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Journal of Controlled Release 143 (2010) e1–e6

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Journal of Controlled Release j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / j c o n r e l

Journal of Controlled Release Vol. 143, No. 1, 2010 Contents

COVER STORY Monitoring intracellular degradation of exogenous DNA by FCS and FCCS

p1

Kinam Park

REVIEW Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes

pp 2–12

Geneviève Gaucher, Robert H. Marchessault, Jean-Christophe Leroux ⁎

RESEARCH PAPERS An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation E.E. Paoli, D.E. Kruse, J.W. Seo, H. Zhang, A. Kheirolomoom, K.D. Watson, P. Chiu, H. Stahlberg, K.W. Ferrara ⁎ Combining PET and optical imaging is useful in the assessment and design of temperature-sensitive vehicles by allowing real-time monitoring of both the aqueous core and the lipid bilayer.

pp 13–22

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Contents / Journal of Controlled Release 143 (2010) e1–e6

Effect of temporally controlled release of dexamethasone on in vivo chondrogenic differentiation of mesenchymal stromal cells

pp 23–30

Soon Eon Bae, Dong Hoon Choi, Dong Keun Han, Kwideok Park ⁎

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats

pp 31–37

Hilliard L. Kutscher, Piyun Chao, Manjeet Deshmukh, Yashveer Singh, Peidi Hu, Laurie B. Joseph, David C. Reimer, Stanley Stein, Debra L. Laskin, Patrick J. Sinko ⁎ Passive entrapment due to size of microparticles was determined after IV injection to rats. Size plays a critical role in microparticle biodistribution, suggesting a possible pulmonary targeting route besides inhalation.

Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery

pp 38–44

J.R. Eisenbrey, O. Mualem Burstein, R. Kambhampati, F. Forsberg, J.-B. Liu, M.A. Wheatley ⁎ Drug loaded, echogenic ultrasound contrast agents have been developed and optimized. Doxorubicin was successfully loaded onto poly-L-lactic acid capsules with preservation of their echogenicity, enabling monitored delivery of chemotherapeutics to tumors.

Local controlled release of VEGF and PDGF from a combined brushite–chitosan system enhances bone regeneration Beatriz De la Riva, Esther Sánchez, Antonio Hernández, Ricardo Reyes, Faleh Tamimi, Enrique López-Cabarcos, Araceli Delgado ⁎, Carmen Évora ⁎ PDGF and VEGF loaded brushite–chitosan systems provide sustained GF levels in bone during 2 and 4 weeks, respectively. The effect on bone formation was considerably enhanced with PDGF/VEGF combination.

pp 45–52

Contents / Journal of Controlled Release 143 (2010) e1–e6

Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers

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pp 53–63

R. Chapanian, B.G. Amsden ⁎

Enhancement of TAT cell membrane penetration efficiency by dimethyl sulphoxide

pp 64–70

Hu Wang, Chun-Yan Zhong, Jiang-Feng Wu, Yu-Bin Huang ⁎, Chang-Bai Liu ⁎ Addition of dimethylsulfoxide (DMSO) significantly enhances the internalization efficiency of arginine-rich cell penetrating peptides (CPPs) and fusion protein.

Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics

pp 71–79

Jihua Liu, Hillevi Bauer, Jon Callahan, Pavla Kopečková, Huaizhong Pan, Jindřich Kopeček ⁎ Cell entry and subsequent intracellular trafficking of polymeric drug carriers are strongly dependent on the physicochemical characteristics of the nanocarrier, such as charge and molecular weight.

GENE DELIVERY Assessment of siRNA pharmacokinetics using ELISA-based quantification Eun-Joong Kim, Tae Gwan Park, Yu-Kyoung Oh, Chang-Koo Shim ⁎ Simple and sensitive ELISA-based quantification assay was developed for pharmacokinetics of siRNAs administered in lipoplexes. This assay will be useful for evaluation of siRNA delivery systems from a pharmacokinetic perspective.

pp 80–87

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Contents / Journal of Controlled Release 143 (2010) e1–e6

Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice

pp 88–94

Ji Hoon Jeong ⁎, Sun Hwa Kim, Minhyung Lee, Won Jong Kim, Tae Gwan Park, Kyung Soo Ko, Sung Wan Kim Polyethylenimine(PEI)-mediated delivery of Fas siRNA protects NOD mice from cyclophosphamide-induced insulitis and diabetes.

Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds

pp 95–103

Anita Saraf, L. Scott Baggett, Robert M. Raphael, F. Kurtis Kasper, Antonios G. Mikos ⁎

Monitoring intracellular degradation of exogenous DNA using diffusion properties

pp 104–111

Akira Sasaki, Masataka Kinjo ⁎ Our method using noninvasive monitoring of the diffusion properties of DNA provides information on the fate of intracellular exogenous DNA and the efficiency of DNA integration in living cells.

Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle Keiji Itaka, Kensuke Osada, Katsue Morii, Pilhan Kim, Seok-Hyun Yun, Kazunori Kataoka ⁎

pp 112–119

Contents / Journal of Controlled Release 143 (2010) e1–e6

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NANOMEDICINE Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance

pp 120–127

Mariska de Smet, Sander Langereis, Sandra van den Bosch, Holger Grüll ⁎

Novel fibrillar insulin formulations for oral administration: Formulation and in vivo studies in diabetic mice

pp 128–135

Y. Dekel, Y. Glucksam, R. Margalit ⁎

Department of Biochemistry, the George W. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect

pp 136–142

Changyou Zhan, Bing Gu, Cao Xie, Jin Li, Yu Liu, Weiyue Lu ⁎ Paclitaxel-loaded c(RGDyK)-PEG-PLA micelle was developed. It was much effective to the subcutaneous and intracranial glioblastoma models.

New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: Part I — Formulation development and in-vitro characterization Steliyan Tinkov, Gerhard Winter, Conrad Coester ⁎, Raffi Bekeredjian

pp 143–150

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Contents / Journal of Controlled Release 143 (2010) e1–e6

Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100

pp 151–158

Feng Li, Yan Lu, Wei Li, Duane D. Miller, Ram I. Mahato ⁎

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA

Thank you to reviewers

pp 159–163

OTHER CONTENTS Calendar of Events

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⁎ Corresponding author

Cited in: BIOSIS/Biological Abstracts; CAB Abstracts; Chemical Abstracts Services; Current Contents (Life Sciences); EMBASE/ Excerpta Medica; International Pharmaceutical Abstracts; PUBMED/MEDLINE/Index Medicus; Polymer Contents; Science Citation Index. Also covered in the abstract and citation database SCOPUS®. Full text available in ScienceDirect®

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