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Heart-valve disease linked to autoimmunity
Journal of Immunological Methods, 28 (1979) 199
199
© Elsevier/North-Holland Biomedical Press
Immunodiagnostic news H E A R T - V A L V E DISEASE LINKED TO AUTOIMMUNITY Sera of a group of patients with cardiac mitral valve disorder gave a positive test for antinuclear antibodies six times more frequently than sera of a matched control group, according to the report of Dr. Candace L. Miklozek and colleagues of the Emory University in Atlanta, presented at a meeting of the American Heart Association in Dallas, Texas, in November 1978.
Vaccination news SYNTHETIC VACCINES ARE FEASIBLE In the first J.T. Baker Nobel Laureate Lecture delivered at Yale University in November 1978, Dr. Christian Anfinsen, chief of the NIAMDD laboratory of chemical biology at the National Institutes of Health in Bethesda, MD, U.S.A., discussed the possibility of using synthetic vaccines against pathogenic viruses. Such vaccines might be prepared by attaching covalently antigenic fragments of viral coat proteins, obtained b y trypsin cleavage, to a multichain lysine-alanine copolymer which is endowed with adjuvant activity. A model of such a synthetic vaccine has been prepared from the coat protein of coliphage MS II.
A vaccine against gastroenteritis has been developed by Dr. Friedrich Dorner of the Sandoz Research Laboratories in Vienna, Austria. He isolate~i the enterotoxin from coli bacteria and converted it into toxoid, a single injection of which is capable of inducing protective immunity in humans.
199
© Elsevier/North-Holland Biomedical Press
Immunodiagnostic news H E A R T - V A L V E DISEASE LINKED TO AUTOIMMUNITY Sera of a group of patients with cardiac mitral valve disorder gave a positive test for antinuclear antibodies six times more frequently than sera of a matched control group, according to the report of Dr. Candace L. Miklozek and colleagues of the Emory University in Atlanta, presented at a meeting of the American Heart Association in Dallas, Texas, in November 1978.
Vaccination news SYNTHETIC VACCINES ARE FEASIBLE In the first J.T. Baker Nobel Laureate Lecture delivered at Yale University in November 1978, Dr. Christian Anfinsen, chief of the NIAMDD laboratory of chemical biology at the National Institutes of Health in Bethesda, MD, U.S.A., discussed the possibility of using synthetic vaccines against pathogenic viruses. Such vaccines might be prepared by attaching covalently antigenic fragments of viral coat proteins, obtained b y trypsin cleavage, to a multichain lysine-alanine copolymer which is endowed with adjuvant activity. A model of such a synthetic vaccine has been prepared from the coat protein of coliphage MS II.
A vaccine against gastroenteritis has been developed by Dr. Friedrich Dorner of the Sandoz Research Laboratories in Vienna, Austria. He isolate~i the enterotoxin from coli bacteria and converted it into toxoid, a single injection of which is capable of inducing protective immunity in humans.