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Hypertension prevalence and risk factors in adults in Istanbul
AEP Vol. 13, No. 8 September 2003: 559–596
ABSTRACTS (ACE)
FGD was significantly higher (P ⬍ 0.0001) in inactive IBD (81.9%; 78.8-85.0) than in Canadian householders (61.7%; 58.964.5). The prevalence of a functional bowel disorder (51.7%), irritable bowel syndrome (20.9%) and functional diarrhea (15.5%) in inactive IBD were significantly greater (P ⬍ 0.01) than in Canadian householders at 41.6%, 12.1% and 8.5%, respectively. The prevalence of functional anorectal disorders at 53.7% and functional incontinence at 35.8% were also significantly higher (p ⬍ 0.001) in inactive IBD compared with Canadian householders at 22.6% and 6.9%, respectively. Age and smoking were the strongest predictors of a FGD in inactive IBD while age and anxiety were the strongest predictors of FGD in inactive CD. CONCLUSION: FGDs, primarily bowel and anorectal, are significantly more prevalent in patients with inactive IBD compared to Canadian householders and may be easily confused with active IBD. (partially funded by IOIBD) doi: 10.1016/S1047-2797(03)00156-X
P023 HYPERTENSION PREVALENCE AND RISK FACTORS IN ADULTS IN ISTANBUL AE Onal1, S Erbil1, S Ozel2, K Aciksari3, Y Tumerdem1, 1 Istanbul University, Istanbul Medical Faculty, Departments of Public Health, 2Istanbul University, Istanbul Medical Faculty, Departments of Biostatistics, 3The Non Governmental Organization of European Turkey, Istanbul, Turkey PURPOSE: Hypertension is one of the serious public health problems in Turkey as it is in other countries. Even mild forms of hypertension are risk for morbidity and mortality in moderate or long term. Therefore, hypertension prevalence and the risk factors were determined among habitants living in the European part of Istanbul and who are 25 years old and above. METHODS: Eight administrative districts were selected with simple random sampling method in the European section of Istanbul. With the aid of a non-governmental organization, the participants were selected through systematic calling from the address lists. At 17-22.06.2002, the questionnaires applied face-to-face to the participants investigated demographic features, smoking habits and consumption of alcohol. Then arterial blood pressures, weights and heights of the participants were measured. RESULTS: Out of 423 adults participating in the study, 35.5% were hypertensive. 34.8% of all female and 38.8% of all male participants were hypertensive. 35.9% of all the participants were obese, 27.9% were overweight, and 2.1% were underweight. The risk factors for hypertension like age, gender, family history of hypertension and cardiovascular disease, diabetes history of participant, smoking and alcohol use of participants and educational status in the hypertensive and non hypertensive groups were investigated by means of logistic regression analysis. Age (Odds Ratio: 6.09, 95% Confidence Interval: 2.48-14.95) and Body Mass Index (OR: 1.12, 95% CI: 1.07-1.17) were determined to be correlated with hypertension. CONCLUSIONS: The results have indicated that obesity, being overweight and aging are risk factors for hypertension. doi: 10.1016/S1047-2797(03)00157-1
567
P024 THE PREVALENCE AND CORRELATES OF ASTHMA IN AMERICAN INDIAN ADULTS F Yeh, ER Rhoades, ET Lee, TK Welty, JL Yeh, PL Enright, From the Center for American Indian Health Research, University of Oklahoma College of Public Health, Oklahoma City OK, and The University of Arizona PURPOSE: To determine the prevalence of asthma and its association with risk factors among three geographically distinct adult Indian populations. METHODS: The Strong Heart Study (SHS) is a multi-center, prospective study of cardiovascular diseases and risk factors among American Indian adults. As part of Phase III examinations (199395), respondents were asked a series of questions relating to asthma and possible risk factors. The study group comprised 3197 American Indians, aged 50-84 years (2/3 female) who were members of 13 tribes residing in Arizona (n ⫽ 1,024), Oklahoma (n = 1,067), and North and