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ID 389 – Studies of neuronal circuits underlying information processing through late P300 event-related potentials in rats
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Abstracts / Clinical Neurophysiology 127 (2016) e18–e132
to symmetric ISPAPB. Mu TRD during bimanual performance also became symmetric, more focal and of lower amplitude than in pre-training, owing to decreased activity over ventral premotor cortices. These bilateral modifications correlated with keyboard performance and NHPT scores. No performance or neurohysiological changes were evidenced in controls. Conclusions: A 10-day piano-training was associated with rebalanced interhemispheric interactions both at rest and during motor activation. Key message: Piano training, in a short timeframe, may reshape local and inter-hemispheric motor cortical circuits. doi:10.1016/j.clinph.2015.11.321
deflection of the event related potential (ERP) over the posterior cortex. In order to reveal more details on the relationship between visual working memory and the slow ERP negativity, we adopted a wellestablished mental rotation paradigm. It has been demonstrated in previous studies that the slow negative wave recorded in this task (termed mental rotation related negativity, RRN) increases with increasing angular deviation of stimuli, i.e. angle of mental rotation. Our investigations show that RRN reflects individual task performance, but only if the ERP is calculated by averaging signals time locked to the response, not stimulus onset. Furthermore, we found that RRN is related to mental manipulation of a visual image rather than its retention in short-term memory. These findings are a step forward in elucidating brain mechanisms of visual working memory. Supported by VEGA Grants 2/0080/13 and 2/0093/14. doi:10.1016/j.clinph.2015.11.323
ID 389 – Studies of neuronal circuits underlying information processing through late P300 event-related potentials in rats—A. Ahnaou, R. Biermans, C. Pett, J.A. Kemp, W.H. Drinkenburg (Dept. of Neurosciences, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium) Cognitive event related potentials (ERPs) and oscillations synchrony (EROS) provide a powerful tool for studying brain’s synaptic function underlying information processing. The P300 component of ERPs indexing attention and working memory is altered in neurologic and psychiatric diseases, and is sensitive to pharmacological agents. Here, we investigated whether the P300-like potentials can be generated in rats performing an active auditory discriminant task, and to what extent this response is sensitive to modulation of the cholinergic neurotransmission. In the active oddball paradigm, behavior and auditory evoked potentials (AEPs) were simultaneously recorded in rats as they were presented with frequent non-target and rare target tones during baseline conditions and following the administration of donepezil and scopolamine. Rats that consistently discriminate target tones showed P300 peaks with early and late components. Donepezil enhanced P300 amplitude and evoked theta/gamma oscillations to target tones and attenuated scopolamine-induced deficits in behavioral and AEPs/EROS. We demonstrate that P300-like response can be elicited by rats engaged in stimulus discrimination processing and outline the relevance of the cholinergic system in this response. The AEP P300 paradigm is valuable for characterizing targets and/or drugs that may contribute to facilitation and/or suppression of synaptic responses underlying early and late P300 components. doi:10.1016/j.clinph.2015.11.322
ID 427 – Morphological and functional markers of visual processing in clinically isolated syndrome: correlation study—J. Kremlácˇek a,b, V. Lehká b, Z. Pavelek b, J. Langrová a,b, M. Vališ b (a Department of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Králové, Czech Republic, b Department of Neurology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic) We explored morphological as well as functional and clinical markers of the vision processing in a cross-sectional study of subjects with Clinically Isolated Syndrome (CIS), often an early stage of the multiple sclerosis. Eighteen subjects (28 [19–47] years, 13 females) were examined within 3 years from the event. Recorded was RNFL thickness, pattern-reversal and motion-onset VEPs (P-VEPs and M-VEPs), low and high contrast Visual Acuity (VA). While the better eyes exhibited the only relevant correlation between age and latency of M-VEPs (r = 0.59, p = 0.012), the worse eyes exhibited also correlation between the disease duration and latency of P-VEPs (r = 0.66, p = 0.004) and M-VEPs (r = 0.54, p = 0.021). Correlations of functional and clinical parameters to an average thickness of the RNFL or to the EDSS did not pass the significance level. In a pilot group of 18 CIS patients we did not find any relationship between clinical parameters and the RNFL, while the functional markers (P-VEP and M-VEP) correlated to the disease duration and seemingly paradoxically improved with the time. These findings confirm superior sensitivity of the functional examination. doi:10.1016/j.clinph.2015.11.324
ID 413 – Event related potential signatures of visual working memory—I. Riecˇansky´ (Laboratory of Cognitive Neuroscience, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovakia, Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria) Visual working memory enables us to hold and manipulate visual information in mind. It is a major challenge for cognitive neuroscience to reveal how this important cognitive process is accomplished by the brain. Electrophysiological investigations in humans show that engagement of visual working memory elicits a slow negative
ID 430 – The value of the P300 event related potential in the ischemic stroke—M. Dejanovic a, V. Ivetic b, V. Nestorovic a, Z. Milanovic a, M. Miric a (a Department of Physiology, Faculty of Medicine, University of Pristina, Kosovska Mitrovica, Serbia, b Laboratory of Neurophysiology, Department of Physiology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia) Objective: So far, only little is known about the impact of stroke on Event Related Potentials. The aim of this prospective study was to
