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parasites

335 Host–microbe interactions: fungi/viruses/parasites Web alert Dietmar Böltner A selection of World Wide Web sites relevant to papers published in ...

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Host–microbe interactions: fungi/viruses/parasites Web alert Dietmar Böltner A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Microbiology. Addresses Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK; e-mail: [email protected] Current Opinion in Microbiology 2000, 3:335

Fungi Medical Mycology http://fungusweb.utmb.edu/mycology/index.html This web site is a valuable source of background information on various aspects of the biology and pathogenicity of fungi. The site begins with general information about mycology and fungal taxonomy followed by sections about diseases caused by fungi, descriptions and images of the different genera of fungi and even keys for the identification of common species. Other sections describe the diagnosis of fungal infections using histopathology and provide numerous laboratory protocols for the handling and the study of fungi. A concise glossary explains many mycological terms.

from various sources on the internet. The viruses are smartly catalogued by name, by genome type, by host and by disease, which easily allows finding the virus of interest. The taxonomy, hosts, genome and morphology of each virus family are explained and the images are accompanied by precise descriptions. Furthermore, numerous links to related web sites are provided. Viral Immune Evasion http://www.panix.com/~iayork/EIV.shtml This succinct review by Ian York summarises some aspects of how viruses avoid the non-specific and the specific host immune response (e.g. by mimicking host immunomodulators). Completed Genomes: Viruses http://www.ebi.ac.uk/genomes/ The fact that viruses possess a relatively small genome, as well as their medical importance, contribute to the rapidly growing number of completed virus genomes available in the database of the European Bioinformatics Institute (EBI).

Parasites Fungal Genetics Stock Center http://www.fgsc.net/ The Fungal Genetics Stock center keeps a huge of collection of wild-type and mutant Neurospora, Aspergillus and other fungal strains as well as a catalogue of cloned genes that can be ordered by researchers. The databases contain a Neurospora gene knockout list, a huge bibliography and a variety of useful laboratory protocols. Cryptococcosis http://www.edae.gr/cryptococcosis.html This web site contains hundreds of links related to Cryptococcus infections, such as transmission, diagnosis and treatment of the disease. Other links provide information about Cryptococcus and other pathogenic fungi.

Viruses Center for Complex Infectious Diseases http://www.ccid.org/ The Center for Complex Infectious Diseases (CCDI) specialises in the study of so-called stealth viruses that are involved with severe illness such as Chronic Fatigue Syndrome, autism and Attention Deficit Disorder without evoking an anti-viral immune response. The ability of these viruses to capture host and even bacterial and fungal sequences, and their presumed oncogenic potential makes them a major medical issue. The CCDI homepage provides a wide array of reviews on virology and related subjects, as well as the CCDI’s publications and presentations on stealth viruses and information about clinical conditions, diagnosis and therapeutical approaches. The Big Picture Book of Viruses http://www.virology.net/Big_Virology/BVHomePage.html The Big Picture Book of Viruses constitutes a huge collection of excellent viral electron microscopy and three-dimensional images

Parasite-Genome http://www.ebi.ac.uk/parasites/parasite-genome.html The European Bioinformatics Institute (EBI) provides access to databases containing sequence data of a growing number of parasites such as Plasmodium, Toxoplasma and trypanosomes. These catalogues are indispensable resources for researchers studying the molecular biology of parasites. A range of excellent tools allows the users to compare their own sequences with the databases using BLAST and to search for protein motifs in the transcripts. Putative protein sequences are classified by their functions and their pathways in the proteome analysis pages, which can be searched for keywords and text terms. Furthermore, a jump station offers links to numerous related internet resources. Leishmania Genome Network http://www.ebi.ac.uk/parasites/LGN/leish2.html The homepage of the Leishmania Genome Network presents the different strategies for the elucidation of the genome of this parasite and makes the results obtained by the collaborating research groups available for the academic community. It provides chromosome maps and DNA sequences with the corresponding BLAST database search results from the currently ongoing sequencing project. The proteome is studied by screening both genomic sequences and expressed sequence tags (ESTs) from different stages of the life cycle of Leishmania for protein motifs. Parasites and Parasitological Resources http://www.biosci.ohio-state.edu/~parasite/home.html This web site consists mainly of a collection of images and concise life-cycle descriptions of a huge number of parasites. Despite the crude layout, the pages constitute a source of useful background information on parasite biology and infections.