H~ridizadon RItcms by Scanning Fomz Mii. /+vc NatI Ad.Scl USA 1993. 90:2509-2511. Ricd T, Lcnguer C. Lipp M. Fischer c. Crenw T, Ward DC: . EvJuation of the Utility d fntuphau Cylagawfa to Dclcct Residual Glls with a Malfgnan~ Ccnorypc in Mixed Cdl Popular a iluddn Lymphoma M&l. DNA Cdl Blol lm3. 12:637&3. [431. Robinson WP, Bernasconi F, Mulirangura A, Ledbener DH, Ian&is 5. Malcolm S. Morris MA, Schinzel M: Nondkjuncdon d O~~mmomc-IS _origin and lkcombimion. AmJ Hum Ge?w 1993.53:740-751. Royle NJ, Armour JAL, Cnsier M. Jeffreys 4l: Abnwmal ~~timdAfkksinCEFHRdigrecDN&A&hg fmm Alkk Loss in Lymph&la&d DNA. Genafcs 199% 15:119-122. Saluna” DL. Ddgdnov GM. Waninglo” JA, Wasnwth u. Lovell M: A physical MID d 15 Lad on Hunun Chzwwm&23q33 hy 2.Cda FlINiN Hybridization. Cenafu 1993, 16:726-732. Song I, Brow” DR. Yamada T. Trenl JM: Mappfn# ddx

hinting

Gent Encoding the IkuSubmit d H+.KtATFax to HUllWlChlWll osanc-13934 by Rh,dN Hybridization. Genomfcs 1992, 14:1114-11 IS. Spolila LD, Sercda L, Pmckop DJ: Rnirl Lwdtsany Maternal Omm -7a”dShmStatweinan

for

481

482

Genetics

of disease Gene mapping

data and bioinformatics

.

Cyqmaks. Eked 1993. ltl:ill~~l24. 1411. Takahashi E Hilcmi A Nakamun y: Short Cammmkadm -aHi&R6du&Qtu&encdcM~dHuma11 ~~-Locrlinliond206NcwCosmid MadlaabyD&cclR~Pi-lNiIu HybrkUndm. Genanla 1993.17:234-236. Tochamenunaphol C. Cmmer M. S&r&k E. Blonden 1. .* Kilhn K, Cmmer T, Rkd T: utUcdor Fluaxwmcc In SIN Hyblidbauon al Metadx19c Chmmand Interphase HaleF.repamUmr Us@ Cosmid and YAC amesrorIbcsimH&h lkauhldon mapping dDekUnminthcDysqhinGenc. HumGmet1970. 93:22+2x 1311. Vana-& N. l&ys G, Vers~eeg R. Opdenakker C, Speleman ccMwingof46DNA F: Hl&f&sdulim Ai+butusrorhcShanArmdHuman~l. Gemmks 1993, l&71-78 Vmijy M, Yu LC. Tkachuk D. Pinkel 0. Johnson D. . GnyJW:Ubr&slarlbchHumanCluwa-, CuwucudfmmSm~FnridwdouwMmmaby IJW Unka-A&aptXII. Am/ Hum Cikmd 1993. 52:58&597. 131. Wang ND, Testa JR, Smith DI: Dctuminadon d the spdMlydAphidicdlrrblducedBruka~d the Humaw3p14.2 pneuC SRc. Genomlcs 1993. 17341-347. Ward BE, Genen SI, Carelli MP, McGuire NM. Dackowski . . WR, Iveinslein M, Sandlin C. Wan-en R. Klinger KW:RauidF’mtatalDiaams&dChmmosumal A#bn&idk~ by Fl&ce In SW Hytnidiaation: ahkal Expakna with 4500 spcdmcns. Am J Hum Cener 1993. 52:854-865. 1521. Weber-Malthicsen K. DcerbcrgJ, Mulkr-HermeUnk A. l Schlegelbcrger 8. Cmle W Rapid lmmunopbmotypic awacurinum dalmmaWmallY Abun” ccm bY UIC New PICnON Mehd. C&&~I Cdl GmeI 1993. 63X3-125. 1441. Wie~pnt J. Wlesmeijjr CC, Hoovers JMN. Schuuring E. l D’A?zo A. Vrolfj J. Tanke HJ. Rasp AK: Muldpk and Smsidw A lw SIN Hybddizadm with Rhodunlnc; Fluumccin.. and Coumarm Labeled DNA% QtpneC G?ll &ei 1593.63~73-76. 181. Zheng Y-L, Caner NP, Price CM. Cdman SM. Milton *a PJ. HackelI GA. Gtuves MF. Ferguson-Smilh MA: Ftenaol Dh@asis 6mn Makmal Blood: Shudb~“u”wbmav~ina and f’LSH d Fetal Nuckati ky%cy& Lsd& b; Ne@w Ma@xUc cdl Sat@. J W Genor 1993. MlMl-1056. t551.

Gene mapping Related review: (pp 383-388)

data and bioinformatics Bioinformatics

Akschul SF, Bo$usW MS, Gish W, Woouon Jc: Issues . in scaldI@ Mdecular sequl!ncc mcabua. hWure Gem 1994.6:119-129. [161. Anderson L4, Friedman L, Ostamelawrencc S. Lynch E. WeL%senbachJ. Bowcock A. King MC: Hi&Density GalcdcMapdtbcBftcAlRcgiondalmm17qlzqzI. Gm0mk.s 1993. 17xw3-623. Anronankis SE: m Rcpm - 3rd Intunatimal WakshoPmHumaa -21. Gmomlcs 1992. 14:llW1132. Avramopoulos D, Chaknnni A, Antonarakis SE: DNA ~~~msinIJntm”slaud Fk@n d -21. Genomks 1993. 1598-102. Bowski MS, Lowe TM, ToLuoshev CM: clbm - Database . fa ‘Eapcacd Scqumcc Tagr’. Abfum Gmel lw3, 4:332-333. W. Bow-k A, Osbornelawrence S. Barnes R. Chakravarti A, WashQton S, Dunn C: MkmsareUi~~ Fdymorph&m UnlugcMapdHunul -13q. Gmomlcs 1993.1*376-386. Bowcwk AM, Barnes RI. While RI. Kruw TA. Tsipouns P, Sarfanzi hf. Jenkins T, Viljjn C. WII M. Kramer Pl+ Murny JC, Vegnaud G: llzc CEFII conromium UnkaaeMa~dHuman~wnne ISa. G?nmnlcr 1992,:4:83--0. Bowcock AM, f&ken SC. Barnes RI, Shiing R. Jabs EW. Warren AC, Anlonankii S. Relief AE, Vergnaud G. Leppm M. lalouel JM, While RL. Cavalliiforu LL;TheCEPHCmsadumUnka~MapdHumaa -13. Ge?nnnlcr 199i,la4&4%. Brzuaiowin LM. Mereue C. Xie X. Townsend L. Gilliam TC. Otl J: &cutar md St&ical Apqmaks to the-ndCanrniondErrminGcnorypc m~.AmJHum~~993.53:l137-7-1l45.

Cohen D. Chumakov I. W-elssenbach J: A FimtGencration l Physicll Map d ti Humaa Gnome. Ntiurc 1993, 366698-701. [Zl. Cmingham RW, ldury RM. SchatTer AA: Faster Sequauial Genelie Unkag Cnmpuladms. Am J Ikm Met 1993. 53252-263. Culicchia AJ, Chippcmeld MA, Poncr CJ. Kcams W, PearsmPL:Manag@ABIhmByta-chcHuman Gmunc Project. Scknce 1993. 262:4718. Dasgupla R. Morrow 8. Mamndel I. Patim S. Goci Vl Gruen J. Weissman S. Skoukchi A, Kuchcrlapali R: An Inqjraled Apprcach fix Iden~ and Mapping Human Gxcs. Pmc Nall Acati Scf 0 S A 1993. 9Q4364-4368. Dawsm E. Shaikh S. Webcr Jl. Wan8 ZY. Wissenbach J. Powell JF, Gill M: Shari Communicadon - a OmUnuous lAnka Map d 22 Shm Tandem Repeat pdymorphisms on Humaa Chmm12. Gmomfcs 1993. 17:245-248. Dizier MH. Bmailipellii C. Ckrgc~darpoua F: POINTER Carrecdy Esdmaus tk Tmnsndssion Pmbabilitks Undcrd~~ccncnlTnnsmksl unM&lintbcCued Incompktc Sekcdon Ilma]. Am J Hum Get&V 1992. 51:144e1450. Fdiwial: Network Enha. h’CB/ News 1993. 2:l. 1141. . Fmi M. Fuiiwan Y, Nakamura Y: A Primary Genetic Unka& Map of I+polymorphic Loci I& dx Shon Arm d Hwnaa Chmmosomc-8. Gmomlcs 1993. I5:5?&534. Engelstein M. Hudson TJ. lane JM. Lee MK. Lever& 8, Ian&s GM, Peltmen L. W&w JL, Dracopli NC: A POWad li”kwe Map d Human Chmmosome-I Gemmlcs 1993. 15:251-258. En& ML, Burks C: Arteiauy Gnmtcd mu scu for Testing DNA Sequence Assembly Algorirhms -Short Cammunkation. Gbnomlcr 1993.16:28&2&3. Eveu IW, Scnnage J. Pinchin R: An ~&ration d the Advanyrs d FfIiciem StaUsUcal Medmb for RFIP hatysis in Forensic Science. Am J Hum Gene/ 1993. 52498-505. Farrdll M: Hmway#usiry Mapping -PamiSarity Bmccb Dcbilhy. NaNm Gmel 1993. 5:107-108. Feingold E. Brown PO, Siegmund D: Gaussian M&Is for Genetic Linkas Analysb Using Compku Hi& lksdulion Maps d ldendly by DCSCUII. Am J Hum Osne11993. 53234-251. Freimer NB. Sandkuijl LA, Blower SM: Incorrect Spcci6cah d Marker Alkk Frequencks . Eliem an Unkag Anal@. Am J Hum Gewf 1993. 52:1102-1110. Gerken S. Leppen M. Oconncll P, Cavencc W. James CD, Ballard L, Stauffer D. ELsncr T. Plaelkc Il. lalourl JM. While R: A Genetic linkage Map with 29 Loci Spannimq Human Ouvm13q. Gmomlcs 1993? 16:515-519. Gish W. Stales DJ: kknd6cation d Pmtcin Coding Rqions by Data& Simikuiy Search. NaIure C%net 1993, 3~266-272. GolUmuntz E& Remmers EF. Zha HB. Cash JM. Malhern P, Crofford LJ. Wilder RL: Gcnedc Map d I2 Gemmfcs Polymorphic Loci on Rat Al. 1993. l&761-764. Greenberg DA: m Analysis d Necessary Dixasc Loci Vcmus Suscepdbilily Loci. Am J hm Gene11993, 52:135-143. Gri&~orkv AV: ThcweUal RedkUms and Expcrimcnlal Observatica of Gcnumic Mapping by Anchoring Randa Ilones. Cenmfcs 1993, 15x311-316. Heath H. Jackson CE. Oucrud B. Lcppen MF: Genetic ““kae h=b3b in FNd,Q, knian fHv,~~alchaic) Hrpc;;almrja . Evidence for Locus Hetcm-it+, Am J Hum GeneI 1993,53:193-200. Helms C. Miihn SK, Riethrmn H, Burgess AK, Ramachandra S. Tiemey C, florsey D. Dmiskelkr H:aosurCcfaGcncdcliakagcMapdHuman Ouwnosome7q wirh Cat& &J Tclomac Folvmamhisms. Gwomfcs 1992. 14:1041-1054. Henske’EP~&lius L, Gusella JF,~&?es JL. Kwialkmvski DJ: A Hi&Resdudon Unkas Map d Human 9qU. I. Gemmia 1993. 17587-591. Hodee SE: Lwlw Anal@ Vcmus huociation Analysis. Dislh~BQween lb0 Mod& that Explain DisaseMtier Associadonr. Am J Hum GeneI 1993. 53367-384. Holmans p: Aaympludc Fmpenks d Affcctc&S~bPair Linkas Analysis. Am J Hum Genm 1993. 52:362-374. Jo& LB, Watkins WS. Viskochil D. Ocmnell P, Ward K:

