- Email: [email protected]
[I182] Dosimetry in radiopharmaceutical therapy
70
Abstracts / Physica Medica 52 (2018) 1–98
addresses ascertaining exposure information for individual patients for error investigation and tracking exposure history for individualized justification and optimization. In addition to metrology and analysis, the document will offer description of electronic and manual strategies for data management and workflow, as well as the needed features, access, and interface for effective utilization of patient exposure data monitoring systems, considering the needs and constraints of less-resourced countries. Conclusions. It is expected that the publication will support the implementation of the BSS requirements. https://doi.org/10.1016/j.ejmp.2018.06.253
[I182] Dosimetry in radiopharmaceutical therapy Manuel Bardies * Centre de Recherches En Cancérologie de Toulouse, Université Toulouse III - Paul Sabatier, Inserm, Umr1037 Crct, Toulouse, France ⇑ Corresponding author. Purpose. EFOMP-IAEA collaboration in the field of Nuclear Medicine dosimetry is very active. Amongst other activities, the collaboration to disseminate knowledge can be seen in the IAEA support of ESMPE lectures in Prague, and EFOMP participation to ICTP-IAEA courses. In addition, EFOMP supports the IAEA project of a book focused on Molecular Radiotherapy dosimetry. The IAEA recently launched a Coordinated Research Project (CRP E2.30.05) on ‘‘Dosimetry in Radiopharmaceutical Therapy for personalized patient treatment” to support the standardization and dissemination of dosimetric methods in nuclear medicine therapy. The CRP will assist Member States in testing and adopting harmonized dosimetric protocols and to assess the typical accuracy with which dosimetry can be reached in nuclear medicine practice. Methods. Within the CRP, Common activities will aim at: 1. Identify software and analysis methods appropriate for dosimetry of RPT. 2. Perform all the tasks needed to estimate tumour and normal organ absorbed doses on clinical and simulated data sets 3. Provide a written report, identifying the most challenging steps, or those that are subject to the greatest uncertainty. 4. Select one or more patient cases for whom dosimetry has been calculated at all the participating sites and assess the variability in absorbed dose determination. 5. Help disseminate each site’s experience, producing teaching material and tutorial documents on dosimetry for molecular radiotherapy based on the experience gained during the CRP. Conclusions. The Call for Proposals, which included tentative research topics and the scoring methodology, was extensively advertised for CRP participants. Among the 33 research projects proposals received, 10 participating institutions have been selected from Colombia, Croatia, Cuba, France, India, Indonesia, South Africa and USA. The project has a 4 years duration, and the first Research Coordination Meeting took place in November 2017. All participants are currently working to derive the dosimetry of a set of clinical images. Discussions between participants are ongoing to define the prerequisite for the generation of simulated datasets. https://doi.org/10.1016/j.ejmp.2018.06.254
[I183] Guidelines for medical physics staffing requirements in diagnistic imaging and radionuclide therapy Gian Luca Poli a,*, Harry Delis a, Marco Brambilla b, Soren Holm c, Melissa C. Martin d, Donald McLean e
a
Iaea, Dosimetry and Medical Radiation Physics, Vienna, Austria University Hospital ‘‘Maggiore Della Carità”, Medical Physics, Novara, Italy c Rigshospitalet, University Hospital Copenhagen, 3982 Clinical Physiology, Nuclear Medicine and Pet, Copenhagen, Denmark d Therapy Physics, Signal Hill, Ca, United States e The Canberra Hospital, Medical Physics and Radiation Engineering, Camberra, Australia ⇑ Corresponding author. b
Purpose. Over the last decades, the rapid technological development of diagnostic and interventional radiology and nuclear medicine has made them major tools of modern medicine. However, at the same time, the involved risks, the growing number of procedures and the increasing complexity of the procedures require competent professional staff to ensure safe and effective patient diagnosis, treatment and management. Medical physicists have been recognized as vital health professionals with important and clear responsibilities related to quality and safety of applications of ionizing radiation in medicine. The aim of the IAEA Human Health Reports No. 15 is to provide guidance on appropriate staffing levels to support