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Hemodynamic and arrhythmogenic effects of ionic and non-ionic contrast agents in the presence of verapamil in the rat heart
IONIC CONT
T~ffiE~I~ EFFECTS IW THE PRESENCE OF
Gary 6~rate~b~ith~ M.D., P.W.C.C. Hospital; Baltimore, MD.
John8
~OPki~5
se reported to be aoeociated ignificant hemodynamic dysfunction and with more than ventricular arrhythmi This is thought to be leaet aid to be ion flux and hemodynamic depression i exacerbated in the presence of calcium blocking agents. To determine if v rapamil (V), alters the responee to these agent& isolated retrogradely perfused, paced rate hearts were exposed to 15.25 r@n~g~~ff~~~~6 (I) or to iopamidol (NI) in standard ?iEES buffer with and without V, 125 ug/L. V itself resulted in a decrease in developed pressure (DP) to 44 + 4.0% of control (n=l2). The addition of I resulted in a further depression of DP to 13 f 1.9% (n=6), whereas the addition of NI resulted in an actual increase in DP to 86.4 + 5% of control (n of 6 hearts When infusion with I alone was terminated, developed sudden ventricular tachycardia, whereas no arrhythmias occurred when I infusion was sltoppedin the preeence of V. None of the hearts infused with WI developed arrhythmias. These results suggest the better hemodynamic profile associated with NI infusion is maintained in the presence of V and tachyarrhythmias associated with the use of I occurring at the washout phase may be mediated by increased trane-sarcolemmal calcium influx. Calcium antagoniste may protect against the development of ventricular tachyarrhythmiae in patients receiving ionic contrast.
c arch
(N=5), inlravenfricular
used to capture each anatomic level at multiple cardiac phases. In selected cases, three-dimensional reconstructions were employed to supplemenl the planar images. played all shunt- or ba
selected anatomic questions lends itself to three-dime assessment of intraabial baf
T~ffiE~I~ EFFECTS IW THE PRESENCE OF
Gary 6~rate~b~ith~ M.D., P.W.C.C. Hospital; Baltimore, MD.
John8
~OPki~5
se reported to be aoeociated ignificant hemodynamic dysfunction and with more than ventricular arrhythmi This is thought to be leaet aid to be ion flux and hemodynamic depression i exacerbated in the presence of calcium blocking agents. To determine if v rapamil (V), alters the responee to these agent& isolated retrogradely perfused, paced rate hearts were exposed to 15.25 r@n~g~~ff~~~~6 (I) or to iopamidol (NI) in standard ?iEES buffer with and without V, 125 ug/L. V itself resulted in a decrease in developed pressure (DP) to 44 + 4.0% of control (n=l2). The addition of I resulted in a further depression of DP to 13 f 1.9% (n=6), whereas the addition of NI resulted in an actual increase in DP to 86.4 + 5% of control (n of 6 hearts When infusion with I alone was terminated, developed sudden ventricular tachycardia, whereas no arrhythmias occurred when I infusion was sltoppedin the preeence of V. None of the hearts infused with WI developed arrhythmias. These results suggest the better hemodynamic profile associated with NI infusion is maintained in the presence of V and tachyarrhythmias associated with the use of I occurring at the washout phase may be mediated by increased trane-sarcolemmal calcium influx. Calcium antagoniste may protect against the development of ventricular tachyarrhythmiae in patients receiving ionic contrast.
c arch
(N=5), inlravenfricular
used to capture each anatomic level at multiple cardiac phases. In selected cases, three-dimensional reconstructions were employed to supplemenl the planar images. played all shunt- or ba
selected anatomic questions lends itself to three-dime assessment of intraabial baf