-

..

unkaggDisqdmium in dK Neum6bmInalc5icl

(NPD Ration _lmdicadons fur Gcnc Maodnn. Am I ifurn & 1993:53:1038-1050. . . .. Kong A, Frigge M. Irwin M. Cox N: lmfwtance Sampling. I. Computi~ Mddmcdcl-p Values in Linka- r\nalvsis. Am I Hum GeneI 1992. 51:1413-1429. Kml E: ?be Who* Int& User’s G&k b Catalog. erln 2. l * S&w@, Cai!bmla O’Reilly G Asociah?s lnc 1994. :. 1121.

Laimwe ‘IC. Dou Ss. Howe JR, Chi D. Cxlson K. Veile R. Mishn SK, Wells SA. Dunkkeller I-I: A I .SMegrbasc Ycvl Ani6cial Ovanfmm Human almnlosomc IOql I.2 CoMetin(l3 Genetic Loci (ISKY, Dlos94, and DlOSl02) Closely Linked (0 the MENZA Incus. Pmc Nat1 Acad Scl US A 1993. 90:492--L%. Lawrence S, Collins A, Keats BJ. Hullen M, Morton NE: buegntion d Gene Maps. olmmosw-21. Prm Nat/ AcdSdUSA 1993, 90:721&7214. Lichtcr JB. Dihlippanmnio MJ. Pakslis AJ, Goodfellow PJ, Ward DC. Kidd KK: Physical and Genetic Maps for Chrom-IO. Gnomics 19939 16:320-324. Lien S. Kaminski S. Aleswum P, Rogne s: A Simpk and Powsfui M&xl fur Unkagc Analysis by Ampliftcation of DNA from Sinpk Sperm tills. Gc?w?llcs 1993. 16:41-44. Lulhlla G. Cardiner K. Uzc G: A New Member d the Cydhe Rcccptor Gcnc Punily Maps un Ch~um-21 al kss Than 35 Kb from IPNAR. Gmomlcs 1993. 16366-373. Maclcan CJ. Hishop DT, Sherman SL. Diehl SR: Distribution of lnd Scorrs Under llncuuin Mode d Inhaitancc. Am I Hum GeneI 1993. 52355361. Malo D. ?idal SM. Hu JX, Skamene e. Gras P: High. Resdulial Linkaw Map in Ihc Vicinity d Ihc HIXI Resb”ncc Lacws Beg. Cknomlu I993q 16:65%3. Ma&t& F. Shin EK. Naaaoka H. MaIsumura R. llaino M. Fukita Y. Takaishi .?, lmai T, Riley JH. Anand R. Soeda E. Honju T: Structure and Ph+al Map of 64 Variabk &uncnts in Ihc 3(ljO.l$Mc@asc Ref#on of Ihe Human Immunaglubulin Hear/Chain Locus. Nolure Gwet 1993. 38894. Mcinnis MG. Chakmvani A, Blaschak J. PTlwsen MB. Sharma V. Avramo~oulus D. Blouin IL. Konin U. Brahu C. Ma& TC, Warren AC. T&OI CC: Vanb&ckhoven C. Li” M. Amonankis SE: A linkage Map of Human ChnnnosomC21 .43 FCR Markers al Avaa8c Intervals of 2.5 CM. Gwonrlc.~ 1993. 16562-571. Melki J. Burlcl P, Ckmwnt 0. Pascal F, Paul B, Aixklhak S. Sherrington R. Gurling H. Nakamura Y. Wcissenbach I. lathmu M. Munnich A: RcSncd ljnkaae Mar, of -(ilrmnosomc5 in Ihc Region uf the Spi&l M;scular Avophy Gene. Goromlcs 1993, 15:521-524. Milchison HM. Thommun AD. Mullev IC. Kozman HM. Richards iI. Call& DF. S&llings’Ri. .&,geu NA. Auwood J. Mckay TR. Sutherland CR. Gardiner RM: Fine Genetic Mapping d ti Batten Disease Locus (CLN3) by Naplutyfx Analysis and Dcm-(ion of AU&c Association with Chmmusomc-l6p Micmsatellile Loci. Gmomfcr 1993. 16:455-K& Mole SE. Jackson MS. Tokino T. Nakamun Y. Ponder BAJ: Assignment d 54 Casmid aunts to 5 Regions or aumnawmr IO. CetlOrnlcc 1993, 15:457-w. Nakai K. Kanehisa M: A Knowledge Base for Redkdng Prowin tihation Sites in Eukaryudc Cells. C~non~lcs 1992, l&897-911. Nelson SF, Mccusker JH. Sander MA. Kee Y. Modrich R Brown PO: Genomic Mismatch Scanning - a New Approach to Genetic Unkaftc Mapping. NII/U~ GorcC 1993, 4:l J-18. Oconncll P, Plaetkc R, Matsunami N. Odelherg S. Jordr L. Chance P. Leppen M. lalouel JM. While R: An 8xtended Gmedc Unkapc Map and an Index Map for Human Chmm17. ck?lo”rlcr 1993. 15:w7. Olson MV: The Human Gmanc l’rokct. Prtx Na/l AC& Scl US A 1993, w:433&4344. ’ Petrukhin KE. Speer MC. Cayanis E, Bonaldo MD. Tanrravahi U. Seams MB, Fischer SC, Warbunon 0. Gilliam TC. 011J: A Microsatellite Genetic Linkagc Map of Human Chran -13. Gmonrlu 1993, 15:76+i5. Poner JC. Ram KT, Puck JM: 12 New Pulymorphic MicmsateUita m Human Chmm--22. Gmomlcr 1993, 15:57-61. Polier MC. Dwiaux A. Lambolcz 8. Bwhel P, Rossier J: Llrkf Repon . Assignment of the Human Glwmatc Receptor Gene GLURS 10 2lq22 by Stxening a Chmm-21 YAC Ii-m-~. Cenon~lcc 1993. 15:69&597. Risch N. Ghosh S. Todd JA: Sudstical Evaluadun d Mdtiokhcus ljnkaae mm in EaDclimenIal smxics and IIs Rckvancc to Human Studia . Application to Nonobcx Diabetic (NOD) Mouse and Human bwulin. Dependent LXabccsMcUitus ODDhI). Am J Hum GnN 1993. 53~702-714. Ro@ko A, Zacks s: D&ring Genes cOntilin~ rhc Dedsh-F.n’or PmbabUitk% Am J flum GeneI 1993, 52~947-957. Robs K. Straub RE. Kunz A. Fedcr M. Mewar R. Gilliam TC. Ovcrhauser J: Idendfxadoa and Loca8udc.n of Micmsatcllitc Ma&cm Covering Human Owumosomc18. Genomfa 1992. 14:1095-l&7. Rodwchild CD. Akoo G. Havwonh R. Pcwnali MI. Rae PN. Wood P, Stolz FM. Hansmann I, Serino K. Keith TP. Fawns SS. Bowdcn DW: A Genetic Map Of Chmmusomc 2OqlZqJ 3. I -Muldpk Highly

Conlig

.,

_.

Genetics Polymc+k Micraratclli~c and RlW Makers Linked 10 Ihc ManuilyOnvl Diabetes d the Yolnq (MODY) l.ocu5. Am I Hum Cmd 1993.52:110-123.

