Geranyl oxyacetaldehyde

Fragrance raw materials monographs

789

GERANYL OXYACETALDEHYDE Synonym: Geranoxy acetaldehyde. Str~wture: CH3- C(CH~):CH'[CH ,]2 "C(CHj):CH -CH 99O" CH2 "CHO. Description m~d physical pr,.:pertws: A eolourless viscous liquid. Occt~rret,ce: Has apparently not been reported to occur in nature. Prep+~ratio,: Analogous with the preparation of cilronellyl oxyacetaldehyde (Arctander, 1969). Uses: In public use since the 1950s. Use in fragrances in the USA amounts to less than 10001b/yr. Concentration in final product t~ Usual M :tximum

Soap 0.01 0' 1

Deter~lent O-001 0.01

CreanL~,h~tions 0-005 0.03

Perfume O-I 0.4

Status Geranyl oxyacetaldehyde is not included in the listings of the FDA, FEMA (1965) or the Council of Europe (1974) or in the Food Chemicals Codex (1972). CAS Registry No, 65405-73.--4.

Biological data Acute toxicity. Both the acute oral LD~e, in rats aod the acute dermal LDso in rabbits exceeded 5 g/kg (Moreno, 1976), Irritt~tioJl. Gcranyl oxyacetaldehyde applied full strength to intact or abraded rabbit skin for 2zl hr under occlusion was moderately irritating (Moreno, 1976). Sensiti'.atio~l. A maximization test (Kligman. 1966; Kligman & Epstein, 1975),was carried out on 25 volunteers. The material (RIFM no. 75-188) was tested at a concentration of 4Y, in petrolatum and produced no sensitization reactions {Frost. 1976).

References Arcta.ndcr, S. (1969). Perfume trod Flavor Chemical~ (Aroma Chemicals). Vol. l, no. 1428. S. Arctander, Montclair. NJ. Council of Europe (1974). Natural Flavouring Substances, Their Sources, and Added Artificial Flavouring Substances. Partial Agreement in the Social and Public Health Field. Strasbourg. Flavoring Extract Manufacturers' Association (1965l. Survey of flavoring ingredient usage levels. Fd Technol., Champaign 19 (2[ part 2, 155. Food CVwmical~ Codex (19721. 2nd Ed. Prepared by the Committee on Specifications. Food Chemicals Codex, of the Committee on Food Protection. National Academy of Sciences-National Research Council Publ. 1406. Washington. DC. Frost. P. (1976} Report to RIFM. 3 February. Kligman. A. M. (1966). The identification of contact allergens by human assay. Ill. The maximization test. A procedure for screening and riJting contact scnsitizers. 2. ire'ext. Derm. 47. 393. Kligman. A. M. & Epstein. W. 0975). Updating the maximization test for identifying contact allergens. Contact Derm~aitis l, 231. Moreno. O. M. (1976). Report to RIFM. 13 March,