Human herpesvirus-8 DNA in an immunocompetent patient with multifocal anglosarcoma of the face and scalp

Free comnumication

IFCIO 6

FCll.

Melanocytic

Granulomatous vulvitis, granulomatous cheilitis: Two aspects of the same disease

S. Thiriar, E. Deroux, L. Evrard, N. Dourov, M.O. Peny, P, Simon, D. Parent. Hapita Erasme, CJniversit6 Libre de Bruxelles,

Belgique

We report two cases of patients suffering from Crohn’s disease. A 58-year-old woman had presented two years earlier an erythematous swollen right iabium majus and a red lichenified perianal area. A topical treatment with potent corticoids was successful and she has been free of symptoms for 2 years. She comes back because of a vulvar swelling of the left labium majus. The same treatment results again in a good clinical response. A 19-year-old man presents a 2 month-old homogenous and painless swelling of the upper lip. Topical corticosteroids are ineffective but the increase in the systemic methylprednisolone dose is followed by a decrease in the swelling. Both lesions (oral and vulvar) have a granulomatous histology. To our knowledge, reported cases of vulvar (indurated swelling of the labia majora, ulcerations, “knife cut sign”, flesh tinted papules or nodules, pustular eruption, satellite adenopathy, vaginal discharge), and oral (macrocheilia, median fissure of the lower lip, angular cheilitis, ulcerations, cobblestone aspect or indurated polypoid skin tags on the vestibular or retromolar mucosa, adenopathy) lesions of the Crohn’s disease are quite scarce in the literature, but the disease might be underdiagnosed. The evolution of these oral and vulvar lesions might be independent of the digestive lesions course. FClO-7

Reactive skin lesions in B-cell chronic lymphocytic leukemia

M. Balabanova’, E. Obreshkova’, 1. Goranova’. ‘Department of Dermatology and Venereology; 2Department Medical University, Sofia, Bulgaria

of Pathology,

The presence of skin lesions in patients with leukemia may be due to either specific cutaneous leukemic infiltration or other nonspecific processes. The differentiation between the two groups can be difficult due to considerable clinical and histologic overlap among the different skin lesions in the setting of leukemia. We present five patients with B-cell chronic lymphocytic leukemia and skin lesions: two - with papular urticaria, one - with bullae, two - with postherpetic scars and one - with dermatitis. Despite of the various clinical morphology, immnophenotype of specific infiltrate was found in all the cases. Different factors could triggered the pouring out of the neoplastic cells into the skin and caused the appearance of reactive specific lesions. The prognostic value of latter in comparison with the one of spontaneously arising specific skin infiltration in leukemia was evaluated. FClO-8

Human herpesvirus- DNA in an immunocompetent patient with multifocal angiosarcoma of the face and scalp

W.-H.Boehncke, K. Spieth, M. Walter, H. SchSfer, R. Kaufmann. Department of Dermatology, University Frankfurt,

of

Germany

Human herpesvirus-

(HHVI)

is a novel virus first identified

naevi -Malignant

s145

melanoma

in Kaposi’s sarcoma (KS) of HIV+ patients. We studied 3 immunocompetent patients with multilocular angiosarcoma of the face and scalp. Besides histological features more typical for angiosarcoma one of these patients exhibited a KS-like histology in some areas of the tumor: In the lower dermis incomplete slit-like vascular spaces were observed, together with empty lacunary vascular channels wrapped around pre-existing vessels. In this case presence of HHV8 DNA was demonstrated by nested PCR, whereas both other patients yielded negative PCR results. It is intriguing to speculate whether HHVS is capable of inducing a histological pattern characterized by development of slit-like vascular spaces and lacunary vascular channels wrapped around pre-existing vessels, a pattern characteristic for but not unique to KS.

Melanocytic naevi - Malignant melanoma

FCll. FCll-1

Pigmented spindle cell nevus (PSCN) and videomicroscopy: Morphological features and digital parameters

G. Pellacani, M. Martini, B. Mariotti, S. Seidenari. Department of Dermatology,

University

of Modena,

Italy

22 PSCN images, recorded by means of a videomicroscope provided with polarized light at a 20 fold and 50 fold magnification, were described according to morphological features recognized on the image, and analyzed employing a dedicated program, designed for the quantitative characterization of clinically significant features of pigmented skin lesion images (DBDermoMIPS, Studio Dell’Eva-Burroni. Firenze). The program calculates different parameters related to the geometry, the color distribution and the internal pattern of the lesion. Characteristic morphological descriptors of PSCN referring to videomicroscopy were identified. Moreover, parameter values of pigmented spindle cell nevi significantly differed from values calculated on melanocytic nevi and melanomas. Automatic classification based on the discriminant analysis approach enabled the distinction between pigmented spindle cell nevi and melanomas with a sensitivity of 100% and a specificity of 91%. 1FCll-2

1 Toxicity and feasibility of adjuvant high dose interferon alpha-2b in patients with melanoma

C. BBdane’, A. Ravaud*, L. Geoffrois3, T. Lesimple4, M. Delaunay*, J.M. Bonnetblanc’. t CHU Dupuytren, L-images; 21nstitut 4Centre

Bergonik, Bordeaux; 3Centre Alexis EugPne Marquis, Rennes, France

Vautrin,

Nancy;

A prospective follow-up of patients with malignant cutaneous melanoma, classified as T4 and/or Nl, treated by regional lymph node dissection, followed by interferon alpha-2b given IV at a dose of 20 MIU/m 5, 5 days a week for 4 weeks (induction phase) and subcutaneously at a dose of 10 MIU/m 5, 3 times a week for 11 months (consolidation phase) was performed. The treatment was started in the 6 weeks following the definitive surgical treatment. The evaluation was performed outside a clinical trial, and no mandatory skills, but recommen-