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Handbook of lipid research, vol. 7
Prostaplandm~ Leukatienes and Essential Fatty Acids C1994) 50, 365-366 B Longman Group Lfd 1994
BOOK REVIEWS Synthesis of Selenium - Containing Proteins, Professor Dr A. Bock, Universitat Mtinchen. Germany. Antioxidant Nutrients and Selenium-Iodine Interactions in Human Disease, Professor A. T. Diplock, Guy’s and St Thomas’s Medical and Dental School, England. Desaturation/Elongation of the Shorter-Chain Essential Fatty Acids and its Physiological Implications, Associate Prof. Dr H. Hansen, The Royal Danish School of Pharmacy, Denmark. Metabolic Transformations of PUFAs via Cyclooxygenase Pathway, Dr E. Granstrom, Karolinska Hospital, Sweden. Human Lipoxygenases and Related Enzymes: a Review on Genes, Molecular Structures, and Biological Roles, Prof. S. Hammarstrom, Linkoping University. Sweden. The Non-Eicosanoid Utilisation and Oxidation of Polyunsaturated Fatty Acids, Associate Prof. Dr S. Cunnane, University of Toronto, Canada. Modulation of Eicosanoid Generation by N-3/N-6 Polyunsaturated Fatty Acids, Professor V. A. Ziboh, University of California, Davis, USA. Medical Uses of Essential Fatty Acids (EFAs) Dr D. Horrobin. Efamol Research Institute, Canada. Dietary Fatty Acids and Tumorigenesis. Professor C. Galli, University of Milan, Italy.
Antioxidants, Free Radicals and Polyunsaturated Fatty Acids in Biology and Medicine Edited by A. T. Diplock, J. M. C. Gutteridge, V. K. S. Shukla Published by International Food Science Centre A/S 1993, 233 pages, ISBN: 87-984166-2-6 This book is a collection of papers presented at an international conference entitled Polyunsatured Fatty Acids, Eicosanoids and Antioxidants in Biology and Human Disease held in Copenhagen, 24-28 May, 1993. Antioxidants, free radicals and polyunsaturated fatty acids (PUFAs) are inextricably linked, and of considerable Interest to scientists working in the fields of medicine, nutrition, food technology and the edible oil industry. This conference was conceived as a unique opportunity to bring together scientists from these different disciplines to discuss common problems and new developments and had the aim of convening discussion on the importance of understanding the diverse aspects of the oxidative metabolism and degradation of polyunsaturates (PUFA) in relation to health and disease. 19 eminent scientists provided the theme of this book, and the contents are as follows: Mecnanisms of Oxidation-Autoxidation and Enzymatic Oxictation, Prof. G. Holmer, Technical University of Denmark. The Role of Lipoprotein Oxidation in Atherogenesis, Prof Dr H. Esterbauer, Universitat Graz, Austria. Formation of Haem Protein Radicals and the Implications in Human Disease, Dr C. Rice-Evans, Guy’s and St Thomas’s Medical and Dental School, England. Lipid Peroxidation in Human Low Density Lipoprotein: Interactions between Antioxidants Transition Metals and Lipid Hydroperoxides. Dr V. Darley-Usmar, The We1Icome Research Laboratories, England. BIological Antioxidants and Metal Chelation - An Introduction, Prcjfessor J. M. C. Gutteridge, Royal Brompton National Heart & Lung Hospitals, England. C<)nrparative Toxicology of BHA, BHT and Vitamin F-. Professor Dr H. Kappus. Freie Universitat Berlin, Germany. Design and Development of Therapeutically useful Iron Cheiators. Dr S. Singh, King’s College London, England. Antioxidant Activity of Selenium Dependent Peroxidases: the Molecular Basis of the Synergistic Effect Between Selenium and Vitamin E, Professor Dr F. Ursini, Universita Degii Studi Di Padova, Italy.
