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Hodgkin Lymphoma Primary of The Oral Mucosa: Case Report
OOOO Volume 117, Number 2 sebaceous cystic choristoma to highlight the cystic component of this distinct gingival lesion.
AO-22 - GLANDULAR ODONTOGENIC CYST: CASE REPORT. MAYSA NOGUEIRA DE BARROS MELO, PIETRY DY TARSO INÃ ALVES MALAQUIAS, SANYRA LOPES DIAS, GABRIEL QUEIROZ VASCONCELOS OLIVEIRA, BRÁULIO CARNEIRO JÚNIOR, ANDRÉ FREITAS, VIVIANE ALMEIDA SARMENTO. UNIVERSIDADE FEDERAL DA BAHIA. Glandular odontogenic cyst is a rare tumor in the oral cavity. It appears in the jaws in the tooth area and promotes bone erosion, bicortical bone expansion, and tooth movement. It can mimic conditions along a wide clinicopathologic spectrum and is considered unpredictable but aggressive. Brazilian woman, 48, came to the Oral and Maxillofacial Surgery unit of Federal University of Bahia in August 2012 with an asymptomatic but progressively growing swollen area in the left mandibular anterior region. The fluctuant swelling extended from 43 to 45 regions. The overlying mucosa was normal in color and appearance. Histopathological analysis revealed a diagnosis of glandular odontogenic cyst. Glandular odontogenic cyst was recently discovered. Treatment consists of diminishing the chances of recurrence. This cyst develops because of the multilocular nature and tendency of the epithelium to separate from connective tissue. Conservative treatment is another contributing factor.
AO-23 - HETEROTOPIC GASTROINTESTINAL MUCOSA OF THE TONGUE: REPORT OF A CONGENITAL CASE. ROBERTA REZENDE ROSA, TAMÍRIS SABRINA RODRIGUES, LUIZ ANTÔNIO VITORIA, LUIZ HENRIQUE NASCIMENTO NETO, GEORGE SOUZA BURGHGRAVE, CARLA SILVA SIQUEIRA, SERGIO VITORINO CARDOSO. UNIVERSIDADE FEDERAL DE UBERLANDIA. Heterotopic gastrointestinal mucosa is rarely reported in the mouth, with most cases affecting male infants and children. Girl, 2, had a congenital painless lesion on the dorsum of the tongue apparently related to sucking her thumb. The patient was otherwise healthy. Oral examination revealed a red, pedunculated, solid nodule 1.0 cm long at the midline of the dorsum of the tongue and anterior to the circumvallate papillae. An excisional biopsy under local anesthesia was performed. Microscopic evaluation showed it was composed of cryptic epithelium with a usually gastric appearance but some focal gut-like differentiation. Epithelial atypia and intense inflammation were also observed. The epithelium was positive for cytokeratins 7, 8, 18, and 19 and negative for CK20. A diagnosis of heterotopic gastrointestinal mucosa was made. The patient developed no recurrence in the 6 months after surgical treatment.
AO-24 - HODGKIN LYMPHOMA PRIMARY OF THE ORAL MUCOSA: CASE REPORT. CIZELENE DO CARMO FALEIROS VELOSO GUEDES, LAURA MOUKACHAR RAMOS OLIVEIRA, LUIS CLÁUDIO DE CARVALHO DUARTE, ANA LUISA RIUL SÓRIO, PAULO ROGÉRIO DE FARIA, ADRIANO MOTA LOYOLA, SÉRGIO VITORINO CARDOSO. UNIVERSIDADE FEDERAL DE UBERLÂNDIA. Hodgkin’s lymphoma (HL) rarely affects the oral mucosa as a primary event. Woman, 27, came for treatment of a painful mouth ulcer. The patient associated the lesion with an episode of trauma 6 months previously and mentioned the use of topical corticosteroid and anesthetic ointment with no remission. Medical history revealed myasthenia gravis treated by thymectomy. Extraoral examination found no abnormalities. Intraoral inspection
ABSTRACTS Abstracts e125 revealed a 2-cm ulcer with erythematous margins extending from the mucosa at the right maxillary tuber into the deep vestibule. Incisional biopsy revealed dense lymphohistiocytic cells intermingled with eosinophils that evidenced large nuclei and nucleoli. These cells were positive for CD30 and CD15, while the others had a mixed CD3/CD20 profile. A pathological diagnosis of classical HL was suggested. The patient underwent chemotherapy, with complete remission and no recurrence after 1 year follow-up.
