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Hydatid cyst of the uterus (a case report)
IAP 2014 ABSTRACTS
Results: Patient age range was 48–87 years. Tumor size range was 0.4–5.0 cm. Seven cases were cavernous type and three were mixed cavernous and capillary types. Each expressed CD31, CD34, FLI-1, ERG but not D2–40. Follow up ranged from 1–139 months. All patients were disease free. All cases were negative for EWSR1 rearrangement; however, two cases demonstrated additional intact copies of EWSR1 indicating aneusomy 22 or a structural abnormality of chromosome 22. Conclusions: Ovarian hemangiomas are benign neoplasms that may achieve large size, clinically and radiologically mimicking malignancy. The histologic features of ovarian hemangiomas are similar to those of other sites. Although hemangiomas of the ovary do not appear to harbor EWSR1 rearrangements, a subset contain abnormalities of chromosome 22 Reference 1. Arbajian E, Magnusson L, Brosjo¨ O. A benign vascular tumor with a new fusion gene: EWSR1-NFATC1 in hemangioma of the bone. Am J Surg Pathol 2013; 37: 613–6.
Gynecologic Pathology: Poster#151 HISTOMORPHIC AND DEMOGRAPHIC PROFILE OF PATIENTS WITH OVARIAN NEOPLASMS AT A TERTIARY GOVERNMENT HOSPITAL IN MANILA Eric Manila Mirandilla and Sergio P. Paguio Ospital ng Maynila Medical Center, Manila, the Philippines Ovarian neoplasms have been an important health issue. Ovarian carcinoma is the ninth most common cancer in women and is the fifth ranked cause of cancer deaths among women. The objective of this study is to determine the histomorphic and demographic profile of patients with ovarian neoplasms at Ospital ng Maynila Medical Center from the years 2010–2012. This is an epidemiological descriptive study in which all the ovarian neoplasms, from the years 2010–2012 were included. There was a total of 141 cases of ovarian neoplasms: 117 were benign (83%), 22 were malignant (16%) and two were borderline (1%). The most common benign neoplasm was mature cystic teratoma with 70 cases (50%) out of 117. Among the malignant neoplasms, mucinous cystadenocarcinoma was the most common with 8 cases (36%) out of 22. Age distribution among the benign ovarian neoplasms fell on the 21–30 year age range. For the malignant neoplasms, the majority fell on the 41–50 year age range based on the 22 cases of ovarian malignancies. The mean age of diagnosis was 49 years old.
References 1. Laudico AV, Mirasol-Lumague MR, Mapua CA, et al. Cancer incidence and survival in Metro Manila and Rizal Province, Philippines, 2010. Jpn J Clin Oncol 2010; 40: 603–12. 2. International Agency for Cancer Research (IARC). GLOBOCAN 2012: Estimated Cancer Incidence, Prevalence and Moratality Worldwide in 2012. Lyon, IARC, 2012.
Gynecologic Pathology: Poster#152 HYDATID CYST OF THE UTERUS (A CASE REPORT) Fatima Salih Ali1, Ahmed Mohamed Bahar2 and Abdulrahman El sheikh Mohamed3
S87
1Department of Histopathology, National Health Laboratory, Khartoum, Sudan, 2Department of Obstetrics and Gynecology, Fadail Hospital, Khartoum, Sudan, and 3Department of
Medicine, Royal Hospital, Khartoum, Sudan Echinococcosis or hydatid cyst disease is a common parasitic disease. Echinococcosis manifests as a cyst formation. It is caused by E. granulosis. We present a case report of a hydatid cyst of the uterus.The patient was a 35-year-old female, gravida 2. She presented with abdominal distension and lower abdominal pain for 6 months. Her bowel habits were normal and she had no gastrointestinal symptoms or urinary symptoms. Her periods were regular and heavy, but there was no dysmenorrhea. She had no past history of gastrointestinal disease or any disease of note. Laparotomy showed a cystic mass football size continuous with the uterus. Both tubes and ovaries were normal. The mass contained clear fluid and white membrane. The false capsule was removed and cavity curetted. No other cysts were detected in the abdomen. The abdomen was closed in layers. The histology showed a hydatid cyst composed of laminated acellular membrane and single layer of germinal epithelium with multiple broad capsules and scolices. The patient had an uneventful postoperative course and was referred to an internist for treatment of the hydatid disease. She was put on albendazole and praziquantel.
