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Haematological and serum protein changes caused by Trypanosoma vivax infections in East African Zebu cattle
THIRTEENTH SEMINAR ON TRYPANOSOMIASIS
287
Work is going on to compare the sensitivity to Ethidium of T. brucei subgroup organisms isolated from cattle, game and tsetse flies, in order to establish whether this is a general resistance or a resistance resulting from the passage of the strains through cattle. REFERENCES .'Vt.WAMBU, P. M., MAYENDE, J. P. & MASINDE, A. (1970). E.A.T.R.O. Annual Report, 1969,
pp. 128-130. ---& M.AYENDE,J. S. P. (1971). Acta trop., 28, 206. - &- - . In preparation. ONYANGO, R. J., VAN HOEVE, K. & DE RAADT, P. (1966). Trans. R. Soc. trop. Med. ttyg., 60, 175. VAN HOEVE, K. & GRAINGE, E. B. (1966). E.A.T.R.O. Annual Report, 1965, p. 62.
T r a n s m i s s i o n o f Trypanosoma brucei to cats a n d d o g s b y f e e d i n g on i n f e c t e d goats S. K. M O L O O , G. J. L O S O S AND S. B. K U T U Z A
East African Trypanosomiasis Research Organization, Tororo, Uganda Study of the transmission of Trypanosoma brucei to cats and dogs by feeding on infected goats was carried out. 5 goats were infected with T. brucei ( E A T R O 1822) by intramuscular inoculation. 1 month after the parasitaemia was first detected 1 goat was fed every week to 16 cats and 13 dogs. Samples of various tissues of the goats and infected carnivores were examined histologically. T h e prepatent period in the goats was 6 days. Clinically there was no evidence of the disease in the goats and the parasitaemia remained scanty throughout the course of the infection. Very few extravascular trypanosomes were observed. Th e infection was nevertheless transmitted to 3 cats (19%) and 6 dogs (46%). Th e trypanosomes invaded the buccal mucosa and spread to the regional lymphatic system. It is suggested that this oral mode of transmission might be operative in areas where carnivores such as lions and hyaenas are frequently found infected.
H a e m a t o l o g i c a l a n d s e r u m p r o t e i n c h a n g e s c a u s e d b y Trypanosoma vivax i n f e c t i o n s i n E a s t A f r i c a n Z e b u cattle F. K. D A R , J. P A R I S AND A. J. W I L S O N
East African Trypanosomiasis Research Organization, Tororo, Uganda T h e course of infection with 6 East African strains and 1 West African strain of T. vivax was followed, in 1 year-old East African Zebu cattle. All the 7 strains showed a fluctuating parasitaemia with a depression of RBC, WBC, PCV and Hb values, associated with the different waves of parasitaemia. Over the 200 days period of observations, however, there were no overall changes in any of the haematological values, for after each parasitaemic period; recovery to normal and near normal values was rapid. There was no loss of appetite and the animals appeared healthy throughout this period. Compared with the uninfected control group, however, there was no increase in body weight in the experimental group of animals. Initial results of serum protein analyses show that compared to the uninfected controls, there was an appreciable increase in both the IgM and IgG levels in the experimental group of animals.
S o m e o b s e r v a t i o n s on a h e r d o f cattle m a i n t a i n e d u n d e r c h e m o t h e r a p e u t i c c o v e r i n a n a r e a o f h i g h tsetse fly c h a l l e n g e A. J. W I L S O N , F. K. D A R AND 7. P A R I S
East African Trypanosomiasis Research Organization, Tororo, Uganda A herd of East African Zebu cattle has been maintained at Lugala, South Busoga in Uganda, for over 2 years. Groups of cattle were introduced to the challenge area at various times so that to date there are 60 heads, including 9 calves all born at Lugala. These cattle
287
Work is going on to compare the sensitivity to Ethidium of T. brucei subgroup organisms isolated from cattle, game and tsetse flies, in order to establish whether this is a general resistance or a resistance resulting from the passage of the strains through cattle. REFERENCES .'Vt.WAMBU, P. M., MAYENDE, J. P. & MASINDE, A. (1970). E.A.T.R.O. Annual Report, 1969,
pp. 128-130. ---& M.AYENDE,J. S. P. (1971). Acta trop., 28, 206. - &- - . In preparation. ONYANGO, R. J., VAN HOEVE, K. & DE RAADT, P. (1966). Trans. R. Soc. trop. Med. ttyg., 60, 175. VAN HOEVE, K. & GRAINGE, E. B. (1966). E.A.T.R.O. Annual Report, 1965, p. 62.
T r a n s m i s s i o n o f Trypanosoma brucei to cats a n d d o g s b y f e e d i n g on i n f e c t e d goats S. K. M O L O O , G. J. L O S O S AND S. B. K U T U Z A
East African Trypanosomiasis Research Organization, Tororo, Uganda Study of the transmission of Trypanosoma brucei to cats and dogs by feeding on infected goats was carried out. 5 goats were infected with T. brucei ( E A T R O 1822) by intramuscular inoculation. 1 month after the parasitaemia was first detected 1 goat was fed every week to 16 cats and 13 dogs. Samples of various tissues of the goats and infected carnivores were examined histologically. T h e prepatent period in the goats was 6 days. Clinically there was no evidence of the disease in the goats and the parasitaemia remained scanty throughout the course of the infection. Very few extravascular trypanosomes were observed. Th e infection was nevertheless transmitted to 3 cats (19%) and 6 dogs (46%). Th e trypanosomes invaded the buccal mucosa and spread to the regional lymphatic system. It is suggested that this oral mode of transmission might be operative in areas where carnivores such as lions and hyaenas are frequently found infected.
H a e m a t o l o g i c a l a n d s e r u m p r o t e i n c h a n g e s c a u s e d b y Trypanosoma vivax i n f e c t i o n s i n E a s t A f r i c a n Z e b u cattle F. K. D A R , J. P A R I S AND A. J. W I L S O N
East African Trypanosomiasis Research Organization, Tororo, Uganda T h e course of infection with 6 East African strains and 1 West African strain of T. vivax was followed, in 1 year-old East African Zebu cattle. All the 7 strains showed a fluctuating parasitaemia with a depression of RBC, WBC, PCV and Hb values, associated with the different waves of parasitaemia. Over the 200 days period of observations, however, there were no overall changes in any of the haematological values, for after each parasitaemic period; recovery to normal and near normal values was rapid. There was no loss of appetite and the animals appeared healthy throughout this period. Compared with the uninfected control group, however, there was no increase in body weight in the experimental group of animals. Initial results of serum protein analyses show that compared to the uninfected controls, there was an appreciable increase in both the IgM and IgG levels in the experimental group of animals.
S o m e o b s e r v a t i o n s on a h e r d o f cattle m a i n t a i n e d u n d e r c h e m o t h e r a p e u t i c c o v e r i n a n a r e a o f h i g h tsetse fly c h a l l e n g e A. J. W I L S O N , F. K. D A R AND 7. P A R I S
East African Trypanosomiasis Research Organization, Tororo, Uganda A herd of East African Zebu cattle has been maintained at Lugala, South Busoga in Uganda, for over 2 years. Groups of cattle were introduced to the challenge area at various times so that to date there are 60 heads, including 9 calves all born at Lugala. These cattle