Ro”lca”

GA, E&n”el

B.5: Meed& l&cpm .Romdln@

of the 2nd l”tematio~I auo”wsomc22 w&shop. Genomks 1992. 1411251126. Sail0 S. Nakamura Y: A Genetic Urtkap Mapwirh ICRFLP Mo”thcDistall.ongArmdHumanClmnnrxwm&. Genomlcs 1993,15:103-106. S&aid DJ, Sonuner SS: Genmype Rcl~dve Risks. Mclhalr for Des&n and Mysir of CrndidateGenc association S~dies.AmJHun1~1993.53:111C1126. Schork NJ, Bochnke M. Tenvilliger JO. 011 J: 2.Tnit-locus Llnkagc AmlysLc . a P”wxful stntegy la h+zppi”g Comokx Ccnnic Tniu. Am I Hum Gen.9 1993. 5j:ii27-1136. Selo D. Koop BF. Hood L: Shon Cunnwnintion . UI mpcrimcndiy D&vcd Dal Set Cawuctcd fg Testin Lqc-kak DNA Sequmce Assanbly Qorhns. Chomlcc 1993. 15t673-676. Slinwwilz JR, Cohc” JE: Vidatiarr d rhe Ceiling Principk - Exact Gmdhions and Statistical Evidenrr. Am J Hum GeneI lS93. 53:314-323. Spun NK. Cox S. Blyanl SP, Alnvood J. Rubs”” EB. Shields DC. S!ei”brucck T. Jenkins T. Murray JC. Kidd KK. Sununar ML, Tslpouras P, Relief AR. Kfusc TA. Bale AE. Vergnaud G. Weber JL, M&ride OW, Doniskcller H. White RL: The CE?H Co&urn linkage Map of Hlt”U”ChlV”l awnnc2. Gwomfcs 1992. 14:1055-1063. Swvens G, Ranwy M. Kluvebeckerman B. Jenkitts T: A New Ne@d&Specif~ Hi”dll, Pdy”,orphb” In Ihc Serum AmyloiQAl (SAAl) Gene lncrrva thcusd”lnessofrhesMLoclalnunk3gcst”dks. Gmomlcs 1993. 15:242-243. Srraub RE. Speer MC, Luo Y, Robs K. Ovcrhauser J. 0” J, Gilliam TC: A Micrcsatc8ilc Genetic Linkage Map “i Hu”un Chnxn18. Gnomfcs 1993. 1’5:48-56. Thomas W, Rubenstein M. GOIO M. Drnyna c A Genetic Analysis d the Wemu Syndrome Re@on cm Human Chmmosciw8p. Genomfcs 1993, 16685690. Todd S. Sherman SL. Naylor SL: Dinuck”tide Repeat Loci conuiite Highly lnlomulivc Gmcdc Markas to dw Human Chnnn -2 Lhkag Map. cenomrcs 1993. 16:612-618. Vanbiezen NA. Dcprcz RIIL. Thiis A. Hculink P, Rostra BA. Vankessci AHMG. Zwanhoff EC: Isolation and ~urcterintio” d 25 Uniauc DNA Mtias for Hunu” Chrmncsonw 22. G?mrnlcs 1993* 1~20&20!3. Wang ND. Testa JR. Smkh DI: Locallntion of 3 Novel Hybrid Bmkpd”U and Ruinanent of 18 Marker krd~ls in the Hunun 3cen-pZl.l Rqtion. Genomlc.5 1992, 14:891-8%. Ward PJ: Son% Dcvclop”~“ts on the AlTccte&Rdi~Member Method d lhkagc Adysis. Am J Hulum Gem-t 1993, 52:120&1215. WarringIon JA. WaSmuth JJ: Sublwalindon d 7 Humvl Shnpk Sequence Repeat P”lymaphic Markers. DSS349. D5S351. and D55355 to 5qll.Zq13.1. D5S350 To 5p13.l-pl4. D5S352 1” 5q31.2q33.1. DSS353 10 5q33.2qlcr. and D5S354 1” 5ql3.2q15. Gmmnlcs 1993. 15:241-243. Wcbcr JL. Wang ZY. Hansen K. Stephenson M. Kapprl C. Salzman S. Wilkie PJ. Keats B. Dncopoli NC, Bnndriff BF. Olrn AS Evidcncc for Hum%” M&tic Rccombimukm lnrexference Obtained Throu@ cONuucdon da Shwt Tan&m Repeat-Fulymorphisn~ unk!ag Map of awo”losomc 19. An J Hum G-WI 1993. 53:107%1095. White A, Tomfohrdc J. 8ewan E, Barnes R, Lcpaslier D. Weissenbach J. Cawllisforw L. Fanw L, Bowcock A: A QSMe@w Yeast ArdBcial Chmmaromc Contin fmm Human Chrcmlk14.3 Orderinn 9pol&.rphic Microsatellites (22 Se&“&-T.ggcd“ Sites) II&& lAnked, to tic Wti D&au Locus. Pnx Na//Acxx&Scl USA 1993, w:1010~10109. Whitehouv WP, Rees M. Cunis D. Sundqvin A, Parker K. Chung E. Baralle D. Gardiner RM: linkage Analysis of idiopathic Gencnlized Ep8epsy OCE) md Marker Loci on Chmmcsome6p In Pmllks d Rtknm whh Jwcnik Myalortic Eplkpsy _ no Evidence for an Epilepsy Incus in the HLA Region. Am J Hum Gewt 1993. 53z652-662. Wilkie AOM: 8rmrs in Hunun Gene Mapping41 &rttcr]. Am I Hum Gwu?f 1993.52z440-441. Wilkie Pj, Polymempoul& MH. Trenl JM, Small KW. Wcbcr JL: Gmctic md Phy&%I Map d 1I Short Tandem Repeat PalynxxphLsn~~ on Human auwmcsmne6. Gmomlcr 1993. 15:225-227. Wilkin DJ. Koprivnikar KE. Cohn DH: Hclcrodupkx Analysis can InIhc l”&r”lativc”ns of PCRAntplihcd VNTR Markers. Application Using a Mzrkcr Ti&dy linked 10 the COL2Al ccnc. G?nomlcs 1993. 15372-375. Winh 8. Voarn B. Rohrig D. Knapp M. Piechaczek B. Rudnikschoncborn S. Zerrcs K: FUK Mapping and Narmwi~ c.f thc CaKdc ln~erval d tie

Spinal Mdu Atrophy Rc@” by Unka8z S~dks. Gen0”1lc~1993. 15:113-118. Zhang MQ. Man TG: Gznune Mwb by N”“t-andc,n ArUhOrinn .a Llbcrcte Theorctkd Analvsii. Pm.z Nail AdSd-IJSA 1993,91MW&14. ’

Gene mapping Related review: mouse genome

in the mouse Integrating maps (pp 389-394)

of the

Avraham KR. Cho BC. Gilben D. Fujii H. Okamom K. Shimazaki T. Ilo T. Shoii H. Wakamatsu Y, Kondoh H. nkahashi N. Muranwsu M. Harnada H, CoDeland NC. knkins NA: Mwine Chranoaorml L&don d F&r avslll Pou Tnnscription Pxtws - Shac Conununication. Gemw”lcs 19%, 18:131-133. Bain PA. Meiskr MH. Tavlor DA. Pavnc AH: The Gem GO”&, Ad N&c&l Fanrr Of 3,,&. Hydmxystcroid DehydnwmzwDcIu~~DcltXO lJomaucYCao6CiyU”kcdcflMOUrCo110m~ 3. G?nwnfcs 1993, 16:219-223. Baldini A, Gress T, Pale1 K. Muresu R. Chiario!li L, Williamson P, Boyd Y. Casciano I, \zlclla V, Bnrni CD. Mallucci L. Siniscalm M: Mapping on Hun%m and Moux Chmn~as”nws dthcGencfortbcBelaGalactosldc-Binding Protein, an Autw~N~dve Growth Factor. Genomlcs 1993. l5:216-218. Buckwaher MS, Testa CM, Noebels JL. Camper SA: Gmcdc Mapping and Enluadon of Candidate Gents for Spumodlc. a Ne”Iolo&d Mouse Mutadon with Abmmul Stank Respcase. Cenomks 1993, 17:279-286. Bultnw SJ. Michaud EJ. Woychik RP: Molecular l * Chmctcrbation d ti Mouse agatli Incus. Cell 1992, 71:119>12M. 1491. Bureau JF, Monlagulelli X. Bihl F, Lefebvre S, Guenel JL. Brahic M: Mapping l@zi l”8uencing rhe Rrsktence of Theikfs Virus In the Murinc CmWal Nervas System Nalure Gma 1993. 5:87-91. Capccchi MR: Mouse Gnedn. YAO to the Rescue. Nahrre 1’??3, 362:20~206. Challerjw A. FlusI CJ. Molinari-Slorey L, Kiahis P, Pow& . A, Herman GE: A 2.3 Mb Yeast Artificial Chmmawrmc CcmligSpanni~ from Gabra3 10 Gdpr on Ihc Mouse X Clmmosome. Genmlcr 1994. (in Rar):. [Zl]. Cooper P, Keer JT. Mnabe VM. Hamvas RMJ. Brown SDM. Rastan S. Brockdortl N: Physical Mappping of zOo@kb dIhcMc.uscX-osomcln~VlcinitydchcXb~ Lmus. Cennmlcs 1993, 15570-575. Copeland NC. Gilbc” DJ. Li K. Sawamun D. Giudice GJ, Chu ML, Jenkins NA. Uiuo J: Ctmxnosonul Locallntion d Mouse Bullaa Rmphiudd AntiBPAGl and A”d8a+BPACZ. ldenribc&on of a-i+zw Re@on of Homology Mouse md Human Chmmasomes. Gmnmks 1993, 15:180-181. Copeland NG. Jenkins NA. Gilben DJ. Nadeau JH. Miller l * JC. D&rich V/T, Weaver A, Lincc~ln SE. Steen RG. Stein LD. lander ES: A Genetic U”kagc Map of tic Mouse: Cumznt Applications and Future FTospccts. Science 1993,262:57&. I71. Cox R. Whillinglon J. Shedlovsky A. Donnelly C-5, Dove l WF. Goklsw”hy M, larin 2, Lehnch H: Deralkd Physical and Gawk Mapping in chc R&m d Fluminogn. Dl7Rpl7e. and Qua8dng. Mamm G3Iome 1993, 4687-694. [221. Dancigcr M. Farber DB. Kozak CA: Ccnctic Mapping of 3 GABA Rcccp~edubunit Genes in Ihc Mouse. Gmon110 1993, 16361-365. Delamo FF, Gendronmaguim M. Swialek PJ.Jenkins NA. Copeland NG, Gridky T: ao”in& A”alysis, and Chmmnsomd l.ocalhdon of Notch-1.1 Mouse Honmlos of Drowphila Notch. Gnomlcs 1993, 15:25!&264. Dietrich W. Katz H. Lincoln SE, Shin HS. Friedman J. l * Draropoli N. Lander ES A Gcnedc Map d the Mouse Suiubk for Ming lntmsp&8c Gztues. Gmerlcs 1992, 131:42H47. 161. Editorial: 8ncyclqxdia of Ihc Moue Genonxc 111: l Chumcsome Comminec Reports d Ihc Mouse. Manrm Genonre 1993. 4:Sl-&i. Il21. Enstein DI. Vonan KI. Tnsler DC. Gms P: A Mutadon .’ Within In&n i& the P-3’ Gcnc Rodum Abcmndy Spiked MRNA Tnnrripts in the S@otcb tsp., Moue Mutant. Proc Nail Acad Scl USA 1993. 9Oz532-536. 1421. Fowler KJ. Mann GB. Dunn AR: U&w d ti Murinc Tmnsfor”~@ Growh Partw&lp~ Ge”e with l&, Ly-2. and Fabpl on auwnosonw6. G??mmla 1993. 16:782-784. Geng Y, Lkrry JMJ. Hendrickx J. Cwcke P. Willems PR. Barnard PJ: Mappi” of 1 Urn Phosphoryluc Kbnse Alpha-Subunit Cknc on the Moue XChromosome. G&m& 1993, 15:191-193. Goulding M. Sterrcr S. Fleming J. Balling R, Nadeau J. . Moore KJ, Brown SDM. Steel KP, Gruss p: Analysb

