- Email: [email protected]
High density lipoprotein as a protective factor against coronary heart disease. The Framingham study
Coronary heart disease
Lipids
Fungemia Infectious disease
Neoplastic disease
Leukemia
--
During a 14 month period there were 384 episodes of bacteremia andjungemia at Memorial Sloan-Kettering Cancer Center. In patients with leukemia or lymphoma (group I), Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus were the most frequentty isolatedorganisms. The mortality in this group was 40.5 per cent. In the patients with soI@ tumors (group 2), Esch. coli, Staph. aureus, Bacteroktes sp. and Car&% sp. were most frequent. Mortality was 27.8 per cent. The source of infection in both groups was often indeterminate. Factors of prognostic significance were the causative microorganism, source of infection and shock. The mortality in this series was low considering the severity of the underlying diseases and the immunosuppressed state of many of the Patients. Severe fungal superinfection. predominantly aspergillosis and candidiasis, was found in 52 per cent of the autopsy patients in group 1, but in only 8 per cent of those in group 2.
Singer C, Kaplan MH, Armstrong D: Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases. Am J Med 62: 731-742,1977.
Bacteremle Lymphoma
Fasting triglycerides and high density lipoproteins (HDL), low density lipoproteins and total chol&erof ievels were obtafnedon 2.815 men and ~~49~82y~~~ 1969 and 197 i at Framingham. In the approximately four years following the characterization of lipids, coronary heart diwase developed in 79 of the 1,025 men and 83 of the 1,445 women free of ccronaryheartdiseases. At these ok&r ages the major potent lipid risk factor was HDL cholesterol, which had an inverse association with the incidence of coronary heart disease (p
GorUonT, Castelli WP, Hjortland h4C. Kannel WB, Dawber TR: Hi@ density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 62: 707-714, 1977.
High density lipoprotein Triglycerides
WPW syndrome Tachyarrhythmias 1977.
Prolonged QRS complex A-V node
The diagnosis of hereditary nephritis in the absence of a clear family history or the presence of characteristic ancillary abnormaliiies is difficult, but it has considerable prognostic importance. The recent recognition of an ultrastructural lesion characteristic of this disease, although not present in all families, is of considerable value. This report describes a kindred with the lesion-associated disease that differs from those previouslydescribed in that the lesion developed during the course of the disease, was not present in all affected members and appeared to be the result of paternal transmission.
Beathard GA, Granholm NA: Development of the characteristic ultrastructural lesion of hereditary nephritis during the course of the disease. Am J Med 62: 751-756, 1977.
Renai failure Hereditary nephritis Ultraatructural lesion Basement membrane Protelnurla Hematurla
The preexcitation syndrome, long a medical mystery although known clinically for more than 60 years, is at last appreciated in depth as to its basic mechanisms, rare but serious dangers, and finally, when indicated, its surgical cure.
Ferrer MI: Preexcitation. Am J Med 62: 715-730,
Preexcitation Short P-R interval
Lipids
Fungemia Infectious disease
Neoplastic disease
Leukemia
--
During a 14 month period there were 384 episodes of bacteremia andjungemia at Memorial Sloan-Kettering Cancer Center. In patients with leukemia or lymphoma (group I), Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus were the most frequentty isolatedorganisms. The mortality in this group was 40.5 per cent. In the patients with soI@ tumors (group 2), Esch. coli, Staph. aureus, Bacteroktes sp. and Car&% sp. were most frequent. Mortality was 27.8 per cent. The source of infection in both groups was often indeterminate. Factors of prognostic significance were the causative microorganism, source of infection and shock. The mortality in this series was low considering the severity of the underlying diseases and the immunosuppressed state of many of the Patients. Severe fungal superinfection. predominantly aspergillosis and candidiasis, was found in 52 per cent of the autopsy patients in group 1, but in only 8 per cent of those in group 2.
Singer C, Kaplan MH, Armstrong D: Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases. Am J Med 62: 731-742,1977.
Bacteremle Lymphoma
Fasting triglycerides and high density lipoproteins (HDL), low density lipoproteins and total chol&erof ievels were obtafnedon 2.815 men and ~~49~82y~~~ 1969 and 197 i at Framingham. In the approximately four years following the characterization of lipids, coronary heart diwase developed in 79 of the 1,025 men and 83 of the 1,445 women free of ccronaryheartdiseases. At these ok&r ages the major potent lipid risk factor was HDL cholesterol, which had an inverse association with the incidence of coronary heart disease (p
GorUonT, Castelli WP, Hjortland h4C. Kannel WB, Dawber TR: Hi@ density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 62: 707-714, 1977.
High density lipoprotein Triglycerides
WPW syndrome Tachyarrhythmias 1977.
Prolonged QRS complex A-V node
The diagnosis of hereditary nephritis in the absence of a clear family history or the presence of characteristic ancillary abnormaliiies is difficult, but it has considerable prognostic importance. The recent recognition of an ultrastructural lesion characteristic of this disease, although not present in all families, is of considerable value. This report describes a kindred with the lesion-associated disease that differs from those previouslydescribed in that the lesion developed during the course of the disease, was not present in all affected members and appeared to be the result of paternal transmission.
Beathard GA, Granholm NA: Development of the characteristic ultrastructural lesion of hereditary nephritis during the course of the disease. Am J Med 62: 751-756, 1977.
Renai failure Hereditary nephritis Ultraatructural lesion Basement membrane Protelnurla Hematurla
The preexcitation syndrome, long a medical mystery although known clinically for more than 60 years, is at last appreciated in depth as to its basic mechanisms, rare but serious dangers, and finally, when indicated, its surgical cure.
Ferrer MI: Preexcitation. Am J Med 62: 715-730,
Preexcitation Short P-R interval