South Dakota (n ⫽ 1,106). The prevalence of current asthma was determined by positive responses to the following questions, “Have you ever had asthma?” and “Do you still have it?” or (for probable asthma) “Have you had wheezing or whistling in your chest at any time during the last 12 months?” Univariate and multivariate methods were used for the data analyses. RESULTS: 251 (8.1%) had current asthma and 177 (5.7%) had probable asthma. Based on the univariate analysis, more than half of the participants (52.9%) were obese and obesity was significantly associated with asthma, as 17% of those obese participants had current or probable asthma, as compared to 10% of those nonobese (odds ratio ⫽ 1.7, 95% CI 1.5 to 2.0). Other significant correlates of asthma included female gender, hay fever, diabetes, emphysema, and bronchitis. Two-thirds reported ever smoking, but smoking status was not associated with asthma. CONCLUSION: Asthma, previously considered to be uncommon among Indians, was found to affect nearly one in 7 adults. This may be the first population-based survey of asthma among Indian adults. Asthma is an important disease among Indian adults, and is associated with obesity and diabetes, but not smoking. doi: 10.1016/S1047-2797(03)00158-3
P025 GENOME WIDE SEARCH FOR BLOOD PRESSURE SUSCEPTIBILITY LOCI IN WEST AFRICAN TYPE 2 DIABETES PATIENTS G Chen, J Zhou, Y Chen, H Daniel, C Rotimi, National Human Genome Center, Howard University, Washington, DC PURPOSE: Why humans develop elevated blood pressure is still poorly understood. An understanding of the genetic influence on hypertension would help unravel the pathophysiology. METHODS: To identify genes contributing to blood pressure (BP) variation, we conducted a genome wide scan for blood pressure in an average 9cM genome map of 373 type 2 diabetes affective sib-pairs study in 343 families, the odds ratio of diabetes and hypertension was 1.84 (95%CI 1.34 – 2.53), in West Africa. Multipoint variance components approach was used to identify linkage signals. RESULTS: We observed suggestive evidences of linkage (LOD ⭓ 1.9) on chromosome 6 (LOD ⫽ 2.0 for DBP and a LOD ⫽ 1.92
ABSTRACTS (ACE)
FGD was significantly higher (P ⬍ 0.0001) in inactive IBD (81.9%; 78.8-85.0) than in Canadian householders (61.7%; 58.964.5). The prevalence of a functional bowel disorder (51.7%), irritable bowel syndrome (20.9%) and functional diarrhea (15.5%) in inactive IBD were significantly greater (P ⬍ 0.01) than in Canadian householders at 41.6%, 12.1% and 8.5%, respectively. The prevalence of functional anorectal disorders at 53.7% and functional incontinence at 35.8% were also significantly higher (p ⬍ 0.001) in inactive IBD compared with Canadian householders at 22.6% and 6.9%, respectively. Age and smoking were the strongest predictors of a FGD in inactive IBD while age and anxiety were the strongest predictors of FGD in inactive CD. CONCLUSION: FGDs, primarily bowel and anorectal, are significantly more prevalent in patients with inactive IBD compared to Canadian householders and may be easily confused with active IBD. (partially funded by IOIBD) doi: 10.1016/S1047-2797(03)00156-X
P023 HYPERTENSION PREVALENCE AND RISK FACTORS IN ADULTS IN ISTANBUL AE Onal1, S Erbil1, S Ozel2, K Aciksari3, Y Tumerdem1, 1 Istanbul University, Istanbul Medical Faculty, Departments of Public Health, 2Istanbul University, Istanbul Medical Faculty, Departments of Biostatistics, 3The Non Governmental Organization of European Turkey, Istanbul, Turkey PURPOSE: Hypertension is one of the serious public health problems in Turkey as it is in other countries. Even mild forms of hypertension are risk for morbidity and mortality in moderate or long term. Therefore, hypertension prevalence and the risk factors were determined among habitants living in the European part of Istanbul and who are 25 years old and above. METHODS: Eight administrative districts were selected with simple random sampling method in the European section of Istanbul. With the aid of a non-governmental organization, the participants were selected through systematic calling from the address lists. At 17-22.06.2002, the questionnaires applied face-to-face to the participants investigated demographic features, smoking habits and consumption of alcohol. Then arterial blood pressures, weights and heights of the participants were measured. RESULTS: Out of 423 adults participating in the study, 35.5% were hypertensive. 