- Email: [email protected]
HAV IgG Status in Cirrhotic in A Tertiary Care Setup Coastal Region of South East India
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
NAFLD. Only the primary caregiver that is, the immediate family member who spent the most time with the patient was included. Caregiver burden was assessed by the Zarit Caregiver Burden Interview (ZBI) scale. Socio demographic variables and clinical variables including age at onset of the illness, duration of the illness, reason for admission, model for end-stage liver disease (MELD) score, CHILD status were compared. Results: Baseline characteristics of ALD (n = 25) and NAFLD (n = 25) patients were comparable. Mean age of the caregivers in ALD was 39 ± 7.6years. 21 females (84%), spouses 18 (72%). In NAFLD group mean age of the caregivers was 44 ± 9.4 years. 20 females (80%), spouses 15(60%). We observed a significantly higher caregiver burden in ALD compared to NAFLD (45.0 ± 9.7 vs 25.95 ± 14 t = 5.64, P = 0.00) and in ALD group a significant higher burden was observed when the care giver was not the spouse (t = 3.97, P = 0.001) Conclusion: Primary caregivers of patients with ALD have significantly higher caregiver burden compared to NAFLD. Among caregivers of ALD patients, burden is significantly higher if the care giver is not the spouse.
Results: Till now 22 patients were studied from March 2017. ALD was the commonest etiology. Followed by HCV and NASH. HBV was less common. More than 70% are males. Childs B status was more common, followed by child A. One patient, alcoholic cirrhotic, tested negative for HAV IgG antibodies. None of the age matched controls were negative for antibodies. Further data need to be collected. Conclusion: Though the general consensus is that Indian adults are immune to hepatitis A infection it is prudent to test for antibodies especially in cirrhotics and vaccinate them if no protective antibodies are found especially when planning for liver transplant.
CONFLICTS OF INTEREST
http://dx.doi.org/10.1016/j.jceh.2017.05.125
PREVALENCE AND PATTERN OF SPONTANEOUS BACTERIAL PERITONITIS (SBP) ITS MICROBIOLOGICAL PROFILE AND ITS COMPARISON WITH NON-SBP IN CLD PATIENTS
38
Dheeraj Jeswani ∗ , Goldie Longjam
HAV IGG STATUS IN CIRRHOTIC IN A TERTIARY CARE SETUP COASTAL REGION OF SOUTH EAST INDIA
E-mail address: dj [email protected] (D. Jeswani).
Srinivas Nistala Apollo Hospitals, Visakhapatnam, India
E-mail address: [email protected]. Background and Aim: The natural history of a cirrhotic patient can be altered by many factors both external and internal like bleeding, SBP, superimposed viral infections etc. Vaccination can prevent superimposed acute hepatitis B and hepatitis A. Studies in the past have shown that persons beyond 15 years of age in the general population in Indian subcontinent are already immune to hepatitis A, it is not recommended to vaccinate Indian cirrhotic with hepatitis A vaccine as a routine unlike recommendation from the west. Most of the stuides of immune status of HAV in cirrhotics and general population have come from north India or down south. No studies were done in this part of India. The study was done to know the prevalence of HAV IgG status in this part of India and to see if any geographic variation is seen. Methods: 50 consecutive cirrhotics and age matched controls tested for HAV IgG prospectively.
The author has none to declare. http://dx.doi.org/10.1016/j.jceh.2017.05.126
39
SHIJA Hospitals and Research Institute, Imphal West, Manipur, India
Background and Aim: Spontaneous bacterial peritonitis (SBP) is the most common infection of ascitic fluid that occurs in about 10–30% of patients with ascites, mortality rates due to SBP to be as high as 80–90%, but this can be decreased to 20–40% with early diagnosis and effective therapy with broad-spectrum antibiotics. The study was done to evaluate the microbiological profile with sensitivity pattern to aid in empiric therapy and various other correlations. Methods: We conducted analytical cross sectional observational study of 103 CLD patients with ascites (27 SBP) between July 2015 and June 2017 at the SHIJA Hospitals, Imphal. All patients undergone paracentesis prior to antibiotic administration which was sent for analysis along with hematological variables, A unpaired-t test was performed for quantitative data with P value <0.05 as significant using software SPSS version 20. Results: Chronic alcoholism is major etiological factor present in 79.6% cases followed by HCV infection in 22.3% cases while 13.6% cases overlap in both categories. Prevalence of SBP found out to be 26.2% (i.e. 27 cases out of 103), 20 of them were culture negative neutrophilic
Journal of Clinical and Experimental Hepatology July 2017 Vol. 7 No. S2
S67
CIRRHOSIS AND COMPLICATIONS
The authors have none to declare.
