- Email: [email protected]
Health effects of lead at low exposure levels in children
Poster Session 2L Teratology and Reproduction the pulsatile pattern of ACTH. The mean values of ACTH during the bleeding period and the absolute pulse amplitude of ACTH peaks were significantly decreased, whereas a significant increase of pulse frequency of this hormone, by acute cadmium administration, was observed. On the other hand, cadmium administration did not change neither pulse duration nor relative amplitude of the ACTH peaks. These data suggest that acute cadmium chloride administration in adult male rats is followed by changes in the pulsatile ACTH pattern, which might be part of the mechanism to explain cadmium effects on the pituitary-adrenal axis.
Keywords: cadmium; ACTH; pulsatile secretion
The data show that in the area where the traffic is very heavy, tooth lead levels are elevated. Children who live in Ankara have a relatively high degree of tooth lead contamination, particularly in the urban area. These data should encourage Turkish authorities to increase the control of lead emission sources. [1] Brown AA, Taylor A, Analyst, 110, 579-582, 1985.
Keywords: lead; air pollution; deciduous teeth
P2H-2281 ASSESSMENT OF PARTICULATE MATTER AND ATMOSPHERIC MANGANESE IN IRON AND STEEL FACTORY AND BLOOD MANGANESE LEVELS FOR THE EXPOSED WORKERS
]
P2H-2261 HEALTH EFFECTS OF LEAD AT LOW EXPOSURE J
LEVELS IN CHILDREN
Eva ~ovcikova *, Monika Urs2~nyovfi, Ladislava Wsolov~. Institute
of Preventive and Clinical Medicine, Bratislava, Slovak Republic The effects of lead had long been recognized to cause adverse effect on psychic, behavioral activities and others body changes after long exposure to low levels of lead. We selected 395 children aged 9-10 years from Bratislava which is an industrial city with heavy traffic. Blood lead (PbB) level was detected by AAS method. In children were investigated sensomotor, attentional and mental functions; body temperature, systolic, diastolic blood pressure, electrical skin resistance, 2-min continual ecg record; weight, height, thickness of fat layer on arm, under shoulder-blade, health and social history of children was orientated on prenatal and postnatal development and on quality of life of all family. Significantly worse were performed intelligence, memory and attention tests in children with higher PbB (over 40 /zg/L); level of this lead cumulation was manifested also by lower body height, decreasing of body basal temperature. These children were from smoking families and their mothers had lower education. Conclusions: The interaction of psychic, somatic and social variables with PbB is important for the explanation of risk factors influence on development of children living in polluted areas of environment.
Keywords: neurotoxicity; blood lead level; environment
63
Gamal E1 Sarura 1, Alia Abdel Shakour * 2, Ali Nasser 3, Manal Joussef 4. i Faculty of Medicine, Cairo university, Egypt;
2Airpollution department, National Research center, Cairo, Egypt; 3 Military Medical Academy, Cairo, Egypt Particulate matter was measured in the work atmosphere in the different departments of the iron and steel factory most of the industrial processes in iron and steel manufacture produce dust. The dust particles lie within wide range. The maximum concentration of deposited dust (coarse particles) was detected in the sintering section. This may be due to the large amount of coarse particles emitted during the ore crushing processes which easily settled and are collected as deposited dust. The highest concentration of total suspended particulate (TSP) was detected in the atmosphere of the main foundry. This concentration was about fifty time greater than the Egyptian limit value set for TSP (150 ug/m3). Concentrations of manganese were detected in deposited and total suspended particles were precipitated in high rates at the sintering section, where manganese oxide is the main raw material. The concentration of manganese in total suspended particulate matter exceeded the (TIV) recommended for manganese (5 mg/m 3). The blood manganese level was detected in ninety exposed workers and twenty five subjects unexposed to manganese in their workplace. It was found that the normal level of blood manganese was 3.24 ug/dl mean while it was 8.6 ug/dl for the exposed workers,
Keywords: iron and steel; particulate matter; manganese; blood manganese
I P2H-227.1TOOTH LEAD LEVELS OF CHILDREN LIVING IN I I
--
I I
DIFFERENT AREAS OF ANKARA (TURKEY)