&di”~

of disease Gene mapping

in the mouse

drhcPar-3GcncinthcMouxMutanrSpkWb. ce?wmlO 1993. 17:355-363. Ill). Gouyon 8. Melanitou E, Richard MF, Rquanh M. Hahn . IH. Guenel JL, Duncnair F. Julier C, Iathrop GM. Boilwd C. Avner P: Gmxdc Analyak d Dhbctcs md 1mlitisinmhlcrspcdhcCmsrd~NNorrObsc Dbbd~ Muse wllh MISS SpCnrr. PtDc Nail Acad Scl USA 1993, 9Ozl87?-1881. [57j. Grimes R, Reddy SV. Leach RJ, Scarcez T, Roodman CD. hkagxhl AY. Ialley PA. Windk JJz A.w@nx”t of Ihe Mouu T-llaiamn~csiayrt Add phosphaasc Gene (Acp5) 10 Ouaaromc-9. Gmomla 1993. l5d21-422. Hamvas RMJ. Larln Z. Bmckdmff N. Rastan S, Lehnch . H. Chanier FL, Brown SDM: YAC aonc Cmt&s Sunoundlng~ZZj*andAJlrLoclm(hcMascX OUW”-. Genontla 1993. 17:52-58. ml. Heard E. Simmlcr MC, L&-in Z. Rougeulle C, Cou”ier 8. . Lehnch H. Avner P: Pbysicrl Mqplq~ md YAC conpig XlSiO”dlCMC3.SC MdkReBionSm x allwmmw. G?nmnks 1993. 15:55+569. 1191. Hinunelbauer H. Silver LM: Hi&Rmoludon Compamdivc Genomks 1993, M~~dMouseChrnm -17. Hoffer MJV, Vaneck MM. Havekes LM. Hofker MH. Fnnlr RR:TheM”uscAwlic.wmub&lGmc-Smrnnr and Exprr+ri”“. &e&?&s 1993,18:37-i2. Hum CR, Gaser DL, Chaplin DD, Pierce JC, Kozak CA: Ch-amosarulLoc.lintimd5M”rineHS?70Gnc Family Membm - Hsp’lOl, Hsp7&22. Hsp70.3, I&701. uld Grp78. Genomfcs 1993. 16:19%198. Jones JM. Albin RL, Feldman EL, Skein K, Schuster TG. Dunnick WA. Collins JT, Chrisp C& Taylor BA. Meiskr MH: nmd2 - 1 New Mouse Mukl d f”baited Maa Neunm Dkasc. Gmmnks 1993. lC669-6m. Kelly CL, Hinsdale ME, Wxd PA: a and ourrcccrinti~“fthcMO”5C~~ACyl. cd DehydragcNx CDNA . sbm canmlmladon. Genomlcc 1993. 18:137-140. Kingsley DM. Bland AE. Gnrbber JM. Marker PC, Russell l * LB, Copland NG. Jenkins NA: The Mouse rborl J&w SkeknlMorphq)nwdrLocusbA.wchudwilh DdecmlnrBoneMoqhqmedcMcmbudthc TGpeSuw. Ceu 1992. 71:399-i10. [521. Kingsmore SF, Walson Mb Seldin MF: ccmic Mappin# dtheHi&NiidryNcrveGrcwthPlclarRecqtar Gene. Ntil, 1” MCIUU --Rkflkpon. c2?mmla 1993. 17794-795. Li K. Chrisdam, AM. Copeland NC. Gilben DJ. Chu ML. Jenkins NA. Uillo J: EDNA ami”8 md avamvrml Mnpp~dtheMouu~VUCdlqmGcnc ol7al) - Evidmcr fa Rapid 8volum Divcgcrm d the Gene. Genomlcr 1993, 16:733-739. Luongo C. Gould KA. Su LK. Kinder KW, Vq@lei” 8. Diehich W, Ian&r ES. Moser AR: Mlppine d Multipk 1ntesd”al Neoplasia (mi”) 10 Roximid -18 d ti Mouse. Cpnomfcs 1993.15z3-8. Malo D, Vidal S. Lieman JH. Ward DC. Glos P: Pbyrkrl lk8neatim of the MInimal ovammrml Sqmmt Ea~comwwinn the Mutine HOM Re&unce -WT. Ge?lnnlrcr 1993, 17rti7-675. Marini JC. Nelson KK. Balky J, Sincun LD. The Pi~uiury HcmnonesAr&ineVwxncs& Ncumphydrr ll md Oxyw&Neumph;sirrl Show aosc u with lnlcrkukin-1 on Marv auomosmw-2. G?nomlcr 1993, 15:2c&202. Mallei MG, Bruce 8. Kanenly G: M”ux+h,l l)pe V Collrgol Gene Maps to the [AZ-B] Rgion d Chrunmanc-2. Gennmlcr 1993. 16:78&788. Mielnicki LM. Elliott RW. Pmill SC: Lcalizatim d the Murinc Acdvadn8 Tnnscripd”” Fxmr-4 Gau to Mou5camnl -15. G?nomlcs 1993, 11:1¶-199. Miller MW, Duhl DMJ. Vrielin8 H. Codes SP, Olkmnn MM. l * Winkes BM, Barsh GS: aon@ d dw Mow -cl Geac Redkm a .5eucNd mndn llbiq”ltoudy Exprcss.wdinMiccOryingthclcdnIycUau Mutation. Genes aa, 1993.73454-467. [So]. Miaawedl AE. alm” MP, Reeves RH: Hi&t&wltio” Mlppin8 d DI6Lcd.I, Cm. Gas.+ Ox, PqM, a”d&?onDiaaMMourc auanosanc-16. G?nm?llcr 1993. 17:382-386. Morahan G. R&x S: Locpuntio” d tbc M”mu Na+/H+ ExchaIl8erGcneoIlDbml m. Genomk.9 1993, 15231-232. Morris DJ. Adler ID. Robinson TJ: Sonwk Cdl Hybrid Mappin@ on Mowc Chmmaurmc- 11
483

484

Genetics

of disease Gene

mapping

in other non-human

A.%lgMU”tddUGCIKtOOUO”lI-a0sc Evdutlonary Rclrdonship to Gxnpkmcnt Factor-H. Genantfa 1993, 15535-542. O’Brien SJ. Wonwck JE, Lyons LA, Mwre KJ. Jenkins NA. Copcla”d NG: Anehucd lkfauwx LOCI for Gmpmw.lvc Gcmmc h(rppins in Mammals. Nalurc G&f 1993. 3103. Poner’BE. luaice Ml. Cooeland NC. knkins NA. Hunter DD, ticrlic JP. &-&JR: S& . Map& to Mouse Chrcin~9 and Ikprasion in Ihc linked Mutsmz TFppy and Ducky Short Gmummicatlon. Gwomlcs 1993. 16278-281. Rawll”~p DJ. S&a” DC, Tsukada S, largacspada DA, l Crkmldi JC. Cohen L, Mohr RN, Baran JF, Howard