AO-25 - JUVENILE HYALINE FIBROMATOSIS: CLINICOPATHOLOGICAL FEATURES, IMMUNOHISTOCHEMICAL ANALYSIS, AND GENETIC DATA IN TWO PATIENTS. LUCIANA YAMAMOTO DE ALMEIDA, JULIANA JOSAHKIAN, MARIA CRISTINA BORSATTO, RICARDO DELLA COLETTA, JORGE ESQUICHE LEÓN, ANA CAROLINA FRAGOSO MOTTA, JOÃO MONTEIRO DE PINA NETO. FACULDADE DE ODONTOLOGIA DE PIRACICABA - UNICAMP/FACULDADE DE ODONTOLOGIA DE RIBEIRÃO PRETOeUSP. Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disorder characterized by the abundant deposition of hyaline eosinophilic material in the connective tissue during the first few years of life. Different mutations of the anthrax toxin receptor-2 (ANTXR2) gene have been found to be responsible for this disorder. Patients affected by JHF present cutaneous lesions (nodules and/or pearly papules), gingival hyperplasia, bone and visceral involvement, and progressive contracture of the joints. Histopathological findings show abundant homogenous deposits of eosinophilic material in the connective tissue. Skin and oral lesions are mainly managed by surgical excision. Mutation analysis of genes is important in understanding the pathogenesis of this disease and may contribute for genetic counseling for families. We present our experience in the care of two patients from different families who underwent clinical, histopathological, histochemical, immunohistochemical, and genetic analysis.
AO-26 - JUVENILE OSSIFYING FIBROMA: CASE REPORT, EMPHASIZING HISTOPATHOLOGICAL FEATURES AND CHALLENGE OF REHABILITATION. ESAU PINHEIRO DOS SANTOS, MARCELO MINHARRO CECCHETTI, GUSTAVO GROTHE MACHADO, LUIZ CARLOS ISHIDA, ANDRÉ CAROLI ROCHA. HOSPITAL DAS CLÍNICAS DA FACULDADE DE MEDICINA DA UNIVERSIDADE DE SÃO PAULO (HC-FMUSP). Juvenile ossifying fibroma is a rare controversial fibro-osseous lesion affecting the craniofacial skeleton and occurring commonly in children and young adults. Its clinical behavior varies but it is highly aggressive, often invading and destroying adjacent anatomic structures and exhibiting a strong tendency to recur. Because of its high recurrence rate (30% to 58%), complete excision is essential. Two distinctive microscopic patterns have been described: a trabecular variant and a psammomatous variant. Woman, 18, exhibited a growth extending from the left hemimaxilla to the orbit ipsilaterally and from the lateral incisor to the molar region. This produced facial deformity and orbital displacement. Clinical and imaging aspects are presented, emphasizing histopathological features, surgical treatment, and aesthetic and functional rehabilitation, along with the reintegration of the patient into society.
AO-27 - JUVENILE SPONGIOTIC GINGIVITIS: CASE REPORT. SORAYA DE MATTOS CAMARGO GROSSMANN, GIOVANNA RIBEIRO SOUTO, TARCÍLIA APARECIDA DA
AO-22 - GLANDULAR ODONTOGENIC CYST: CASE REPORT. MAYSA NOGUEIRA DE BARROS MELO, PIETRY DY TARSO INÃ ALVES MALAQUIAS, SANYRA LOPES DIAS, GABRIEL QUEIROZ VASCONCELOS OLIVEIRA, BRÁULIO CARNEIRO JÚNIOR, ANDRÉ FREITAS, VIVIANE ALMEIDA SARMENTO. UNIVERSIDADE FEDERAL DA BAHIA. Glandular odontogenic cyst is a rare tumor in the oral cavity. It appears in the jaws in the tooth area and promotes bone erosion, bicortical bone expansion, and tooth movement. It can mimic conditions along a wide clinicopathologic spectrum and is considered unpredictable but aggressive. Brazilian woman, 48, came to the Oral and Maxillofacial Surgery unit of Federal University of Bahia in August 2012 with an asymptomatic but progressively growing swollen area in the left mandibular anterior region. The fluctuant swelling extended from 43 to 45 regions. The overlying mucosa was normal in color and appearance. Histopathological analysis revealed a diagnosis of glandular odontogenic cyst. Glandular odontogenic cyst was recently discovered. Treatment consists of diminishing the chances of recurrence. This cyst develops because of the multilocular nature and tendency of the epithelium to separate from connective tissue. Conservative treatment is another contributing factor.
AO-23 - HETEROTOPIC GASTROINTESTINAL MUCOSA OF THE TONGUE: REPORT OF A CONGENITAL CASE. ROBERTA REZENDE ROSA, TAMÍRIS SABRINA RODRIGUES, LUIZ ANTÔNIO VITORIA, LUIZ HENRIQUE NASCIMENTO NETO, GEORGE SOUZA BURGHGRAVE, CARLA SILVA SIQUEIRA, SERGIO VITORINO CARDOSO. UNIVERSIDADE FEDERAL DE UBERLANDIA. Heterotopic gastrointestinal mucosa is rarely reported in the mouth, with most cases affecting male infants and children. Girl, 2, had a congenital painless lesion on the dorsum of the tongue apparently related to sucking her thumb. The patient was otherwise healthy. Oral examination revealed a red, pedunculated, solid nodule 1.0 cm long at the midline of the dorsum of the tongue and anterior to the circumvallate papillae. An excisional biopsy under local anesthesia was performed. Microscopic evaluation showed it was composed of cryptic epithelium with a usually gastric appearance but some focal gut-like differentiation. Epithelial atypia and intense inflammation were also observed. The epithelium was positive for cytokeratins 7, 8, 18, and 19 and negative for CK20. A diagnosis of heterotopic gastrointestinal mucosa was made. The patient developed no recurrence in the 6 months after surgical treatment.