medical physics services in medical imaging and radionuclide therapy. Methods. The roles and responsibilities of the medical physicist defined in international guidelines are the basis for different elements of the IAEA staffing algorithm. The components of the algorithm include input variables and weighting factors, with the output being the number of medical physicists (FTE) needed to deliver the service. To ensure the general applicability of the algorithm, a survey has been used to test it and obtain feedback from medical physicists throughout the world, representing different regions and different country health care levels. Results. The IAEA staffing algorithm calculates the total number of medical physicists required by considering factor which are equipment dependent, patient dependent, radiation protection related, service related, training related and academic teaching and research related. This approach allows the needed flexibility to give appropriate staffing levels over a wide range of facility sizes and local conditions. Advantages of medical physics departments in terms of efficiencies gained are also explained and quantified. Conclusions. The IAEA Human Health Reports No. 15 (endorsed by IOMP) contains a comprehensive method for the estimation of the number of medical physicists needed to ensure safe, effective and efficient diagnostic imaging and radionuclide treatment of patients. The algorithm described in this guidance document has been tested under a variety of field conditions. An accompanying spreadsheet is also available to facilitate calculations of the staffing needs following these recommendations. https://doi.org/10.1016/j.ejmp.2018.06.255
[I184] Benefits of MRI for radiation therapy Heinz-Peter Schlemmer * Dkfz, Heidelberg, Germany Corresponding author.
⇑
The treatment success of radiotherapy depends on the capability of imaging to precisely localize and delineate the tumor including its biological and functional heterogeneity. Advances of radiation therapy are therefore intrinsically and inevitably linked to advances of imaging for visualizing individual morphologic, functional and molecular tumor characteristics with high spatial and temporal resolution. In order to achieve optimized tumor control and to minimize side effects 3D/4D treatment planning, guidance, and
Abstracts / Physica Medica 52 (2018) 1–98
addresses ascertaining exposure information for individual patients for error investigation and tracking exposure history for individualized justification and optimization. In addition to metrology and analysis, the document will offer description of electronic and manual strategies for data management and workflow, as well as the needed features, access, and interface for effective utilization of patient exposure data monitoring systems, considering the needs and constraints of less-resourced countries. Conclusions. It is expected that the publication will support the implementation of the BSS requirements. https://doi.org/10.1016/j.ejmp.2018.06.253
[I182] Dosimetry in radiopharmaceutical therapy Manuel Bardies * Centre de Recherches En Cancérologie de Toulouse, Université Toulouse III - Paul Sabatier, Inserm, Umr1037 Crct, Toulouse, France ⇑ Corresponding author. Purpose. EFOMP-IAEA collaboration in the field of Nuclear Medicine dosimetry is very active. Amongst other activities, the collaboration to disseminate knowledge can be seen in the IAEA support of ESMPE lectures in Prague, and EFOMP participation to ICTP-IAEA courses. In addition, EFOMP supports the IAEA project of a book focused on Molecular Radiotherapy dosimetry. The IAEA recently launched a Coordinated Research Project (CRP E2.30.05) on ‘‘Dosimetry in Radiopharmaceutical Therapy for personalized patient treatment” to support the standardization and dissemination of dosimetric methods in nuclear medicine therapy. The CRP will assist Member States in testing and adopting harmonized dosimetric protocols and to assess the typical accuracy with which dosimetry can be reached in nuclear medicine practice. Methods. Within the CRP, Common activities will aim at: 1. Identify software and analysis methods appropriate for dosimetry of RPT. 2. Perform all the tasks needed to estimate tumour and normal organ absorbed doses on clinical and simulated data sets 3. Provide a written report, identifying the most challenging steps, or those that are subject to the greatest uncertainty. 4. Select one or more patient cases for whom dosimetry has been calculated at all the participating sites and assess the variability in absorbed dose determination. 