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Hyperuricemia or uric-acid stone; which increases the risk of renal function deterioration?
32nd Annual EAU Congress, 24-28 March 2017, London, United Kingdom
4
Hyperuricemia or uric-acid stone; which increases the risk of renal function deterioration? Eur Urol Suppl 2017; 16(3);e7
Tanaka T., Htakeyama S., Terayama Y., Saitoh F., Saitoh H., Yamamoto H., Imai A., Yoneyama T., Hashimoto Y., Koie T., Ohyama C. Hirosaki University Graduate School of Medicine, Dept. of Urology, Hirosaki, Japan INTRODUCTION & OBJECTIVES: Although both hyperuricemia and uric-acid (UA) stone are potential risk factors for Chronic Kidney Disease (CKD), it is unknown which increase the risk of renal function deterioration. We accessed the influence of uric-acid stone on renal function in comparison with community-dwelling population by serum UA concentration stratification. MATERIAL & METHODS: Between 2010 and 2014, we treated 1793 consecutive patients with urolithiasis in our hospital, and identified stone components available 473 patients. Of those, 123 patients with UA stone were included in the present study. Age, sex, and serum UA concentration adjusted control subjects were selected from 3089 community-dwelling population in each group by propensity-score matching. Subjects were divided into two groups; hyperuricemia or non-hyperuricemia groups according to the serum UA concentrations (serum UA ≥7.0 or < 7.0 mg/mL). We compared renal function between the UA stone and control subjects in each group. The renal function was evaluated as estimated glomerular filtration rate (eGFR). The independent risk factor for impaired renal function were investigated by multivariate logistic regression analysis. RESULTS: UA stone patients had significantly lower in eGFR (P<0.01) compared with control subjects regardless of serum UA concentrations. Multivariate logistic regression analysis revealed that age, pasthistory of cardiovascular disease, serum UA, and stone former were significant factors for stage 3 CKD. UA stone component had 3-fold chance to develop stage 3 CKD than serum UA concentration.
Eur Urol Suppl 2017; 16(3);e7
32nd Annual EAU Congress, 24-28 March 2017, London, United Kingdom
4
Hyperuricemia or uric-acid stone; which increases the risk of renal function deterioration? Eur Urol Suppl 2017; 16(3);e8
CONCLUSIONS: Uric acid stone components may strongly influence on renal function deterioration than hyperuricemia.
Eur Urol Suppl 2017; 16(3);e8 Powered by TCPDF (www.tcpdf.org)
4
Hyperuricemia or uric-acid stone; which increases the risk of renal function deterioration? Eur Urol Suppl 2017; 16(3);e7
Tanaka T., Htakeyama S., Terayama Y., Saitoh F., Saitoh H., Yamamoto H., Imai A., Yoneyama T., Hashimoto Y., Koie T., Ohyama C. Hirosaki University Graduate School of Medicine, Dept. of Urology, Hirosaki, Japan INTRODUCTION & OBJECTIVES: Although both hyperuricemia and uric-acid (UA) stone are potential risk factors for Chronic Kidney Disease (CKD), it is unknown which increase the risk of renal function deterioration. We accessed the influence of uric-acid stone on renal function in comparison with community-dwelling population by serum UA concentration stratification. MATERIAL & METHODS: Between 2010 and 2014, we treated 1793 consecutive patients with urolithiasis in our hospital, and identified stone components available 473 patients. Of those, 123 patients with UA stone were included in the present study. Age, sex, and serum UA concentration adjusted control subjects were selected from 3089 community-dwelling population in each group by propensity-score matching. Subjects were divided into two groups; hyperuricemia or non-hyperuricemia groups according to the serum UA concentrations (serum UA ≥7.0 or < 7.0 mg/mL). We compared renal function between the UA stone and control subjects in each group. The renal function was evaluated as estimated glomerular filtration rate (eGFR). The independent risk factor for impaired renal function were investigated by multivariate logistic regression analysis. RESULTS: UA stone patients had significantly lower in eGFR (P<0.01) compared with control subjects regardless of serum UA concentrations. Multivariate logistic regression analysis revealed that age, pasthistory of cardiovascular disease, serum UA, and stone former were significant factors for stage 3 CKD. UA stone component had 3-fold chance to develop stage 3 CKD than serum UA concentration.
Eur Urol Suppl 2017; 16(3);e7
32nd Annual EAU Congress, 24-28 March 2017, London, United Kingdom
4
Hyperuricemia or uric-acid stone; which increases the risk of renal function deterioration? Eur Urol Suppl 2017; 16(3);e8
CONCLUSIONS: Uric acid stone components may strongly influence on renal function deterioration than hyperuricemia.
Eur Urol Suppl 2017; 16(3);e8 Powered by TCPDF (www.tcpdf.org)