Mice. SC& 1993, 261:358&l. 1451. Rikkc DA, Pinto LH. Corin MB. liardies SC: Mus Spmus spccmc UNBI DNA FnJhcs AppIkd 10 the aoning or chc Murinc Rarl Leas. Gmomfcr 1993.15291-296. Takahashi N. Ko MSH: The Short 3’End R&n of canp*mcn~ DNAs as FCR.Bz?ed po)ymorphk Markers la an Expmssicm Map d mC Mouse Gcnanc. Genomfcs 1993. 16:161-168. Tavabch# M. Read AP, Newlon VE, Harris R. Balling R, l GNS P, Stnchan T: Waardenhurg’s Syndrome Rtkms have Mutadons I” Ihe Human Hamologuc of ti Par-3 F’akd Box Gmc. Nafun? 1992,3553635-636 1401. Taylor BA. Rcwe L, Grleco DA: lhc MEV Ma6~ Iinkag Test@ Stock. Mqping 30 N-1 Pro&d lnvniolrr and Espblihmcnt da” hnpw+cd Stock. Gencmtfcs 1993, 16:380-394. Taylor RG. Grieco D. Clarke GA. Mcinnes RR, Taylor BA: Idmdlicadm of Ihc Muado” in Muhe H&ddi”r”da (hLs) and Gmcdc Mapping of the Mwinc Hi&id&w bcus wan On chmnl-10. Gewrnfcr 1993. 16231-240. Thomas JD. Sidcras P, Smilh CIE, Vorechovsky I, l Chapmn V, Paul \vE: Cdocalindon d X-Linked eulinmir and X-linltcd Imnumod8icicncy Gems. sck??Ke 1993,26l:355-3YJ. 1461. Tsui Mz, Tsui HW, Mok S. Mlinaric I. Copeland KG. Gilbert DJ. Jenkins NA, Sirninovitch KA: MokcuIv Charxtaintio” and Mappine of Mudnc Gmcs Encoding 3 Mcmhcrs d the Sw6” h”lily d cyJtci”c Racinrrc I”hibira-3. Genomfcc 1993, 15507-514. V&l SM. Malo D. Vegan E. Skamenc 8. Gras p: Natural l . It&smcc 10 I”fccfi0” tilh 1nuacc8uhI Rnritcs: lsdrdo” of 1 Camndatc fix R-g. cau 1993.73:469-w5. 1511. Xia YR. Bachinsky DR. Smhh JA. McCluskey RT, Warden CH. Lusis AJ:- Mapping d dx Glycopmuin330 (GoNO) Gene to Moue Chrcm-2 _ Short Canunudcadon Gmomfo 1993, 17:78&781. Zhou P. Zanelli E. Sman M. David C: Gmcmic Ch’ganiadon and Tw Expression of Mnusc PIVIGene Imp2. Genomfo 1993. 16:664-f!&.

. ..

Gene mapping species Related review: (CID 395-400)

in other non-human Mapping

of the pig genome

Andem 1 Archibald AL, Gellin J. khook LB: 1st pig . Gem Mq@qq Wadshop fPGM1). 7 Augw 1992. Intcdakcn. Swltrrrhnd. Anfm C&e+ 1993. 24:2OCr216. t37l. Bcnoni L. Allolini C. Sinxi S. Giulono E: Localintion of lhCClllncsCnYnnaCADGC”CRcvnLrHOmOIOgy lktwcc” HCl~ran-2p and Chkxsc Hynncr 7a. G?nomfcs 1993. 16:77+781. Burkin DJ. Mo& HG. Broad e; Pear@z PD. Ansari HA. Lewis PE. Jones c: Mrpph?# the Sheep Gcnomc Pmducdon of chanad zcd sheep x tl!mlsler Cc8 Hybrids. Genomfcs 1993. 36466-472. Ciclh GT, Rapt JP, Wang JM. Sdezl” E. Ng SC, Kunz Tw: Unkagc of 11&cta.Hydroxykisc Mutadons with ARcred StcmidBiosynlhaira”dBloodPrewurcinIhc~ Rat. Na4unz Grief 1993. 3346-353. Clamp PA. Fckcs R. Shalhew D. Bcevcr JE. Nat E. Schook LB: unkqs Rchdomhlps lknvcc” AWL, EN01 . GPI. PGD. and TGFBl m pacinc Chrcinosan~b. Genomfcs 1993; 17~324-329. Deukl T, Golla A, lies D. Meindl A, MeRinger T. . Schindelhauer D. De Vrks A, Pongralz D. MacLennan DH. lohnson KI. Lehnunn-Horn F: Evkkncc for G&k Hctm<y d Mdignant Hrparhcmw Suxrppwlity. An#[email protected].

WI. Dubay C. Vincent M, Samani NJ, Hilbcn P, Kaiser MA, tkrcssl JP, Kolekvtsev Y. Beckmann JS. Soubrier F, Sassard J. lathmp GM: Genetic -ants of IXaudkmdPuIscRcssurcMap~oDUlacntl&i” Lyon Hypetunsirc Rats. Naltm? GentI 1993, 3~354-357.

species . Genetics

of human

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Nalwc?

1992, 2:128-131. [241. Smilh SA. Easlon DF, Ford D, Pelo J, Anderson K, Averill D. Slralton hi. Ponder M, Pye C. Ponder BAJ: Gcnctic Hciety and Loalindon d.a Familial m. OvariariCrnmCmmavanoMnnc 17ql2q21. Am I Hun Gener 1993. 52:767-776.

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disease

Wlliman Cl+ Sever CE. Pallavicini MC. Hatada H. Tanaka N. Slovak ML. Yamamolo Ii. Hamda K. Mcckcr TC. Lisl AF. Tzmirmchi T: D&don of IRFI. Ma~oinn ,o&& 5q31.1 in Human L&a& and Frckukcmic Myclodyspluir S&we 1993, 259-71. Yamammo T, Nakamura T. Noble NA. Ruoslahli E. Border WAz Expmssion of Transforming Growth Faaor&m k Ekvatcd in Human and Expa+wnul Dbbcdc Ncphmpathy. Pmc N/J// Acal Scf IJ S A 1993. ~1814-1818. Ye BH. Lista F. Lamm F, Knowles DM. Offit K. Chaganti RSK, Dallafavcn R: Allcntions da Zinc Fingr EnmdhP Gem. Lu2.4. in lxoiL5e Lvgccll Lymph&a. Science 1993. 262747-750. Ycung RS. Buemw Ktl. Tesla JR. Knudson AG: Swcepdbilily 10 Raial Carcinoma in the Eker Rar Invulvcs a Tumor suppwsor Gcnc al ChmmIO. l4uc Nat/ AC& SC1US A 1993, 90~8038-8042. Zhou J. Mochizuki 1; Smccts Ii. Antignac C. lauriln P, lk~epe A Tryggvason K, Rwders ST: Dcktiun d the Paid AlphaixIy) and Alpham Col@n GIKS in lnhedrcd Smooth Murk nmwrs. Sclnrce 1993. 261:1167-1169. Ziegler A, LetTell DJ. Kunaki S. Sharma I-IW, Gailani M. Simon JA, Halperin AJ, Bade” HP, Shapim PE. Bale AE, Brash DE~Mutaion Hotspas Due 10 Sunli&l in Ihc P53 Gaw d N-lanoma Skin Cancers. Prw Zimmcrmann W, Bender E. Rohde K. Reis A, Wirman R. Fulreal A. Krause Ii. Pmkooh Ii. Wcmer S. Scherneck s: link& Amlysis k G&an Bkr Can&f Families with Fdy Onsn d ti Discuc. Usiw Hi&ly Polymorphic Markers horn Ihe Chmm-l7ql I924 Region. AmJ Hum GeneI 1993.52789-791. Zou 2. Anisowicz A, Hendrix MJC. Thor A. New” M. . Sheng S. Rafidi K. Sefmr E, Sager R: Maspin. s Sapin with nmwursUpprcssing Activity in Human Mammary Ephhclial GUS. Sckwce 1994. 263:526-529. [741.

Animal

models

of human

disease

Related reviews: Murine genetic models of human disease (pp 453460); Transgenic and knockout models for studying diseases of the immune system (pp 461-465)t Adachi M. Walanabefukunaga R. Nagala S: Abemnr Transcription Caused by tic Insada, of a” Early Tnnrpowbk Eknwm in an lnuon of Ihc Fas hdgcn Gene d Lpr Mice. PIOC Nafrl Acad Scl US A 1993.90:1756-1760. Aldrovandi GM, Feucr G. Gao LY, Jamieson 8. Kfisleva M. Chcn ISY, Zack JA: ‘fix SODhu Mow as a Makl for HIV-1 Infection. Nafure 1993, 365732-736. Akon EWPW, Middleton PG. Caplen NJ, Smilh SN. Slcel DM, Munkonge FM, Jeffcry PK. Geddcs DM. Han St. Williamson R. Fasold KI. Miller AD. Dickinson P, Slevenson BJ, Mclachlan G. Dorin JR. Poneous DJ: Non4nvasivc Uposo~Mcdia~cd Gene Delivery canGxrcaLhelonTnnspor8D&ctinCysdcFibmsk Mutant Mice. Nature rk=nd 1993, 5:135-142. Boulechfar S. Lamoril J. Montagurelli X. Guenc~ JL. Deybach JC. Nordmann Y. Dailey H. Gmndchamp 8. i)eve&uil H: Fumchrlalasc Suucnvll Mucan; @ech(mlPas)) in Ihc House Mmnc. Genomla 1993. 16x54%48. Brenner S. El@r G. Sandford R. Macrae A. Venkawsh B. Apaticio 5: Chamauintiun d the Puff&sh (yupu) Gnome u a Cmnprc~ Model Vertcbn~ Gmomc. Nalum 1993. 36626’r268. Brcslow JL: Tram~nic Mouse Mud& of tipoprotcin Mcubolkm and AthemcM. Rut Narl Acmi Scl US A 1993, 9&8314-6318. Dueler H, [email protected] A, Sailer A, Grciner R-A, Auknried . P, Ague1 M. \Veissmann C: MiCc Devoid of Rp ax rtcdsunt (0 Saapic. cell 1993. 7331339-1347. 1101. Bullman SJ. Michaud EJ. Woychik RP: Molecular oUncvrindm d the Mouse Agwti Locus. Cd 1992. 71:119Cr1204. Campbell IL. Abraham CR, Ma&ah E. Kcmpcr P, In&s JD. Oldslone MBA. Mucke L: Neumio& Disease induced in Truwgcnic Mice by cclrbral Overorpraj~n d lnm-kuki&. Fnx Nail Acad Scl US A 1993. 9aloG61-10065. Cauanach BM. BarrJA. Evans EP. Buncnshaw M. lkechey CV, Leff SE. Bnnnan Cl, Copcland NC. Jenkins NA. lones I: A &&iLtc Mouse Model for Frxkr-WU i)ndnunc Wldd~ Shows a” Abscncc “f Snrpn Expr&shm.Naiure GeneI 1992. 2:27&274. Chidambanm A. law IC. Ferrcll RE: Diffcrcncn in Hypcrv&ilify $&ii Ihc Rcdncblvlo~ Gene in di Gmt Apa. Gi’non~f~ 1992, 14:lIl2-11 I3 Chin H. Krall M. Kim HL, Koclk CA, Mock B: The Gxc fur Ihc Alphal.SubunR of Ihc Skckul Musck

