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Gram-negative bacillary endocarditis. Interpretation of the serum bactericidal test
Prophylaxis
Private urban hospital
The data in 41 cases of tuberculosis admitted to a private urban hospital during 1971-1972 were reviewed to assess the spectrum of disease and the problems created by the closing of sanitoriums. Almost half the cases were misdiagnosed, exposing an average of 35 personnel to unisolated smear-positive patients. Clinical manifestations often were subtle. Transfer to ambulatory care for half the patients was complicated by having different physicians manage their hospital and outpatient care with poor communication between the two. Similarly, slowness in case reporting impaired contact investigation. Improved diagnostic ability, better communication with public health workers and attention to details of transfer to ambulatory care are necessary for effectively integrating the present components of tuberculosis management.
Tuberculosis
Steroid production, plasma renin activity (PRA) and plasma renin substrate (PRS) were measured in eight patients with hypertension due to Cushing’s syndrome of benign origin. Although cortisol secretion was increased in all patients, one patient with a functioning adrenal adenoma had hypokalemia and suppressed PRA. PRA was normal in six patients on an unrestricted sodium intake but markedly elevated in two others on low salt diets. PRS was significantly increased during active disease but decreased substantially with treatment. The absence of uniform hypokalemia and renin suppression indicates that mineralocorticoid production could not account for the increased arterial pressure. It is suggested that gtucocortico&induced hypertension may be initiated by alterations in vascular responsiveness to pressor agents and that elevated PRS may contribute to increased angiotensin formation.
Plasma renin substrate
Plasma renin activity
MacGregor RR: A year’s experience with tuberculosis in a private urban teaching hospital in the postsanitorium era. Am J Med 58: 221-228, 1975.
Cushing’s syndrome 17-Ketosteroids
1975,
Krakoff L, Nicolis G, Amsel B: Pathogenesis of hypertension in Cushing’s syndrome. Am J Med 58: 216-220, 1975.
17-Hydroxysteroids
Hypertension
complicating acute ischemic heart disease. Am J Med 58: 199-268,
Three cases of gram-negative bacillary endocarditis were encountered in 1 year at a Veterans Administration hospital. Serum bactericidal titers were considered necessary to identify inadequate antibiotic regimens or to avoid unnecessary drug toxicity. A detailed study of the interaction of the complement-dependent bactericidal system of serum with eight antibiotics is presented, In the context of the serum bactericidal test, the interaction was additive or synergistic in 15 of 16 determinations indicating the need to include a control study of serum sensitivity of the infecting microorganism in each case.
Serum bactericidal test
PractOlOl was used in the management of ventricular and supraventricular dysrhythmias associated with acute myocardial infarction in 134 patients and in the management of these dysrhythmias in 19 patients with acute myocardial ischemia. Practolol was frequently effective in controlling ventricular dysrhythmias occurring in the first 24 hours after the onset of myocardial infarction and ak0 in controlling the ventricular dysrhythmias which occurred after resuscitation from ventricular fibrillation. It was of particular value when lidocaine in therapeutic doses had been ineffective. There was no correlation between the effectiveness of practolol and the blood concentration of the drug. An adverse effect was the occurrence of sinus bradycardia with or without an increase in the frequency of ventricular ectopic beats. Hypotension occurred in some patients.
Gram-negative bacillary endocarditis
Bryan CS, Marney SR Jr, Alford RH, Bryant RE: Gram-negative bacillary endocarditis. Interpretation of the serum bactericidal test. Am J Med 58: 209-215, 1975.
lschemic heart disease
Allen JD, Pantridge JF, Shanks RG: The effects of practolol on the dysrhythmias
Practolol Dysrhythmias Acute myocardial infarction
Private urban hospital
The data in 41 cases of tuberculosis admitted to a private urban hospital during 1971-1972 were reviewed to assess the spectrum of disease and the problems created by the closing of sanitoriums. Almost half the cases were misdiagnosed, exposing an average of 35 personnel to unisolated smear-positive patients. Clinical manifestations often were subtle. Transfer to ambulatory care for half the patients was complicated by having different physicians manage their hospital and outpatient care with poor communication between the two. Similarly, slowness in case reporting impaired contact investigation. Improved diagnostic ability, better communication with public health workers and attention to details of transfer to ambulatory care are necessary for effectively integrating the present components of tuberculosis management.
Tuberculosis
Steroid production, plasma renin activity (PRA) and plasma renin substrate (PRS) were measured in eight patients with hypertension due to Cushing’s syndrome of benign origin. Although cortisol secretion was increased in all patients, one patient with a functioning adrenal adenoma had hypokalemia and suppressed PRA. PRA was normal in six patients on an unrestricted sodium intake but markedly elevated in two others on low salt diets. PRS was significantly increased during active disease but decreased substantially with treatment. The absence of uniform hypokalemia and renin suppression indicates that mineralocorticoid production could not account for the increased arterial pressure. It is suggested that gtucocortico&induced hypertension may be initiated by alterations in vascular responsiveness to pressor agents and that elevated PRS may contribute to increased angiotensin formation.
Plasma renin substrate
Plasma renin activity
MacGregor RR: A year’s experience with tuberculosis in a private urban teaching hospital in the postsanitorium era. Am J Med 58: 221-228, 1975.
Cushing’s syndrome 17-Ketosteroids
1975,
Krakoff L, Nicolis G, Amsel B: Pathogenesis of hypertension in Cushing’s syndrome. Am J Med 58: 216-220, 1975.
17-Hydroxysteroids
Hypertension
complicating acute ischemic heart disease. Am J Med 58: 199-268,
Three cases of gram-negative bacillary endocarditis were encountered in 1 year at a Veterans Administration hospital. Serum bactericidal titers were considered necessary to identify inadequate antibiotic regimens or to avoid unnecessary drug toxicity. A detailed study of the interaction of the complement-dependent bactericidal system of serum with eight antibiotics is presented, In the context of the serum bactericidal test, the interaction was additive or synergistic in 15 of 16 determinations indicating the need to include a control study of serum sensitivity of the infecting microorganism in each case.
Serum bactericidal test
PractOlOl was used in the management of ventricular and supraventricular dysrhythmias associated with acute myocardial infarction in 134 patients and in the management of these dysrhythmias in 19 patients with acute myocardial ischemia. Practolol was frequently effective in controlling ventricular dysrhythmias occurring in the first 24 hours after the onset of myocardial infarction and ak0 in controlling the ventricular dysrhythmias which occurred after resuscitation from ventricular fibrillation. It was of particular value when lidocaine in therapeutic doses had been ineffective. There was no correlation between the effectiveness of practolol and the blood concentration of the drug. An adverse effect was the occurrence of sinus bradycardia with or without an increase in the frequency of ventricular ectopic beats. Hypotension occurred in some patients.
Gram-negative bacillary endocarditis
Bryan CS, Marney SR Jr, Alford RH, Bryant RE: Gram-negative bacillary endocarditis. Interpretation of the serum bactericidal test. Am J Med 58: 209-215, 1975.
lschemic heart disease
Allen JD, Pantridge JF, Shanks RG: The effects of practolol on the dysrhythmias
Practolol Dysrhythmias Acute myocardial infarction