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Higher Resting Heart Rate Is Associated With Poorer Spirometric Parameters
Obstructive Lung Diseases SESSION TITLE: COPD I SESSION TYPE: Original Investigation Poster PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
Higher Resting Heart Rate Is Associated With Poorer Spirometric Parameters Aisya Musa MBBCh* Mohd Mohd Zim Mohd Fadzil Norhaya Mohd Razali Jyi Lin Wong Razul Md Nazri Md Kassim Tengku Ismail Mohammed Fauzi Abdul Rani; and Ahmad Ismail UITM, Shah Alam, Malaysia PURPOSE: Resting heart rate is proven to be one of the predictor of mortality in COPD patients (Jensen, Marott et al. 2013). We aim to assess the correlation between resting heart rate and spirometric parameters in a cohort of Malaysian COPD patients.
OBSTRUCTIVE LUNG DISEASES
METHODS: This is a cross-sectional multi-centre study in Malaysia (total of 8 centres) of COPD patients attending a routine clinic visit. A total of 389 stable COPD patients after at least 3 months of an acute exacerbation were included in the study. Their baseline demographics, resting heart rate and post bronchodilator spirometry testing based on ATS criteria were recorded. Patients with known history of ischaemic heart disease or are on beta blockers or any rate modifying drugs are excluded from the study. RESULTS: The mean resting heart rate for this study is 86.81 16.5 beats per minute. The mean for predicted FEV1 is 46.31 16.25% and the mean predicted FVC is 46.31 22.63%. There is a significant negative correlation between resting heart rate and predicted FEV1 (r ¼ 0.140, p ¼ 0.008) and FVC (r ¼ 0.207, p < 0.001) There is a statistically significant difference in both mean predicted FEV1 and FVC when comparing patients with heart rate < 80 beats per minute and those with heart rate $ 80 beats per minute. The mean predicted FEV1 was significantly higher in patients with heart rate < 80 beats per minute as compared to those with heart rate > 80 beats per minute (65.49 22.05% Vs 58.69 22.62%) (M ¼ 6.80, SE ¼ 2.46, t(361) ¼ 2.76, p ¼ 0.006). This trend was also similar for mean predicted FVC in which it was also higher in patients with heart rate < 80 beats per minute as compared to those with heart rate < 80 beats per minute (52.03 20.84% Vs 43.20 19.03%) (M ¼ 8.83, SE ¼ 2.17, t(359) ¼ 4.07, p < 0.001). CONCLUSIONS: The higher the heart rate, the poorer the spirometric parameters in patients with stable COPD. Further analysis revealed that resting heart rate of higher than 80 beats per minute is also significantly associated with poorer spirometric data. These findings may indicate that resting heart rate can be a significant surrogate clinical marker of spirometric parameters. CLINICAL IMPLICATIONS: Further larger studies are needed to explore this relationship and whether reduction in heart rate improves spirometric parameters in COPD patients. DISCLOSURE: The following authors have nothing to disclose: Aisya Musa, Mohd Mohd Zim, Mohd Fadzil, Norhaya Mohd Razali, Jyi Lin Wong, Razul Md Nazri Md Kassim, Tengku Ismail, Mohammed Fauzi Abdul Rani, Ahmad Ismail No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.02.391
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
376A
[
149#4S CHEST APRIL 2016
]
Higher Resting Heart Rate Is Associated With Poorer Spirometric Parameters Aisya Musa MBBCh* Mohd Mohd Zim Mohd Fadzil Norhaya Mohd Razali Jyi Lin Wong Razul Md Nazri Md Kassim Tengku Ismail Mohammed Fauzi Abdul Rani; and Ahmad Ismail UITM, Shah Alam, Malaysia PURPOSE: Resting heart rate is proven to be one of the predictor of mortality in COPD patients (Jensen, Marott et al. 2013). We aim to assess the correlation between resting heart rate and spirometric parameters in a cohort of Malaysian COPD patients.
OBSTRUCTIVE LUNG DISEASES
METHODS: This is a cross-sectional multi-centre study in Malaysia (total of 8 centres) of COPD patients attending a routine clinic visit. A total of 389 stable COPD patients after at least 3 months of an acute exacerbation were included in the study. Their baseline demographics, resting heart rate and post bronchodilator spirometry testing based on ATS criteria were recorded. Patients with known history of ischaemic heart disease or are on beta blockers or any rate modifying drugs are excluded from the study. RESULTS: The mean resting heart rate for this study is 86.81 16.5 beats per minute. The mean for predicted FEV1 is 46.31 16.25% and the mean predicted FVC is 46.31 22.63%. There is a significant negative correlation between resting heart rate and predicted FEV1 (r ¼ 0.140, p ¼ 0.008) and FVC (r ¼ 0.207, p < 0.001) There is a statistically significant difference in both mean predicted FEV1 and FVC when comparing patients with heart rate < 80 beats per minute and those with heart rate $ 80 beats per minute. The mean predicted FEV1 was significantly higher in patients with heart rate < 80 beats per minute as compared to those with heart rate > 80 beats per minute (65.49 22.05% Vs 58.69 22.62%) (M ¼ 6.80, SE ¼ 2.46, t(361) ¼ 2.76, p ¼ 0.006). This trend was also similar for mean predicted FVC in which it was also higher in patients with heart rate < 80 beats per minute as compared to those with heart rate < 80 beats per minute (52.03 20.84% Vs 43.20 19.03%) (M ¼ 8.83, SE ¼ 2.17, t(359) ¼ 4.07, p < 0.001). CONCLUSIONS: The higher the heart rate, the poorer the spirometric parameters in patients with stable COPD. Further analysis revealed that resting heart rate of higher than 80 beats per minute is also significantly associated with poorer spirometric data. These findings may indicate that resting heart rate can be a significant surrogate clinical marker of spirometric parameters. CLINICAL IMPLICATIONS: Further larger studies are needed to explore this relationship and whether reduction in heart rate improves spirometric parameters in COPD patients. DISCLOSURE: The following authors have nothing to disclose: Aisya Musa, Mohd Mohd Zim, Mohd Fadzil, Norhaya Mohd Razali, Jyi Lin Wong, Razul Md Nazri Md Kassim, Tengku Ismail, Mohammed Fauzi Abdul Rani, Ahmad Ismail No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.02.391
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
376A
[
149#4S CHEST APRIL 2016
]