Dihydmpyridinescluidve Calcium Channel (Cchlla3) Mms to Mouse auumosomc I. Gmomlcs 1992. I4:ioR9-lc?x. Chipman SD. Swccl 110. Mchride DJ. Davisson MT, Marks SC, Shuldincr AR. WasImp RJ, Rowe DW. Shapiro Ilk Dckctivc Prcai~hrUD Collaucn Svmhcsis in a kcccssivc Mutation in Mire . a &ki of Human Ostcogencsk Impafccla. Pnw Null Auwl Scl US A 1993,90:1701-1705. Choi TK, llolknbach PW, I’cnmn BE. Ueda RM. Wrddell . GN. Kunhan CG. Woodhouse CS. Kny RM. Lorin~ JF: Transgcnic Mice Conwining a Human Heavy Chain Immunoaldwlin Gene Pnamcnc CImcd in a Yeast Ardhcii Uuomosome. N~/~rc &nel 1993. 4:117-123. [SRI. Clarke AR. Gledhill S, Hwpcr ML, Bird CC, Wyllic AH: . p53 Dcpcndcncc d Early Apopmtic and Pmliindw Rcsponxs Whhin Ihc Mouse Intcsdnc Followinp y lmdiadon. chm3gf3wI (in Rcss):. 1371. Clarke AH. Purdic CA. Harrison DJ. Morris RG, Bird CC, l * I-looper ML. Wyllie AH: Thymucyw Apuplosk lndurcd by P53-Dcpcndcnl and lndcpoldcnt Pathways. Na!rrre 1993. 362:84+S52. 1341. Cole F, Collard JF. Julien JP: Pm@rssivc Ncumnopalhy in Tnnsgcnic Mice Expmssing Ihc Human Ncurufilamcn~ Heavy Gcnc . I Mouse Model cd Amyovophic lacnl Sckrosb. Cdl 19933.73~35-46. Cox GA, Cole NM, Mltsumnn K, Camphell KI: Fwlkner l JA. Chamberlain JS: Ovcrapmssion of Uysvophin in Tnnsgerdc mdr Micr Eliminaws D)%mphic Symptoms Withma Toxichy. Nafwe 1993, 3&1:72%729. 141. Crosby JL. Vamum DS. Nadcau JII: 2.Hit Ma*1 for Sporadic Gngcnhal Anmalks in Mice wilh rhc Dkoq@vtion Mutation. Ant J llrrm Ckwl 1993. 52:l%&a74. Cultal Cr, Swbbs L. Nicholls RD. Monlgumety CS. Russell LB, Johnson DK. Rinchik EM: Concordance Lkrwccn Isolated Cleft Fatarc in Mice and Ahcndons W&bin 1 Regi0” hC1”di”,3 the G-CM Encodi~ Ihc Bclti3> Subunit of the TypeA Gammahminoburyric Acid Recepmr. /4uc NatI Acarl Scl US A 1993, 9Q510~5109. De@wyon B. Melanilou E. Richard MF, Hequanh M. Hahn II-I. Guenet JL, Dcmcnais 11Julia C. lalhrop GM. Boitsrd C. Avner P: Gcncdc Analysis of Diabcla and lnsulitis in an lmcrspccihc Guss uf Ihe Nunobcx Dkbcdc Mouse wilh Mw-Sprrrur. Pmc Narl Acal Scl USA l99j.9o:lB77-18Hl. E2aki 0. Florcsrivcras JR. Kae~lncr KII. Gwrhan J. lane MD: Regulated Expression of an Insulii-Rcsponsivc Glucusc Tmnsponcr (GLUl’4) Minigcnc in 3T3L.I Adipucyacs and Trrnsgrnic Mice. Pmc Null Acti Scl US A 1993. 9&3348-3352. Gacnslcr KML. Kkamun M. Kan YW: Germ-Line Transmission and DevelopmcnLal Regulation d 1 150&b Ycul Anititial Chmmosomc Containing the Human BctaClobin Locus in Tnnsgcnic Mkt. Fnx NallAcarlSclUSAl393,W:llLI-11385. Garibaldi M. Mancnli G. Canzian F. Falvclla FS, Radicc MT. Pieroui MA. Dellarxlna G. Binelli G. Draaani TA:. A Major Su&dbility Locus 10 Murinc L& Carcinogmcsis Maps on Chmmosmnc.6. Nature C&net 1993. 3~132-136. Gudfrcy P, Rahal JO, Bcanlcr WG. Copeland NG. Jenkins NA. Mayo KE: GHRH Rcccptor uf Liuk Mice Conlainr a Mkscnx Mulation in Ihc Extncellulu Dmnain that Disrupls Rcccplor Puncdon. Nal~wc Cew11993, 4:227-2j2. Condo Y. GardnerJM. Nakatsu Y. Durhampierre D. Dcvcau SA. Kupcr C. Brilliam MH: High.Fmqucnry Gaelic Reversion Mediated by a DNA Duplication - Ihc Mouse Pink-Eyed Urwabk Mutation. /4w Narl Acad SC{US A 1993, 90~297-301. Cowerman J. Woods A. Larson L. Wcincr LP. Hood 1 lalier DM: Trmsgcnic Mice lhar Express a Myclin Basic Rocci~S~~ciiic TCCII RCCCD~OTDcvcloo S~onlv~ws Au~oimm~nity. Gil l99j. 72:551-560. . . tktx J. Gerard RD: Admoviru+Mcdialed Transfer of Low Density Lipapmwin Receptor Gene Acutely Acccknto Chukstcrol Clearance in Normal Mice. ProcNa/lAcarlScfUSA1~3.90:2812-2816. Ho DY. Mucarski FS, Sapolsky RM: ARcring Central Nervous System Phvsioloev wilh a Dcfccdvc Heroes Simpkx V&s V&r Ex&ssii~ Ihc Glucose Tnnsponcr Gene. Pnx Nail Acati SC1US A 1993. 903655-3659. Hodgkinson CA. Mcorc KJ. Nakayama A. Sleingrimsson E. Copcland NC. Jenkins NA. Amhciter H: Mutations al Ihc Mouse Micmphlhalmia Locus ue Associated with Dcfeas in a Gene Encodina a Novel Basic-Hclix.Loop Helix-Zipper Rolein. Ceil l-993. 74:395-404. I-IotTer MJV. Vaneck MM. Havckes LM. Hokcr MI-I. Franu RR: Suucrurc and Expmsion of dx MWSC Aputipopncin C2 Gene. Ge?mmlct 1993, 17:45-51. Iioma&s~G~. Snrhh TJ. Zhang Sll. Lcr D. Yang SC. Macda N: Targeted Madifindon of chc Apulipopmwirr B Gnc Rcsul~ in Hypobaalipoprotcincmla and

