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Hyprthermia as a radiation adjuvant: An effective fractionation regime
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HYPERTHERMIA AS A RADIATION ADJUVANT: AN EFFECTIVE FRACTIONATIONREGIME Haim I. Bicher, M.D., Ph.D. Taljit S. Sandhu, Ph.D. Fred W. Hetzel, Ph.D. Henry Ford Hospital Department of Therapeutic Radiology 2799 West Grand Boulevard Detroit, Michigan 48202
A fractionation regime has been devised and clinically tested to use a combination of Hyperthermia and low dose radiation therapy to treat tumors with a curative intent. Hyperthermia is induced using microwaves delivered to a defined tissue volume through specially designed applicators. Frequencies of 2450, 915 or 300 MHz are used according to desired penetration depth. Each treatment lasts for 90 minutes. The skin is cooled by an air jet. When Hyperthermia alone is used tissue temperature is kept at 45'C. When Hyperthermia is given following radiation tissue temperature is kept at 42-43OC. Patients are treated twice a week with 72 hour intervals between treatments. The regime consists of 4 treatments of Hyperthermia alone follwed by a week of rest. Thereafter each Hyperthermia treatment is preceded by a 400 rad fraction of x-irradiation, to a total of 1600 rads delivered in 4 combined treatments. This low total radiation dose allows retreatment of previously irradiated areas or organs. No toxicity induced by this combination has been detected, even in areas previously raaiated to high doses. Tnirty patients have been entered into the protocols. All tumors responded to treatment, most of these with total disappearance. Skin, brain, breast and spinal cord are among the treated areas. Melanomas and lymphomas are the most sensitive tumors, sarcomas the most resistant, with adeno and squamous cell carcinoma in between.
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PHASE I-II STUDY OF IRRADIATION AND HYPERTHERMIA ON HUMAN NEOPLASIAS--PRELIMINARY FINDINGS C.A. Perez, M.D. I, W.J. Kopecky, Ph.D.l R. Baglan, M.D.l, V. Rao, M.D.l, R. Johnson, M.D.2 lwashington University School of Medicine, St. Louis, MO. 2Roswell Park Memorial Institute, Buffalo, N.Y.
At this institution we have treated 40 superficial lesions in 25 patients according to a non-randomized protocol which has two arms: 1) hyperthermia alone for 43OC (+ .5O) for 90 minuies and 2) 400 rads radiation followed immediately by hyperthermia for 43OC (- .5o) for 90 minutes. I,naddition, 25 other patients were treated on a Radiation Therapy Oncology Group randomized protocol comparing three fractions of 500 rad followed by hyperthermia (42.5oC, 90120 minutes) with three fractions of irradiation alone of 600, 700 or 800 rad each delivered every 72 hours. Irradiation was delivered with electrons or ASTR 21st Annual Meeting
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HYPERTHERMIA AS A RADIATION ADJUVANT: AN EFFECTIVE FRACTIONATIONREGIME Haim I. Bicher, M.D., Ph.D. Taljit S. Sandhu, Ph.D. Fred W. Hetzel, Ph.D. Henry Ford Hospital Department of Therapeutic Radiology 2799 West Grand Boulevard Detroit, Michigan 48202
A fractionation regime has been devised and clinically tested to use a combination of Hyperthermia and low dose radiation therapy to treat tumors with a curative intent. Hyperthermia is induced using microwaves delivered to a defined tissue volume through specially designed applicators. Frequencies of 2450, 915 or 300 MHz are used according to desired penetration depth. Each treatment lasts for 90 minutes. The skin is cooled by an air jet. When Hyperthermia alone is used tissue temperature is kept at 45'C. When Hyperthermia is given following radiation tissue temperature is kept at 42-43OC. Patients are treated twice a week with 72 hour intervals between treatments. The regime consists of 4 treatments of Hyperthermia alone follwed by a week of rest. Thereafter each Hyperthermia treatment is preceded by a 400 rad fraction of x-irradiation, to a total of 1600 rads delivered in 4 combined treatments. This low total radiation dose allows retreatment of previously irradiated areas or organs. No toxicity induced by this combination has been detected, even in areas previously raaiated to high doses. Tnirty patients have been entered into the protocols. All tumors responded to treatment, most of these with total disappearance. Skin, brain, breast and spinal cord are among the treated areas. Melanomas and lymphomas are the most sensitive tumors, sarcomas the most resistant, with adeno and squamous cell carcinoma in between.
(150)
PHASE I-II STUDY OF IRRADIATION AND HYPERTHERMIA ON HUMAN NEOPLASIAS--PRELIMINARY FINDINGS C.A. Perez, M.D. I, W.J. Kopecky, Ph.D.l R. Baglan, M.D.l, V. Rao, M.D.l, R. Johnson, M.D.2 lwashington University School of Medicine, St. Louis, MO. 2Roswell Park Memorial Institute, Buffalo, N.Y.
At this institution we have treated 40 superficial lesions in 25 patients according to a non-randomized protocol which has two arms: 1) hyperthermia alone for 43OC (+ .5O) for 90 minuies and 2) 400 rads radiation followed immediately by hyperthermia for 43OC (- .5o) for 90 minutes. I,naddition, 25 other patients were treated on a Radiation Therapy Oncology Group randomized protocol comparing three fractions of 500 rad followed by hyperthermia (42.5oC, 90120 minutes) with three fractions of irradiation alone of 600, 700 or 800 rad each delivered every 72 hours. Irradiation was delivered with electrons or ASTR 21st Annual Meeting
171