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Identification of an at risk group for osteoporosis using heel ultrasound measurement in primary care
320
Abstracts
Bone Vol. 17, No. 3 September 1995:315c331
identified We have screened two human or&o&stoma libraries using & sequence derived probes; pot sequence containing clones have yet to be identified. Southern blot analysis of human and rabbit genomic DNA and northern blotting of human tissues revealed identical banding patterns between pot and 81. This suggests that pot may be an alternatively spliced variant of 81. PCR analysis of genomic DNA and Bl genomic clones using universal and sequence-specific primers is being applied to test this possibility.
of an at risk group for cetcoporosis using heel in primary care P Thompson, J Taylor, J Newth, A Fisher, D Rogers, C Jones Osteoporosis Dorset, Shelley Road, Bournemouth, BHI 4]Q 05. Identification
ultrasound
mclsunment
All women between 45 and 75 years registered in 2 practices were sent a letter inviting them to complete a questionnaire and attend for heel ultrasound (Us) measurement (Lunar Achilles). The results of the questionnaire were compared for the lowest 10% and the highest 90% of age adjusted stiffness (CM squared). The demographic characteristic of both practices were similar so the results were pooled. Of the 4018 women identified, 79% were scanned, 13% defaulted, 6% percent declined and 2% were untraceable. The distribution of the results for age adjusted stiffness were normal with a mean (SD) of 98(18)% The lowest 10% of women more frequently reported past history of fractures over 45 years (31% vs 1396, p
06.
‘Ilw effects of oral disodium pamidronate on bone density in postmenopausal women B Lees, SW Garland, MI Whitehead*, JC Stevenson Wynn Institute for Metabolic Research, 21 Wellington Road, London, NW8 9SQ and *Menopause Clinic, King’s College Hospital, London, SE5 8RX
The aim of this randomised double-blind study was to determine if oral disodium pamidronate (AI’D) can prevent bone loss in the lumbar spine (LS) and proximal femur (PF) of healthy postmenopausal women. 130 women (meantiD age 58*4 years; meanj5D time since menopause 90&42 months) were randomised into three groups. Group A received 4 weeks APD 008mg/day), no treatment for 4 weeks, followed by 4 weeks of placebo capsules then no treatment for 4 weeks. Group B received 4 weeks APD (15Omg/day), no treatment for 4 weeks, followed by 4 weeks APD fEOmg/day) then no treatment for 4 weeks. Group C received placebo capsules for 4 weeks, no treatment for 4 weeks, followed by placebo capsules for 4 weeks and then no treatment for 4 weeks. Six 16 week cycles were undertaken. Bone mineral density measurements (BMD) of the LS and PF were made at baseline and at 6 month intervals throughout the study using dual-energy X-ray absorptiometry (Lunar DPX). LS BMD fL2-L4) increased significantly compared to baseline in groups A and B after 2 years of treatment (mean&D 3.Of2.2% and 3.Of2.9% respectively, both p
07. Vitamin D receptor alleles, bone mineral density and osteopomtic fracture: studies in a UK population LA Houston, SFA Grant, DM Reid, SH Ralston Department of Medicine and Therapeutics, Polwarth Building, University of Aberdeen, Aberdeen Polymorphisms in the vitamin D receptor (VDR) gene have been shown to correlate with bone density (BMD) in some, but not all populations. We investigated the relationship between VDR alleles, BMD and osteoporotic fracture in a UK population. Three plrouus were studied; women with osteonorotic vertebral fracture (nz38; man age 6i) yrs), non-osteopor&c age-matched controls (n=35; mean age 65 yrs) and healthy perimenopausal women, drawn at random from the population fn=59; mean aged 50 years). VDR genotyping was by PCR with 8smI digest as described by Morrison et al (Nature 1994). Distribution of VDR alleles did not differ significantly in osteoporotic women, compared with age matched controls without osteoporosis (Table). control csteoporotic BB 5 (14.3%) 8 (21.0%) Bb 17 (48.6%) 15 (39.5%) tb 13 (37.1%) 15 (39.5%) Furthermore, we found no significant relationship between VDR alleles and BMD in these women (data not shown). In agreement with the data of Morrison et al, we confirmed that BB individuals in the perimenopausal age group tended to have had slightly reduced bone density compared with bb/Bb individuals (BMD; median Z score = -0.11 (BB) vs +0.05 @b/b); p=ns). Our findings would be consistent with a model whereby VDR alleles exert a weak effect on peak BMD. The lack of correlation between VDR alleles and BMD or osteoporotic fracture in older women suggest that the main effect is on peak ’BMD rather than rate of bone loss.