Genetics Dcvclapmmul Almomulitks in Mice. I4vc Nafl Acad .%I lJ S A I993. 90:2%9-2j93. llui CC, Joyncr AL: A Mouse MC&I of Grcig Gpbalopoly%yndactyly syndmmc - lllc Extn-tooo) Mutation Contains an lntngcnic Deletion of Ihe Gli3 Gene. Narure Gnef 1993. $241-246. llkobovits A. Moore AL. Gwen LL. Vcrpan GL. Mavnard. Cunic &. Austin tiA, Klaphoiz S:‘&mt&x ’ limsmirrion and Expression of a HumanDcrivcd Ycvt Artikial Chmmosome. Nalum 1993, 362:255-258. 1571. Januni JL. Azrolan N. Oconncll A. Aaltcactzda K. B~slow JL: Cbvrctcrinlicm of Ihe Moue Apolipopmwin Apol-I/Apoc-3 Gnc Locus. Gcnmnic. Mcsscngcr RNA. and Pmtcin Scqumces wid~ Compariwns to other species. Grnonlfcs 1992. 14:lwll-IOtlBHR. Jcwcn NA. Rodriguez ML, Garvcy JS. Miller CA, llwd I.: Tmsgcnic Mouse Model for Neurcaistopatby Schwamwmas and Facial Bone Tumors. /4w Naff ,jcad Scl USA 199). w:j192-jl%. Kaufman DL. ClawSalzer M. Tian J. Forsthubcr T. . Ting GSP, Robinson P, Atkinson MA. Scrcar~ EE. Tobin AJ, Lchmann PV: Spontanmus Loss OlTCell Tolmncc to Clutamic Acid Decarboxylvc in Murinc Insulin-Dcpmuknl lXabctes. Nalrrn? l99j. j66z69-72. 1521. Kay DG. Gnvcl C. Pothicr Ii Lapcnicn: A. Robilailk Y. Jolicazur P: Ncumlaginl Dixvc Induced in Tnnsgcnic Mice Expressing dx Em Gene of dw CuBr-E Muinc Retmvkus. Pmc Null Acarl SC/ 0 S A I99j. 90:45jR-4542. Kemp CJ. Donehower L. Bradley A, Balnmin A: Reduction . of P53 Gale Dosag Does not 1nClCasc lnitiatiml or Promotion Rut Fnlunccs Malignant Progrc&on of Chcmicatly Induced Skin mmors. Cell 1993. 74:glj-822. i3ll. Kinioh K. Kvoaoku M. Good RA: Gncdc Sckction ’ for t&&l, Formation Yiildr MOLLY strain widl Rapidly Pmgmssivc Glanauloncphritis and Small Vessel Vaxulitis. Pmc Narl Acorl Scl US A IS9j. 9ozj4l>j417. Koprowski H. Zheng YM. Hchrkalz E. Fmscr N. Rorkc L. 1% %F, Hanlon C. Dietzschold it: lnvivo Expmssion of Inducibk Nitric Oxide Syndwc in Experimentally Induced Ncumlogic Diseases. Pmc Nail Acad SC1US A Wlj, 9o:jU24-j027. Kuhn R. Lohler J. Rennick D. Ra@vsky K. Muller W: l * Intcrkuki~lOIkticknt Mice Develop Chronic Entemolids. Cell 199j. 75263-274. [l’lt) Kulksmi AD. Huh CC. Becker D. Gciscr A, Lyght M. Flanders KC, Rolxns AR. Span MB. Ward JM, Karlsson S: Trutsforming Gmwb Factor-beta1 Null Mutation in Mkc Cauus Excessive lnftammatory Rcsponrc and Early Dcalh. Pm NoI/ Acti Scl 0 S A 1993.90370-774. Kulkami All. Huh C-G. Becker D, Geiser A, Lyght M. . Flanders KC. Roberts AD. Sporn MB, Ward JM. Karlsson S: Tnnsfotig Gmwtb Factor PI Null Mutation in Minx Causes Ewxssivc Inflammatory Response and Early Death Pmc Nail Atal Scl USA 1993. 90370-774. 119*1. Lamb BT. Sisodia SS. Lawlcr AM. Slunt IIH. Kilt CA, Kcams WC. Pearson PL. Pricp DL. Gcarhan Jo: Intrcduction and Expression of dtc 400 Kilobuc Rccwsor Amyloid Rotein Gene in Transtwnic Mice. NaIrre Gina l%J3. 5:22-29. Lcguuis H. Cohensalmon M. DclcasUllo I, Lcvillien J. Capy L, Momon JP, Petit C: Cbvactai?aticm d rhc Chicken and Quail Homologua of dtc Human Gene Rcsponsibk for the X-linked Wlmarm Syndrome. GRlOrnlcF 1993, 17:516-518. I.ipcs MA, Rosennveig A. Tan K-N. Tanigawa G. ladd D. Scidman IG. Eisenbarth GS: Romwsicm to Dtabctcs in Non&& Diabdc (NOD) M&with Transgcnic T Gil Rcccptws. Sclertcc 1993. 259:1165-l 168. Liu JP, Baker J. Perkins AS, Robcnson EJ. Efstratiadis A: Miax Carwing Null Mutationr of the Gcncs Encadin~ lnsul~w;c &cwh Factor-1 (lgf-I, and Type-1 ICF .. Receptor Ogflr). Cdl 199j. 75:59-72. Liu ML. Gibbs EM, Mccoid SC. Milici AJ, Stukenbmk HA, Mcphcrson RK. Treadway JL. Pcssin JE: Trans@znic Mice Expressing dtc Human GLUT4/?4usck-Pat Facilitative Glucose Transpcacr Protein Exhibit E&km Glyccmic Control. I+oc Nat/ Acad Scl US A 1993, w:l134~11350. Lotem J. Sachs L: Hcmatopoktk Glls from Mice Dcticicnt . in Wil&Typc P53 11c Mmc Resistant to Inductim of Apoptosis by Some Agznls. Hiowl l99j. 82:1092-10%. 1351. Law C. Yoneda T. Boyce BF. Chcn tl. Mundy GR. Soriano I’: Ostmpctmsis in SrcDuicknt Mice is Due to an Au~ommous Dcfca of Ostcoclats. Pmc Null AC& Scf US A l99j* 90:44gW4li9. Lowe SW. Ruley HE, Jacks T, Hmwman DE: ~53 l * Dependent Apoptosi!i Modulates Ihc Cylotoxicity of Anticmccr Agcnls. Cd 199j. 74:957-967. 13g1.

;

of disease Animal

LoHv SW, Schmitt EM, Smith SW, Osborne BA. Jacks T: ~53 l * Is Rcquifrd for Radiation.lnduccd Apoptosls in Mouse Ihymocyws. Nalum 1993, 362817-849. 1331. lawll BB. Susulic VS. Hamann A. Lawills IA. HimmsI-la& J. Boycr B’B. Koak Lg Flier JS~dcvelopmcm of obesity in Trmsgcnic Mice atier Gmctic Ablation of Brown Adipose Tii. Nalum 1993, 36674&741. Lubahn DB. Moyer JS. Gelding TS. Cousc JF, Konch KS. Smithies 0: Ahetxkm of ftcpmducdw Ftmcdon But “M Prenatal sexual Dcvclopmcnt after JnscnioNl DLwpdom of the Mouse Estrogen Receptor Gene. Prw Nall Acad Scl US A 1993. 9o:lI162-1 II66 Macicjcwskiknoir D. Jirikowski GF, Sanna PP, Bloom FE: Reduction Of ExOgrnous Vvopressi” RNA Poly(A) Tail Length Inarrvs Its Effcctivcncrrr in Transkmly Correcting Diabctcslnsipidus in dtc Bmtdebom Rat. Pmc Nall AcadSci IJSA 1993, %14j+l439. Msrotti KR. Castle CK, Boyle TP, Lin AH. Murray RW, Melchior GW: Scvcrr Alhcmsckrosis in Tmnsgmic Mice Expressing Simian Chokstcyl Ester Transfer Protein. Nolure 1993. 364:7?-75. M;m J: Neurobiology. New Lead to an Alzbcima’s Mouse. Sclcr~e 1993, 261:1520. Mxyadas TN. Johnson KC. Hayburn H. llynes RO. Wagner . DD: lrukocytc Rdliig and Extrwuation arc Scwmly Compromised in P Sekct&Ddicknt Mice. cell l99j, 74:541-554. 129t1. McWhir J. Selfridgc J, Harrison DJ. Squirts S. Melton DW: . Mice with DNA Repair Gene (ERccf) Dchcicncy have Ekvated Levels of P53. Liver Nuclar Abnamali&!s and Die Before Waning. NINure Ceaef 1993, 5:217-223. 1401. Mcrrit AJ. Pollen CS, Kemp CJ. Hickman JA, Balnwin A. . Lane DP, Hall PA: The Role of P53 in Spontaneous and Radiation-Induced Apoptosis in the Gastmintadnal Tract of Normal and P53 Dcficicnt Mice. Cancer Rs 1994. 54:611-617. [?A]. htichalska AE. Chow KHA: Targeting and -line Trmsminicm of a Null Mutation at dx Mctallodtiawin I-Loci and I&Loci in Mouse Pnx Nalf Acad SC/ US A I99j. 9o:RaY%SQ92. Miller RD. Ozaki Jl I. Riblct R: The Mouse Scwrc Ccmbincd Immune Dcfickncy &id) Muution is acecly Unkcd to the BGII-Spccifac Dcvdopmcntal Gates VpmLt and Lambda-S. Gmomlcs 1993. 16:74&744. Minu B. Silvws WK: Tnns@c Moue Model of Maligaunt Skin Melanoma. Rx Nail Acad Scl 0 S A 1993, 9o:BH17+BZl. Mintz B. Silvers WK. Klcinszanto AJJP:Histqntbogrnal of Malignant Skin Melanoma Inducrd in Gmcdcrlly Swxptibk Tnmgaic Mice. Rvc Nor1 Awd Scf US A l99j. 9OSR22-8826. Mombaens P, Mizoguchi E, Grusby MJ. Climcher LH. Bhan AK, Toncgawa s: Spontanats Dcv&pmcnt d lntlammatw Bowl Disease in T Ccl1 Rccaxor Mutant Mice. Cdl l’%3, 75275-282. [St]. . Naash MI. Hollyheld JG. Alubaidi MR. Baehr W: Simulation of Human Autascmal Dominant Rctiniti.+Pigmattosa in Tnnsgcnic Mice Expressing a Mutated Mtuinc Opsin Gnc. l4uc Nat/ Acad Scl US A 1993, 90:5499-5503. Nlkata K. Ono K. Miyazaki J. Olsen BR. Mungaki Y. Adachi E. Yamamurd K. Kimura T: Ostecarduitir Associated with Mild Cbondralysplvia in Transgcnic Mice Expressing Alpha-IO Cotlagcn Cbains widt a Centi Dcktion. Fnx Nat! Acad Scf US A 1993. 9xxn&zBI4. Mtkatsu Y, Tyndak RF, DeLorcy TM. Durham-Piem D. GardnerJM. McDanel HJ. Nguyen Q. Wagstaff J. Lalande M. Sikela IM. Olsen RW. Tobin Al. Bdlliant MH: A O&r Orilu& GABA a-Rcrcptc&btmit Gncs is Deleted in a rntm@ical Mutant of tbc Mouse P Locus. Na/ure 1993. m44g-449. Nwisawa S. Smans KA. Avis J. Hoylaens MF, Millan JL: Tmwgmk MiCc Expressing tbc nmor Marker Grm Gil Alkalii Pharphatasc - a” Inviva lItmax M&l for Human Canca Antigens. Fmc Nail Acad Scl 0 S A 199j. 90:5txl-5085. Nasonburchcnal K. W&T L: Activation of Cmyb is an Evly Bone-Mmw Event in a Muhe M&l far Acute Pmmonocylic Lakmia. PKK Nail Ad Scf U SA l99j3. w:l6l~l62j. Parsons WJ. Richardson JA, Graves KH. Williams RS. Morcadith RW: Gndicnts of Trawgcnc Exprrssim Dimcld by the Human Myoglcbin Remoter in Ihc Dcvcloping Mouse Hart. Pros NatI AC/& Scf 0 S A I99j. 9Or172617jO. 1Sttcrson DF, Pcxicder T. Schnln Wit. Navratil T, Alaili R: A Single Major-Grnc Dcfcct Undcdying Cardiac Con-cl3 Malformations lnlerfcrn with Mytxwdlal GroPnh During Embryonic Dnclopncnt _Studies in tbcCTDLincdKcc?hondDogs.AmJHum~ l99j, 52:jw-j97. Pexson BE, Choi TK: Expmssion of dx Human Lkta amyloid Pmausor Protein Gene from a Yea Ardticial Chromaromc in Ttans~ic Mkt. Fmc Nalf Acaf Scf U SA I99j. w:lG57.%lO5t32.