Handbook
of Lipid Research, VOL. 7
Series Editor Dr F. Synder Published by Plenum Press 1993, 290 pages, ISBN: o-306-4436 l-9 This new volume of the excellent series Handbook cf Lipid Research is an up-to-date review of mass spectrometry techniques and their application to analysis of selected classes of lipids. Beginning with a chapter that reviews the basic principles of mass analysis using different types of instruments, the book presents two additional introductory chapters dealing with traditional ionization techniques such as electron ionization, chemical ionization, and electron capture ionization, as well as fast-atom bombardment and the recently developed and most promising electrospray ionization. The third chapter discusses sample introduction modes, including direct insertion probes, gas chromatography, and liquid chromatography, and the various interfaces involved. The five following chapters deal with mass spectrometry of different classes of lipids: fatty acids. eicosanoid, 365
366
Prostaglandins
Leukotrienes
and Essential
Fatty Acids
tri-, di-, and monoacyl glycerols, glycerophospholipids, and sphingolipids. Each of these chapters contains specific information on mass spectral data obtained using different ionization modes, as well as discussion on ion chemistry. All chapters are heavily illustrated with mass spectra; schemes depicting fragmentation patterns, rearrangements, and mechanisms of ion formation; and tables. In summary, the book contains an abundance of information on conventional and recently developed instrumentation and techniques for mass spectrometry, as well as descriptions of the reactions supporting the fragmentation of simple and complex lipids. Perhaps the most important feature of this book is that the author has succeeded remarkably in providing a highly informative description of ion chemistry in a style and form comprehensible to scientists with a modest knowl-
edge of chemistry. Therefore, the book has the merit of bringing mass spectrometry within the reach of most investigators in the biomedical sciences who might benefit from this powerful analytical tool. The book provides a review much needed because of the tremendous progress of the field in the last decade; it constitutes an indispensable resource to all persons requiring access to mass spectrometry for solving problems in lipid biochemistry. PIERRE BORGEAT Centre de recherche en Inflammation Immunologie et Rhumatologie Centre de recherche du CHUL and Universite Lava1 Quebec, Canada
BOOK REVIEWS Synthesis of Selenium - Containing Proteins, Professor Dr A. Bock, Universitat Mtinchen. Germany. Antioxidant Nutrients and Selenium-Iodine Interactions in Human Disease, Professor A. T. Diplock, Guy’s and St Thomas’s Medical and Dental School, England. Desaturation/Elongation of the Shorter-Chain Essential Fatty Acids and its Physiological Implications, Associate Prof. Dr H. Hansen, The Royal Danish School of Pharmacy, Denmark. Metabolic Transformations of PUFAs via Cyclooxygenase Pathway, Dr E. Granstrom, Karolinska Hospital, Sweden. Human Lipoxygenases and Related Enzymes: a Review on Genes, Molecular Structures, and Biological Roles, Prof. S. Hammarstrom, Linkoping University. Sweden. The Non-Eicosanoid Utilisation and Oxidation of Polyunsaturated Fatty Acids, Associate Prof. Dr S. Cunnane, University of Toronto, Canada. Modulation of Eicosanoid Generation by N-3/N-6 Polyunsaturated Fatty Acids, Professor V. A. Ziboh, University of California, Davis, USA. Medical Uses of Essential Fatty Acids (EFAs) Dr D. Horrobin. Efamol Research Institute, Canada. Dietary Fatty Acids and Tumorigenesis. Professor C. Galli, University of Milan, Italy.
