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HALOTHANE VS ISOFLURANE IN CANINE ANAESTHESIA
Pnmedinps of the 4th International Conems of Veterinarv Anaesthesia
HALOTHANE VS ISOFLURANE IN CANINE ANAESTHESIA
G. Trucchi, M. Mauthe von Degerfeld and P. Moretta. Department of Animal Pathology, University of Turin, Italy. I. group, while recovery was more rapid in the same group (extubation: 9’ vs 12;sternal recumbency: 25’ vs 36’). The average anaesthetic concentration delivered into the system for maintenance was 15% for either agent (range: H.: 0.9+25; I.: 0.7+2.9). In both groups, males required a non significant slightly higher percentage of drugs than females did. Satisfactory operating conditions were achieved in both groups. Clinical impression did not suggest any difference in muscular relaxation. Either agent seem to behave as a respiratory depressant, but dogs given I. usually breathed at a lower frequency per minute and many showed transient apnoeic period after earlier admiitration of the drug. No remarkable arrhythmias were seen with either agents, even if a more marked cardiac rate increase was constantly seen during I. maintenance. The urine production was similar in both groups (0.7 vs 0.6 ml/kg/h). The patterns of almost all the haematological parameters under investigation were similar in both groups: PCV, Hb, RBC, WBC progressively fell throughout anaesthesia, electrolytes, serum proteins and creatinine concentration remained relatively stable throughout anaesthesia. Some variations were recorded for hepatic enzymes. Glucose concentration values were higher in dogs given H. and in those involved in major orthopaedic surgery, and a similar trend was observed for cortisol concentration. Generally, for the parameters considered, sigoifbnt temporal differences were found within each group, while very few were between groups.
Materials and metbods Two comparable premedicated groups, each of thirty mixed breed and sex dogs of varying ages and weight, scheduled for various surgical procedures, after giving an IV sodium Thiopentone dose sufficient to allow intubation, were adminis-
tered either Halothane (H.) or Isoflurane (I.) delivered into a to-and-fro circuit with soda lime absorption. The mean concentration delivered to achieving surgical anaesthesia was 1.8 % (0.6+3) for H. and 1.6 % (0.9+3) for I. Anaesthesia was maintained with the drug being studied at a clinically estimated equivalent depth, adequate for surgery to be performed. The mean duration of anaesthesia was 84 mins for the H.group and 76 mins for the I. group. Both agents were employed in three dogs being twice anaesthetized. Respuatory rate was recorded before premedication, before induction and at regular intervals during anaesthesia. Heart rate and rhythm were obtained from the recorded ECG. As an indirect tool to measuring blood pressure, the total urine production and specilic gravity were considered. Serial venous blood samples were taken for assay of RBC, WBC, Hb, PCV, total serum proteins, sodium, potassium, calcium, GOT, GPT, gammaGT, GLDH, glucose and cortisol. The results were analyzed for significance by paired and grouped t-test, ANOVA for repeated measures, and Duncan test when appropriate. A level of P c 0.05 was considered sigdicant. Result$ Although induction and recovery times were not significantly different and correlation was not found between their durations in either group, induction time was slightly longer (9’vs 7’) in the
Acknowledgements This study was supported by a grant from M.U.R.S.T.(60%).
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HALOTHANE VS ISOFLURANE IN CANINE ANAESTHESIA
G. Trucchi, M. Mauthe von Degerfeld and P. Moretta. Department of Animal Pathology, University of Turin, Italy. I. group, while recovery was more rapid in the same group (extubation: 9’ vs 12;sternal recumbency: 25’ vs 36’). The average anaesthetic concentration delivered into the system for maintenance was 15% for either agent (range: H.: 0.9+25; I.: 0.7+2.9). In both groups, males required a non significant slightly higher percentage of drugs than females did. Satisfactory operating conditions were achieved in both groups. Clinical impression did not suggest any difference in muscular relaxation. Either agent seem to behave as a respiratory depressant, but dogs given I. usually breathed at a lower frequency per minute and many showed transient apnoeic period after earlier admiitration of the drug. No remarkable arrhythmias were seen with either agents, even if a more marked cardiac rate increase was constantly seen during I. maintenance. The urine production was similar in both groups (0.7 vs 0.6 ml/kg/h). The patterns of almost all the haematological parameters under investigation were similar in both groups: PCV, Hb, RBC, WBC progressively fell throughout anaesthesia, electrolytes, serum proteins and creatinine concentration remained relatively stable throughout anaesthesia. Some variations were recorded for hepatic enzymes. Glucose concentration values were higher in dogs given H. and in those involved in major orthopaedic surgery, and a similar trend was observed for cortisol concentration. Generally, for the parameters considered, sigoifbnt temporal differences were found within each group, while very few were between groups.
Materials and metbods Two comparable premedicated groups, each of thirty mixed breed and sex dogs of varying ages and weight, scheduled for various surgical procedures, after giving an IV sodium Thiopentone dose sufficient to allow intubation, were adminis-
tered either Halothane (H.) or Isoflurane (I.) delivered into a to-and-fro circuit with soda lime absorption. The mean concentration delivered to achieving surgical anaesthesia was 1.8 % (0.6+3) for H. and 1.6 % (0.9+3) for I. Anaesthesia was maintained with the drug being studied at a clinically estimated equivalent depth, adequate for surgery to be performed. The mean duration of anaesthesia was 84 mins for the H.group and 76 mins for the I. group. Both agents were employed in three dogs being twice anaesthetized. Respuatory rate was recorded before premedication, before induction and at regular intervals during anaesthesia. Heart rate and rhythm were obtained from the recorded ECG. As an indirect tool to measuring blood pressure, the total urine production and specilic gravity were considered. Serial venous blood samples were taken for assay of RBC, WBC, Hb, PCV, total serum proteins, sodium, potassium, calcium, GOT, GPT, gammaGT, GLDH, glucose and cortisol. The results were analyzed for significance by paired and grouped t-test, ANOVA for repeated measures, and Duncan test when appropriate. A level of P c 0.05 was considered sigdicant. Result$ Although induction and recovery times were not significantly different and correlation was not found between their durations in either group, induction time was slightly longer (9’vs 7’) in the
Acknowledgements This study was supported by a grant from M.U.R.S.T.(60%).
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