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HP-09-003 Evaluation of testosterone replacement therapy (TRT) in hypogonadal diabetic men
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anxiety, anemia and higher CRP were associated with the prevalence of erectile dysfunction. Policy of full disclosure: None. HP-09-003 EVALUATION OF TESTOSTERONE REPLACEMENT THERAPY (TRT) IN HYPOGONADAL DIABETIC MEN Gvasalia, B.1; Belous, A.2; Serebrennikov, V.2; Kuryleva, Y.2 1 Moscow, Russia; 2Central Military Hospital, Moscow region, Russia Objective: Diabetes mellitus is a common chronic disease, affecting 0.5-2% worldwide. Type 2 diabetes is associated with low total serum testosterone (TT) identified in several studies and systemic analyses. This study aimed to determine the effect of testosterone replacement therapy in hypogonadal diabetic men. Methods: This study included 121 (median age: 51.7 years) men with testosterone deficiency syndrome and type 2 diabetes, who were enrolled and treated with TRT for at least 12 months. We evaluated the following measurements before and after six and twelve months of treatment: homeostasis model assessment of insulin resistance (HOMA-IR), glycemic control, lipids, and sexual function (International Index of Erectile Function 5 (IIEF-5)). Results: Testosterone replacement therapy reduced HOMA-IR in all patients by 13.9% at 6 months (P ¼ 0.011) and 15.1% at 12 months (P ¼ 0.009). Following twelve months of TRT, the levels of testosterone, was significantly increased from baseline (P ¼ 0.013), while total cholesterol level was significantly decreased from baseline(P ¼ 0.026). TRT improved all domains of sexual function at 6 and 12 months (erectile function, P ¼ 0.022 vs P ¼ 0.009 ; intercourse satisfaction, P ¼ 0.035 vs P ¼ 0.012 ; sexual desire, P ¼ 0.009 vs P ¼ 0.001 ; overall satisfaction, P ¼ 0.05 vs P ¼ 0.008 ; and orgasm, P ¼ 0.06 vs P ¼ 0.021) There were no significant adverse events. Conclusion: TRT is an effective and safe treatment for hypogonadal men with type 2 diabetes and associated with beneficial effects on insulin resistance, total cholesterol, and sexual function. Policy of full disclosure: None. HP-09-005 SEX HORMONE PROFILE ON HEMODIALYSIS Ati, N.1; Elati, Z.2; Sofiene, R.3; Mnasser, A.3; Zakhama, W.4; Binous, M.Y.3 1 Departement of urology, Ghomrassen, Tunisia; 2Department of Nephrology, Ghomrassen, Tunisia; 3Department of Urology, Mahdia, Tunisia; 4Department of Urology, mahdia, Tunisia Objective: Sexual dysfunction is one of the numerous consequences of chronic renal failure. The aim of this study is the search for the origin of these sexual disturbances, through the investigation of the hypothalamohypophysogonadic axis in kidney failure patients.
HP-09 Hormones
Methods: We measured FSH, LH, testosterone, prolactin and TSH in male patients undergoing hemodialysis (patient group ¼ 55 subjects) and in virile, fertile men from Gynecology department of Tahar Sfar hospital (control group ¼ 55 subjects). Results: The average age of patients was 48.2 ± 11.8 years and 47.89 ± 5.93 years in control group (p ¼ 0.87). All patients were fertile and had a normal sexual activity before undergoing hemodialysis. Patients had low testosterone value (3.84 ± 1.77 ng/ mL vs 5.41 ± 2.03 ng/mL; p ¼ 0.004) compared to control group. The levels of FSH and LH were higher in patients undergoing hemodialysis (respectively8.83 ± 6.5 UI/L vs 4.31 ± 2.62 UI/L; p ¼ 0.002 and14.62 ± 8.86 UI/L vs 6.43 ± 3.79 UI/ L; p < 0.001). Even levels of prolactin were higher significantly among these patients (respectively 465.54 ± 299.66 mU/L vs 234.66 ± 131.68 mU/L; p ¼ 0.007). However, no significant difference was noted between the 2 groups for the LH / FSH ratio (p ¼ 0.36). Among the study, only 5 patients had serum thyroid stimulating hormone levels above the laboratory reference range (> 4.5 mIU/L) without any differences between subjects and patients group. Conclusion: Abnormal hormonal could be an important factors involved in the complex pathogenesis of sexual dysfunction in chronic renal failure undergoning hemodialysis. Clinicians should pay attention on sexual hormones disorder to prevent the negative impact on male sexuality which is a significant predictor of quality of life of patients on hemodialysis. Policy of full disclosure: None. HP-09-006 REPRODUCTIVE HEALTH: PORTUGUESE MALE RESOURCES REGARDING CONTRACEPTIVE LITERACY AND THEIR ACCESS TO REPRODUCTIVE HEALTH CARE Tereso, A.1; Pedro, P.2 1 ESEL, maternal health, Lisbon, Portugal; 2ESEnfC, Coimbra, Portugal Objective: This study aimed to identify Portuguese men access to reproductive health care, their resources regarding contraceptive literacy and their relation with socio-demographic variables (age, education level and marital status). Hypothesis 1: Therés a relation between the resources regarding contraceptive literacy and socio-demographic variables. Methods: Data were collected from a convenience sampling of 57 men, ranged in age 30-60, with different levels of education (higher 36.8%, secondary 29.8% and basic 33.3%) and with different marital status (with or without a relationship). Structured interviews were conducted and statistical analysis (descriptive and inferential) was carried out using Statistical Package for Social Sciences 21. Results: 82.5% of the participants mentioned that they never had access to reproductive health care and evoked as reasons: “no need” (29.8%); “not interested” (10.5%); “women matters” (8.8) and “schedule difficulties” (1.8%). Considering J Sex Med 2016;13:S139eS141