Antioxidants, Free Radicals and Polyunsaturated Fatty Acids in Biology and Medicine Edited by A. T. Diplock, J. M. C. Gutteridge, V. K. S. Shukla Published by International Food Science Centre A/S 1993, 233 pages, ISBN: 87-984166-2-6 This book is a collection of papers presented at an international conference entitled Polyunsatured Fatty Acids, Eicosanoids and Antioxidants in Biology and Human Disease held in Copenhagen, 24-28 May, 1993. Antioxidants, free radicals and polyunsaturated fatty acids (PUFAs) are inextricably linked, and of considerable Interest to scientists working in the fields of medicine, nutrition, food technology and the edible oil industry. This conference was conceived as a unique opportunity to bring together scientists from these different disciplines to discuss common problems and new developments and had the aim of convening discussion on the importance of understanding the diverse aspects of the oxidative metabolism and degradation of polyunsaturates (PUFA) in relation to health and disease. 19 eminent scientists provided the theme of this book, and the contents are as follows: Mecnanisms of Oxidation-Autoxidation and Enzymatic Oxictation, Prof. G. Holmer, Technical University of Denmark. The Role of Lipoprotein Oxidation in Atherogenesis, Prof Dr H. Esterbauer, Universitat Graz, Austria. Formation of Haem Protein Radicals and the Implications in Human Disease, Dr C. Rice-Evans, Guy’s and St Thomas’s Medical and Dental School, England. Lipid Peroxidation in Human Low Density Lipoprotein: Interactions between Antioxidants Transition Metals and Lipid Hydroperoxides. Dr V. Darley-Usmar, The We1Icome Research Laboratories, England. BIological Antioxidants and Metal Chelation - An Introduction, Prcjfessor J. M. C. Gutteridge, Royal Brompton National Heart & Lung Hospitals, England. C<)nrparative Toxicology of BHA, BHT and Vitamin F-. Professor Dr H. Kappus. Freie Universitat Berlin, Germany. Design and Development of Therapeutically useful Iron Cheiators. Dr S. Singh, King’s College London, England. Antioxidant Activity of Selenium Dependent Peroxidases: the Molecular Basis of the Synergistic Effect Between Selenium and Vitamin E, Professor Dr F. Ursini, Universita Degii Studi Di Padova, Italy.
Handbook
of Lipid Research, VOL. 7
Series Editor Dr F. Synder Published by Plenum Press 1993, 290 pages, ISBN: o-306-4436 l-9 This new volume of the excellent series Handbook cf Lipid Research is an up-to-date review of mass spectrometry techniques and their application to analysis of selected classes of lipids. Beginning with a chapter that reviews the basic principles of mass analysis using different types of instruments, the book presents two additional introductory chapters dealing with traditional ionization techniques such as electron ionization, chemical ionization, and electron capture ionization, as well as fast-atom bombardment and the recently developed and most promising electrospray ionization. The third chapter discusses sample introduction modes, including direct insertion probes, gas chromatography, and liquid chromatography, and the various interfaces involved. The five following chapters deal with mass spectrometry of different classes of lipids: fatty acids. eicosanoid, 365
366
Prostaglandins
Leukotrienes
and Essential
Fatty Acids
tri-, di-, and monoacyl glycerols, glycerophospholipids, and sphingolipids. Each of these chapters contains specific information on mass spectral data obtained using different ionization modes, as well as discussion on ion chemistry. All chapters are heavily illustrated with mass spectra; schemes depicting fragmentation patterns, rearrangements, and mechanisms of ion formation; and tables. In summary, the book contains an abundance of information on conventional and recently developed instrumentation and techniques for mass spectrometry, as well as descriptions of the reactions supporting the fragmentation of simple and complex lipids. Perhaps the most important feature of this book is that the author has succeeded remarkably in providing a highly informative description of ion chemistry in a style and form comprehensible to scientists with a modest knowl-
edge of chemistry. Therefore, the book has the merit of bringing mass spectrometry within the reach of most investigators in the biomedical sciences who might benefit from this powerful analytical tool. The book provides a review much needed because of the tremendous progress of the field in the last decade; it constitutes an indispensable resource to all persons requiring access to mass spectrometry for solving problems in lipid biochemistry. PIERRE BORGEAT Centre de recherche en Inflammation Immunologie et Rhumatologie Centre de recherche du CHUL and Universite Lava1 Quebec, Canada