34.8% of all female and 38.8% of all male participants were hypertensive. 35.9% of all the participants were obese, 27.9% were overweight, and 2.1% were underweight. The risk factors for hypertension like age, gender, family history of hypertension and cardiovascular disease, diabetes history of participant, smoking and alcohol use of participants and educational status in the hypertensive and non hypertensive groups were investigated by means of logistic regression analysis. Age (Odds Ratio: 6.09, 95% Confidence Interval: 2.48-14.95) and Body Mass Index (OR: 1.12, 95% CI: 1.07-1.17) were determined to be correlated with hypertension. CONCLUSIONS: The results have indicated that obesity, being overweight and aging are risk factors for hypertension. doi: 10.1016/S1047-2797(03)00157-1
567
P024 THE PREVALENCE AND CORRELATES OF ASTHMA IN AMERICAN INDIAN ADULTS F Yeh, ER Rhoades, ET Lee, TK Welty, JL Yeh, PL Enright, From the Center for American Indian Health Research, University of Oklahoma College of Public Health, Oklahoma City OK, and The University of Arizona PURPOSE: To determine the prevalence of asthma and its association with risk factors among three geographically distinct adult Indian populations. METHODS: The Strong Heart Study (SHS) is a multi-center, prospective study of cardiovascular diseases and risk factors among American Indian adults. As part of Phase III examinations (199395), respondents were asked a series of questions relating to asthma and possible risk factors. The study group comprised 3197 American Indians, aged 50-84 years (2/3 female) who were members of 13 tribes residing in Arizona (n ⫽ 1,024), Oklahoma (n = 1,067), and North and South Dakota (n ⫽ 1,106). The prevalence of current asthma was determined by positive responses to the following questions, “Have you ever had asthma?” and “Do you still have it?” or (for probable asthma) “Have you had wheezing or whistling in your chest at any time during the last 12 months?” Univariate and multivariate methods were used for the data analyses. RESULTS: 251 (8.1%) had current asthma and 177 (5.7%) had probable asthma. Based on the univariate analysis, more than half of the participants (52.9%) were obese and obesity was significantly associated with asthma, as 17% of those obese participants had current or probable asthma, as compared to 10% of those nonobese (odds ratio ⫽ 1.7, 95% CI 1.5 to 2.0). Other significant correlates of asthma included female gender, hay fever, diabetes, emphysema, and bronchitis. Two-thirds reported ever smoking, but smoking status was not associated with asthma. CONCLUSION: Asthma, previously considered to be uncommon among Indians, was found to affect nearly one in 7 adults. This may be the first population-based survey of asthma among Indian adults. Asthma is an important disease among Indian adults, and is associated with obesity and diabetes, but not smoking. doi: 10.1016/S1047-2797(03)00158-3
P025 GENOME WIDE SEARCH FOR BLOOD PRESSURE SUSCEPTIBILITY LOCI IN WEST AFRICAN TYPE 2 DIABETES PATIENTS G Chen, J Zhou, Y Chen, H Daniel, C Rotimi, National Human Genome Center, Howard University, Washington, DC PURPOSE: Why humans develop elevated blood pressure is still poorly understood. An understanding of the genetic influence on hypertension would help unravel the pathophysiology. METHODS: To identify genes contributing to blood pressure (BP) variation, we conducted a genome wide scan for blood pressure in an average 9cM genome map of 373 type 2 diabetes affective sib-pairs study in 343 families, the odds ratio of diabetes and hypertension was 1.84 (95%CI 1.34 – 2.53), in West Africa. Multipoint variance components approach was used to identify linkage signals. RESULTS: We observed suggestive evidences of linkage (LOD ⭓ 1.9) on chromosome 6 (LOD ⫽ 2.0 for DBP and a LOD ⫽ 1.92