.

models of human

disease

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,

inticaosurcolrkslanrl

l

chlwn--gthc~vccawconfus

Copy Number Dcpmuknt Exparssion in Tmns&rnk Mke. Nolure 1993. 362~258-261. [II. Shackleford GM, MacArthur CA, Kwan H. Vamws HE: . Mouse Mammary lbmour Vii ldectlon Accekntes Mammary Carcinogmsb in Wm.1 Tmnsgcnk Mice by lnscrtional Actlvatim of fnt-UPsr-j and HsvPgf-4. Proc Narl Acad Scl USA 1993. w:74&744. 1211. Shehce WR. Oliver P, Smithies 0: lethal lhaluscmia after l lnsntional Dis~ption d dtc Mow Majar Adult IkUGlobln Gnc. Rx Nail AcadScl USA 1993, 90377-mm. [III. Shull MM. Omxsby I. Kicr AD. Pawlowski S. Diebold RJ. . Yin M. Allen R. Sidman C, Pretzel G. Calvin D. Et AL: Tygctcd Disruption d the Mouse Tmnsfwming GmwIh FactorB Gene Restda in Muldfcal lnftammatay &case. Na/ul~ 1992.35969+599. [Elf]. Siracusa LD, Christner P, Mcgrath R. Mowers SD, Nelson KK. Jimcnez M: Tbc light Skin t.Tsk) Mu&on in tbc Mouse. a Model for Human Fibrotic Discas, is Tigltdy linked to the ecu(~Micm@c4ulin (T&t) Cm on Cluunosanc2 _ Short Communkatian. G?nomlcr 1993, 17:74t?-751. Sligh JE. Ballantyne CM, Rich Ss. Hawkins HK. Smith . CW. Bradley A, Beaudet AL: InOammatory and Immune Responses arc Impaired in Mice Ikticknt In lntcrrclltdu Adhesion Mokcuk I. t’mc NoI1 Acad Scf USA 1993, 90:852~533. [Ztlf]. Smcync RJ, Vendrell M. Hayward ht. Baker SJ. Miao GC, . Schillina K. Robertson LM. Curmn T. Moman II:

conunuouJ c.JTn Expmsim

RmdQ

RGgiakd

GU Death ha Wvo. Nolure 1993. 363:166-169. [19]. Smil JJM. Schinkel AH. Elferink RPJO, Gmen AK, Wagenaar E, Vandccmter L, Mel CAAM. Ottenhoff R. Vandedugt NMT. Vanroon MA, Vandewalk MA, Ofkrhaus GJA, Bcms AJM. Bon1 P: Homazygcw DLwuption of ti Mwlnc Mdr2 PGlycqmwin Gene Lads to a Gxtmkcc Abscncc of Pbosnhdipid from Etik and to tiwz-Dlseasc. cell 1993,7j:451>62. Smithies 0: Animal M&Is of Human Gmctic Diwua. l 7Fem&Genecl993.9.112-116. 121. Stewan TA. Hultgren B. Hung X. Pittsmcek S, Hully J. Maclachlan NJ: Induction d rupc-l Diabetes by lntcrfcron-alptu in mw+~mic Mice. Scfence 1993. 2bckl~942-,946

495

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Genetics

of disease Gene therapy

. Clinical

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Sci

Gene therapy Related review: (DIJ 466471)

Cystic

fibrosis

gene

therapy

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Naiun?

genetics -comno” or*

lo” lkamspmlkrccl in cystic

Fibcask Tran?+$“k Micr by Gene Therapy. NOIUIV 1593. 362:25&254. 1421. liao S. Gurevich V. wlff IA: LoneTerm Correcdun c4 Rat &dcl d Fxrl&c&Diulu by Gene Therapy. Nalurc 1993. M2:4SM52. Kay MA. Rothenbcrg S. Linden CN, Bcllingcr DA, Lcland F, Tontm C. Finegold M, Thompson AH. Read MS. Brinkhous KM. WOO SLC: 1” vi” Ckr~ Tharu~ of HanophU~B~ Sustai”cd pucial Carrccdo” i” FactorIX-Dcfacknr Dqs. Scierrce 1993. 262:117-l 19. Lisricwicz J. Sun D. Smythc J. lasso P, Lori F, Louie A. Markham P, Rossi J. Reilz M. Gallo RC: lnh~bitiun of Huntan fmmun&hciency Virus Type1 Rcplimtio” by Regulated Expression da Polynxric Tat Activation Response RNA Decoy as a Strategy fur Gcnc Thcnpy in NIX. Prac Nail Acad Sci S A 1993.9o:~xM. Mmx J: Gnctic Diraxs - I 1st Step Toward Gene Therapy for HnnoohilhB. Sclpnce 1993.262~29-30. Mulligan RC: The Bait Scicrvx d Gene Therapy. Sclnce 1993. 26&92&932. Sly Ws: Gmc Therapy on dx Sly. Nalure Gcnef 1993, 4:105--106. Wilson JM: Cysdc Fib&s - Vchickr fur Gcnc Thharpy. Naiure 1993. 365691492. irnbner J. Coulure L& Gregory RJ. Graham SM. Smith AE, . . wish JM: AdcnovirWMdatd Gc”c Transfer Tnndcndv rZamxts tbc Chloride Tranmor tDcrccti” Nasal Epi&lia uf Padents wirh Cystic ~bmsis. Cell lB3, 75:207-216. (24). Zabner J. Pelerscn DM, Puga AP, Gmham SM. Cculurc IA. . Kcycs LD, Lukason MJ. 51 George Jh. Gregory RJ. Smith AE. Welsh MJ: Safety and FRicacy of Rcpctitivc AdcnwirusMcdklcd Tran&r of (FI11 CDNA to Nrway Epitbelii uf Prinxua and Cuuon Rats. Nuhrre Genei 1994. 6:7583. 1251. Zhu N. Liggil D, Liu Y, D&s R: Syxtemic Gene Exprasiun l after lnvavmaus DNA Delivery into Adull Mice. Sckrtcpl993, 261:209-211. 1371.

..

..

11

Clinical

genetics

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Aldhous P: Malaria - Focus on Mcsquiro Genes. 1993, 261:546548 Arngrknsson R. Purandare S. Connor M. Walker JJ. Bprnsson S. Soubricr F, Kowknscv YV. Geirsson RT, Dpmsson H: Angiu~cnsinogcn . a Candidarc Gene lnvohrd in Pmckmpsk IL.mcrl. Nuirrre Genei 1993. 4:114-115. Barbour AG. Fish D: The Biulc&al and Social Fhc”amao” d Lynlc Diiasc. Sclewc 1993, 260:16x-1616. Bckensrein JW, Lothman Ev: Damancy d lnhibitury lntcmcuronr in a M&l uf TnnporaJ Lobe Epilepsy. Scierr~ 1993, 259:97-100. Benson MD, Liepnieks J. Uemichi T. Whcckr G. Corrca R: Hcrcdiraty Renal Amyloidusis Associated witi a Mutant FibrinAlphaChain. Narure G&c/ 1993, 3~252-255. Bcrnhagcn J. Calandra T. Miwhell RA. Martin SB. Trxey KJ. Vceker W. Manoguc KR. Ccranli A, Bucala R: MIP k a Phuitary-Daivcd Cytokinc rhat Futentiarcs Lethal Endotoxacmk. Naiurc 1993, 365756-759. Blccher SR: Anwlugcnin Gem and Sexual Dimorphism of Tcah in Hunvans and Mice [Luff]. Am J iium GeneI 1992. 51:1451-1452. Boilcau C, Jondcau G. Babron MC. Coulon M. Alexandre JA. Sakai 1 Melki J. Delorme G. Dubourg 0. Bonailipcllie C. Buurdarias JP, Junk” C: Autcwrnd Do”luu”r Marfan-like connccd~.Tll DkoKkr with Aordc Dikdun and Skeletal Anomalies not linked to the Fibrillin Gaxs. Am J fium Genei 1933. 55465.1. Brady STt Motor Ncumns and Ncumfilamcnts in Sickness and in Hrrlrh. cell 1993.73:1-i). Carslea ED, Polymeropoulos MCI. Parker CC, Cctcravadkigh SD, Oneill RR. Palwson MC, Goldin E. Xiao H. Suaub RE. Vanier MT. Brady RO. Pentchev PC: linkage of Nicnwnn+ick Discasc rypeC to Hunran Chmmusomc. lR.hxNallAc&iSciiJSA 1993,90:2002-2004. Chance PF, AlderJon MK. Lcppig KA, Lensch MW, Mmunami N. Smkh B. Swanson PD. Odelbcrg SJ. Disleche CM, Bird TD: DNA Deletion Ass&ad whh Hcrediury Ncumparhy wRh Liability to Erasure F-al&s. cell 1993.72:143-151. Chelly J. Turner 2, Tonnesen T, Peuerson A. Ishikawabrush Y, Tonunerup N. Horn N, Monaco AP: lsuladon uf a’ CAndidate Gene for Makes Disease tit E”cwks a Fmcntial Heavy Metal Binding Pmwin. Nolure G&ret 1993,3:14-19. Chenevixucnch G. Jones K. Green AC. Duffy DL. Manin NG: Ocn Lip with or without OCn Rlalc . A.ssodatiw with Tmrwfwrning Gruwh Factor-Alpha and Rainoic Acid Receptor Loci. Am J Hum G=?IPI lS92. 51:1377-13ll5.

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