5. Help disseminate each site’s experience, producing teaching material and tutorial documents on dosimetry for molecular radiotherapy based on the experience gained during the CRP. Conclusions. The Call for Proposals, which included tentative research topics and the scoring methodology, was extensively advertised for CRP participants. Among the 33 research projects proposals received, 10 participating institutions have been selected from Colombia, Croatia, Cuba, France, India, Indonesia, South Africa and USA. The project has a 4 years duration, and the first Research Coordination Meeting took place in November 2017. All participants are currently working to derive the dosimetry of a set of clinical images. Discussions between participants are ongoing to define the prerequisite for the generation of simulated datasets. https://doi.org/10.1016/j.ejmp.2018.06.254
[I183] Guidelines for medical physics staffing requirements in diagnistic imaging and radionuclide therapy Gian Luca Poli a,*, Harry Delis a, Marco Brambilla b, Soren Holm c, Melissa C. Martin d, Donald McLean e
a
Iaea, Dosimetry and Medical Radiation Physics, Vienna, Austria University Hospital ‘‘Maggiore Della Carità”, Medical Physics, Novara, Italy c Rigshospitalet, University Hospital Copenhagen, 3982 Clinical Physiology, Nuclear Medicine and Pet, Copenhagen, Denmark d Therapy Physics, Signal Hill, Ca, United States e The Canberra Hospital, Medical Physics and Radiation Engineering, Camberra, Australia ⇑ Corresponding author. b
Purpose. Over the last decades, the rapid technological development of diagnostic and interventional radiology and nuclear medicine has made them major tools of modern medicine. However, at the same time, the involved risks, the growing number of procedures and the increasing complexity of the procedures require competent professional staff to ensure safe and effective patient diagnosis, treatment and management. Medical physicists have been recognized as vital health professionals with important and clear responsibilities related to quality and safety of applications of ionizing radiation in medicine. The aim of the IAEA Human Health Reports No. 15 is to provide guidance on appropriate staffing levels to support medical physics services in medical imaging and radionuclide therapy. Methods. The roles and responsibilities of the medical physicist defined in international guidelines are the basis for different elements of the IAEA staffing algorithm. The components of the algorithm include input variables and weighting factors, with the output being the number of medical physicists (FTE) needed to deliver the service. To ensure the general applicability of the algorithm, a survey has been used to test it and obtain feedback from medical physicists throughout the world, representing different regions and different country health care levels. Results. The IAEA staffing algorithm calculates the total number of medical physicists required by considering factor which are equipment dependent, patient dependent, radiation protection related, service related, training related and academic teaching and research related. This approach allows the needed flexibility to give appropriate staffing levels over a wide range of facility sizes and local conditions. Advantages of medical physics departments in terms of efficiencies gained are also explained and quantified. Conclusions. The IAEA Human Health Reports No. 15 (endorsed by IOMP) contains a comprehensive method for the estimation of the number of medical physicists needed to ensure safe, effective and efficient diagnostic imaging and radionuclide treatment of patients. The algorithm described in this guidance document has been tested under a variety of field conditions. An accompanying spreadsheet is also available to facilitate calculations of the staffing needs following these recommendations. https://doi.org/10.1016/j.ejmp.2018.06.255
[I184] Benefits of MRI for radiation therapy Heinz-Peter Schlemmer * Dkfz, Heidelberg, Germany Corresponding author.
⇑
The treatment success of radiotherapy depends on the capability of imaging to precisely localize and delineate the tumor including its biological and functional heterogeneity. Advances of radiation therapy are therefore intrinsically and inevitably linked to advances of imaging for visualizing individual morphologic, functional and molecular tumor characteristics with high spatial and temporal resolution. In order to achieve optimized tumor control and to minimize side effects 3D/4D treatment planning, guidance, and