Abstracts
Bone Vol. 17, No. 3 September 1995:315c331
identified We have screened two human or&o&stoma libraries using & sequence derived probes; pot sequence containing clones have yet to be identified. Southern blot analysis of human and rabbit genomic DNA and northern blotting of human tissues revealed identical banding patterns between pot and 81. This suggests that pot may be an alternatively spliced variant of 81. PCR analysis of genomic DNA and Bl genomic clones using universal and sequence-specific primers is being applied to test this possibility.
of an at risk group for cetcoporosis using heel in primary care P Thompson, J Taylor, J Newth, A Fisher, D Rogers, C Jones Osteoporosis Dorset, Shelley Road, Bournemouth, BHI 4]Q 05. Identification
ultrasound
mclsunment
All women between 45 and 75 years registered in 2 practices were sent a letter inviting them to complete a questionnaire and attend for heel ultrasound (Us) measurement (Lunar Achilles). The results of the questionnaire were compared for the lowest 10% and the highest 90% of age adjusted stiffness (CM squared). The demographic characteristic of both practices were similar so the results were pooled. Of the 4018 women identified, 79% were scanned, 13% defaulted, 6% percent declined and 2% were untraceable. The distribution of the results for age adjusted stiffness were normal with a mean (SD) of 98(18)% The lowest 10% of women more frequently reported past history of fractures over 45 years (31% vs 1396, p
06.
‘Ilw effects of oral disodium pamidronate on bone density in postmenopausal women B Lees, SW Garland, MI Whitehead*, JC Stevenson Wynn Institute for Metabolic Research, 21 Wellington Road, London, NW8 9SQ and *Menopause Clinic, King’s College Hospital, London, SE5 8RX
The aim of this randomised double-blind study was to determine if oral disodium pamidronate (AI’D) can prevent bone loss in the lumbar spine (LS) and proximal femur (PF) of healthy postmenopausal women. 130 women (meantiD age 58*4 years; meanj5D time since menopause 90&42 months) were randomised into three groups. Group A received 4 weeks APD 008mg/day), no treatment for 4 weeks, followed by 4 weeks of placebo capsules then no treatment for 4 weeks. Group B received 4 weeks APD (15Omg/day), no treatment for 4 weeks, followed by 4 weeks APD fEOmg/day) then no treatment for 4 weeks. Group C received placebo capsules for 4 weeks, no treatment for 4 weeks, followed by placebo capsules for 4 weeks and then no treatment for 4 weeks. Six 16 week cycles were undertaken. Bone mineral density measurements (BMD) of the LS and PF were made at baseline and at 6 month intervals throughout the study using dual-energy X-ray absorptiometry (Lunar DPX). LS BMD fL2-L4) increased significantly compared to baseline in groups A and B after 2 years of treatment (mean&D 3.Of2.2% and 3.Of2.9% respectively, both p
07. Vitamin D receptor alleles, bone mineral density and osteopomtic fracture: studies in a UK population LA Houston, SFA Grant, DM Reid, SH Ralston Department of Medicine and Therapeutics, Polwarth Building, University of Aberdeen, Aberdeen Polymorphisms in the vitamin D receptor (VDR) gene have been shown to correlate with bone density (BMD) in some, but not all populations. We investigated the relationship between VDR alleles, BMD and osteoporotic fracture in a UK population. Three plrouus were studied; women with osteonorotic vertebral fracture (nz38; man age 6i) yrs), non-osteopor&c age-matched controls (n=35; mean age 65 yrs) and healthy perimenopausal women, drawn at random from the population fn=59; mean aged 50 years). VDR genotyping was by PCR with 8smI digest as described by Morrison et al (Nature 1994). Distribution of VDR alleles did not differ significantly in osteoporotic women, compared with age matched controls without osteoporosis (Table). control csteoporotic BB 5 (14.3%) 8 (21.0%) Bb 17 (48.6%) 15 (39.5%) tb 13 (37.1%) 15 (39.5%) Furthermore, we found no significant relationship between VDR alleles and BMD in these women (data not shown). In agreement with the data of Morrison et al, we confirmed that BB individuals in the perimenopausal age group tended to have had slightly reduced bone density compared with bb/Bb individuals (BMD; median Z score = -0.11 (BB) vs +0.05 @b/b); p=ns). Our findings would be consistent with a model whereby VDR alleles exert a weak effect on peak BMD. The lack of correlation between VDR alleles and BMD or osteoporotic fracture in older women suggest that the main effect is on peak ’BMD rather than rate of bone loss.