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HLA class II antigens
loumai of Reproductive Immunology, 11 (1987) 155 Elsevier Scientific Publishers Ireland Ltd.
155
JRI 00470
Book Review H L A Class H Antigens B.G. Solheim, E. M~ller, S. Ferrone (Eds.) Springer-Verlag, Berlin, Heidelberg, New York, Tokyo (1986) 563 pp., DM 226 This volume is subtitled A comprehensive Review of Structure and Function and does indeed contain reviews of many aspects of HLA class II antigens. There are 29 chapters grouped under the headings of molecular biology, biochemistry, serological definition, cellular detection, regulation and expression, molecular genetics and biological implications. The section on serological definition includes chapters on both alloantisera and monoclonal antibodies. The section on regulation and expression includes chapters on the distribution of class II antigens on both normal and malignant cells and the effects of both T-cell activation and the addition of interferons on expression while the section on biological implications includes chapters on class II HLA antigens and autoimmune disease as well as on clinical kidney transplantation. There are further sections on differences between ethnic groups, cross-reactions between HLA antigens of various species and a chapter devoted to the class II antigens of the mouse. The contributing authors are distinguished and it is convenient to have in one volume articles on fairly disparate aspects of class II molecules. The volume is not particularly directed towards sciefftists with interests in reproductive immunology. In the chapter on the distribution of class II antigens on normal tissues, I found only one brief reference to the placenta. However, the subject of class II antigens is of such central importance that I think most immunologists would find the volume interesting to read and useful for reference.
R.J. T. Hancock
155
JRI 00470
Book Review H L A Class H Antigens B.G. Solheim, E. M~ller, S. Ferrone (Eds.) Springer-Verlag, Berlin, Heidelberg, New York, Tokyo (1986) 563 pp., DM 226 This volume is subtitled A comprehensive Review of Structure and Function and does indeed contain reviews of many aspects of HLA class II antigens. There are 29 chapters grouped under the headings of molecular biology, biochemistry, serological definition, cellular detection, regulation and expression, molecular genetics and biological implications. The section on serological definition includes chapters on both alloantisera and monoclonal antibodies. The section on regulation and expression includes chapters on the distribution of class II antigens on both normal and malignant cells and the effects of both T-cell activation and the addition of interferons on expression while the section on biological implications includes chapters on class II HLA antigens and autoimmune disease as well as on clinical kidney transplantation. There are further sections on differences between ethnic groups, cross-reactions between HLA antigens of various species and a chapter devoted to the class II antigens of the mouse. The contributing authors are distinguished and it is convenient to have in one volume articles on fairly disparate aspects of class II molecules. The volume is not particularly directed towards sciefftists with interests in reproductive immunology. In the chapter on the distribution of class II antigens on normal tissues, I found only one brief reference to the placenta. However, the subject of class II antigens is of such central importance that I think most immunologists would find the volume interesting to read and useful for reference.
R.J. T. Hancock