AO-24 - HODGKIN LYMPHOMA PRIMARY OF THE ORAL MUCOSA: CASE REPORT. CIZELENE DO CARMO FALEIROS VELOSO GUEDES, LAURA MOUKACHAR RAMOS OLIVEIRA, LUIS CLÁUDIO DE CARVALHO DUARTE, ANA LUISA RIUL SÓRIO, PAULO ROGÉRIO DE FARIA, ADRIANO MOTA LOYOLA, SÉRGIO VITORINO CARDOSO. UNIVERSIDADE FEDERAL DE UBERLÂNDIA. Hodgkin’s lymphoma (HL) rarely affects the oral mucosa as a primary event. Woman, 27, came for treatment of a painful mouth ulcer. The patient associated the lesion with an episode of trauma 6 months previously and mentioned the use of topical corticosteroid and anesthetic ointment with no remission. Medical history revealed myasthenia gravis treated by thymectomy. Extraoral examination found no abnormalities. Intraoral inspection
ABSTRACTS Abstracts e125 revealed a 2-cm ulcer with erythematous margins extending from the mucosa at the right maxillary tuber into the deep vestibule. Incisional biopsy revealed dense lymphohistiocytic cells intermingled with eosinophils that evidenced large nuclei and nucleoli. These cells were positive for CD30 and CD15, while the others had a mixed CD3/CD20 profile. A pathological diagnosis of classical HL was suggested. The patient underwent chemotherapy, with complete remission and no recurrence after 1 year follow-up.
AO-25 - JUVENILE HYALINE FIBROMATOSIS: CLINICOPATHOLOGICAL FEATURES, IMMUNOHISTOCHEMICAL ANALYSIS, AND GENETIC DATA IN TWO PATIENTS. LUCIANA YAMAMOTO DE ALMEIDA, JULIANA JOSAHKIAN, MARIA CRISTINA BORSATTO, RICARDO DELLA COLETTA, JORGE ESQUICHE LEÓN, ANA CAROLINA FRAGOSO MOTTA, JOÃO MONTEIRO DE PINA NETO. FACULDADE DE ODONTOLOGIA DE PIRACICABA - UNICAMP/FACULDADE DE ODONTOLOGIA DE RIBEIRÃO PRETOeUSP. Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disorder characterized by the abundant deposition of hyaline eosinophilic material in the connective tissue during the first few years of life. Different mutations of the anthrax toxin receptor-2 (ANTXR2) gene have been found to be responsible for this disorder. Patients affected by JHF present cutaneous lesions (nodules and/or pearly papules), gingival hyperplasia, bone and visceral involvement, and progressive contracture of the joints. Histopathological findings show abundant homogenous deposits of eosinophilic material in the connective tissue. Skin and oral lesions are mainly managed by surgical excision. Mutation analysis of genes is important in understanding the pathogenesis of this disease and may contribute for genetic counseling for families. We present our experience in the care of two patients from different families who underwent clinical, histopathological, histochemical, immunohistochemical, and genetic analysis.
AO-26 - JUVENILE OSSIFYING FIBROMA: CASE REPORT, EMPHASIZING HISTOPATHOLOGICAL FEATURES AND CHALLENGE OF REHABILITATION. ESAU PINHEIRO DOS SANTOS, MARCELO MINHARRO CECCHETTI, GUSTAVO GROTHE MACHADO, LUIZ CARLOS ISHIDA, ANDRÉ CAROLI ROCHA. HOSPITAL DAS CLÍNICAS DA FACULDADE DE MEDICINA DA UNIVERSIDADE DE SÃO PAULO (HC-FMUSP). Juvenile ossifying fibroma is a rare controversial fibro-osseous lesion affecting the craniofacial skeleton and occurring commonly in children and young adults. Its clinical behavior varies but it is highly aggressive, often invading and destroying adjacent anatomic structures and exhibiting a strong tendency to recur. Because of its high recurrence rate (30% to 58%), complete excision is essential. Two distinctive microscopic patterns have been described: a trabecular variant and a psammomatous variant. Woman, 18, exhibited a growth extending from the left hemimaxilla to the orbit ipsilaterally and from the lateral incisor to the molar region. This produced facial deformity and orbital displacement. Clinical and imaging aspects are presented, emphasizing histopathological features, surgical treatment, and aesthetic and functional rehabilitation, along with the reintegration of the patient into society.
AO-27 - JUVENILE SPONGIOTIC GINGIVITIS: CASE REPORT. SORAYA DE MATTOS CAMARGO GROSSMANN, GIOVANNA RIBEIRO SOUTO, TARCÍLIA APARECIDA DA