anxiety, anemia and higher CRP were associated with the prevalence of erectile dysfunction. Policy of full disclosure: None. HP-09-003 EVALUATION OF TESTOSTERONE REPLACEMENT THERAPY (TRT) IN HYPOGONADAL DIABETIC MEN Gvasalia, B.1; Belous, A.2; Serebrennikov, V.2; Kuryleva, Y.2 1 Moscow, Russia; 2Central Military Hospital, Moscow region, Russia Objective: Diabetes mellitus is a common chronic disease, affecting 0.5-2% worldwide. Type 2 diabetes is associated with low total serum testosterone (TT) identified in several studies and systemic analyses. This study aimed to determine the effect of testosterone replacement therapy in hypogonadal diabetic men. Methods: This study included 121 (median age: 51.7 years) men with testosterone deficiency syndrome and type 2 diabetes, who were enrolled and treated with TRT for at least 12 months. We evaluated the following measurements before and after six and twelve months of treatment: homeostasis model assessment of insulin resistance (HOMA-IR), glycemic control, lipids, and sexual function (International Index of Erectile Function 5 (IIEF-5)). Results: Testosterone replacement therapy reduced HOMA-IR in all patients by 13.9% at 6 months (P ¼ 0.011) and 15.1% at 12 months (P ¼ 0.009). Following twelve months of TRT, the levels of testosterone, was significantly increased from baseline (P ¼ 0.013), while total cholesterol level was significantly decreased from baseline(P ¼ 0.026). TRT improved all domains of sexual function at 6 and 12 months (erectile function, P ¼ 0.022 vs P ¼ 0.009 ; intercourse satisfaction, P ¼ 0.035 vs P ¼ 0.012 ; sexual desire, P ¼ 0.009 vs P ¼ 0.001 ; overall satisfaction, P ¼ 0.05 vs P ¼ 0.008 ; and orgasm, P ¼ 0.06 vs P ¼ 0.021) There were no significant adverse events. Conclusion: TRT is an effective and safe treatment for hypogonadal men with type 2 diabetes and associated with beneficial effects on insulin resistance, total cholesterol, and sexual function. Policy of full disclosure: None. HP-09-005 SEX HORMONE PROFILE ON HEMODIALYSIS Ati, N.1; Elati, Z.2; Sofiene, R.3; Mnasser, A.3; Zakhama, W.4; Binous, M.Y.3 1 Departement of urology, Ghomrassen, Tunisia; 2Department of Nephrology, Ghomrassen, Tunisia; 3Department of Urology, Mahdia, Tunisia; 4Department of Urology, mahdia, Tunisia Objective: Sexual dysfunction is one of the numerous consequences of chronic renal failure. The aim of this study is the search for the origin of these sexual disturbances, through the investigation of the hypothalamohypophysogonadic axis in kidney failure patients.
HP-09 Hormones
Methods: We measured FSH, LH, testosterone, prolactin and TSH in male patients undergoing hemodialysis (patient group ¼ 55 subjects) and in virile, fertile men from Gynecology department of Tahar Sfar hospital (control group ¼ 55 subjects). Results: The average age of patients was 48.2 ± 11.8 years and 47.89 ± 5.93 years in control group (p ¼ 0.87). All patients were fertile and had a normal sexual activity before undergoing hemodialysis. Patients had low testosterone value (3.84 ± 1.77 ng/ mL vs 5.41 ± 2.03 ng/mL; p ¼ 0.004) compared to control group. The levels of FSH and LH were higher in patients undergoing hemodialysis (respectively8.83 ± 6.5 UI/L vs 4.31 ± 2.62 UI/L; p ¼ 0.002 and14.62 ± 8.86 UI/L vs 6.43 ± 3.79 UI/ L; p < 0.001). Even levels of prolactin were higher significantly among these patients (respectively 465.54 ± 299.66 mU/L vs 234.66 ± 131.68 mU/L; p ¼ 0.007). However, no significant difference was noted between the 2 groups for the LH / FSH ratio (p ¼ 0.36). Among the study, only 5 patients had serum thyroid stimulating hormone levels above the laboratory reference range (> 4.5 mIU/L) without any differences between subjects and patients group. Conclusion: Abnormal hormonal could be an important factors involved in the complex pathogenesis of sexual dysfunction in chronic renal failure undergoning hemodialysis. Clinicians should pay attention on sexual hormones disorder to prevent the negative impact on male sexuality which is a significant predictor of quality of life of patients on hemodialysis. Policy of full disclosure: None. HP-09-006 REPRODUCTIVE HEALTH: PORTUGUESE MALE RESOURCES REGARDING CONTRACEPTIVE LITERACY AND THEIR ACCESS TO REPRODUCTIVE HEALTH CARE Tereso, A.1; Pedro, P.2 1 ESEL, maternal health, Lisbon, Portugal; 2ESEnfC, Coimbra, Portugal Objective: This study aimed to identify Portuguese men access to reproductive health care, their resources regarding contraceptive literacy and their relation with socio-demographic variables (age, education level and marital status). Hypothesis 1: Therés a relation between the resources regarding contraceptive literacy and socio-demographic variables. Methods: Data were collected from a convenience sampling of 57 men, ranged in age 30-60, with different levels of education (higher 36.8%, secondary 29.8% and basic 33.3%) and with different marital status (with or without a relationship). Structured interviews were conducted and statistical analysis (descriptive and inferential) was carried out using Statistical Package for Social Sciences 21. Results: 82.5% of the participants mentioned that they never had access to reproductive health care and evoked as reasons: “no need” (29.8%); “not interested” (10.5%); “women matters” (8.8) and “schedule difficulties” (1.8%). Considering J Sex Med 2016;13:S139eS141