CONFLICTS OF INTEREST
NAFLD. Only the primary caregiver that is, the immediate family member who spent the most time with the patient was included. Caregiver burden was assessed by the Zarit Caregiver Burden Interview (ZBI) scale. Socio demographic variables and clinical variables including age at onset of the illness, duration of the illness, reason for admission, model for end-stage liver disease (MELD) score, CHILD status were compared. Results: Baseline characteristics of ALD (n = 25) and NAFLD (n = 25) patients were comparable. Mean age of the caregivers in ALD was 39 ± 7.6years. 21 females (84%), spouses 18 (72%). In NAFLD group mean age of the caregivers was 44 ± 9.4 years. 20 females (80%), spouses 15(60%). We observed a significantly higher caregiver burden in ALD compared to NAFLD (45.0 ± 9.7 vs 25.95 ± 14 t = 5.64, P = 0.00) and in ALD group a significant higher burden was observed when the care giver was not the spouse (t = 3.97, P = 0.001) Conclusion: Primary caregivers of patients with ALD have significantly higher caregiver burden compared to NAFLD. Among caregivers of ALD patients, burden is significantly higher if the care giver is not the spouse.
Results: Till now 22 patients were studied from March 2017. ALD was the commonest etiology. Followed by HCV and NASH. HBV was less common. More than 70% are males. Childs B status was more common, followed by child A. One patient, alcoholic cirrhotic, tested negative for HAV IgG antibodies. None of the age matched controls were negative for antibodies. Further data need to be collected. Conclusion: Though the general consensus is that Indian adults are immune to hepatitis A infection it is prudent to test for antibodies especially in cirrhotics and vaccinate them if no protective antibodies are found especially when planning for liver transplant.
CONFLICTS OF INTEREST
http://dx.doi.org/10.1016/j.jceh.2017.05.125
PREVALENCE AND PATTERN OF SPONTANEOUS BACTERIAL PERITONITIS (SBP) ITS MICROBIOLOGICAL PROFILE AND ITS COMPARISON WITH NON-SBP IN CLD PATIENTS
38
Dheeraj Jeswani ∗ , Goldie Longjam
HAV IGG STATUS IN CIRRHOTIC IN A TERTIARY CARE SETUP COASTAL REGION OF SOUTH EAST INDIA
E-mail address: dj [email protected] (D. Jeswani).
Srinivas Nistala Apollo Hospitals, Visakhapatnam, India
E-mail address: [email protected]. Background and Aim: The natural history of a cirrhotic patient can be altered by many factors both external and internal like bleeding, SBP, superimposed viral infections etc. Vaccination can prevent superimposed acute hepatitis B and hepatitis A. Studies in the past have shown that persons beyond 15 years of age in the general population in Indian subcontinent are already immune to hepatitis A, it is not recommended to vaccinate Indian cirrhotic with hepatitis A vaccine as a routine unlike recommendation from the west. Most of the stuides of immune status of HAV in cirrhotics and general population have come from north India or down south. No studies were done in this part of India. The study was done to know the prevalence of HAV IgG status in this part of India and to see if any geographic variation is seen. Methods: 50 consecutive cirrhotics and age matched controls tested for HAV IgG prospectively.
The author has none to declare. http://dx.doi.org/10.1016/j.jceh.2017.05.126
39
SHIJA Hospitals and Research Institute, Imphal West, Manipur, India
Background and Aim: Spontaneous bacterial peritonitis (SBP) is the most common infection of ascitic fluid that occurs in about 10–30% of patients with ascites, mortality rates due to SBP to be as high as 80–90%, but this can be decreased to 20–40% with early diagnosis and effective therapy with broad-spectrum antibiotics. The study was done to evaluate the microbiological profile with sensitivity pattern to aid in empiric therapy and various other correlations. Methods: We conducted analytical cross sectional observational study of 103 CLD patients with ascites (27 SBP) between July 2015 and June 2017 at the SHIJA Hospitals, Imphal. All patients undergone paracentesis prior to antibiotic administration which was sent for analysis along with hematological variables, A unpaired-t test was performed for quantitative data with P value <0.05 as significant using software SPSS version 20. Results: Chronic alcoholism is major etiological factor present in 79.6% cases followed by HCV infection in 22.3% cases while 13.6% cases overlap in both categories. Prevalence of SBP found out to be 26.2% (i.e. 27 cases out of 103), 20 of them were culture negative neutrophilic
Journal of Clinical and Experimental Hepatology July 2017 Vol. 7 No. S2
S67
CIRRHOSIS AND COMPLICATIONS
The authors have none to declare.
CONFLICTS OF INTEREST