- Email: [email protected]
Histaminase in the treatment of hay fever
SEIXCTED
631
ABSTRAICTS
vases. The family history was positive in 53 per cent. The pollen sensitivity was that of trees, grass, and ragweeds. Most patients were sensitive to more than one pollen; 20 per cent Caere sensitive to ragweed pollen alone, and (i per cent to timothy alone. The remaining 74 per cent were sensitive to both grasses and WOPdS. Good results in treatment were obtainetl in 80 per cent of the cases; the remaining 20 per cent consistetl of fair results or failures.
Hemp Pollen braska
Sensitivity
State
M.
J.
in Omaha. 25:
190,
Jlnlone\,
13. 8.. nntl Brotlkey,
RI. H.:
Ne-
1940.
Since hemp was introtlucrtl into Nebraska in 3859 in order to produce raw materials for the production of twine, it has groxn wild all 0Ter the state. Consequently, hemp pollen is an important cause of pollen sensitivity in Omaha, and it is estimated that it constitutes about 17 per cent of the pollen in the air during the fall. The periotl of pollination of hemp is from early July through August, terminating about the middle of September. The symptoms of the majority of those sensitive start just before the middle of *July. In a series of 119 testecl cases, the authors found a total of twenty-eight or 2% per vent, giving positire reactions to hemp. Of these twenty-eight persons, eleven reacted to hemp pollen alone, and serenteen rractell to hemp and other pollen. All of these patients had symptoms of hap fever (luring the hemp pollinating season. The eleven patients givin g reactions to hemp alone had symptoms only during the hemp pollinating season, with no increase in symptoms at the onset of the ragweed season. It was noticed that in these hemp-sensitive persons, both testing and treating had to be umlertaken with care, as reactions, both local and general, occurred readily.
Oral Pollen
Therapy
8. M., Foran, J., and Zeller,
in Ragweed
Pollinosis.
A Cooperative
1’. L., Lichtenstein, M. R., Padnos, 11.: J. il. M. A. 115: 23, 1940.
E.,
Study.
Rappaport,
H. Z.,
Feinberg, Sheldon,
A cooperative stutly on the question of the oral treatment of rxgweetl pollinosis was carried out by the allergy clinics of four medical whools-University of Illinois, Northwestern University, University of Michigan, and Rush Medical College. .i total of 130 patients with hay ferrr or asthma were given ragweed pollen in c~apsules, in most cases, lwginning with closes of jO0 pollen units ant1 reaching a maximum dose of from 120,000 to 240,000 units. In some instances doses as high as 640,000 units were reachetl. The treatment in the majority of cases was given preseasonally. Control groups received either plawbo c-apsules, injections of normal salt solution, or standard hypodermic pollen therapy. Although 29.8 per cent of the group receiving oral treatment displayed some degree of bmcfit, 21.9 per Gastrointestinal recent of those receiving placebo capsules were also benefited. actions were frequent. The conclusion is reached that the therapeutic effectiveness of oral pollen therapp IS, at, the highest estimate, of a minor grade, particularly in the control of asthma.
Histaminase 2448,
in the Treatment
of Hay Fever.
l
J.
:I.
hr.
n.
114:
1940.
In a group of fifteen ragwrecl hay fever patients (luring the 1939 ragweed season, histaminasr, in doses of from 45 to 75 units daily, was administered orally. In none of the patients was there any degree of relief other than that attributable to fluctuation in atmospheric pollen concentration. Preseasonal quantitative intrncutaneous tests were made with histamine and compared with the reactions obIn none of these patients xas tained when histaminase therapy was terminated. there an appreciable change in the histamine reaction.
631
ABSTRAICTS
vases. The family history was positive in 53 per cent. The pollen sensitivity was that of trees, grass, and ragweeds. Most patients were sensitive to more than one pollen; 20 per cent Caere sensitive to ragweed pollen alone, and (i per cent to timothy alone. The remaining 74 per cent were sensitive to both grasses and WOPdS. Good results in treatment were obtainetl in 80 per cent of the cases; the remaining 20 per cent consistetl of fair results or failures.
Hemp Pollen braska
Sensitivity
State
M.
J.
in Omaha. 25:
190,
Jlnlone\,
13. 8.. nntl Brotlkey,
RI. H.:
Ne-
1940.
Since hemp was introtlucrtl into Nebraska in 3859 in order to produce raw materials for the production of twine, it has groxn wild all 0Ter the state. Consequently, hemp pollen is an important cause of pollen sensitivity in Omaha, and it is estimated that it constitutes about 17 per cent of the pollen in the air during the fall. The periotl of pollination of hemp is from early July through August, terminating about the middle of September. The symptoms of the majority of those sensitive start just before the middle of *July. In a series of 119 testecl cases, the authors found a total of twenty-eight or 2% per vent, giving positire reactions to hemp. Of these twenty-eight persons, eleven reacted to hemp pollen alone, and serenteen rractell to hemp and other pollen. All of these patients had symptoms of hap fever (luring the hemp pollinating season. The eleven patients givin g reactions to hemp alone had symptoms only during the hemp pollinating season, with no increase in symptoms at the onset of the ragweed season. It was noticed that in these hemp-sensitive persons, both testing and treating had to be umlertaken with care, as reactions, both local and general, occurred readily.
Oral Pollen
Therapy
8. M., Foran, J., and Zeller,
in Ragweed
Pollinosis.
A Cooperative
1’. L., Lichtenstein, M. R., Padnos, 11.: J. il. M. A. 115: 23, 1940.
E.,
Study.
Rappaport,
H. Z.,
Feinberg, Sheldon,
A cooperative stutly on the question of the oral treatment of rxgweetl pollinosis was carried out by the allergy clinics of four medical whools-University of Illinois, Northwestern University, University of Michigan, and Rush Medical College. .i total of 130 patients with hay ferrr or asthma were given ragweed pollen in c~apsules, in most cases, lwginning with closes of jO0 pollen units ant1 reaching a maximum dose of from 120,000 to 240,000 units. In some instances doses as high as 640,000 units were reachetl. The treatment in the majority of cases was given preseasonally. Control groups received either plawbo c-apsules, injections of normal salt solution, or standard hypodermic pollen therapy. Although 29.8 per cent of the group receiving oral treatment displayed some degree of bmcfit, 21.9 per Gastrointestinal recent of those receiving placebo capsules were also benefited. actions were frequent. The conclusion is reached that the therapeutic effectiveness of oral pollen therapp IS, at, the highest estimate, of a minor grade, particularly in the control of asthma.
Histaminase 2448,
in the Treatment
of Hay Fever.
l
J.
:I.
hr.
n.
114:
1940.
In a group of fifteen ragwrecl hay fever patients (luring the 1939 ragweed season, histaminasr, in doses of from 45 to 75 units daily, was administered orally. In none of the patients was there any degree of relief other than that attributable to fluctuation in atmospheric pollen concentration. Preseasonal quantitative intrncutaneous tests were made with histamine and compared with the reactions obIn none of these patients xas tained when histaminase therapy was terminated. there an appreciable change in the histamine reaction.