Gynecologic Pathology: Poster#153 IMMUNOPHENOTYPIC COMPARISON OF CK7 AND CK5 IN NORMAL AND NEOPLASTIC FALLOPIAN TUBE MUCOSA Suchanan Hanamornroongruang1, Brooke E. Howitt2, Gang Ning3, Christopher P. Crum2 and Wa Xian3 1Mahidol Hospital, Bangkok, Thailand, 2Brigham and Womens Hospital, Boston, MA, USA, and 3Jackson Laboratory for Genomic Medicine, Farmington, CT, USA In the lower genital tract, CK7 is most strongly expressed in the cervical squamocolumnar junction and surface endometrial lining suggesting a link to progenitor cells; CK5 is typically expressed in basal and reserve cells and related proliferations. Both are expressed in the mesothelium. We studied 38 benign and neoplastic tissue sections from 18 high grade serous carcinomas (HGSCs) and clonogenic cell cultures from adult and fetal fallopian tube. CK7þ cells in vitro behaved as progenitor cells, becoming CK7- upon ciliated or basal (CK5þ) differentiation. In normal tube, CK7þ was most intense in the apices and sides of the plicae and occasionally diffuse in atrophic epithelium. In intramucosal (STICs) and invasive HGSCs, CK7þ was typically non-uniform and strongest on the luminal borders, while CK5 staining was usually less intense albeit occasionally strong. These findings support a model where progenitor CK7þ cells give rise to CK5þ in both benign and malignant tubal epithelium. In this model, the apical localization of CK7þ suggests that progenitor-type cells in this setting might actually be luminal rather than basal. Given the unique location of CK7þ to CK5þ transitions in the fimbria, the possibility of a novel tumorigenic pathway near the Mullerian-mesothelial junction bears further study.
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.
Results: Patient age range was 48–87 years. Tumor size range was 0.4–5.0 cm. Seven cases were cavernous type and three were mixed cavernous and capillary types. Each expressed CD31, CD34, FLI-1, ERG but not D2–40. Follow up ranged from 1–139 months. All patients were disease free. All cases were negative for EWSR1 rearrangement; however, two cases demonstrated additional intact copies of EWSR1 indicating aneusomy 22 or a structural abnormality of chromosome 22. Conclusions: Ovarian hemangiomas are benign neoplasms that may achieve large size, clinically and radiologically mimicking malignancy. The histologic features of ovarian hemangiomas are similar to those of other sites. Although hemangiomas of the ovary do not appear to harbor EWSR1 rearrangements, a subset contain abnormalities of chromosome 22 Reference 1. Arbajian E, Magnusson L, Brosjo¨ O. A benign vascular tumor with a new fusion gene: EWSR1-NFATC1 in hemangioma of the bone. Am J Surg Pathol 2013; 37: 613–6.
Gynecologic Pathology: Poster#151 HISTOMORPHIC AND DEMOGRAPHIC PROFILE OF PATIENTS WITH OVARIAN NEOPLASMS AT A TERTIARY GOVERNMENT HOSPITAL IN MANILA Eric Manila Mirandilla and Sergio P. Paguio Ospital ng Maynila Medical Center, Manila, the Philippines Ovarian neoplasms have been an important health issue. Ovarian carcinoma is the ninth most common cancer in women and is the fifth ranked cause of cancer deaths among women. The objective of this study is to determine the histomorphic and demographic profile of patients with ovarian neoplasms at Ospital ng Maynila Medical Center from the years 2010–2012. This is an epidemiological descriptive study in which all the ovarian neoplasms, from the years 2010–2012 were included. There was a total of 141 cases of ovarian neoplasms: 117 were benign (83%), 22 were malignant (16%) and two were borderline (1%). The most common benign neoplasm was mature cystic teratoma with 70 cases (50%) out of 117. Among the malignant neoplasms, mucinous cystadenocarcinoma was the most common with 8 cases (36%) out of 22. Age distribution among the benign ovarian neoplasms fell on the 21–30 year age range. For the malignant neoplasms, the majority fell on the 41–50 year age range based on the 22 cases of ovarian malignancies. The mean age of diagnosis was 49 years old.