Ali Esat Karakaya * J, Asuman Karakaya 2, Tezer Ulusu 3
Department of Toxicology, I Gazi University, 2Ankara University, 3 Faculty of Dentistry, Gazi University, Ankara, Turkey Lead is one of the most common pollutants in the environment and especially dangerous for young children. In Turkey, motor gasoline contains a maximum of 0.5 g lead/L. In Ankara, the effect of this high level of lead emitted into the ambient environment may have increased due to a doubling in the number of vehicles on the road in the last 2-3 years and higher fuel consumption. The present study is a comparison of lead burden of children deciduous teeth collected in suburban and urban areas of Ankara. Shed teeth from 103 primary school children aged 7 to 12 years (53 boys, 50 girls) who have been living in Ankara from birth were collected. Lead measurements were performed with flame atomic absorption spectrophotometer combining the techniques of chelating-extraction and atom trapping [1]. The results show that children from suburban area (n = 49) have a mean tooth lead level of 1.69 4- 0.25 g,g/g, whereas children form urban area (n = 53) have much higher tooth lead levels (4.99 4- 0.46/zg/g). The differences in the group means are extremely significant at the p < 0.0001 level. The average dentin lead concentration of two groups is 3.42 4- 0.31 ~g/g (mean 4- s.c.).
P21. Teratology and Reproduction ~ F I V E
GENERATION REPRODUCTION STUDIES WITH PRODUCT OF BIOLOGICAL INDUSTRY
Vitalija ~imkevi~iene. Institute of Biochemistry, Department of
Bioorganic Compounds Technology, Vilnius, Lithuania Fruitful use of industrial waste requires that it must be applied to local needs. The plant, producing fodder yeast has industrial mud. Specially dried, prepared dry hydrolized mud (DHM- containing protein, mineral salts, vitamins of B groups and others) was obtained from Biochemical plant. Some our previous studies have reported the low toxicity of DHM in animals [1-4] and it can be used as fodder premix with positive effect for animals. The objective of the present investigation was to examine DHM effect for reproductive toxicity on fifth generation rats (Fs). DHM (25% of total protein was replaced by DHM) was administered in mixed feed ration to rats over five generations in chronic experiment. Administration of DHM to rats produced no effect on the percentage of female pregnancy. Duration of pregnancy was 22.5 + 0.2 days for both groups. The number of litters (9-12) and their birth weights (6.5-6.8 g) in the experimental
Keywords: cadmium; ACTH; pulsatile secretion
The data show that in the area where the traffic is very heavy, tooth lead levels are elevated. Children who live in Ankara have a relatively high degree of tooth lead contamination, particularly in the urban area. These data should encourage Turkish authorities to increase the control of lead emission sources. [1] Brown AA, Taylor A, Analyst, 110, 579-582, 1985.
Keywords: lead; air pollution; deciduous teeth
P2H-2281 ASSESSMENT OF PARTICULATE MATTER AND ATMOSPHERIC MANGANESE IN IRON AND STEEL FACTORY AND BLOOD MANGANESE LEVELS FOR THE EXPOSED WORKERS
]
P2H-2261 HEALTH EFFECTS OF LEAD AT LOW EXPOSURE J
LEVELS IN CHILDREN
Eva ~ovcikova *, Monika Urs2~nyovfi, Ladislava Wsolov~. Institute
of Preventive and Clinical Medicine, Bratislava, Slovak Republic The effects of lead had long been recognized to cause adverse effect on psychic, behavioral activities and others body changes after long exposure to low levels of lead. We selected 395 children aged 9-10 years from Bratislava which is an industrial city with heavy traffic. Blood lead (PbB) level was detected by AAS method. In children were investigated sensomotor, attentional and mental functions; body temperature, systolic, diastolic blood pressure, electrical skin resistance, 2-min continual ecg record; weight, height, thickness of fat layer on arm, under shoulder-blade, health and social history of children was orientated on prenatal and postnatal development and on quality of life of all family. Significantly worse were performed intelligence, memory and attention tests in children with higher PbB (over 40 /zg/L); level of this lead cumulation was manifested also by lower body height, decreasing of body basal temperature. These children were from smoking families and their mothers had lower education. Conclusions: The interaction of psychic, somatic and social variables with PbB is important for the explanation of risk factors influence on development of children living in polluted areas of environment.