Abstracts / Clinical Neurophysiology 127 (2016) e18–e132
to symmetric ISPAPB. Mu TRD during bimanual performance also became symmetric, more focal and of lower amplitude than in pre-training, owing to decreased activity over ventral premotor cortices. These bilateral modifications correlated with keyboard performance and NHPT scores. No performance or neurohysiological changes were evidenced in controls. Conclusions: A 10-day piano-training was associated with rebalanced interhemispheric interactions both at rest and during motor activation. Key message: Piano training, in a short timeframe, may reshape local and inter-hemispheric motor cortical circuits. doi:10.1016/j.clinph.2015.11.321
deflection of the event related potential (ERP) over the posterior cortex. In order to reveal more details on the relationship between visual working memory and the slow ERP negativity, we adopted a wellestablished mental rotation paradigm. It has been demonstrated in previous studies that the slow negative wave recorded in this task (termed mental rotation related negativity, RRN) increases with increasing angular deviation of stimuli, i.e. angle of mental rotation. Our investigations show that RRN reflects individual task performance, but only if the ERP is calculated by averaging signals time locked to the response, not stimulus onset. Furthermore, we found that RRN is related to mental manipulation of a visual image rather than its retention in short-term memory. These findings are a step forward in elucidating brain mechanisms of visual working memory. Supported by VEGA Grants 2/0080/13 and 2/0093/14. doi:10.1016/j.clinph.2015.11.323
ID 389 – Studies of neuronal circuits underlying information processing through late P300 event-related potentials in rats—A. Ahnaou, R. Biermans, C. Pett, J.A. Kemp, W.H. Drinkenburg (Dept. of Neurosciences, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium) Cognitive event related potentials (ERPs) and oscillations synchrony (EROS) provide a powerful tool for studying brain’s synaptic function underlying information processing. The P300 component of ERPs indexing attention and working memory is altered in neurologic and psychiatric diseases, and is sensitive to pharmacological agents. Here, we investigated whether the P300-like potentials can be generated in rats performing an active auditory discriminant task, and to what extent this response is sensitive to modulation of the cholinergic neurotransmission. In the active oddball paradigm, behavior and auditory evoked potentials (AEPs) were simultaneously recorded in rats as they were presented with frequent non-target and rare target tones during baseline conditions and following the administration of donepezil and scopolamine. Rats that consistently discriminate target tones showed P300 peaks with early and late components. Donepezil enhanced P300 amplitude and evoked theta/gamma oscillations to target tones and attenuated scopolamine-induced deficits in behavioral and AEPs/EROS. We demonstrate that P300-like response can be elicited by rats engaged in stimulus discrimination processing and outline the relevance of the cholinergic system in this response. The AEP P300 paradigm is valuable for characterizing targets and/or drugs that may contribute to facilitation and/or suppression of synaptic responses underlying early and late P300 components. doi:10.1016/j.clinph.2015.11.322
ID 427 – Morphological and functional markers of visual processing in clinically isolated syndrome: correlation study—J. Kremlácˇek a,b, V. Lehká b, Z. Pavelek b, J. Langrová a,b, M. Vališ b (a Department of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Králové, Czech Republic, b Department of Neurology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic) We explored morphological as well as functional and clinical markers of the vision processing in a cross-sectional study of subjects with Clinically Isolated Syndrome (CIS), often an early stage of the multiple sclerosis. Eighteen subjects (28 [19–47] years, 13 females) were examined within 3 years from the event. Recorded was RNFL thickness, pattern-reversal and motion-onset VEPs (P-VEPs and M-VEPs), low and high contrast Visual Acuity (VA). While the better eyes exhibited the only relevant correlation between age and latency of M-VEPs (r = 0.59, p = 0.012), the worse eyes exhibited also correlation between the disease duration and latency of P-VEPs (r = 0.66, p = 0.004) and M-VEPs (r = 0.54, p = 0.021). Correlations of functional and clinical parameters to an average thickness of the RNFL or to the EDSS did not pass the significance level. In a pilot group of 18 CIS patients we did not find any relationship between clinical parameters and the RNFL, while the functional markers (P-VEP and M-VEP) correlated to the disease duration and seemingly paradoxically improved with the time. These findings confirm superior sensitivity of the functional examination. doi:10.1016/j.clinph.2015.11.324
ID 413 – Event related potential signatures of visual working memory—I. Riecˇansky´ (Laboratory of Cognitive Neuroscience, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovakia, Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria) Visual working memory enables us to hold and manipulate visual information in mind. It is a major challenge for cognitive neuroscience to reveal how this important cognitive process is accomplished by the brain. Electrophysiological investigations in humans show that engagement of visual working memory elicits a slow negative
ID 430 – The value of the P300 event related potential in the ischemic stroke—M. Dejanovic a, V. Ivetic b, V. Nestorovic a, Z. Milanovic a, M. Miric a (a Department of Physiology, Faculty of Medicine, University of Pristina, Kosovska Mitrovica, Serbia, b Laboratory of Neurophysiology, Department of Physiology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia) Objective: So far, only little is known about the impact of stroke on Event Related Potentials. The aim of this prospective study was to