References 1. Laudico AV, Mirasol-Lumague MR, Mapua CA, et al. Cancer incidence and survival in Metro Manila and Rizal Province, Philippines, 2010. Jpn J Clin Oncol 2010; 40: 603–12. 2. International Agency for Cancer Research (IARC). GLOBOCAN 2012: Estimated Cancer Incidence, Prevalence and Moratality Worldwide in 2012. Lyon, IARC, 2012.
Gynecologic Pathology: Poster#152 HYDATID CYST OF THE UTERUS (A CASE REPORT) Fatima Salih Ali1, Ahmed Mohamed Bahar2 and Abdulrahman El sheikh Mohamed3
S87
1Department of Histopathology, National Health Laboratory, Khartoum, Sudan, 2Department of Obstetrics and Gynecology, Fadail Hospital, Khartoum, Sudan, and 3Department of
Medicine, Royal Hospital, Khartoum, Sudan Echinococcosis or hydatid cyst disease is a common parasitic disease. Echinococcosis manifests as a cyst formation. It is caused by E. granulosis. We present a case report of a hydatid cyst of the uterus.The patient was a 35-year-old female, gravida 2. She presented with abdominal distension and lower abdominal pain for 6 months. Her bowel habits were normal and she had no gastrointestinal symptoms or urinary symptoms. Her periods were regular and heavy, but there was no dysmenorrhea. She had no past history of gastrointestinal disease or any disease of note. Laparotomy showed a cystic mass football size continuous with the uterus. Both tubes and ovaries were normal. The mass contained clear fluid and white membrane. The false capsule was removed and cavity curetted. No other cysts were detected in the abdomen. The abdomen was closed in layers. The histology showed a hydatid cyst composed of laminated acellular membrane and single layer of germinal epithelium with multiple broad capsules and scolices. The patient had an uneventful postoperative course and was referred to an internist for treatment of the hydatid disease. She was put on albendazole and praziquantel.
Gynecologic Pathology: Poster#153 IMMUNOPHENOTYPIC COMPARISON OF CK7 AND CK5 IN NORMAL AND NEOPLASTIC FALLOPIAN TUBE MUCOSA Suchanan Hanamornroongruang1, Brooke E. Howitt2, Gang Ning3, Christopher P. Crum2 and Wa Xian3 1Mahidol Hospital, Bangkok, Thailand, 2Brigham and Womens Hospital, Boston, MA, USA, and 3Jackson Laboratory for Genomic Medicine, Farmington, CT, USA In the lower genital tract, CK7 is most strongly expressed in the cervical squamocolumnar junction and surface endometrial lining suggesting a link to progenitor cells; CK5 is typically expressed in basal and reserve cells and related proliferations. Both are expressed in the mesothelium. We studied 38 benign and neoplastic tissue sections from 18 high grade serous carcinomas (HGSCs) and clonogenic cell cultures from adult and fetal fallopian tube. CK7þ cells in vitro behaved as progenitor cells, becoming CK7- upon ciliated or basal (CK5þ) differentiation. In normal tube, CK7þ was most intense in the apices and sides of the plicae and occasionally diffuse in atrophic epithelium. In intramucosal (STICs) and invasive HGSCs, CK7þ was typically non-uniform and strongest on the luminal borders, while CK5 staining was usually less intense albeit occasionally strong. These findings support a model where progenitor CK7þ cells give rise to CK5þ in both benign and malignant tubal epithelium. In this model, the apical localization of CK7þ suggests that progenitor-type cells in this setting might actually be luminal rather than basal. Given the unique location of CK7þ to CK5þ transitions in the fimbria, the possibility of a novel tumorigenic pathway near the Mullerian-mesothelial junction bears further study.
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.