- Email: [email protected]
Highlight section: Copper and zinc in cell signaling and disease
ABB Archives of Biochemistry and Biophysics 463 (2007) 133 www.elsevier.com/locate/yabbi
Guest Editorial
Highlight section: Copper and zinc in cell signaling and disease This Highlight Section addresses the biochemistry of two essential transition metals, copper and zinc, with a focus on cellular signaling processes. Metal-related signaling events are examined at different levels, including signaling processes that affect Cu or Zn homeostasis and processes modulated by exogenously applied as well as by endogenous Cu or Zn ions. We hope that it will become clear not only that copper and zinc homeostasis is tightly regulated but also vice versa that copper and zinc ions serve as signaling mediators, initiating cellular signaling processes that are related to pathophysiological processes and disease. We thank the editors of ABB and the experts in the field who served as reviewers and, above all, we are
indebted to the authors who contributed to this Highlight Section. Elena A. Ostrakhovitch 1 Department of Biochemistry, The University of Western Ontario, 1400 Western Road, SDRI Rm 112, London, Canada ON N6G 2V4 E-mail address: [email protected] Lars-Oliver Klotz * Department of Molecular Aging Research, Institut f u€r umweltmedizinische Forschung (IUF) at the Heinrich-Heine-Universita¨t D€ usseldorf, Auf’m Hennekamp 50, 40225 D€ usseldorf, Germany E-mail address: [email protected]
* 1
0003-9861/$ - see front matter Ó 2007 Elsevier Inc. All rights reserved. doi:10.1016/j.abb.2007.06.008
Corresponding author. Fax: +49 211 3389 331. Fax: +1 519 661 3175.
Guest Editorial
Highlight section: Copper and zinc in cell signaling and disease This Highlight Section addresses the biochemistry of two essential transition metals, copper and zinc, with a focus on cellular signaling processes. Metal-related signaling events are examined at different levels, including signaling processes that affect Cu or Zn homeostasis and processes modulated by exogenously applied as well as by endogenous Cu or Zn ions. We hope that it will become clear not only that copper and zinc homeostasis is tightly regulated but also vice versa that copper and zinc ions serve as signaling mediators, initiating cellular signaling processes that are related to pathophysiological processes and disease. We thank the editors of ABB and the experts in the field who served as reviewers and, above all, we are
indebted to the authors who contributed to this Highlight Section. Elena A. Ostrakhovitch 1 Department of Biochemistry, The University of Western Ontario, 1400 Western Road, SDRI Rm 112, London, Canada ON N6G 2V4 E-mail address: [email protected] Lars-Oliver Klotz * Department of Molecular Aging Research, Institut f u€r umweltmedizinische Forschung (IUF) at the Heinrich-Heine-Universita¨t D€ usseldorf, Auf’m Hennekamp 50, 40225 D€ usseldorf, Germany E-mail address: [email protected]
* 1
0003-9861/$ - see front matter Ó 2007 Elsevier Inc. All rights reserved. doi:10.1016/j.abb.2007.06.008
Corresponding author. Fax: +49 211 3389 331. Fax: +1 519 661 3175.