Keywords: neurotoxicity; blood lead level; environment
63
Gamal E1 Sarura 1, Alia Abdel Shakour * 2, Ali Nasser 3, Manal Joussef 4. i Faculty of Medicine, Cairo university, Egypt;
2Airpollution department, National Research center, Cairo, Egypt; 3 Military Medical Academy, Cairo, Egypt Particulate matter was measured in the work atmosphere in the different departments of the iron and steel factory most of the industrial processes in iron and steel manufacture produce dust. The dust particles lie within wide range. The maximum concentration of deposited dust (coarse particles) was detected in the sintering section. This may be due to the large amount of coarse particles emitted during the ore crushing processes which easily settled and are collected as deposited dust. The highest concentration of total suspended particulate (TSP) was detected in the atmosphere of the main foundry. This concentration was about fifty time greater than the Egyptian limit value set for TSP (150 ug/m3). Concentrations of manganese were detected in deposited and total suspended particles were precipitated in high rates at the sintering section, where manganese oxide is the main raw material. The concentration of manganese in total suspended particulate matter exceeded the (TIV) recommended for manganese (5 mg/m 3). The blood manganese level was detected in ninety exposed workers and twenty five subjects unexposed to manganese in their workplace. It was found that the normal level of blood manganese was 3.24 ug/dl mean while it was 8.6 ug/dl for the exposed workers,
Keywords: iron and steel; particulate matter; manganese; blood manganese
I P2H-227.1TOOTH LEAD LEVELS OF CHILDREN LIVING IN I I
--
I I
DIFFERENT AREAS OF ANKARA (TURKEY)
Ali Esat Karakaya * J, Asuman Karakaya 2, Tezer Ulusu 3
Department of Toxicology, I Gazi University, 2Ankara University, 3 Faculty of Dentistry, Gazi University, Ankara, Turkey Lead is one of the most common pollutants in the environment and especially dangerous for young children. In Turkey, motor gasoline contains a maximum of 0.5 g lead/L. In Ankara, the effect of this high level of lead emitted into the ambient environment may have increased due to a doubling in the number of vehicles on the road in the last 2-3 years and higher fuel consumption. The present study is a comparison of lead burden of children deciduous teeth collected in suburban and urban areas of Ankara. Shed teeth from 103 primary school children aged 7 to 12 years (53 boys, 50 girls) who have been living in Ankara from birth were collected. Lead measurements were performed with flame atomic absorption spectrophotometer combining the techniques of chelating-extraction and atom trapping [1]. The results show that children from suburban area (n = 49) have a mean tooth lead level of 1.69 4- 0.25 g,g/g, whereas children form urban area (n = 53) have much higher tooth lead levels (4.99 4- 0.46/zg/g). The differences in the group means are extremely significant at the p < 0.0001 level. The average dentin lead concentration of two groups is 3.42 4- 0.31 ~g/g (mean 4- s.c.).
P21. Teratology and Reproduction ~ F I V E
GENERATION REPRODUCTION STUDIES WITH PRODUCT OF BIOLOGICAL INDUSTRY
Vitalija ~imkevi~iene. Institute of Biochemistry, Department of
Bioorganic Compounds Technology, Vilnius, Lithuania Fruitful use of industrial waste requires that it must be applied to local needs. The plant, producing fodder yeast has industrial mud. Specially dried, prepared dry hydrolized mud (DHM- containing protein, mineral salts, vitamins of B groups and others) was obtained from Biochemical plant. Some our previous studies have reported the low toxicity of DHM in animals [1-4] and it can be used as fodder premix with positive effect for animals. The objective of the present investigation was to examine DHM effect for reproductive toxicity on fifth generation rats (Fs). DHM (25% of total protein was replaced by DHM) was administered in mixed feed ration to rats over five generations in chronic experiment. Administration of DHM to rats produced no effect on the percentage of female pregnancy. Duration of pregnancy was 22.5 + 0.2 days for both groups. The number of litters (9-12) and their birth weights (6.5-6.8 g) in the experimental